ebselen has been researched along with Necrosis in 4 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with ebselen at oral doses from 10 to 100 mg/kg significantly inhibited such lesion formation induced by either necrotizing agent in a dose-related manner, and the inhibition at the highest dose (100 mg/kg p." | 1.28 | Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats. ( Akasaki, M; Kurebayashi, Y; Tabuchi, Y, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guérin, PJ | 1 |
| Gauthier, ER | 1 |
| Sata, N | 1 |
| Klonowski-Stumpe, H | 1 |
| Han, B | 1 |
| Häussinger, D | 1 |
| Niederau, C | 1 |
| Kotamraju, S | 1 |
| Konorev, EA | 1 |
| Joseph, J | 1 |
| Kalyanaraman, B | 1 |
| Kurebayashi, Y | 1 |
| Tabuchi, Y | 1 |
| Akasaki, M | 1 |
4 other studies available for ebselen and Necrosis
| Article | Year |
|---|---|
Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Azoles; Caspases; | 2003 |
Cytotoxicity of peroxynitrite in rat pancreatic acinar AR4-2J cells.
Topics: Animals; Antioxidants; Apoptosis; Azoles; Calcium; DNA Fragmentation; Dose-Response Relationship, Dr | 1997 |
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Azoles; Cattle; Cyclic N-Oxides; Cytochrome c Group | 2000 |
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Or | 1989 |