Page last updated: 2024-08-07 23:12:33
Cytochrome P450 1A2
A cytochrome P450 1A2 that is encoded in the genome of rat. [OMA:P04799, PRO:DNx]
Synonyms
EC 1.14.14.1;
CYPIA2;
Cholesterol 25-hydroxylase;
Cytochrome P-448;
Cytochrome P-450d;
Cytochrome P450-D;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| melatonin | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| miconazole | Rattus norvegicus (Norway rat) | IC50 | 4.5500 | 1 | 1 |
| 4-ethynylbiphenyl | Rattus norvegicus (Norway rat) | Ki | 0.8700 | 1 | 1 |
| 9-ethynylphenanthrene | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | Ki | 57.4000 | 1 | 1 |
| osteum | Rattus norvegicus (Norway rat) | Ki | 16.7000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| niraparib | Rattus norvegicus (Norway rat) | EC50 | 0.0240 | 1 | 1 |
| niraparib | Rattus norvegicus (Norway rat) | EC50 | 0.0040 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenacetin | Rattus norvegicus (Norway rat) | Km | 16.0500 | 2 | 2 |
| phenacetin | Rattus norvegicus (Norway rat) | KmH | 8.7000 | 2 | 2 |
| lidocaine hydrochloride | Rattus norvegicus (Norway rat) | KmH | 2,881.0000 | 2 | 2 |
| niraparib | Rattus norvegicus (Norway rat) | EC90 | 0.2200 | 1 | 1 |
| niraparib | Rattus norvegicus (Norway rat) | EC90 | 0.0450 | 1 | 1 |