Proteins > Bifunctional purine biosynthesis protein ATIC
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Bifunctional purine biosynthesis protein ATIC
A bifunctional purine biosynthesis protein ATIC that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31939]
Synonyms
AICAR transformylase/inosine monophosphate cyclohydrolase;
ATIC
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aica ribonucleotide | Homo sapiens (human) | Km | 1.9000 | 1 | 1 |
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.The Journal of biological chemistry, , Apr-27, Volume: 282, Issue:17, 2007
A multisubstrate adduct inhibitor of AICAR transformylase.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor Bioorganic & medicinal chemistry, , 05-01, Volume: 37, 2021
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor Bioorganic & medicinal chemistry, , 05-01, Volume: 37, 2021
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.Journal of medicinal chemistry, , Sep-11, Volume: 51, Issue:17, 2008
Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.Journal of medicinal chemistry, , May-18, Volume: 49, Issue:10, 2006
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| IMP cyclohydrolase activity | molecular function | Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. [EC:3.5.4.10] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| phosphoribosylaminoimidazolecarboxamide formyltransferase activity | molecular function | Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. [EC:2.1.2.3] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|
| brainstem development | biological process | The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph] |
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| GMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732] |
| 'de novo' IMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. [GOC:mah, ISBN:0716720094] |
| response to inorganic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm] |
| cerebellum development | biological process | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| cerebral cortex development | biological process | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| animal organ regeneration | biological process | The regrowth of a lost or destroyed animal organ. [GOC:mah] |
| 'de novo' AMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). [GOC:ecd, PMID:10888601] |
| dihydrofolate metabolic process | biological process | The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate. [ISBN:0198506732] |
| tetrahydrofolate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732] |
| 'de novo' XMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927] |
| cellular response to interleukin-7 | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. [GOC:BHF, GOC:mah] |