Disintegrin and metalloproteinase domain-containing protein 17

An ADAM 17 endopeptidase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P78536]

Synonyms

ADAM 17;
EC 3.4.24.86;
Snake venom-like protease;
TNF-alpha convertase;
TNF-alpha-converting enzyme

Research

Bioassay Publications (38)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (5.26)	18.2507
2000's	26 (68.42)	29.6817
2010's	10 (26.32)	24.3611
2020's	0 (0.00)	2.80

Compounds (546)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
thyroxine	Homo sapiens (human)	Potency	25.1189	1
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate	Homo sapiens (human)	Potency	25.1189	1
tyrphostin 25	Homo sapiens (human)	Potency	25.1189	1
amoxapine	Homo sapiens (human)	Potency	19.9526	1
anthralin	Homo sapiens (human)	Potency	25.1189	1
astemizole	Homo sapiens (human)	Potency	8.8006	1
aurintricarboxylic acid	Homo sapiens (human)	Potency	19.9526	1
benzbromarone	Homo sapiens (human)	Potency	0.6310	1
bay h 4502	Homo sapiens (human)	Potency	25.1189	1
broxyquinoline	Homo sapiens (human)	Potency	3.9811	1
bumetanide	Homo sapiens (human)	Potency	6.3096	1
busulfan	Homo sapiens (human)	Potency	15.8489	1
candesartan cilexetil	Homo sapiens (human)	Potency	0.7943	1
chelerythrine	Homo sapiens (human)	Potency	25.1189	1
chromone-2-carboxylic acid	Homo sapiens (human)	Potency	31.6228	1
clioquinol	Homo sapiens (human)	Potency	1.7901	1
clofoctol	Homo sapiens (human)	Potency	10.0000	1
clotrimazole	Homo sapiens (human)	Potency	18.9338	1
dephostatin	Homo sapiens (human)	Potency	15.8489	1
dichlorophen	Homo sapiens (human)	Potency	25.1189	1
diflunisal	Homo sapiens (human)	Potency	6.3096	1
dipyridamole	Homo sapiens (human)	Potency	7.9433	1
domperidone	Homo sapiens (human)	Potency	10.0000	1
embelin	Homo sapiens (human)	Potency	3.1623	1
fenofibrate	Homo sapiens (human)	Potency	6.3096	1
fluphenazine	Homo sapiens (human)	Potency	18.8541	1
fluspirilene	Homo sapiens (human)	Potency	7.9433	1
fosfosal	Homo sapiens (human)	Potency	3.9811	1
gossypol	Homo sapiens (human)	Potency	13.5571	1
batyl alcohol	Homo sapiens (human)	Potency	25.1189	1
indirubin-3'-monoxime	Homo sapiens (human)	Potency	25.1189	1
iodoacetamide	Homo sapiens (human)	Potency	25.1189	1
iodoquinol	Homo sapiens (human)	Potency	0.3162	1
juglone	Homo sapiens (human)	Potency	12.5893	1
lidoflazine	Homo sapiens (human)	Potency	10.0000	1
loperamide	Homo sapiens (human)	Potency	5.0119	1
loratadine	Homo sapiens (human)	Potency	12.5893	1
mebendazole	Homo sapiens (human)	Potency	15.8489	1
meclofenamate sodium anhydrous	Homo sapiens (human)	Potency	10.0000	1
vitamin k 3	Homo sapiens (human)	Potency	6.3096	1
methyl methanesulfonate	Homo sapiens (human)	Potency	15.8489	1
etoposide phosphate	Homo sapiens (human)	Potency	10.0000	1
papaverine	Homo sapiens (human)	Potency	12.5893	1
pargyline	Homo sapiens (human)	Potency	5.0119	1
pentoxifylline	Homo sapiens (human)	Potency	25.1189	1
perphenazine	Homo sapiens (human)	Potency	12.5893	1
phenazopyridine	Homo sapiens (human)	Potency	3.9811	1
pipobroman	Homo sapiens (human)	Potency	10.0000	1
pirenzepine	Homo sapiens (human)	Potency	12.5893	1
piretanide	Homo sapiens (human)	Potency	7.9433	1
piribedil	Homo sapiens (human)	Potency	3.9811	1
pomiferin	Homo sapiens (human)	Potency	10.0000	1
1,2,5,8-tetrahydroxy anthraquinone	Homo sapiens (human)	Potency	3.9811	1
quipazine	Homo sapiens (human)	Potency	5.0119	1
raloxifene	Homo sapiens (human)	Potency	5.0119	1
riluzole	Homo sapiens (human)	Potency	5.0119	1
roxarsone	Homo sapiens (human)	Potency	1.2589	1
saccharin	Homo sapiens (human)	Potency	19.9526	1
sanguinarine	Homo sapiens (human)	Potency	25.1189	1
spiperone	Homo sapiens (human)	Potency	15.8489	1
sulfanilamide	Homo sapiens (human)	Potency	10.0000	1
sulfasalazine	Homo sapiens (human)	Potency	6.3096	1
ticlopidine	Homo sapiens (human)	Potency	10.0000	1
ici 136,753	Homo sapiens (human)	Potency	7.9433	1
trigonelline	Homo sapiens (human)	Potency	12.5893	1
6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone	Homo sapiens (human)	Potency	12.5893	1
alloxan	Homo sapiens (human)	Potency	10.0000	1
papaverine hydrochloride	Homo sapiens (human)	Potency	12.5893	1
quinacrine monohydrochloride	Homo sapiens (human)	Potency	0.6310	1
7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione	Homo sapiens (human)	Potency	10.0000	1
acriflavine chloride	Homo sapiens (human)	Potency	0.6310	1
betazole	Homo sapiens (human)	Potency	5.0119	1
amprolium hydrochloride	Homo sapiens (human)	Potency	2.5119	1
triflusal	Homo sapiens (human)	Potency	5.0119	1
chrysophanic acid	Homo sapiens (human)	Potency	25.1189	1
gentian violet	Homo sapiens (human)	Potency	10.0000	1
2-amino-4-phenylphenol	Homo sapiens (human)	Potency	3.1623	1
5-hydroxyindole	Homo sapiens (human)	Potency	7.9433	1
pimozide	Homo sapiens (human)	Potency	2.5119	1
pontamine sky blue	Homo sapiens (human)	Potency	10.0000	1
piperacetazine	Homo sapiens (human)	Potency	5.0119	1
hydroxyzine pamoate	Homo sapiens (human)	Potency	5.0119	1
diacerein	Homo sapiens (human)	Potency	25.1189	1
mitoxantrone hydrochloride	Homo sapiens (human)	Potency	25.1189	1
topotecan hydrochloride	Homo sapiens (human)	Potency	10.0000	1
verapamil hydrochloride	Homo sapiens (human)	Potency	10.0000	1
sulconazole, mononitrate, (+-)-isomer	Homo sapiens (human)	Potency	25.1189	1
telmisartan	Homo sapiens (human)	Potency	10.0000	1
trifluoperazine hydrochloride	Homo sapiens (human)	Potency	15.8489	1
xanthoxyline	Homo sapiens (human)	Potency	15.8489	1
fluphenazine hydrochloride	Homo sapiens (human)	Potency	10.0000	1
2,3-trimethylene-4-quinazolone	Homo sapiens (human)	Potency	3.9811	1
2,6-dimethoxy-1,4-benzoquinone	Homo sapiens (human)	Potency	7.9433	1
miconazole nitrate	Homo sapiens (human)	Potency	25.1189	1
econazole nitrate	Homo sapiens (human)	Potency	19.9526	1
masoprocol	Homo sapiens (human)	Potency	31.6228	1
aceclofenac	Homo sapiens (human)	Potency	3.1623	1
fluphenacur	Homo sapiens (human)	Potency	12.5893	1
nonoxynol-9	Homo sapiens (human)	Potency	2.5119	1
pramoxine hydrochloride	Homo sapiens (human)	Potency	12.5893	1
atovaquone	Homo sapiens (human)	Potency	10.0000	1
1,8-diazabicyclo(5.4.0)undec-7-ene	Homo sapiens (human)	Potency	15.8489	1
prochlorperazine edisylate salt	Homo sapiens (human)	Potency	12.5893	1
coumarin 7	Homo sapiens (human)	Potency	0.1995	1
osajin	Homo sapiens (human)	Potency	15.8489	1
4-methoxydalbergione	Homo sapiens (human)	Potency	12.5893	1
alexidine dihydrchloride	Homo sapiens (human)	Potency	31.6228	1
harmalol hydrochloride	Homo sapiens (human)	Potency	1.5849	1
chrysene-1,4-dione	Homo sapiens (human)	Potency	3.1623	1
benfluorex hydrochloride	Homo sapiens (human)	Potency	25.1189	1
4-amino-N-(4-methoxyphenyl)-2-(methylthio)-5-thiazolecarboxamide	Homo sapiens (human)	Potency	25.1189	1
5-demethylnobiletin	Homo sapiens (human)	Potency	10.0000	1
arachidonic acid	Homo sapiens (human)	Potency	3.1623	1
retinol	Homo sapiens (human)	Potency	10.0000	1
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol	Homo sapiens (human)	Potency	25.1189	1
diethylstilbestrol	Homo sapiens (human)	Potency	25.1189	1
6-bromoindirubin-3'-oxime	Homo sapiens (human)	Potency	12.5893	1
isotetrandrine	Homo sapiens (human)	Potency	10.0000	1
2-furancarboxylic acid [4-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester	Homo sapiens (human)	Potency	3.1623	1
2-[[(6-bromo-1H-benzimidazol-2-yl)thio]methyl]-1-methylbenzimidazole	Homo sapiens (human)	Potency	6.3096	1
tolfenamic acid	Homo sapiens (human)	Potency	10.0000	1
