| Assay ID | Title | Year | Journal | Article |
|---|
| AID253822 | Elimination phase half-life after administration to rats at a dose of 2.5 mg/kg orally | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID1872646 | Modulation of gamma-secretase in human H4 cells expressing APPswe mutant assessed as reduction in amyloid beta 42 by ELISA | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Small molecules targeting γ-secretase and their potential biological applications. |
| AID255938 | Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cells | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692107 | Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutations assessed as reduction in plaque area in brain cortex dosed for 6 months | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID253637 | Area under curve after administration to rats at a dose of 2.5 mg/kg orally | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID255950 | Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID253783 | Maximum time corresponding to maximum concentration after administration to rats at a dose of 2.5 mg/kg orally | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID255934 | Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cells | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692153 | Drug level in brain of Tg2576 mouse expressing human APP Swedish mutant at 60 mg/kg/day after 17 weeks | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID689133 | Modulation of gamma-secretase | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. |
| AID1872648 | Half life in rat | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Small molecules targeting γ-secretase and their potential biological applications. |
| AID253643 | Area under curve after administration to rats at a dose of 0.5 mg/kg intravenously | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID635714 | Modulation of gamma-secretase-mediated cleavage of APP assessed as reduction in amyloid beta42 production | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach. |
| AID253844 | Concentration ratio in cerebrospinal fluid and plasma | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID253588 | Total body clearance after administration to rats at a dose of 2.5 mg/kg intravenously | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID256532 | Permeability in the Caco-2 cell; high absorption | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692104 | Brain penetration in mouse assessed as brain/plasma ratio at 100 or 300 mg/kg/day for 4 to 5 days | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID1872647 | Oral bioavailability in rat | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Small molecules targeting γ-secretase and their potential biological applications. |
| AID692105 | Drug level in mouse brain dosed for 4 weeks | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID692111 | Antialzheimer activity in transgenic Alzheimer disease mouse model assessed as increase in recognition index at 125 ppm dosed for 10 months by object recognition memory test (Rvb = 48.9%) | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID253568 | Absolute oral bioavailability after administration to rats at a dose of 0.5 mg/kg orally | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID592746 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 1 uM after 24 hrs by MTT assay relative to control | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. |
| AID254823 | Concentration required to inhibit A beta 40 peptide 100 uM | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692109 | Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutations assessed as reduction in plaque number in brain cortex dosed for 6 months | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID592745 | Antiamyloidogenic activity in mouse N2A cells transfected with human APP Swedish mutant assessed as reduction of amyloid beta (1 to 42) level at 1 uM after 24 hrs by ELISA relative to control | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. |
| AID692152 | Drug metabolism in Alzheimer disease patient assessed as formation of compound -glucoronide metabolite dosed po as six ascending doses ( 25, 50, 100, 200, 400 and 600 mg) | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID253727 | Maximal concentration in rats after 0.5 mg/kg intravenous dose | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID253891 | In vivo steady state metabolic clearance of the compound | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID592744 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay relative to control | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. |
| AID692103 | Inhibition of gamma secretase assessed as reduction in Abeta42 production | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID256360 | Percent inhibition against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) at 100 uM | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692106 | Drug level in mouse plasma dosed for 4 weeks | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID692110 | Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutations assessed as reduction in plaque number in brain hippocampus dosed for 6 months | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID255936 | Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cells | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID689134 | Ratio of tarenflurbil EC50 to compound EC50 for gamma-secretase | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. |
| AID692112 | Antialzheimer activity in transgenic Alzheimer disease mouse model assessed as increase in recognition index at 375 ppm dosed for 10 months by object recognition memory test (Rvb = 48.9%) | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID253719 | Maximal concentration in rats after 2.5 mg/kg oral dose | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID692108 | Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutations assessed as reduction in plaque area in brain hippocampus dosed for 6 months | 2011 | Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
| γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. |
| AID1383010 | Inhibition of gamma-secretase (unknown origin) | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. |
| AID255271 | Percent inhibition against cyclooxygenase-1 at 100 uM in rat blood | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |