Page last updated: 2024-12-07

n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride

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Description

N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride: structure given in first source; a lipid regulator [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131678
CHEMBL ID542103
SCHEMBL ID5973583
MeSH IDM0212874

Synonyms (38)

Synonym
nevanimibe hydrochloride [usan]
unii-tk694zfs57
133825-81-7
tk694zfs57 ,
pd 132301-2
n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride
n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hcl
pd132301-2
pd-132301-2
urea, n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)-, monohydrochloride
pd 132301-02
atr-101
atr-101 hydrochloride
pd132301-02
CHEMBL542103 ,
pd-132301 hydrochloride
nevanimibe hydrochloride
pd-132301-02
urea, n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)-, hydrochloride (1:1)
n-(2,6-bis(propan-2-yl)phenyl)-n'-((1-(4-(dimethylamino)phenyl) cyclopentyl)methyl)urea hydrochloride
SCHEMBL5973583
DTXSID10158389
133825-81-7 (hcl)
AKOS032954251
atr-101 hcl
nevanimibe hydrochloride (usan)
D11311
1-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-3-[2,6-di(propan-2-yl)phenyl]urea;hydrochloride
1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride
HY-100399A
CS-0018786
Q27289998
MS-28369
urea, n-[2,6-bis(1-methylethyl)phenyl]-n'-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-, hydrochloride (1:1)
atr101 hydrochloride
atr101 hydrochloridepd-132301 hydrochloride
urea, n-[2,6-bis(1-methylethyl)phenyl]-n inverted exclamation marka-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-, hydrochloride (1:1)
1[[1[4(dimethylamino)phenyl]cyclopentyl]methyl]3[2,6di(propan2yl)phenyl]urea hydrochloride
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Adenosine receptor A1Rattus norvegicus (Norway rat)IC50 (µMol)0.05200.00020.552110.0000AID31069
Acyl-CoA:cholesterol acyltransferase Oryctolagus cuniculus (rabbit)IC50 (µMol)0.05200.00600.98467.6000AID31069
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay IDTitleYearJournalArticle
AID172583Compound was evaluated in experiment 1 for change in non High density lipoprotein at the doses at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171573Compound was evaluated in experiment 1 for Change in High density lipoproteins at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID174757Percent change in total cholesterol in peanut oil (5.5%)-, cholic acid (0.3%)-, Cholesterol (1.5%)-fed rats after a single dose.1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171583Compound was evaluated in experiment 1 for Change in total cholesterol at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID179920Compound was evaluated in experiment 1 for High density lipoproteins at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171571Compound was evaluated in experiment 1 for Change in High density lipoproteins at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171574Compound was evaluated in experiment 1 for Change in High density lipoproteins at 3.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189410Compound was evaluated in experiment 2 for non High density lipoproteins at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID179922Compound was evaluated in experiment 1 for High density lipoproteins at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID172585Compound was evaluated in experiment 1 for change in non High density lipoprotein at the doses at 3.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID21340Solubility at, pH 7.41994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189406Compound was evaluated in experiment 1 for non High density lipoproteins at 3.0(mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171725Compound was evaluated in experiment 2 for Change in total cholesterol at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189952Compound was evaluated in experiment 2 for Total cholesterol at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171585Compound was evaluated in experiment 1 for Change in total cholesterol at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189404Compound was evaluated in experiment 1 for non High density lipoproteins at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID21339Solubility at, pH 4.01994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171586Compound was evaluated in experiment 1 for Change in total cholesterol at 3.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID179921Compound was evaluated in experiment 1 for High density lipoproteins at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID172590Compound was evaluated in experiment 2 for change in non High density lipoprotein at the doses at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189403Compound was evaluated in experiment 1 for non High density lipoproteins at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID172584Compound was evaluated in experiment 1 for change in non High density lipoprotein at the doses at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189947Compound was evaluated in experiment 1 for Total cholesterol at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171584Compound was evaluated in experiment 1 for Change in total cholesterol at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189946Compound was evaluated in experiment 1 for Total cholesterol at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID172586Compound was evaluated in experiment 1 for change in non High density lipoprotein at the doses at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189405Compound was evaluated in experiment 1 for non High density lipoproteins at 10 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171572Compound was evaluated in experiment 1 for Change in High density lipoproteins at 1.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID179923Compound was evaluated in experiment 1 for High density lipoproteins at 3.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189945Compound was evaluated in experiment 1 for Total cholesterol at 0.3 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID189948Compound was evaluated in experiment 1 for Total cholesterol at 3.0 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID21338Solubility at, 0.1 N HCl1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID171578Compound was evaluated in experiment 2 for Change in High density lipoproteins at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID31069Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
AID180063Compound was evaluated in experiment 2 for High density lipoproteins at 30 (mg/kg) dose1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (61.54)18.2507
2000's0 (0.00)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.61 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]