4-(2-pyridinylthio)benzofuro[3,2-d]pyrimidine	Homo sapiens (human)	Potency	3.9811	1
N-(2-fluorophenyl)-2-(3-methoxyphenyl)imino-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide	Homo sapiens (human)	Potency	15.8489	1
3-[[2-[[4-ethyl-5-[(4-methylanilino)methyl]-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]benzoic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
3-[(1-cyclopentyl-5-tetrazolyl)-(3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	5.0119	1
3-[[1,3-benzodioxol-5-ylmethyl-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]amino]methyl]-6-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	6.3096	1
1-(2-furanyl)-N-[[1-[(4-methylphenyl)sulfonylmethyl]-5-tetrazolyl]methyl]-N-(thiophen-2-ylmethyl)methanamine	Homo sapiens (human)	Potency	12.5893	1
LSM-19079	Homo sapiens (human)	Potency	10.0000	1
3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide	Homo sapiens (human)	Potency	5.0119	1
2-[[4-(3-methoxyphenyl)-5-[(4-methylphenoxy)methyl]-1,2,4-triazol-3-yl]thio]acetic acid	Homo sapiens (human)	Potency	12.5893	1
2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]-1-[4-(2-methoxyphenyl)-1-piperazinyl]ethanone	Homo sapiens (human)	Potency	12.5893	1
2-[[3-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]acetic acid methyl ester	Homo sapiens (human)	Potency	12.5893	1
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(3,4-dimethoxyphenyl)-5-tetrazolyl]thio]acetamide	Homo sapiens (human)	Potency	7.9433	1
2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide	Homo sapiens (human)	Potency	10.0000	1
2-(6-cyano-1-indolyl)-N-cyclohexylacetamide	Homo sapiens (human)	Potency	25.1189	1
6-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]quinoline	Homo sapiens (human)	Potency	5.0119	1
6-amino-4-(2-methoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile	Homo sapiens (human)	Potency	12.5893	1
7,8-dimethyl-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-4-phenyl-3H-1,5-benzodiazepin-2-one	Homo sapiens (human)	Potency	10.0000	1
4-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-2-methyl-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	5.0119	1
N-[2-(5-chloro-2-methoxyanilino)-2-oxoethyl]-N-cyclohexyl-2-furancarboxamide	Homo sapiens (human)	Potency	10.0000	1
5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid	Homo sapiens (human)	Potency	6.3096	1
N-[4-[3-[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-2-hydroxypropoxy]phenyl]acetamide	Homo sapiens (human)	Potency	10.0000	1
3-[[1,3-benzodioxol-5-ylmethyl-[(1-cyclopentyl-5-tetrazolyl)methyl]amino]methyl]-6-ethyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	5.0119	1
1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea	Homo sapiens (human)	Potency	12.5893	1
2-[cyclohexyl-(2,4,6-trimethylphenyl)sulfonylamino]-N-(3-pyridinylmethyl)acetamide	Homo sapiens (human)	Potency	12.5893	1
1-(4-chlorophenyl)sulfonyl-N-[3-methoxy-4-(1-tetrazolyl)phenyl]-4-piperidinecarboxamide	Homo sapiens (human)	Potency	12.5893	1
2-[(5-amino-1-phenacyl-1,2,4-triazol-3-yl)thio]-N-(3-cyano-4,5-dimethyl-2-thiophenyl)acetamide	Homo sapiens (human)	Potency	15.8489	1
3-[[[1-[1-(2-furanylmethyl)-5-tetrazolyl]-2-methylpropyl]-(2-oxolanylmethyl)amino]methyl]-8-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	25.1189	1
N-[4-[[4-(4-methylphenyl)sulfonyl-1,4-diazepan-1-yl]sulfonyl]phenyl]acetamide	Homo sapiens (human)	Potency	12.5893	1
4-[4-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]-(3-pyridinyl)methyl]-1-piperazinyl]phenol	Homo sapiens (human)	Potency	19.9526	1
8-[(1-cyclohexyl-5-tetrazolyl)methyl]-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol	Homo sapiens (human)	Potency	12.5893	1
4-methoxy-1,3-dimethyl-6-thiophen-2-yl-8-cyclohepta[c]furanone	Homo sapiens (human)	Potency	7.9433	1
6-methyl-3-[[[1-(phenylmethyl)-5-tetrazolyl]methyl-(thiophen-2-ylmethyl)amino]methyl]-1H-quinolin-2-one	Homo sapiens (human)	Potency	12.5893	1
4-[2-[1-(4-methoxyphenyl)sulfonyl-2-benzimidazolyl]ethyl]morpholine	Homo sapiens (human)	Potency	25.1189	1
5-(2-furanyl)-3-[2-methoxy-6-(4-methylphenyl)-3-pyridinyl]-1,2,4-oxadiazole	Homo sapiens (human)	Potency	7.9433	1
6-ethoxy-3-[[2-oxolanylmethyl-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]amino]methyl]-1H-quinolin-2-one	Homo sapiens (human)	Potency	10.0000	1
3-[1-azepanyl-[1-(phenylmethyl)-5-tetrazolyl]methyl]-7-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	12.5893	1
N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-[[3-(2-furanylmethyl)-4-oxo-2-quinazolinyl]thio]acetamide	Homo sapiens (human)	Potency	5.0119	1
5-(1,3-benzodioxol-5-yl)-1-methyl-2-imidazolamine	Homo sapiens (human)	Potency	15.8489	1
3-[[[1-(2-furanylmethyl)-5-tetrazolyl]methyl-[(2-methoxyphenyl)methyl]amino]methyl]-6-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	2.5119	1
2-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]-4-(3-methoxyphenyl)thiazole	Homo sapiens (human)	Potency	7.9433	1
N-[4-[oxo-(2-pyridinylamino)methyl]phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	12.5893	1
1-(1,3-benzodioxol-5-ylmethyl)-3-(4-methylphenyl)-1-[(7-oxo-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]urea	Homo sapiens (human)	Potency	3.9811	1
N'-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]-N'-(3-fluorophenyl)-N-(3-pyridinyl)butanediamide	Homo sapiens (human)	Potency	15.8489	1
1-[(1-tert-butyl-5-tetrazolyl)-thiophen-2-ylmethyl]-3,4-dihydro-2H-quinoline	Homo sapiens (human)	Potency	10.0000	1
N-(1,3-benzodioxol-5-yl)-1-[(4-fluorophenyl)methyl]-4-triazolecarboxamide	Homo sapiens (human)	Potency	7.9433	1
N-tert-butyl-2-(2-furanyl)-2-[[2-[5-(5-methyl-2-furanyl)-2-tetrazolyl]-1-oxoethyl]-(thiophen-2-ylmethyl)amino]acetamide	Homo sapiens (human)	Potency	12.5893	1
2-[(1-cyclohexyl-5-tetrazolyl)thio]-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide	Homo sapiens (human)	Potency	12.5893	1
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	Homo sapiens (human)	Potency	15.8489	1
2-[4-[(1-cyclopentyl-5-tetrazolyl)-(6-quinolinyl)methyl]-1-piperazinyl]-1,3-benzothiazole	Homo sapiens (human)	Potency	3.9811	1
1-(3,5-dimethyl-1-pyrazolyl)-3-[2-(4-methoxyphenyl)-1-indolyl]-2-propanol	Homo sapiens (human)	Potency	12.5893	1
1-(4-fluorophenyl)-4-[[1-(2-phenylethyl)-5-tetrazolyl]-thiophen-2-ylmethyl]piperazine	Homo sapiens (human)	Potency	12.5893	1
6,7-dimethoxy-2-[[2-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]thio]-3-quinolinecarbonitrile	Homo sapiens (human)	Potency	5.0119	1
N-[4-[(tert-butylamino)-oxomethyl]phenyl]-2,3-dihydro-1,4-benzodioxin-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
N-(2,5-diethoxyphenyl)-2-[(3-methyl-2-imidazo[4,5-b]pyridinyl)thio]acetamide	Homo sapiens (human)	Potency	0.2512	1
2,5-diethoxy-N-[2-(2-methylphenyl)ethyl]-4-(1-tetrazolyl)benzenesulfonamide	Homo sapiens (human)	Potency	3.1623	1
6-chloro-2-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-piperidinyl]-1H-benzimidazole	Homo sapiens (human)	Potency	12.5893	1
4-[[4-ethyl-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]thio]-N-(2-methoxyphenyl)-3-oxobutanamide	Homo sapiens (human)	Potency	10.0000	1
3-(3-chlorophenyl)-1-(3-hydroxypropyl)-1-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]urea	Homo sapiens (human)	Potency	12.5893	1
4-bromo-N-[(6-ethoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-(2-hydroxyethyl)benzamide	Homo sapiens (human)	Potency	19.9526	1
3-[3,4-dihydro-1H-isoquinolin-2-yl-[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]-7-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	5.0119	1
