Lethal(3)malignant brain tumor-like protein 4

A lethal(3)malignant brain tumor-like protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NA19]

H-l(3)mbt-like protein 4;
L(3)mbt-like protein 4;
L3mbt-like 4

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bifemelane	Homo sapiens (human)	IC50	100.0000	1	1
chlorpheniramine	Homo sapiens (human)	IC50	100.0000	1	1
maprotiline	Homo sapiens (human)	IC50	100.0000	1	1
oxybutynin	Homo sapiens (human)	IC50	100.0000	1	1
(5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone	Homo sapiens (human)	IC50	39.5000	2	2
entecavir	Homo sapiens (human)	IC50	10.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
histone binding	molecular function	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 2 target(s):

Target	Category	Definition
chromatin organization	biological process	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]