Bcl-2-like protein 1

A Bcl-2-like protein 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q07817]

Synonyms

Bcl2-L-1;
Apoptosis regulator Bcl-X

Research

Bioassay Publications (73)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (16.44)	29.6817
2010's	49 (67.12)	24.3611
2020's	12 (16.44)	2.80

Compounds (35)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
oxamic acid	Homo sapiens (human)	IC50	1,243.1000	1	5
hoe 33342	Homo sapiens (human)	Ki	0.0009	1	1
chelerythrine	Homo sapiens (human)	IC50	100.0000	1	1
gossypol	Homo sapiens (human)	IC50	2.7840	5	10
gossypol	Homo sapiens (human)	Ki	0.6480	10	10
sanguinarine	Homo sapiens (human)	IC50	19.0000	1	1
paclitaxel	Homo sapiens (human)	GI50	10.0000	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	0.5900	1	1
benzo(b)thiophene-2-carboxylic acid	Homo sapiens (human)	Ki	230.0000	1	1
alexidine dihydrchloride	Homo sapiens (human)	IC50	18.3000	1	1
6-n-tridecylsalicylic acid	Homo sapiens (human)	Ki	0.2000	1	1
resveratrol	Homo sapiens (human)	IC50	190.0000	1	1
apogossypol	Homo sapiens (human)	IC50	4.3333	3	6
apogossypol	Homo sapiens (human)	Ki	2.8000	1	1
umi-77	Homo sapiens (human)	Ki	20.4200	2	2
thioguanine anhydrous	Homo sapiens (human)	GI50	183.0000	1	1
5,6-dehydrokawain	Homo sapiens (human)	Ki	23.0000	1	1
kendomycin	Homo sapiens (human)	IC50	12.3000	1	1
rehmannic acid	Homo sapiens (human)	Ki	100.0000	1	1
abt-737	Homo sapiens (human)	IC50	0.9279	18	22
abt-737	Homo sapiens (human)	Ki	0.0644	35	36
N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide	Homo sapiens (human)	IC50	6.5800	1	1
N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide	Homo sapiens (human)	Ki	1.1100	3	3
MI-63	Homo sapiens (human)	IC50	50.0000	1	1
marinopyrrole a	Homo sapiens (human)	IC50	37.4167	4	6
navitoclax	Homo sapiens (human)	IC50	0.0168	5	5
navitoclax	Homo sapiens (human)	Ki	0.0110	8	8
ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate	Homo sapiens (human)	Ki	1,236.0000	1	1
meiogynin a	Homo sapiens (human)	Ki	15.6000	3	4
abt-199	Homo sapiens (human)	IC50	0.4667	4	7
abt-199	Homo sapiens (human)	Ki	0.0346	7	7
jy-1-106	Homo sapiens (human)	IC50	0.3940	1	1
a-1155463	Homo sapiens (human)	IC50	0.0006	2	0
a-1155463	Homo sapiens (human)	Ki	0.0000	3	3
bm-1197	Homo sapiens (human)	Ki	0.0010	3	3
a-1331852	Homo sapiens (human)	Ki	0.0000	3	3
BDA-366	Homo sapiens (human)	Ki	0.5000	1	1
apogossypolone	Homo sapiens (human)	IC50	0.6450	2	2
apogossypolone	Homo sapiens (human)	Ki	0.5800	3	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
chlorcyclizine	Homo sapiens (human)	Kd	700.0000	1	1
gossypol	Homo sapiens (human)	Kd	169.8550	2	2
2-phenylphenol	Homo sapiens (human)	Kd	2,700.0000	1	1
4-phenylphenol	Homo sapiens (human)	Kd	6,000.0000	1	1
5,6,7,8-tetrahydro-1-naphthol	Homo sapiens (human)	Kd	4,300.0000	3	3
kendomycin	Homo sapiens (human)	Kd	1,179.0000	2	2
abt-737	Homo sapiens (human)	EC50	0.0233	3	3
abt-737	Homo sapiens (human)	Kd	0.0002	2	2
navitoclax	Homo sapiens (human)	Kd	0.0021	1	1
a-1155463	Homo sapiens (human)	EC50	0.0650	1	0
apogossypolone	Homo sapiens (human)	Kd	2.8000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
BH3 domain binding	molecular function	Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]
BH domain binding	molecular function	Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial outer membrane	cellular component	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
centrosome	cellular component	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
synaptic vesicle membrane	cellular component	The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrial outer membrane	cellular component	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
Bcl-2 family protein complex	cellular component	A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621]

Involved In

This protein is involved in 41 target(s):

Target	Category	Definition
ovarian follicle development	biological process	The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
release of cytochrome c from mitochondria	biological process	The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]
endocytosis	biological process	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]
germ cell development	biological process	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. [GOC:go_curators]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
male gonad development	biological process	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
apoptotic mitochondrial changes	biological process	The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis]
fertilization	biological process	The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:tb, ISBN:0198506732]
regulation of cytokinesis	biological process	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. [GOC:mah]
positive regulation of mononuclear cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
ectopic germ cell programmed cell death	biological process	Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. [PMID:12814944]
regulation of growth	biological process	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. [GOC:ems, GOC:mah]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of neuron apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
dendritic cell proliferation	biological process	The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, PMID:18469816]
response to cycloheximide	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. [GOC:ef, ISBN:0198506732]
regulation of mitochondrial membrane permeability	biological process	Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf]
epithelial cell proliferation	biological process	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. [ISBN:0721662544]
negative regulation of developmental process	biological process	Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]
neuron apoptotic process	biological process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
defense response to virus	biological process	Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
regulation of mitochondrial membrane potential	biological process	Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:ai]
cellular response to amino acid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]
cellular response to alkaloid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:mah]
cellular response to gamma radiation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:mah]
apoptotic process in bone marrow cell	biological process	The apoptotic process in cells in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, PMID:17063141]
negative regulation of release of cytochrome c from mitochondria	biological process	Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
dendritic cell apoptotic process	biological process	Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]
hepatocyte apoptotic process	biological process	Any apoptotic process in a hepatocyte, the main structural component of the liver. [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]
negative regulation of execution phase of apoptosis	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
negative regulation of protein localization to plasma membrane	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
negative regulation of reproductive process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. [GOC:mah]
negative regulation of dendritic cell apoptotic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]
negative regulation of intrinsic apoptotic signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
intrinsic apoptotic signaling pathway in response to DNA damage	biological process	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]
extrinsic apoptotic signaling pathway in absence of ligand	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]