2-[[5-(phenoxymethyl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	12.5893	1
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide	Homo sapiens (human)	Potency	10.0000	1
N'-[2-(cyclopentylamino)-2-oxoethyl]-N'-(3,4-dimethylphenyl)-N-(2-pyridinyl)pentanediamide	Homo sapiens (human)	Potency	5.0119	1
N-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-[[4-propyl-5-(2-pyridinyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
3-(2-chlorophenyl)-1-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-1-[2-(1-pyrrolidinyl)ethyl]urea	Homo sapiens (human)	Potency	12.5893	1
2-[4-(benzenesulfonyl)phenyl]-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole	Homo sapiens (human)	Potency	7.9433	1
4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-N-(2-oxolanylmethyl)-2-thiazolamine	Homo sapiens (human)	Potency	25.1189	1
1-[4-(2-methoxyphenyl)-1-piperazinyl]-2-[[5-(2-methyl-3-furanyl)-1,3,4-oxadiazol-2-yl]thio]ethanone	Homo sapiens (human)	Potency	12.5893	1
8-[(1-tert-butyl-5-tetrazolyl)-thiomorpholin-4-ylmethyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one	Homo sapiens (human)	Potency	10.0000	1
1-[1-[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-2-methylpropyl]-4-phenylpiperazine	Homo sapiens (human)	Potency	19.9526	1
1-cyclopentyl-1-[(7-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-3-(2-methoxyphenyl)urea	Homo sapiens (human)	Potency	10.0000	1
3-[2-(3-phenoxypropyl)-5-tetrazolyl]pyridine	Homo sapiens (human)	Potency	12.5893	1
2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)thio]-N-(4-phenyl-2-thiazolyl)acetamide	Homo sapiens (human)	Potency	6.3096	1
2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]-1-(4-phenyl-1-piperazinyl)ethanone	Homo sapiens (human)	Potency	10.0000	1
2-[2-[[2-[[1-(4-methoxyphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazole	Homo sapiens (human)	Potency	3.9811	1
N-(1,3-benzodioxol-5-yl)-N-[1-(4-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl]-2-pyrazinecarboxamide	Homo sapiens (human)	Potency	5.0119	1
LSM-34623	Homo sapiens (human)	Potency	10.0000	1
LSM-34679	Homo sapiens (human)	Potency	12.5893	1
2-[(3-cyano-5,7-dimethyl-2-quinolinyl)thio]-N-(2-furanylmethyl)acetamide	Homo sapiens (human)	Potency	3.9811	1
3-[[cyclopentyl-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]methyl]amino]methyl]-7-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	10.0000	1
1-(2-methoxyphenyl)-4-[(4-methylphenyl)-(1-propan-2-yl-5-tetrazolyl)methyl]piperazine	Homo sapiens (human)	Potency	10.0000	1
N,N-diethyl-2-[(3-thiophen-2-yl-7-isothiazolo[4,5-d]pyrimidinyl)thio]acetamide	Homo sapiens (human)	Potency	3.1623	1
3-[[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-(1-pyrrolidinyl)methyl]-8-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	12.5893	1
N-(2-ethoxyphenyl)-1-[4-(1-pyrrolidinylsulfonyl)phenyl]-4-piperidinecarboxamide	Homo sapiens (human)	Potency	12.5893	1
2-(2-cyanophenoxy)-N-[2-[cyclopropyl(oxo)methyl]-3-benzofuranyl]acetamide	Homo sapiens (human)	Potency	6.3096	1
3-[[1-[1-(2-furanylmethyl)-5-tetrazolyl]propyl-(2-phenylethyl)amino]methyl]-7-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	5.0119	1
1-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(2-furanylmethyl)-3-phenylurea	Homo sapiens (human)	Potency	25.1189	1
N-[2-[1,3-benzodioxol-5-yl-[2-(tert-butylamino)-2-oxo-1-pyridin-4-ylethyl]amino]-2-oxoethyl]-2-furancarboxamide	Homo sapiens (human)	Potency	12.5893	1
N-(2-furanylmethyl)-N-[(7-methyl-4-tetrazolo[1,5-a]quinolinyl)methyl]-2-phenoxyacetamide	Homo sapiens (human)	Potency	19.9526	1
2-[5-(3,4-diethoxyphenyl)-2-tetrazolyl]-N-(3-methoxyphenyl)acetamide	Homo sapiens (human)	Potency	10.0000	1
6-amino-4-[3-ethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile	Homo sapiens (human)	Potency	10.0000	1
5-[(2-fluoroanilino)methyl]-8-quinolinol	Homo sapiens (human)	Potency	5.0119	1
N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-(thiophen-2-ylmethyl)-2,1,3-benzothiadiazole-4-sulfonamide	Homo sapiens (human)	Potency	10.0000	1
benzoic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester	Homo sapiens (human)	Potency	1.2589	1
2-[[5-(4-methylphenyl)-3-thiazolo[2,3-c][1,2,4]triazolyl]thio]-N-(6-methyl-2-pyridinyl)acetamide	Homo sapiens (human)	Potency	7.9433	1
N-[2-(4-chloro-N-[2-(cyclohexylamino)-2-oxoethyl]anilino)-2-oxoethyl]-2-furancarboxamide	Homo sapiens (human)	Potency	6.3096	1
N'-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]-N-(5-methyl-3-isoxazolyl)-N'-phenylbutanediamide	Homo sapiens (human)	Potency	12.5893	1
N-[4-(diethylsulfamoyl)phenyl]-2-(2-oxo-1,3-benzothiazol-3-yl)acetamide	Homo sapiens (human)	Potency	7.9433	1
2-[[5-[(2,3-dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]thio]-1-thiophen-2-ylethanone	Homo sapiens (human)	Potency	15.8489	1
1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidinecarboxylic acid	Homo sapiens (human)	Potency	7.9433	1
N-(3,4-dimethylphenyl)-2-[[5-[[(4,6-dimethyl-2-pyrimidinyl)thio]methyl]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	12.5893	1
3-[[4-(1-benzotriazolyl)-1-piperidinyl]sulfonyl]-N-cyclopentylbenzenesulfonamide	Homo sapiens (human)	Potency	6.3096	1
N,N-dimethyl-4-[[4-(5-methyl-1-benzotriazolyl)-1-piperidinyl]sulfonyl]benzamide	Homo sapiens (human)	Potency	12.5893	1
2-[4-[1-[1-[(4-methylphenyl)sulfonylmethyl]-5-tetrazolyl]propyl]-1-piperazinyl]-1,3-benzothiazole	Homo sapiens (human)	Potency	10.0000	1
2-[[5-[[2-(3-chloroanilino)-4-thiazolyl]methyl]-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]thio]acetic acid methyl ester	Homo sapiens (human)	Potency	12.5893	1
5-bromo-3-[[2-(4-cyclohexyl-1-piperazinyl)-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester	Homo sapiens (human)	Potency	10.0000	1
2-amino-1-(1,3-benzodioxol-5-yl)-N-[2-(4-morpholinyl)ethyl]-3-pyrrolo[3,2-b]quinoxalinecarboxamide	Homo sapiens (human)	Potency	7.9433	1
5-chloro-3-[[2-(4-ethoxycarbonyl-1-piperazinyl)-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester	Homo sapiens (human)	Potency	10.0000	1
2-(pyridin-4-yl)-4-(pyrrolidin-1-yl)quinazoline	Homo sapiens (human)	Potency	12.5893	1
3,4,5-trimethoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide	Homo sapiens (human)	Potency	12.5893	1
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	12.5893	1
LSM-27020	Homo sapiens (human)	Potency	10.0000	1
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(8-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone	Homo sapiens (human)	Potency	7.9433	1
2-(2-oxo-3H-1,4-benzoxazin-4-yl)acetic acid [2-(3-bromo-4-methoxyphenyl)-2-oxoethyl] ester	Homo sapiens (human)	Potency	12.5893	1
5,6-dimethoxy-3-[[(3-methoxyphenyl)-oxomethyl]amino]-1H-indole-2-carboxylic acid methyl ester	Homo sapiens (human)	Potency	10.0000	1
2-(butan-2-ylamino)-N-[4-[5-[[2-(butan-2-ylamino)-1-oxoethyl]amino]-1,3-benzoxazol-2-yl]phenyl]acetamide	Homo sapiens (human)	Potency	10.0000	1
2-(butylamino)-N-[4-[5-[[2-(butylamino)-1-oxoethyl]amino]-1,3-benzoxazol-2-yl]phenyl]acetamide	Homo sapiens (human)	Potency	10.0000	1
5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine	Homo sapiens (human)	Potency	12.5893	1
2-[5-[(2-chlorophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridine	Homo sapiens (human)	Potency	15.8489	1
6-(4-methoxyphenyl)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	15.8489	1
4-[4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl]benzofuro[3,2-d]pyrimidine	Homo sapiens (human)	Potency	12.5893	1
