Page last updated: 2024-08-07 15:21:23
Cocaine esterase
A cocaine esterase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00748]
Synonyms
EC 3.1.1.84;
Carboxylesterase 2;
CE-2;
hCE-2;
3.1.1.1;
Methylumbelliferyl-acetate deacetylase 2;
3.1.1.56
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
Compounds (46)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bis(4-nitrophenyl)phosphate | Homo sapiens (human) | IC50 | 5.2150 | 2 | 2 |
| diacetyl | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| 6,7-dichloroquinoxaline-2,3-dione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| benzophenone | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| valproic acid | Homo sapiens (human) | Ki | 7,900.0000 | 1 | 1 |
| flutamide | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | Ki | 0.0063 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | Ki | 0.1090 | 1 | 1 |
| loperamide | Homo sapiens (human) | IC50 | 5.7000 | 2 | 2 |
| loperamide | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| quinone | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| 1,3-ditolylguanidine | Homo sapiens (human) | Ki | 0.0890 | 1 | 1 |
| chloranil | Homo sapiens (human) | Ki | 0.0574 | 1 | 1 |
| benzoin | Homo sapiens (human) | Ki | 2.3700 | 3 | 3 |
| dibenzoylmethane | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| benzil | Homo sapiens (human) | IC50 | 0.0410 | 2 | 2 |
| benzil | Homo sapiens (human) | Ki | 0.0548 | 9 | 9 |
| 1,3-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| dibromsalicil | Homo sapiens (human) | Ki | 0.0727 | 1 | 1 |
| 1-phenyl-1,2-propanedione | Homo sapiens (human) | Ki | 1.8400 | 2 | 2 |
| 2,3-pentanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 1,2-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| acetylacetone | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 3-methyl-1,2-cyclopentanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| alpha-furil | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| 4-benzoylbenzoic acid | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 2-chloranil | Homo sapiens (human) | Ki | 0.8750 | 1 | 1 |
| 3,5-di-tert-butyl-1,2-benzoquinone | Homo sapiens (human) | Ki | 1.3500 | 1 | 1 |
| 2,2-dimethoxy-2-phenylacetophenone | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| anisoin | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| hydrobenzoin | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| tanshinone | Homo sapiens (human) | Ki | 7.9800 | 2 | 2 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | IC50 | 0.0072 | 2 | 2 |
| miltirone | Homo sapiens (human) | Ki | 0.0618 | 2 | 2 |
| cryptotanshinone | Homo sapiens (human) | Ki | 0.2155 | 2 | 2 |
| tanshinone ii a | Homo sapiens (human) | Ki | 1.2597 | 2 | 2 |
| oleuropeic acid | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| lupeol | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| lysophosphatidic acid | Homo sapiens (human) | IC50 | 1.5700 | 1 | 1 |
| Dihydrotanshinone I | Homo sapiens (human) | Ki | 0.9740 | 2 | 2 |
| alisol a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 23-hydroxybetulinic acid | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| tanshinone ii a sodium sulfonate | Homo sapiens (human) | Ki | 16.3450 | 2 | 2 |
| wms 1410 | Homo sapiens (human) | Ki | 0.1940 | 1 | 1 |
Drugs with Other Measurements
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Design, synthesis and biological evaluation of indanone-chalcone hybrids as potent and selective hCES2A inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Yanhusanines A-F, Isoquinoline-Derived Alkaloid Enantiomers from Journal of natural products, , 02-28, Volume: 83, Issue:2, 2020
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| methylumbelliferyl-acetate deacetylase activity | molecular function | Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+. [EC:3.1.1.56, RHEA:12208] |
| carboxylesterase activity | molecular function | Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. [RHEA:21164] |
| carboxylic ester hydrolase activity | molecular function | Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| prostaglandin metabolic process | biological process | The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. [ISBN:0198547684] |