Proteins > Chloroquine resistance transporter
Page last updated: 2024-08-08 00:17:00
Chloroquine resistance transporter
[no definition available]
Synonyms
PfCRT
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| verapamil | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 31.0000 | 3 | 3 |
| chlorpheniramine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 54.0000 | 1 | 1 |
| primaquine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 68.0000 | 1 | 1 |
| promethazine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 85.0000 | 1 | 1 |
| saquinavir | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 13.0000 | 2 | 2 |
Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.ACS medicinal chemistry letters, , May-08, Volume: 5, Issue:5, 2014
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012