8-(1,3-benzothiazol-2-ylthio)-3-methyl-7-pentylpurine-2,6-dione	Homo sapiens (human)	Potency	12.5893	1
2-(5-amino-1-phenyl-1,2,4-triazol-3-yl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione	Homo sapiens (human)	Potency	25.1189	1
4-(1H-benzimidazol-2-ylmethylthio)-2-methylbenzofuro[3,2-d]pyrimidine	Homo sapiens (human)	Potency	12.5893	1
(2S)-4-methyl-2-[[oxo-(1,2,3,4-tetrahydronaphthalen-1-ylamino)methyl]amino]pentanoic acid methyl ester	Homo sapiens (human)	Potency	15.8489	1
3-methoxy-2-(3-pyridinylmethylthio)-4-quinazolinone	Homo sapiens (human)	Potency	3.1623	1
N-[7-(4-chlorophenyl)-5-(4-methoxyphenyl)-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-2-methoxyacetamide	Homo sapiens (human)	Potency	12.5893	1
1-(thiophen-2-ylmethyl)-3-thiophen-2-ylsulfonyl-2-pyrrolo[3,2-b]quinoxalinamine	Homo sapiens (human)	Potency	12.5893	1
3-[[2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester	Homo sapiens (human)	Potency	12.5893	1
3-(3-benzoyl-6-chloro-4,5-dihydroxy-7-benzofuranyl)pentane-2,4-dione	Homo sapiens (human)	Potency	6.3096	1
3-[[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1-oxoethyl]amino]-5-ethoxy-1H-indole-2-carboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	Homo sapiens (human)	Potency	1.2589	1
(3aR,6aS)-3-(2-chlorophenyl)-5-(2,5-dimethoxyphenyl)-3a,6a-dihydropyrrolo[3,4-d]isoxazole-4,6-dione	Homo sapiens (human)	Potency	25.1189	1
N-(4-chlorophenyl)-2-[3-(2-furanylmethyl)-4-imino-6,6-dimethyl-2-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]acetamide	Homo sapiens (human)	Potency	10.0000	1
N-[5-(4-chlorophenyl)-7-(4-methoxyphenyl)-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-2-furancarboxamide	Homo sapiens (human)	Potency	5.0119	1
3-[[2-(3,5-dimethyl-1-pyrazolyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]amino]-1-propanol	Homo sapiens (human)	Potency	10.0000	1
LSM-32568	Homo sapiens (human)	Potency	12.5893	1
2-[3-(2-furanylmethyl)-4-imino-6,6-dimethyl-2-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-phenylacetamide	Homo sapiens (human)	Potency	25.1189	1
3-[(3aR,6aS)-6'-chloro-5-(4-chlorophenyl)-7'-methyl-2',4,6-trioxo-1-spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]yl]propanamide	Homo sapiens (human)	Potency	12.5893	1
7-(3,4-dimethoxyphenyl)-4-methyl-2-[4-(phenylmethyl)-1-piperazinyl]-7,8-dihydro-6H-quinazolin-5-one	Homo sapiens (human)	Potency	12.5893	1
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione	Homo sapiens (human)	Potency	10.0000	1
3-(1-benzotriazolylmethyl)-6-(2-phenylethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	10.0000	1
5-(3-chlorophenyl)-N-[2-methyl-5-(3-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	0.7943	1
3-(4-fluorophenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	5.0119	1
2-amino-4-(3-chlorophenyl)-6-(2-furanylmethyl)-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carboxylic acid methyl ester	Homo sapiens (human)	Potency	15.8489	1
6-amino-1-(4-fluorophenyl)-3-methyl-4-thiophen-2-yl-5-pyrazolo[3,4-b]pyridinecarbonitrile	Homo sapiens (human)	Potency	12.5893	1
6-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]methyl]-N2-(3-methylphenyl)-1,3,5-triazine-2,4-diamine	Homo sapiens (human)	Potency	10.0000	1
4-(3,4-dihydro-2H-quinolin-1-yl)-6-[(4-phenyl-1-piperazinyl)methyl]-1,3,5-triazin-2-amine	Homo sapiens (human)	Potency	10.0000	1
3-(1-benzimidazolylmethyl)-6-[(4-methoxyphenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	10.0000	1
2-[[[5-(3-chlorophenyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1H-benzimidazole	Homo sapiens (human)	Potency	10.0000	1
3-(2,3-dihydro-1,4-benzodioxin-3-yl)-6-(4-fluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	12.5893	1
2-[[2-furanyl(oxo)methyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
N-(2-furanylmethyl)-2-benzofurancarboxamide	Homo sapiens (human)	Potency	12.5893	1
3,4'-dihydroxyflavone	Homo sapiens (human)	Potency	12.5893	1
5-(5-chloro-2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione	Homo sapiens (human)	Potency	10.0000	1
spiro[1,3-dihydroperimidine-2,1'-cycloheptane]	Homo sapiens (human)	Potency	3.1623	1
2-[[2-(5,6-dimethyl-1-benzimidazolyl)-1-oxoethyl]amino]benzoic acid methyl ester	Homo sapiens (human)	Potency	3.1623	1
4-methyl-N-[1-[2-(1-pyrrolidinyl)ethyl]-2-benzimidazolyl]benzamide	Homo sapiens (human)	Potency	12.5893	1
N-(1-naphthalenyl)-4-(phenylmethyl)-1-piperazinecarboxamide	Homo sapiens (human)	Potency	10.0000	1
3,5-dimethyl-1-[(7-methyl-2-naphthalenyl)sulfonyl]pyrazole	Homo sapiens (human)	Potency	3.1623	1
2-methyl-N-(2-naphthalenyl)-3-furancarboxamide	Homo sapiens (human)	Potency	12.5893	1
(2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine)	Homo sapiens (human)	Potency	25.1189	1
4-[5-[oxo-(3-pyridinylamino)methyl]-2-furanyl]benzoic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
N-(1,3-benzodioxol-5-yl)-4-(4-morpholinylmethyl)benzamide	Homo sapiens (human)	Potency	7.9433	1
lupitidine	Homo sapiens (human)	Potency	12.5893	1
N-[3-[(1,3-dioxo-5-isoindolyl)oxy]phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	25.1189	1
N2-(4-fluorophenyl)-6-(3-methyl-2-benzofuranyl)-1,3,5-triazine-2,4-diamine	Homo sapiens (human)	Potency	6.3096	1
thiothixene	Homo sapiens (human)	Potency	10.0000	1
N-(2-hydroxy-5-methoxy-1H-indol-3-yl)acetamide	Homo sapiens (human)	Potency	12.5893	1
2-(3-pyridinyl)-4-[4-(1-pyrrolidinylsulfonyl)phenyl]thiazole	Homo sapiens (human)	Potency	12.5893	1
4-[[[2,3-bis(2-pyridinyl)-6-quinoxalinyl]amino]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	12.5893	1
2-[[5-[(4-methoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]thio]-N-(4-methyl-2-thiazolyl)acetamide	Homo sapiens (human)	Potency	12.5893	1
4-[[[3-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]benzoic acid ethyl ester	Homo sapiens (human)	Potency	15.8489	1
N-[4-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]phenyl]propanamide	Homo sapiens (human)	Potency	12.5893	1
N-(2-furanylmethyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	3.9811	1
4-[4-(benzenesulfonyl)-1-piperazinyl]-2-methylquinoline	Homo sapiens (human)	Potency	3.9811	1
N-(2-furanylmethyl)-2-(4-oxo-6-phenyl-3-thieno[2,3-d]pyrimidinyl)acetamide	Homo sapiens (human)	Potency	25.1189	1
1-(3,4-dimethoxyphenyl)sulfonyl-4-(2-methoxyphenyl)piperazine	Homo sapiens (human)	Potency	10.0000	1
N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-methyl-3-furancarboxamide	Homo sapiens (human)	Potency	5.0119	1
[4-(2-methylphenyl)-1-piperazinyl]-(5-propyl-3-thiophenyl)methanone	Homo sapiens (human)	Potency	10.0000	1
1,4-dioxa-8-azaspiro[4.5]decan-8-yl(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone	Homo sapiens (human)	Potency	19.9526	1
N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]-3-pyridinecarboxamide	Homo sapiens (human)	Potency	10.0000	1
2-[[2-(3,4-dimethylanilino)-2-oxoethyl]thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
1-methylsulfonyl-N-(6,7,8,9-tetrahydrodibenzofuran-2-yl)-2,3-dihydroindole-5-sulfonamide	Homo sapiens (human)	Potency	10.0000	1
2-[2-chloro-4-(2,3-dihydroindol-1-ylsulfonyl)phenoxy]-N-(2-pyridinylmethyl)acetamide	Homo sapiens (human)	Potency	12.5893	1
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide	Homo sapiens (human)	Potency	12.5893	1
N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide	Homo sapiens (human)	Potency	10.0000	1
N-[3-[2-(1-azepanyl)-4,5-dicyanophenoxy]phenyl]acetamide	Homo sapiens (human)	Potency	15.8489	1
3-phenyl-5-[[[4-phenyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole	Homo sapiens (human)	Potency	3.1623	1
