Taste receptor type 2 member 46

A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540]

T2R46;
Taste receptor type 2 member 54;
T2R54

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
isoproterenol	Homo sapiens (human)	EC50	0.0049	1
strychnine	Homo sapiens (human)	EC50	0.6900	1
costunolide	Homo sapiens (human)	EC50	8.6000	1
dextromethorphan	Homo sapiens (human)	EC50	31.0000	1

This protein enables 2 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
bitter taste receptor activity	molecular function	Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
ciliary membrane	cellular component	The portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph]

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is involved in 2 target(s):

Target	Category	Definition
detection of chemical stimulus involved in sensory perception of bitter taste	biological process	The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]