Page last updated: 2024-10-26

ebselen and Necrosis

ebselen has been researched along with Necrosis in 4 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with ebselen at oral doses from 10 to 100 mg/kg significantly inhibited such lesion formation induced by either necrotizing agent in a dose-related manner, and the inhibition at the highest dose (100 mg/kg p."1.28Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats. ( Akasaki, M; Kurebayashi, Y; Tabuchi, Y, 1989)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guérin, PJ1
Gauthier, ER1
Sata, N1
Klonowski-Stumpe, H1
Han, B1
Häussinger, D1
Niederau, C1
Kotamraju, S1
Konorev, EA1
Joseph, J1
Kalyanaraman, B1
Kurebayashi, Y1
Tabuchi, Y1
Akasaki, M1

Other Studies

4 other studies available for ebselen and Necrosis

ArticleYear
Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.
    Journal of cellular biochemistry, 2003, May-01, Volume: 89, Issue:1

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Azoles; Caspases;

2003
Cytotoxicity of peroxynitrite in rat pancreatic acinar AR4-2J cells.
    Pancreas, 1997, Volume: 15, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Azoles; Calcium; DNA Fragmentation; Dose-Response Relationship, Dr

1997
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species.
    The Journal of biological chemistry, 2000, Oct-27, Volume: 275, Issue:43

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Azoles; Cattle; Cyclic N-Oxides; Cytochrome c Group

2000
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:2

    Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Or

1989