Page last updated: 2024-10-26

etidronate and Necrosis

etidronate has been researched along with Necrosis in 9 studies

Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Oral etidronate has been used for 3 weeks, after failure of classical treatment."5.34[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis]. ( Bottu, J; Trullemans, B; Van Nieuwenhuyse, JP, 2007)
"These results suggest that etidronate may 1) inhibit the entry of NBPs into cells related to inflammation and/or necrosis, 2) inhibit the binding of NBPs to bone hydroxyapatite, 3) at least partly eliminate (or substitute for) NBPs that have already accumulated within bones, and thus 4) if used as a substitution drug for NBPs, be effective at treating or preventing NBP-associated osteonecrosis of the jaw."3.76Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs. ( Endo, Y; Funayama, H; Kawamura, H; Kumamoto, H; Kuroishi, T; Oizumi, T; Sasaki, K; Sugawara, S; Takahashi, H; Yamaguchi, K; Yamamoto, M; Yokoyama, M, 2010)
"Oral etidronate has been used for 3 weeks, after failure of classical treatment."1.34[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis]. ( Bottu, J; Trullemans, B; Van Nieuwenhuyse, JP, 2007)
"This osteolysis was evaluated by measuring the increased area of bone resorption in reduced opacity to radiograph and histologic study."1.28Inhibition by a new bisphosphonate (AHBuBP) of bone resorption induced by the MBT-2 tumor of mice. ( Koiso, K; Miyagawa, I; Nemoto, R; Satou, S, 1991)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Okada, S1
Kiyama, T1
Sato, E1
Tanaka, Y1
Oizumi, T2
Kuroishi, T2
Takahashi, T1
Sasaki, K2
Sugawara, S2
Endo, Y2
Funayama, H1
Yamaguchi, K1
Yokoyama, M1
Takahashi, H1
Yamamoto, M1
Kumamoto, H1
Kawamura, H1
Trullemans, B1
Bottu, J1
Van Nieuwenhuyse, JP1
Caldecourt, MA1
Cole, AW1
Kingaby, RO1
Palmer, TN1
Hughes, DE1
Wright, KR1
Uy, HL1
Sasaki, A1
Yoneda, T1
Roodman, GD1
Mundy, GR1
Boyce, BF1
Creutzig, H1
Schulz, D1
Nemoto, R1
Satou, S1
Miyagawa, I1
Koiso, K1
Daoud, AS1
Frank, AS1
Jarmolych, J1
Fritz, KE1
Raper, RF1
Ibels, LS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420]Phase 14 participants (Actual)Interventional2005-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for etidronate and Necrosis

ArticleYear
Inhibition of phosphate transporters ameliorates the inflammatory and necrotic side effects of the nitrogen-containing bisphosphonate zoledronate in mice.
    The Tohoku journal of experimental medicine, 2013, Volume: 231, Issue:2

    Topics: Animals; Bone Resorption; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Foscarnet; Imidazo

2013
Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2010, Volume: 68, Issue:5

    Topics: Alendronate; Animals; Bone Density Conservation Agents; Bone Resorption; Diphosphonates; Ear, Extern

2010
[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:2

    Topics: Adipose Tissue; Calcinosis; Etidronic Acid; Female; Humans; Hypercalcemia; Infant; Kidney Diseases;

2007
Liposome accumulation in chronic ischaemia is dependent on tissue necrosis.
    Bioscience reports, 1984, Volume: 4, Issue:4

    Topics: Animals; Etidronic Acid; Hydrocortisone; Intestines; Ischemia; Liposomes; Male; Necrosis; Pharmaceut

1984
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1995, Volume: 10, Issue:10

    Topics: Animals; Apoptosis; Bone Neoplasms; Cell Survival; Cells, Cultured; Diphosphonates; Etidronic Acid;

1995
[Comparative studies with bone-seeking radiopharmaceuticals on uptake in necrotic tissue].
    Nuklearmedizin. Nuclear medicine, 1977, Volume: 16, Issue:3

    Topics: Animals; Diphosphonates; Etidronic Acid; Indium; Male; Muscles; Necrosis; Organophosphorus Compounds

1977
Inhibition by a new bisphosphonate (AHBuBP) of bone resorption induced by the MBT-2 tumor of mice.
    Cancer, 1991, Feb-01, Volume: 67, Issue:3

    Topics: Alendronate; Animals; Diphosphonates; Etidronic Acid; Female; Mice; Mice, Inbred C3H; Necrosis; Neop

1991
The effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on necrosis of atherosclerotic lesions.
    Atherosclerosis, 1987, Volume: 67, Issue:1

    Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Calcium; Cholesterol; Diet, Atherogenic; DNA; Etidronic

1987
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis.
    Nephron, 1985, Volume: 39, Issue:4

    Topics: Adult; Aluminum Hydroxide; Arteritis; Bone Neoplasms; Calcinosis; Cyclophosphamide; Etidronic Acid;

1985