A trypsin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35030]
EC 3.4.21.4;
Brain trypsinogen;
Mesotrypsin;
Mesotrypsinogen;
Serine protease 3;
Serine protease 4;
Trypsin III;
Trypsin IV
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 18 (51.43) | 29.6817 |
| 2010's | 14 (40.00) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-(n,n-hexamethylene)amiloride | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | Ki | 9.5450 | 2 | 2 |
| camostat | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide | Homo sapiens (human) | IC50 | 0.1690 | 1 | 1 |
| sulfaguanidine | Homo sapiens (human) | Ki | 1.3500 | 1 | 1 |
| isoquinoline-1,3,4-trione | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| amiloride | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| baicalin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| leupeptin | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| p-Aminobenzamidine dihydrochloride | Homo sapiens (human) | Ki | 13.1000 | 1 | 1 |
| mci 9038 | Homo sapiens (human) | Ki | 1.9900 | 1 | 1 |
| sivelestat | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | Ki | 0.6200 | 2 | 2 |
| skullcapflavone ii | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| melagatran | Homo sapiens (human) | IC50 | 0.0119 | 1 | 2 |
| melagatran | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| razaxaban | Homo sapiens (human) | Ki | 6.9714 | 7 | 7 |
| dabigatran | Homo sapiens (human) | Ki | 0.0502 | 2 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Homo sapiens (human) | IC50 | 352.0000 | 1 | 1 |
| wogonoside | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| silybin | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| ganhuangenin | Homo sapiens (human) | IC50 | 88.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| wogonin | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| bms 740808 | Homo sapiens (human) | Ki | 2.8000 | 2 | 2 |
| bms-262084 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| dpc 423 | Homo sapiens (human) | Ki | 0.0600 | 2 | 2 |
| gw 813893 | Homo sapiens (human) | IC50 | 158.0000 | 1 | 1 |
| l 374087 | Homo sapiens (human) | Ki | 3.2000 | 1 | 1 |
| darexaban | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| lb 30057 | Homo sapiens (human) | Ki | 3.2900 | 1 | 1 |
| darexaban glucuronide | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| apixaban | Homo sapiens (human) | Ki | 4.2000 | 1 | 1 |
| rpx7009 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| serine-type peptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| tertiary granule lumen | cellular component | Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| antimicrobial humoral response | biological process | An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. [GOC:go_curators, GOC:mtg_sensu] |
| zymogen activation | biological process | The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd] |
| endothelial cell migration | biological process | The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:go_curators] |