protoporphyrin ix has been researched along with Necrosis in 22 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the potential use of 5-aminolevulinic acid (5-ALA, 5-amino-4-oxovaleric acid) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) of nasopharyngeal carcinoma (NPC) and its related mechanisms of inducing cell death." | 7.71 | In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Lai, JP; Leunig, A; Stepp, H; Xiang, W, 2002) |
| " Treatment with 2500 ppm ACI for 26 weeks after initiation with diethylnitrosamine increased the incidence and multiplicities of altered foci and adenomas in hepatocytes from WT mice; these effects were significantly reduced in CARKO mice." | 3.83 | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2016) |
| "In this study, we evaluated the in vitro cytotoxic effect of PDT at 5J/cm(2) and 10J/cm(2) of red light (633 ± 3nm) using 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) with and without DW, on keloid fibroblasts compared to normal skin fibroblasts." | 3.77 | Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy. ( Allan, D; Allan, E; Bayat, A; Colthurst, J; Sebastian, A, 2011) |
| "The purpose of this study was to investigate the potential use of 5-aminolevulinic acid (5-ALA, 5-amino-4-oxovaleric acid) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) of nasopharyngeal carcinoma (NPC) and its related mechanisms of inducing cell death." | 3.71 | In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Lai, JP; Leunig, A; Stepp, H; Xiang, W, 2002) |
| "Malignant melanoma is an aggressive skin cancer with poor survival outcomes for patients diagnosed at an advanced stage." | 1.56 | Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma. ( Burnett, K; Callan, B; Callan, JF; Dhillon, SK; Matin, RN; McHale, AP; McKaig, T; Nesbitt, H; Porter, SL; Rizk, N; Sheng, Y; White, B, 2020) |
| "Protoporphyrin IX (PpIX) has wide applications in photodynamic diagnosis and photodynamic therapy (PDT) in many human diseases." | 1.43 | Enhanced cellular uptake of protoporphyrine IX/linolenic acid-conjugated spherical nanohybrids for photodynamic therapy. ( Kim, YJ; Lee, HI, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Dhillon, SK | 1 |
| Porter, SL | 1 |
| Rizk, N | 1 |
| Sheng, Y | 1 |
| McKaig, T | 1 |
| Burnett, K | 1 |
| White, B | 1 |
| Nesbitt, H | 1 |
| Matin, RN | 1 |
| McHale, AP | 1 |
| Callan, B | 1 |
| Callan, JF | 1 |
| Erkkilä, MT | 1 |
| Reichert, D | 1 |
| Gesperger, J | 1 |
| Kiesel, B | 1 |
| Roetzer, T | 1 |
| Mercea, PA | 1 |
| Drexler, W | 1 |
| Unterhuber, A | 1 |
| Leitgeb, RA | 1 |
| Woehrer, A | 1 |
| Rueck, A | 1 |
| Andreana, M | 1 |
| Widhalm, G | 1 |
| Guo, S | 2 |
| Sun, X | 2 |
| Cheng, J | 1 |
| Xu, H | 2 |
| Dan, J | 2 |
| Shen, J | 1 |
| Zhou, Q | 1 |
| Zhang, Y | 2 |
| Meng, L | 1 |
| Cao, W | 1 |
| Tian, Y | 2 |
| Yamamoto, J | 1 |
| Ogura, S | 1 |
| Shimajiri, S | 1 |
| Nakano, Y | 1 |
| Akiba, D | 1 |
| Kitagawa, T | 1 |
| Ueta, K | 1 |
| Tanaka, T | 1 |
| Nishizawa, S | 1 |
| Sun, Y | 1 |
| Wang, W | 1 |
| Yao, J | 1 |
| Chen, H | 1 |
| Tian, F | 1 |
| Tian, Z | 1 |
| Kuwata, K | 1 |
| Inoue, K | 1 |
| Ichimura, R | 1 |
| Takahashi, M | 1 |
| Kodama, Y | 1 |
| Shibutani, M | 1 |
| Yoshida, M | 1 |
| Lee, HI | 1 |
| Kim, YJ | 1 |
| Salas-Garcia, I | 1 |
| Fanjul-Velez, F | 1 |
| Ortega-Quijano, N | 1 |
| Arce-Diego, JL | 1 |
| Kim, CH | 1 |
| Chung, CW | 1 |
| Choi, KH | 1 |
| Yoo, JJ | 1 |
| Kim, DH | 1 |
| Jeong, YI | 1 |
| Kang, DH | 1 |
| Sebastian, A | 1 |
| Allan, E | 1 |
| Allan, D | 1 |
| Colthurst, J | 1 |
| Bayat, A | 1 |
| Verwanger, T | 1 |
| Sanovic, R | 1 |
| Aberger, F | 1 |
| Frischauf, AM | 1 |
| Krammer, B | 1 |
| Betz, CS | 1 |
| Lai, JP | 1 |
| Xiang, W | 1 |
| Janda, P | 1 |
| Heinrich, P | 1 |
| Stepp, H | 1 |
| Baumgartner, R | 1 |
| Leunig, A | 1 |
| Robinson, DJ | 1 |
| de Bruijn, HS | 1 |
| Star, WM | 2 |
| Sterenborg, HJ | 1 |
| Wild, PJ | 1 |
| Krieg, RC | 1 |
| Seidl, J | 1 |
| Stoehr, R | 1 |
| Reher, K | 1 |
| Hofmann, C | 1 |
| Louhelainen, J | 1 |
| Rosenthal, A | 1 |
| Hartmann, A | 1 |
| Pilarsky, C | 1 |
