Page last updated: 2024-08-07 17:30:24

Dipeptidyl peptidase 2

A dipeptidyl peptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHL4]

Synonyms

EC 3.4.14.2;
Dipeptidyl aminopeptidase II;
Dipeptidyl peptidase 7;
Dipeptidyl peptidase II;
DPP II;
Quiescent cell proline dipeptidase

Research

Bioassay Publications (38)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.63)18.2507
2000's21 (55.26)29.6817
2010's15 (39.47)24.3611
2020's1 (2.63)2.80

Compounds (14)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
valine-pyrrolidideHomo sapiens (human)IC50188.000044
sitagliptinHomo sapiens (human)IC5094.56981824
vildagliptinHomo sapiens (human)IC50197.71241725
talabostatHomo sapiens (human)IC500.043733
talabostatHomo sapiens (human)Ki41.750033
nvp-dpp728Homo sapiens (human)IC5030.7438711
linagliptinHomo sapiens (human)IC50100.000033
alanylpyrrolidine-boronic acidHomo sapiens (human)IC500.060011
alanylpyrrolidine-boronic acidHomo sapiens (human)Ki0.125011
uamc00039Homo sapiens (human)IC500.000455
uamc00039Homo sapiens (human)Ki0.000111
bms 477118Homo sapiens (human)IC5030.000011
alogliptinHomo sapiens (human)IC50100.000022
gosogliptinHomo sapiens (human)IC503.300011
anagliptinHomo sapiens (human)IC50176.700011
mk-3102Homo sapiens (human)IC5083.500022
rpx7009Homo sapiens (human)IC501,000.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
aminopeptidase activitymolecular functionCatalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]
serine-type peptidase activitymolecular functionCatalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
serine-type exopeptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]
dipeptidyl-peptidase activitymolecular functionCatalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
azurophil granule lumencellular componentThe volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
vesiclecellular componentAny small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
vesiclecellular componentAny small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]

Involved In

This protein is involved in 2 target(s):

TargetCategoryDefinition
proteolysisbiological processThe hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
lysosomal protein catabolic processbiological processAny cellular protein catabolic process that takes place in a lysosome. [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]