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Thymidine kinase, cytosolic
A thymidine kinase, cytosolic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04183]
Synonyms
EC 2.7.1.21
Research
Bioassay Publications (16)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
Compounds (28)
Drugs with Inhibition Measurements
Drugs with Other Measurements
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.Journal of medicinal chemistry, , Oct-25, Volume: 44, Issue:22, 2001
L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.Bioorganic & medicinal chemistry, , Apr-15, Volume: 15, Issue:8, 2007
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.Bioorganic & medicinal chemistry letters, , May-21, Volume: 11, Issue:10, 2001
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:11, 2007
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.Bioorganic & medicinal chemistry, , Apr-15, Volume: 15, Issue:8, 2007
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.Bioorganic & medicinal chemistry letters, , May-21, Volume: 11, Issue:10, 2001
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| thymidine kinase activity | molecular function | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. [EC:2.7.1.21] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| deoxyribonucleoside monophosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |
| thymidine metabolic process | biological process | The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators] |
| thymidine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators] |
| protein homotetramerization | biological process | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators] |
| DNA synthesis involved in mitotic DNA replication | biological process | Any DNA biosynthetic process that is involved in mitotic DNA replication. [GO_REF:0000060, GOC:TermGenie, PMID:16849602] |