Potassium voltage-gated channel subfamily A member 1

A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09470]

Synonyms

Voltage-gated K(+) channel HuKI;
Voltage-gated potassium channel HBK1;
Voltage-gated potassium channel subunit Kv1.1

Research

Bioassay Publications (5)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-aminopyridine	Homo sapiens (human)	IC50	89.0000	1	1
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide	Homo sapiens (human)	IC50	54,954,100,000.0000	1	1
flecainide	Homo sapiens (human)	IC50	209.0000	1	1
nifedipine	Homo sapiens (human)	IC50	96.0000	1	1
tetraethylammonium	Homo sapiens (human)	IC50	30.0000	1	1
diltiazem	Homo sapiens (human)	IC50	144.0000	1	1
capsaicin	Homo sapiens (human)	IC50	29.0000	1	1
clathrodin	Homo sapiens (human)	IC50	30.0000	1	1
oroidin	Homo sapiens (human)	IC50	30.0000	1	1
hymenidin	Homo sapiens (human)	IC50	30.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-methoxypsoralen	Homo sapiens (human)	Kd	200.0000	1	1
cortisone	Homo sapiens (human)	EC50	39.5000	2	2

Enables

This protein enables 6 target(s):

Target	Category	Definition
voltage-gated potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
delayed rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
disordered domain specific binding	molecular function	Binding to a disordered domain of a protein. [GOC:gg, PMID:11746698]
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos]
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	molecular function	Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]

Located In

This protein is located in 20 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
cell junction	cellular component	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
cytoplasmic vesicle	cellular component	A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
paranode region of axon	cellular component	An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]
presynaptic membrane	cellular component	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
axon initial segment	cellular component	Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]
perikaryon	cellular component	The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
axon terminus	cellular component	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
juxtaparanode region of axon	cellular component	A region of an axon near a node of Ranvier that is between the paranode and internode regions. [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
calyx of Held	cellular component	The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
postsynaptic membrane	cellular component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
anchoring junction	cellular component	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. [ISBN:0815332181]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 6 target(s):

Target	Category	Definition
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
paranode region of axon	cellular component	An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
juxtaparanode region of axon	cellular component	A region of an axon near a node of Ranvier that is between the paranode and internode regions. [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 24 target(s):

Target	Category	Definition
startle response	biological process	An action or movement due to the application of a sudden unexpected stimulus. [GOC:dph]
regulation of muscle contraction	biological process	Any process that modulates the frequency, rate or extent of muscle contraction. [GOC:go_curators]
neuroblast proliferation	biological process	The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. [GOC:ai, GOC:mtg_sensu, GOC:sart]
protein localization	biological process	Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]
cell communication by electrical coupling	biological process	The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]
magnesium ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. [GOC:dph, GOC:tb]
neuronal action potential	biological process	An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb]
optic nerve development	biological process	The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
hippocampus development	biological process	The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
cerebral cortex development	biological process	The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
corpus callosum development	biological process	The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
neuronal signal transduction	biological process	The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. [GOC:mtg_signal]
regulation of membrane potential	biological process	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
neuromuscular process	biological process	Any process pertaining to the functions of the nervous and muscular systems of an organism. [GOC:ai]
detection of mechanical stimulus involved in sensory perception of pain	biological process	The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
detection of mechanical stimulus involved in sensory perception of touch	biological process	The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
protein homooligomerization	biological process	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]
regulation of postsynaptic membrane potential	biological process	Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef]
axon development	biological process	The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). [GOC:dph, GOC:pg, GOC:pr]
cellular response to magnesium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
membrane repolarization during action potential	biological process	The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of presynaptic membrane potential	biological process	Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]
action potential	biological process	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]