2-[[2-[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]amino]benzoic acid methyl ester	Homo sapiens (human)	Potency	10.0000	1
N-[2-[4-[(4-chlorophenyl)-oxomethyl]-1-piperazinyl]phenyl]-1,3-benzodioxole-5-carboxamide	Homo sapiens (human)	Potency	3.9811	1
N-[6-(diethylsulfamoyl)-1,3-benzothiazol-2-yl]-2-thiophenecarboxamide	Homo sapiens (human)	Potency	19.9526	1
N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-5-methyl-3-phenyl-4-isoxazolecarboxamide	Homo sapiens (human)	Potency	15.8489	1
2-[[4-(1,3-dioxo-2-isoindolyl)-1-oxobutyl]amino]-N-(2-furanylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
[4-[(2,4-dichlorophenoxy)methyl]phenyl]-(4-methyl-1-piperazinyl)methanone	Homo sapiens (human)	Potency	12.5893	1
N-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]carbamic acid phenyl ester	Homo sapiens (human)	Potency	3.1623	1
darunavir ethanolate	Homo sapiens (human)	Potency	15.8489	1
N-[3-[[2-(2-bromo-4,6-dimethylphenoxy)-1-oxoethyl]amino]phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	3.1623	1
N-[4-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]phenyl]-2-(2-methoxyphenyl)acetamide	Homo sapiens (human)	Potency	10.0000	1
4-(dimethylsulfamoyl)-N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide	Homo sapiens (human)	Potency	3.9811	1
N-(3,4-dimethoxyphenyl)-4-[(4-phenyl-1-piperazinyl)methyl]benzamide	Homo sapiens (human)	Potency	6.3096	1
1-(3-chlorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine	Homo sapiens (human)	Potency	12.5893	1
cis-resveratrol	Homo sapiens (human)	Potency	10.0000	1
4-(4-chlorophenoxy)-1-(4-morpholinyl)-1-butanone	Homo sapiens (human)	Potency	5.0119	1
N-(9-ethyl-3-carbazolyl)-2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	1.5849	1
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[methyl-(phenylmethyl)sulfamoyl]benzamide	Homo sapiens (human)	Potency	10.0000	1
N-(9-ethyl-3-carbazolyl)-2-[5-(4-morpholinylsulfonyl)-2-thiophenyl]acetamide	Homo sapiens (human)	Potency	1.2589	1
7-[[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone	Homo sapiens (human)	Potency	10.0000	1
3-methyl-2-benzofurancarboxylic acid [2-[4-amino-1-methyl-3-(2-methylpropyl)-2,6-dioxo-5-pyrimidinyl]-2-oxoethyl] ester	Homo sapiens (human)	Potency	10.0000	1
N-(3-cyano-2-thiophenyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenoxy]acetamide	Homo sapiens (human)	Potency	12.5893	1
4-(1,3-benzothiazol-2-ylthio)butanoic acid [2-[(3-cyano-2-thiophenyl)amino]-2-oxoethyl] ester	Homo sapiens (human)	Potency	12.5893	1
N-(1,3-benzodioxol-5-ylmethyl)-2-[(3-methyl-4-oxo-5-thiophen-2-yl-2-thieno[2,3-d]pyrimidinyl)thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]ethanone	Homo sapiens (human)	Potency	15.8489	1
1-[4-[(2-hydroxy-5-methylphenyl)-oxomethyl]-1-pyrazolyl]-2-(2-methyl-4-thiazolyl)ethanone	Homo sapiens (human)	Potency	10.0000	1
2-[[2-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-1-oxoethyl]amino]-5-phenyl-3-thiophenecarboxamide	Homo sapiens (human)	Potency	3.1623	1
6-[1-oxo-2-[[4-(phenylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]thio]ethyl]-4H-1,4-benzoxazin-3-one	Homo sapiens (human)	Potency	10.0000	1
4-[bis(2-methylpropyl)sulfamoyl]-N-[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide	Homo sapiens (human)	Potency	3.1623	1
4-[[[5-[(4-chloro-3,5-dimethyl-1-pyrazolyl)methyl]-2-furanyl]-oxomethyl]amino]benzoic acid propan-2-yl ester	Homo sapiens (human)	Potency	12.5893	1
N-(3-dibenzofuranyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)thio]acetamide	Homo sapiens (human)	Potency	5.0119	1
N-[2-[4-[(4-chlorophenyl)-oxomethyl]-1-piperazinyl]phenyl]-2-benzofurancarboxamide	Homo sapiens (human)	Potency	3.9811	1
4-methyl-N-[2-(phenylmethyl)-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazol-8-yl]benzenesulfonamide	Homo sapiens (human)	Potency	7.9433	1
2-[[1-oxo-2-(1H-1,2,4-triazol-5-ylthio)ethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	12.5893	1
N-(2-furanylmethyl)-2-[3-(1-oxo-2-phenoxyethyl)-1-indolyl]acetamide	Homo sapiens (human)	Potency	12.5893	1
N-[3-[[2-(2,6-dimethylphenoxy)-1-oxoethyl]amino]phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	10.0000	1
2-(3,5-dimethylphenoxy)-N-[3-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]phenyl]acetamide	Homo sapiens (human)	Potency	3.9811	1
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-dibenzofuransulfonamide	Homo sapiens (human)	Potency	25.1189	1
1,4-dioxa-8-azaspiro[4.5]decan-8-yl-(5,7-diphenyl-2-pyrazolo[1,5-a]pyrimidinyl)methanone	Homo sapiens (human)	Potency	12.5893	1
2-(2,4-dichloro-6-methylphenoxy)-N-(2-furanylmethyl)acetamide	Homo sapiens (human)	Potency	3.1623	1
LSM-19724	Homo sapiens (human)	Potency	12.5893	1
4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dione	Homo sapiens (human)	Potency	12.5893	1
N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-[(6-methyl-1H-benzimidazol-2-yl)thio]acetamide	Homo sapiens (human)	Potency	5.0119	1
3-[5-(2,5-dimethyl-1-phenyl-3-pyrrolyl)-1,3,4-oxadiazol-2-yl]-1-benzopyran-2-one	Homo sapiens (human)	Potency	3.1623	1
[1-(4-fluorophenyl)sulfonyl-4-piperidinyl]-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methanone	Homo sapiens (human)	Potency	19.9526	1
N-(2,4-dichlorophenyl)-2-[[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
2-[[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)thio]methyl]-1,3-benzothiazole	Homo sapiens (human)	Potency	12.5893	1
5-[2-[[2-[[2-furanyl(oxo)methyl]amino]phenyl]-oxomethoxy]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
2-(1,3-benzodioxol-5-yl)-5-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]methylthio]-1,3,4-oxadiazole	Homo sapiens (human)	Potency	12.5893	1
2-[[[2-[(5-methoxycarbonyl-2-furanyl)methoxy]-2-oxoethyl]thio]methyl]-5-methyl-4-oxo-3H-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
4-cyclopropyl-2-[[2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-1-oxoethyl]amino]-3-thiophenecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	19.9526	1
N-[5-chloro-2-(4-methyl-1-piperazinyl)phenyl]-3-(dimethylsulfamoyl)benzamide	Homo sapiens (human)	Potency	15.8489	1
2-amino-7-methyl-5-oxo-4-(2,3,4-trimethoxyphenyl)-4,6,7,8-tetrahydro-1-benzopyran-3-carbonitrile	Homo sapiens (human)	Potency	25.1189	1
3,4,5-trimethoxy-N-[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]benzamide	Homo sapiens (human)	Potency	10.0000	1
1-(2-furanylmethyl)-3-[(4-methylphenyl)methyl]pyrrolidine-2,5-dione	Homo sapiens (human)	Potency	10.0000	1
2-[(9-tert-butyl-1,5-dicyano-2-oxo-3-azaspiro[5.5]undec-4-en-4-yl)thio]-N-cyclohexylacetamide	Homo sapiens (human)	Potency	12.5893	1
N-[4-[4-(1-pyrrolidinylsulfonyl)phenyl]-2-thiazolyl]-2,3-dihydro-1,4-benzodioxin-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
3-hydroxy-3-[2-oxo-2-[4-(1-pyrrolyl)phenyl]ethyl]-1H-indol-2-one	Homo sapiens (human)	Potency	10.0000	1
N-(5-chloro-2-hydroxyphenyl)-2-ethoxybenzamide	Homo sapiens (human)	Potency	12.5893	1
N-[4-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]phenyl]-2-phenoxybutanamide	Homo sapiens (human)	Potency	12.5893	1
N-[2-[(2-furanylmethylamino)-oxomethyl]phenyl]-4-methyl-3-(1-piperidinylsulfonyl)benzamide	Homo sapiens (human)	Potency	12.5893	1
3-[2-(2,4-dimethyl-3-furanyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-2-indolone	Homo sapiens (human)	Potency	12.5893	1
N-[3-chloro-4-[4-[oxo-(4-propoxyphenyl)methyl]-1-piperazinyl]phenyl]propanamide	Homo sapiens (human)	Potency	6.3096	1
