A sodium/myo-inositol cotransporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWX8]
Na(+)/myo-inositol cotransporter 2;
Sodium-dependent glucose cotransporter;
Sodium/glucose cotransporter KST1;
Sodium/myo-inositol transporter 2;
SMIT2;
Solute carrier family 5 member 11
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| inositol | Homo sapiens (human) | IC50 | 104.0000 | 1 | 0 |
| dapagliflozin | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| myo-inositol transmembrane transporter activity | molecular function | Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| polyol transmembrane transporter activity | molecular function | Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. [ISBN:0198506732] |
| glucose:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| polyol transmembrane transport | biological process | The directed movement of polyols, any polyhydric alcohol, across a membrane. [GOC:ai] |
| myo-inositol transport | biological process | The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:ai] |
| glucose transmembrane transport | biological process | The process in which glucose is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:9090050] |