| Bosserhoff, AK | 1 |
| Knuechel, R | 1 |
| Sol, V | 1 |
| Lamarche, F | 1 |
| Enache, M | 1 |
| Garcia, G | 1 |
| Granet, R | 1 |
| Guilloton, M | 1 |
| Blais, JC | 1 |
| Krausz, P | 1 |
| Grant, WE | 1 |
| Hopper, C | 1 |
| MacRobert, AJ | 2 |
| Speight, PM | 2 |
| Bown, SG | 3 |
| van der Veen, N | 1 |
| van Leengoed, HL | 1 |
| Fromm, D | 1 |
| Kessel, D | 1 |
| Webber, J | 1 |
| Noodt, BB | 1 |
| Berg, K | 1 |
| Stokke, T | 1 |
| Peng, Q | 1 |
| Nesland, JM | 1 |
| Kleemann, D | 1 |
| Mentzel, T | 1 |
| Curnow, A | 1 |
| Haller, JC | 1 |
| Papenbrock, J | 1 |
| Mishra, S | 1 |
| Mock, HP | 1 |
| Kruse, E | 1 |
| Schmidt, EK | 1 |
| Petersmann, A | 1 |
| Braun, HP | 1 |
| Grimm, B | 1 |
22 other studies available for protoporphyrin ix and Necrosis
| Article | Year |
|---|---|
Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Melanoma; | 2020 |
Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Levulinic Acids; NAD; Necrosis; N | 2020 |
Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cytoskeleton; Humans; Macrophages; Necrosis; Protoporphy | 2013 |
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, | 2015 |
Protoporphyrin IX induces a necrotic cell death in human THP-1 macrophages through activation of reactive oxygen species/c-Jun N-terminal protein kinase pathway and opening of mitochondrial permeability transition pore.
Topics: Anthracenes; Cell Death; Cell Line; Cell Survival; Humans; JNK Mitogen-Activated Protein Kinases; Ma | 2014 |
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cell Transformation, Neoplastic | 2016 |
Enhanced cellular uptake of protoporphyrine IX/linolenic acid-conjugated spherical nanohybrids for photodynamic therapy.
Topics: alpha-Linolenic Acid; Apoptosis; Biological Transport; Cell Line, Tumor; Epithelial Cells; Humans; L | 2016 |
Photodynamic effects on basal cell carcinoma with topical Photosensitizer.
Topics: Administration, Topical; Carcinoma, Basal Cell; Dermatology; Humans; Monte Carlo Method; Necrosis; O | 2010 |
Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells.
Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Cell Line, Tumor; Cholangiocarcinoma; Flow Cytometry; Hu | 2011 |
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.
Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Blotting, Western; Case-Control Studies; Caspase 3; Cel | 2011 |
Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Enzyme Induction; Gene Expr | 2002 |
In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Scr | 2002 |
Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin.
Topics: Aminolevulinic Acid; Animals; Female; Kinetics; Mice; Mice, Hairless; Necrosis; Photochemotherapy; P | 2003 |
RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Catalysis; Cell C | 2005 |
Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: potential agents for photodynamic therapy of cancers.
Topics: Antineoplastic Agents; Dihematoporphyrin Ether; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Posi | 2006 |
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser The | 1993 |
In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations.
Topics: Aminolevulinic Acid; Animals; Drug Administration Schedule; Female; Fluorescence; Kinetics; Mammary | 1994 |
Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Biopsy; Colectomy; Colon, Sigmoid; Follow | 1996 |
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Criceti | 1996 |
Photodynamic therapy on the normal rabbit larynx with phthalocyanine and 5-aminolaevulinic acid induced protoporphyrin IX photosensitisation.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Indoles; Larynx; Male; Microscopy, F | 1996 |
Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes.
Topics: Aminolevulinic Acid; Animals; Colon; Female; Light; Monitoring, Physiologic; Necrosis; Oxygen; Photo | 2000 |
Impaired expression of the plastidic ferrochelatase by antisense RNA synthesis leads to a necrotic phenotype of transformed tobacco plants.
Topics: Cloning, Molecular; Ferrochelatase; Gene Expression Regulation, Enzymologic; Gene Expression Regulat | 2001 |