3-fluoro-N-[4-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]phenyl]benzenesulfonamide	Homo sapiens (human)	Potency	19.9526	1
1-[2-(hydroxymethyl)-1-benzimidazolyl]-3-(1-indolyl)-2-propanol	Homo sapiens (human)	Potency	25.1189	1
1-[3-[4-(2-chloro-5-methoxyphenyl)-1-piperazinyl]propyl]-3-(4-methylphenyl)urea	Homo sapiens (human)	Potency	7.9433	1
9-oxo-N-(1-phenylethyl)-3-bicyclo[3.3.1]nonanecarboxamide	Homo sapiens (human)	Potency	5.0119	1
N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-oxolanecarboxamide	Homo sapiens (human)	Potency	10.0000	1
6-(2-chlorophenyl)-3-methyl-2-[4-morpholinyl(oxo)methyl]-1,5,6,7-tetrahydroindol-4-one	Homo sapiens (human)	Potency	12.5893	1
N-[3-chloro-4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]-2-(4-chlorophenyl)acetamide	Homo sapiens (human)	Potency	5.0119	1
4-(1,3-benzodioxol-5-yl)-6-[[2-(4-chlorophenyl)ethylamino]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester	Homo sapiens (human)	Potency	12.5893	1
1-[2-furanyl(oxo)methyl]-6-(1-pyrrolidinylsulfonyl)-2-benzo[cd]indolone	Homo sapiens (human)	Potency	12.5893	1
2-[[[4-(4-methoxyphenyl)-5-phenyl-1,2,4-triazol-3-yl]thio]methyl]-5-phenyl-1,3,4-oxadiazole	Homo sapiens (human)	Potency	12.5893	1
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)propanamide	Homo sapiens (human)	Potency	5.0119	1
7-[[[1-(3-methylphenyl)-2-benzimidazolyl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone	Homo sapiens (human)	Potency	10.0000	1
2-(4-cyanophenoxy)-N-(2-methyl-1-phenyl-5-benzimidazolyl)acetamide	Homo sapiens (human)	Potency	5.0119	1
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[[1-(2-methylpropyl)-2-benzimidazolyl]thio]ethanone	Homo sapiens (human)	Potency	12.5893	1
6-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-ethyl-N-phenyl-3-pyridinesulfonamide	Homo sapiens (human)	Potency	12.5893	1
1-butyl-2-[(1,3-dioxo-2-isoindolyl)methylthio]-5-benzimidazolesulfonamide	Homo sapiens (human)	Potency	10.0000	1
3-(2,5-dimethyl-3-furanyl)-5,6-diphenyl-1,2,4-triazine	Homo sapiens (human)	Potency	10.0000	1
1-(4-fluorophenyl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxylic acid (2-oxo-3-oxolanyl) ester	Homo sapiens (human)	Potency	10.0000	1
7-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-2-hydroxypropoxy]-4-methyl-1-benzopyran-2-one	Homo sapiens (human)	Potency	6.3096	1
3-[(4-phenyl-1-piperazinyl)sulfonyl]benzoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	Homo sapiens (human)	Potency	1.9953	1
1-butyl-2-[(5-phenyl-2-oxazolyl)methylthio]-5-benzimidazolesulfonamide	Homo sapiens (human)	Potency	12.5893	1
2-[(5,6-dithiophen-2-yl-1,2,4-triazin-3-yl)oxy]-N-methyl-N-phenylacetamide	Homo sapiens (human)	Potency	15.8489	1
3-ethyl-4-oxo-1-phthalazinecarboxylic acid [2-(1H-indol-3-yl)-2-oxoethyl] ester	Homo sapiens (human)	Potency	25.1189	1
6-methyl-2-[[2-(4-morpholinyl)-1-oxoethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester	Homo sapiens (human)	Potency	12.5893	1
2-(3,4-dimethoxyphenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester	Homo sapiens (human)	Potency	10.0000	1
3-[(4-methylphenyl)sulfamoyl]benzoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	Homo sapiens (human)	Potency	15.8489	1
N-[1-(1H-benzimidazol-2-yl)-2-phenylethyl]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-oxo-3-pyrrolidinecarboxamide	Homo sapiens (human)	Potency	19.9526	1
Avocadyne	Homo sapiens (human)	Potency	12.5893	1
3-deoxyvasicine, hydrochloride	Homo sapiens (human)	Potency	12.5893	1
N-(2-furanylmethyl)-6-(3-methoxyphenyl)-N-methyl-4-quinazolinamine	Homo sapiens (human)	Potency	25.1189	1
6-(1,3-benzodioxol-5-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine	Homo sapiens (human)	Potency	12.5893	1
6-(2-chlorophenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	12.5893	1
6-(3-furanyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine	Homo sapiens (human)	Potency	7.9433	1
6-(3-furanyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	12.5893	1
6-(3-methoxyphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	10.0000	1
6-(2-chlorophenyl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	Homo sapiens (human)	Potency	15.8489	1
nih-12848	Homo sapiens (human)	Potency	5.0119	1
6-(3-furanyl)-N-(3-pyridinylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	25.1189	1
N-[(3-methylphenyl)methyl]-6-(3-pyridinyl)-4-quinazolinamine	Homo sapiens (human)	Potency	15.8489	1
4-[butan-2-yl-[(3,4-dichloroanilino)-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	12.5893	1
4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-2-methyl-5-furo[3,2-b]pyrrolecarboxylic acid methyl ester	Homo sapiens (human)	Potency	15.8489	1
2-[[3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio]-N-(5-methyl-3-isoxazolyl)acetamide	Homo sapiens (human)	Potency	19.9526	1
3-(1,3-benzodioxol-5-ylmethyl)-7-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-2-sulfanylidene-1H-quinazolin-4-one	Homo sapiens (human)	Potency	7.9433	1
N-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]-3-oxopropyl]-2-(1-oxo-2-isoquinolinyl)acetamide	Homo sapiens (human)	Potency	10.0000	1
6-bromo-3-[4-oxo-4-[4-(2-pyridinyl)-1-piperazinyl]butyl]-2-sulfanylidene-1H-quinazolin-4-one	Homo sapiens (human)	Potency	12.5893	1
2-(2-methoxyphenyl)-N-[4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide	Homo sapiens (human)	Potency	12.5893	1
2-[8-[[bis(phenylmethyl)amino]methyl]-3-methyl-2,6-dioxo-7-purinyl]acetic acid ethyl ester	Homo sapiens (human)	Potency	15.8489	1
N-(3-chlorophenyl)-2-[6,7-dimethoxy-2,4-dioxo-3-(2-oxolanylmethyl)-1-quinazolinyl]acetamide	Homo sapiens (human)	Potency	12.5893	1
1-[2-[3-(N-ethylanilino)propylamino]-3,4-dioxo-1-cyclobutenyl]-4-piperidinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	19.9526	1
4-morpholinecarboxylic acid [4-[6-amino-5-cyano-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]phenyl] ester	Homo sapiens (human)	Potency	12.5893	1
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
N-(2,3-dihydro-1H-inden-5-yl)-2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)thio]acetamide	Homo sapiens (human)	Potency	10.0000	1
3,4-dihydro-2H-quinolin-1-yl-(7-methoxy-4,5-dihydrobenzo[g][1,2]benzoxazol-3-yl)methanone	Homo sapiens (human)	Potency	25.1189	1
N-(5-chloro-2-methoxyphenyl)-2,4-dimethyl-5-oxazolecarboxamide	Homo sapiens (human)	Potency	15.8489	1
1-(4-chlorophenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-4-pyrazolecarboxylic acid	Homo sapiens (human)	Potency	12.5893	1
N-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-2-[[1-oxo-2-(1-oxo-2-isoquinolinyl)ethyl]amino]acetamide	Homo sapiens (human)	Potency	10.0000	1
4-(3,4-dimethoxyphenyl)-2-(1-piperidinyl)-6-(trifluoromethyl)pyrimidine	Homo sapiens (human)	Potency	10.0000	1
N-(3-chlorophenyl)-5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-3-methyl-2-benzofurancarboxamide	Homo sapiens (human)	Potency	12.5893	1
4-[2-[[2-[[4-(1,3-benzodioxol-5-yl)-2-thiazolyl]amino]-2-oxoethyl]thio]-1-oxoethyl]-1-piperazinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	12.5893	1
1-[4-[2-(2,5-dimethyl-1-pyrrolyl)ethyl]-1-piperazinyl]-2-[[3-(4-morpholinyl)-2-quinoxalinyl]thio]ethanone	Homo sapiens (human)	Potency	19.9526	1
2-[(5-bromo-2-thiophenyl)sulfonyl-methylamino]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide	Homo sapiens (human)	Potency	10.0000	1
[1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-3-piperidinyl]-(2-methyl-2,3-dihydroindol-1-yl)methanone	Homo sapiens (human)	Potency	12.5893	1
2-(4-ethoxyphenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid	Homo sapiens (human)	Potency	12.5893	1
