SUMO-activating enzyme subunit 1

A SUMO-activating enzyme subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBE0]

Ubiquitin-like 1-activating enzyme E1A

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
anacardic acid	Homo sapiens (human)	IC50	2.2000	1	1
ginkgolic acid	Homo sapiens (human)	IC50	3.0000	1	1
pevonedistat	Homo sapiens (human)	IC50	4.6000	2	2
largazole	Homo sapiens (human)	IC50	450.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
ubiquitin activating enzyme activity	molecular function	Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
enzyme activator activity	molecular function	Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]
ATP-dependent protein binding	molecular function	Binding to a protein or protein complex using energy from ATP hydrolysis. [GOC:jl]
small protein activating enzyme binding	molecular function	Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is part of 1 target(s):

Target	Category	Definition
SUMO activating enzyme complex	cellular component	A conserved heterodimeric complex with SUMO activating enzyme activity. [PMID:15601841]

This protein is involved in 4 target(s):

Target	Category	Definition
protein ubiquitination	biological process	The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
protein sumoylation	biological process	The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]
positive regulation of protein sumoylation	biological process	Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]
positive regulation of protein targeting to mitochondrion	biological process	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]