Solute carrier family 22 member 7

A solute carrier family 22 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y694]

Synonyms

Novel liver transporter;
Organic anion transporter 2;
hOAT2

Research

Bioassay Publications (6)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
probenecid	Homo sapiens (human)	IC50	668.0000	1	1
probenecid	Homo sapiens (human)	Ki	766.0000	1	1
cephaloridine	Homo sapiens (human)	IC50	4,480.0000	1	1
cephalothin	Homo sapiens (human)	IC50	1,410.0000	1	1
cefoperazone	Homo sapiens (human)	IC50	1,330.0000	1	1
pravastatin	Homo sapiens (human)	IC50	352.0000	1	1
cefamandole	Homo sapiens (human)	IC50	1,570.0000	1	1
cefotaxime	Homo sapiens (human)	IC50	4,680.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
zidovudine	Homo sapiens (human)	Km	26.8000	1	1
dinoprostone	Homo sapiens (human)	Km	0.7130	1	1
dinoprost	Homo sapiens (human)	Km	0.4250	1	1
tetracycline	Homo sapiens (human)	Km	439.9000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]
prostaglandin transmembrane transporter activity	molecular function	Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai]
alpha-ketoglutarate transmembrane transporter activity	molecular function	Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]
sodium-independent organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]
transmembrane transporter activity	molecular function	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
organic anion transport	biological process	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]
prostaglandin transport	biological process	The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
alpha-ketoglutarate transport	biological process	The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]