3-methyl-N,6-diphenyl-2-imidazo[2,1-b]thiazolecarboxamide	Homo sapiens (human)	Potency	10.0000	1
1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-(6-methyl-1,3-benzothiazol-2-yl)-3-piperidinecarboxamide	Homo sapiens (human)	Potency	12.5893	1
1-[[4-[(4-fluorophenyl)methyl]-5-thieno[3,2-b]pyrrolyl]-oxomethyl]-N-(2-furanylmethyl)-4-piperidinecarboxamide	Homo sapiens (human)	Potency	7.9433	1
4-[[2-(3-ethylanilino)-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	10.0000	1
5-bromo-N-[2-(6,7-dimethyl-2-oxo-1H-quinolin-3-yl)ethyl]-2-furancarboxamide	Homo sapiens (human)	Potency	12.5893	1
N-[2-(dimethylamino)ethyl]-2-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]acetamide	Homo sapiens (human)	Potency	25.1189	1
6-[(2-ethylphenyl)sulfamoyl]-N-(2-furanylmethyl)-4-oxo-1H-quinoline-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
2-[[3-oxo-2-[3-oxo-3-(4-phenyl-1-piperazinyl)propyl]-2H-imidazo[1,2-c]quinazolin-5-yl]thio]acetonitrile	Homo sapiens (human)	Potency	10.0000	1
2-amino-4-[5-methyl-2-(methylthio)-3-thiophenyl]-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile	Homo sapiens (human)	Potency	19.9526	1
6-[(2-ethylphenyl)sulfamoyl]-4-oxo-N-(2-oxolanylmethyl)-1H-quinoline-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
N-butyl-2-[[6-(4-morpholinyl)-4-oxo-3-(2-phenylethyl)-2-quinazolinyl]thio]acetamide	Homo sapiens (human)	Potency	12.5893	1
4-(4-methyl-1-oxido-2-triazol-1-iumyl)benzoic acid	Homo sapiens (human)	Potency	10.0000	1
N-(1,3-benzodioxol-5-yl)-2-[(1-ethyl-2-oxo-4-quinolinyl)thio]acetamide	Homo sapiens (human)	Potency	15.8489	1
6-(1-azepanylsulfonyl)-1-ethyl-N-(2-furanylmethyl)-4-oxo-3-quinolinecarboxamide	Homo sapiens (human)	Potency	12.5893	1
3-(2-chlorophenyl)-5-methyl-N-[3-(3-methyl-2-imidazo[1,2-a]pyrimidinyl)phenyl]-4-isoxazolecarboxamide	Homo sapiens (human)	Potency	7.9433	1
N-(1,3-benzodioxol-5-yl)-5-bromo-1-[cyclopropyl(oxo)methyl]-N-ethyl-2,3-dihydroindole-7-sulfonamide	Homo sapiens (human)	Potency	5.0119	1
N-[2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl]-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine	Homo sapiens (human)	Potency	5.0119	1
2-furanyl-[4-(4-tetrazolo[1,5-a]quinoxalinyl)-1-piperazinyl]methanone	Homo sapiens (human)	Potency	7.9433	1
1-acetyl-5-bromo-N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-methyl-2,3-dihydroindole-7-sulfonamide	Homo sapiens (human)	Potency	25.1189	1
6-[2-(5-chloro-2-methoxyanilino)-2-oxoethyl]-5-thieno[2,3-b]pyrrolecarboxylic acid methyl ester	Homo sapiens (human)	Potency	12.5893	1
N-(3,4-dimethylphenyl)-2-[N-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methoxyanilino]acetamide	Homo sapiens (human)	Potency	12.5893	1
N-(1,3-benzodioxol-5-yl)-2-[[6-methyl-4-oxo-3-(phenylmethyl)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamide	Homo sapiens (human)	Potency	12.5893	1
N-(2-chlorophenyl)-5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-3-methyl-2-benzofurancarboxamide	Homo sapiens (human)	Potency	10.0000	1
2-amino-4-[4-(methylthio)phenyl]-5-oxo-1-phenyl-4,6,7,8-tetrahydroquinoline-3-carbonitrile	Homo sapiens (human)	Potency	19.9526	1
2,5-dimethyl-4-(4-methyl-1-piperidinyl)-6-thieno[2,3-d]pyrimidinecarboxylic acid	Homo sapiens (human)	Potency	10.0000	1
N-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-2-[(1-ethyl-2-oxo-4-quinolinyl)oxy]acetamide	Homo sapiens (human)	Potency	12.5893	1
2-[[2-(3-methyl-1-oxo-2-isoquinolinyl)-1-oxoethyl]amino]acetic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
N-(2,3-dimethylphenyl)-3-methyl-5-(4-morpholinylsulfonyl)-2-benzofurancarboxamide	Homo sapiens (human)	Potency	12.5893	1
7-(2,4-dichlorophenyl)-5-oxo-2,3-dihydrothiazolo[3,2-a]pyrimidine-6-carbonitrile	Homo sapiens (human)	Potency	12.5893	1
N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-1-methyl-4-oxo-6-(1-pyrrolidinylsulfonyl)-3-quinolinecarboxamide	Homo sapiens (human)	Potency	3.9811	1
5-(1,3-benzodioxol-5-yl)-3-[3-(methylthio)phenyl]-1H-imidazol-2-one	Homo sapiens (human)	Potency	10.0000	1
N-butan-2-yl-6-[(4-ethoxyphenyl)sulfamoyl]-4-oxo-1H-quinoline-3-carboxamide	Homo sapiens (human)	Potency	12.5893	1
7-[4-[4-(2-fluorophenyl)-1-piperazinyl]-4-oxobutyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one	Homo sapiens (human)	Potency	31.6228	1
N-(2-furanylmethyl)-5,7-dimethyl-6-[(3-methylphenyl)methyl]-3-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	25.1189	1
1-[2-(4-bromophenyl)-2-oxoethyl]-3-(2-furanylmethyl)-6,7-dimethoxyquinazoline-2,4-dione	Homo sapiens (human)	Potency	10.0000	1
8-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]methyl]-3-methyl-7-(2-phenylethyl)purine-2,6-dione	Homo sapiens (human)	Potency	12.5893	1
1-methyl-N-(2-methylcyclohexyl)-4-oxo-6-(1-pyrrolidinylsulfonyl)-3-quinolinecarboxamide	Homo sapiens (human)	Potency	12.5893	1
2-(2-ethoxyphenyl)-8-oxo-9-phenyl-7H-purine-6-carboxamide	Homo sapiens (human)	Potency	12.5893	1
cyclopentanecarboxylic acid [4-(benzenesulfonyl)-2-tert-butyl-5-methyl-3-pyrazolyl] ester	Homo sapiens (human)	Potency	12.5893	1
1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-3-piperidinecarboxamide	Homo sapiens (human)	Potency	10.0000	1
1-[(2-ethoxyphenyl)methyl]-3-thiophen-2-ylurea	Homo sapiens (human)	Potency	25.1189	1
cgp 13501	Homo sapiens (human)	Potency	12.5893	1
2,4-dihydroxyheptadec-16-enyl acetate	Homo sapiens (human)	Potency	15.8489	1
2,4-dihydroxyheptadec-16-ynyl acetate	Homo sapiens (human)	Potency	15.8489	1
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazole	Homo sapiens (human)	Potency	31.6228	1
quercetin	Homo sapiens (human)	Potency	31.6228	1
acacetin	Homo sapiens (human)	Potency	12.5893	1
apigenin	Homo sapiens (human)	Potency	10.0000	1
cyclosporine	Homo sapiens (human)	Potency	10.0000	1
baicalein	Homo sapiens (human)	Potency	0.6310	1
mangostin	Homo sapiens (human)	Potency	10.0000	1
myricetin	Homo sapiens (human)	Potency	1.2589	1
Pinosylvin methyl ether	Homo sapiens (human)	Potency	25.1189	1
10-octadecenoic acid, (z)-isomer	Homo sapiens (human)	Potency	12.5893	1
quercetin	Homo sapiens (human)	Potency	2.5119	1
4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide	Homo sapiens (human)	Potency	3.9811	1
fumarprotocetraric acid	Homo sapiens (human)	Potency	25.1189	1
(5R)-3'-phenyl-1-(phenylmethyl)spiro[1,3-diazinane-5,5'-2,4,4a,6-tetrahydro-1H-pyrazino[1,2-a]quinoline]-2,4,6-trione	Homo sapiens (human)	Potency	10.0000	1
(3S,3'aR,8'aS,8'bS)-5-ethyl-2'-(phenylmethyl)spiro[1H-indole-3,4'-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]-1',2,3'-trione	Homo sapiens (human)	Potency	12.5893	1
aztreonam	Homo sapiens (human)	Potency	12.5893	1
methylbenzethonium chloride	Homo sapiens (human)	Potency	12.5893	1
l 162313	Homo sapiens (human)	Potency	3.1623	1
Garcinolic acid	Homo sapiens (human)	Potency	10.0000	1
sgd 301-76	Homo sapiens (human)	Potency	25.1189	1
meclofenamate sodium anhydrous	Homo sapiens (human)	Potency	7.9433	1
piroxicam	Homo sapiens (human)	Potency	18.8541	1
4-hydroxy-1-(2-methylpropyl)-2-oxo-N-(2-sulfamoylphenyl)-3-quinolinecarboxamide	Homo sapiens (human)	Potency	7.9433	1
4-hydroxy-2-oxo-1-propyl-N-(pyridin-4-ylmethyl)-3-quinolinecarboxamide	Homo sapiens (human)	Potency	25.1189	1
robustic acid	Homo sapiens (human)	Potency	10.0000	1
mobiflex	Homo sapiens (human)	Potency	5.0119	1
isoxicam	Homo sapiens (human)	Potency	10.4304	1
acyclovir	Homo sapiens (human)	Potency	12.5893	1
olanzapine	Homo sapiens (human)	Potency	19.9526	1
zaprinast	Homo sapiens (human)	Potency	7.1950	1
kf38789	Homo sapiens (human)	Potency	3.1623	1
hematein	Homo sapiens (human)	Potency	10.0000	1
4-[[2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
tegaserod maleate	Homo sapiens (human)	Potency	10.0000	1
N-(1,3-benzodioxol-5-ylmethyl)-3-methoxy-N-[(4-oxo-1H-quinazolin-2-yl)methyl]benzamide	Homo sapiens (human)	Potency	12.5893	1
1-cyclopentyl-1-[(4-oxo-1H-quinazolin-2-yl)methyl]-3-(phenylmethyl)urea	Homo sapiens (human)	Potency	15.8489	1
N-[(4-oxo-1H-quinazolin-2-yl)methyl]-N-(2-phenylethyl)butanamide	Homo sapiens (human)	Potency	10.0000	1
2-[(dimethylamino)methyl]-4-spiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclohexane]one	Homo sapiens (human)	Potency	7.9433	1

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gallic acid	Homo sapiens (human)	IC50	200.0000	1	1
way 151693	Homo sapiens (human)	IC50	0.3658	2	4
nevirapine	Homo sapiens (human)	IC50	0.1800	1	1
efavirenz	Homo sapiens (human)	IC50	0.0040	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	21.0000	1	1
arginyl-glycyl-aspartyl-serine	Homo sapiens (human)	IC50	82.0000	1	1
marimastat	Homo sapiens (human)	IC50	5.6679	3	3
marimastat	Homo sapiens (human)	Ki	0.0024	3	3
ilomastat	Homo sapiens (human)	IC50	0.1125	3	3
melagatran	Homo sapiens (human)	IC50	17.3000	1	2
prinomastat	Homo sapiens (human)	IC50	8.3110	2	2
rs-130830	Homo sapiens (human)	IC50	0.1316	5	5
tmi-1	Homo sapiens (human)	IC50	0.0068	6	7
jnj-7706621	Homo sapiens (human)	IC50	0.0062	1	2
batimastat	Homo sapiens (human)	IC50	0.0149	1	1
gi 129471	Homo sapiens (human)	IC50	5.3000	1	1
ik 682	Homo sapiens (human)	IC50	0.0289	4	5
ik 682	Homo sapiens (human)	Ki	0.0001	2	2
ro 32-3555	Homo sapiens (human)	IC50	5.1152	2	2
ro 32-3555	Homo sapiens (human)	Ki	0.2300	1	1
bms561392	Homo sapiens (human)	IC50	0.0002	1	1
sb 3ct compound	Homo sapiens (human)	Ki	3.7000	1	1
ro 31-9790	Homo sapiens (human)	IC50	50.0000	1	1
ro 31-9790	Homo sapiens (human)	Ki	0.0870	1	1
arginyl-glycyl-aspartyl-valine	Homo sapiens (human)	IC50	10.0000	1	1
arp-100	Homo sapiens (human)	IC50	110.0000	2	2
N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide	Homo sapiens (human)	IC50	14.0000	1	1
apratastat	Homo sapiens (human)	IC50	0.1441	6	7
incb3619	Homo sapiens (human)	IC50	0.5070	2	2
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile	Homo sapiens (human)	IC50	74.1310	1	1
grassystatin a	Homo sapiens (human)	IC50	5.6150	2	2
guanosine diphosphate	Homo sapiens (human)	IC50	200.0000	1	1

Enables

This protein enables 14 target(s):

Target	Category	Definition
endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
metalloendopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
Notch binding	molecular function	Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]
interleukin-6 receptor binding	molecular function	Binding to an interleukin-6 receptor. [GOC:ai]
integrin binding	molecular function	Binding to an integrin. [GOC:ceb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
metallopeptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
SH3 domain binding	molecular function	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]
cytokine binding	molecular function	Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]
PDZ domain binding	molecular function	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]
tumor necrosis factor binding	molecular function	Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
metalloendopeptidase activity involved in amyloid precursor protein catabolic process	molecular function	Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process. [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
actin cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 39 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
neutrophil mediated immunity	biological process	Any process involved in the carrying out of an immune response by a neutrophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]
germinal center formation	biological process	The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. [GO_REF:0000022, GOC:jal, ISBN:081533642X]
positive regulation of leukocyte chemotaxis	biological process	Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
membrane protein ectodomain proteolysis	biological process	The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
Notch receptor processing	biological process	The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. [PMID:12651094, PMID:14986688]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
positive regulation of T cell chemotaxis	biological process	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]
protein processing	biological process	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
signal release	biological process	The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. [GOC:mtg_signal]
B cell differentiation	biological process	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]
positive regulation of cell growth	biological process	Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
negative regulation of transforming growth factor beta receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
positive regulation of chemokine production	biological process	Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
regulation of mast cell apoptotic process	biological process	Any process that modulates the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]
T cell differentiation in thymus	biological process	The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. [GOC:add, ISBN:0781735149]
cell adhesion mediated by integrin	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]
wound healing, spreading of epidermal cells	biological process	The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. [GOC:bf, PMID:15269788]
amyloid precursor protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]
positive regulation of blood vessel endothelial cell migration	biological process	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]
positive regulation of cyclin-dependent protein serine/threonine kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr]
positive regulation of epidermal growth factor-activated receptor activity	biological process	Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. [GOC:go_curators]
positive regulation of epidermal growth factor receptor signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]
spleen development	biological process	The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. [GOC:add, ISBN:0781735149]
cell motility	biological process	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
defense response to Gram-positive bacterium	biological process	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]
cellular response to high density lipoprotein particle stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus. [GOC:mah]
commissural neuron axon guidance	biological process	The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:mah]
negative regulation of cold-induced thermogenesis	biological process	Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]
positive regulation of G1/S transition of mitotic cell cycle	biological process	Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
positive regulation of tumor necrosis factor-mediated signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]
positive regulation of vascular endothelial cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
Notch signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, GOC:signaling]