Oxytocin receptor

An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559]

Synonyms

OT-R

Research

Bioassay Publications (44)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (11.36)	18.2507
2000's	11 (25.00)	29.6817
2010's	27 (61.36)	24.3611
2020's	1 (2.27)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
opc 21268	Homo sapiens (human)	Ki	0.1700	1	1
mozavaptan	Homo sapiens (human)	Ki	0.6600	1	1
lixivaptan	Homo sapiens (human)	IC50	0.5190	1	1
oxytocin	Homo sapiens (human)	IC50	0.0027	1	1
oxytocin	Homo sapiens (human)	Ki	0.0026	11	11
deaminooxytocin	Homo sapiens (human)	Ki	0.0003	1	1
arginine vasopressin	Homo sapiens (human)	Ki	0.0047	5	5
atosiban	Homo sapiens (human)	IC50	0.2155	2	2
atosiban	Homo sapiens (human)	Ki	0.1014	5	5
l 372662	Homo sapiens (human)	Ki	0.0041	1	1
way-151932	Homo sapiens (human)	IC50	0.3530	1	1
way-151932	Homo sapiens (human)	Ki	0.1743	3	3
l 371257	Homo sapiens (human)	Ki	0.0092	7	7
l 368899	Homo sapiens (human)	Ki	0.0130	1	1
ssr 149415	Homo sapiens (human)	Ki	0.0161	4	4
gsk221149a	Homo sapiens (human)	Ki	0.0019	2	3
epelsiban	Homo sapiens (human)	IC50	0.0092	1	1
epelsiban	Homo sapiens (human)	Ki	0.0001	1	1
carbetocin	Homo sapiens (human)	Ki	0.0018	1	1
obe001	Homo sapiens (human)	Ki	0.0950	1	1
way 267464	Homo sapiens (human)	IC50	10.0000	1	1
way 267464	Homo sapiens (human)	Ki	0.2348	7	7

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
oxytocin	Homo sapiens (human)	EC50	0.0048	18	18
oxytocin	Homo sapiens (human)	Kd	0.0067	1	1
deaminooxytocin	Homo sapiens (human)	EC50	0.0000	4	4
arginine vasopressin	Homo sapiens (human)	EC50	0.0169	5	6
deamino arginine vasopressin	Homo sapiens (human)	EC50	0.0910	2	2
way-151932	Homo sapiens (human)	EC50	0.1250	1	1
l 371257	Homo sapiens (human)	EC50	0.0046	1	1
carbetocin	Homo sapiens (human)	EC50	0.0109	5	5
vasopressin, 1-deamino-4-val-8-arg-	Homo sapiens (human)	EC50	0.3500	1	1
way 267464	Homo sapiens (human)	EC50	0.2962	10	10

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
way-151932	Homo sapiens (human)	Kinact	0.4880	2	2
l 371257	Homo sapiens (human)	Kinact	0.0009	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
peptide hormone binding	molecular function	Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
peptide binding	molecular function	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]
vasopressin receptor activity	molecular function	Combining with vasopressin to initiate a change in cell activity. [GOC:ai]
oxytocin receptor activity	molecular function	Combining with oxytocin to initiate a change in cell activity. [GOC:ai]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
microvillus	cellular component	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]
adherens junction	cellular component	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 37 target(s):

Target	Category	Definition
suckling behavior	biological process	Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. [GOC:dph, GOC:pr]
response to amphetamine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
muscle contraction	biological process	A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
heart development	biological process	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
lactation	biological process	The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732]
memory	biological process	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
positive regulation of norepinephrine secretion	biological process	Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb]
telencephalon development	biological process	The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
positive regulation of synaptic transmission, GABAergic	biological process	Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]
response to estradiol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
response to progesterone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:sl]
response to anoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. [GOC:kmv]
response to cytokine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:sl]
social behavior	biological process	Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
response to cocaine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]
maternal behavior	biological process	Female behaviors associated with the care and rearing of offspring. [GOC:curators]
sperm ejaculation	biological process	The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
eating behavior	biological process	The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]
response to peptide hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
estrous cycle	biological process	A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. [GOC:jl, Wikipedia:Estrous_cycle]
positive regulation of blood pressure	biological process	Any process in which the force of blood traveling through the circulatory system is increased. [GOC:go_curators, GOC:mtg_cardio]
digestive tract development	biological process	The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]
positive regulation of synapse assembly	biological process	Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]
positive regulation of synaptic transmission, glutamatergic	biological process	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
positive regulation of penile erection	biological process	Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:dph, GOC:tb]
ERK1 and ERK2 cascade	biological process	A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. [PMID:20811974, PMID:23125017, PMID:28903453]
positive regulation of uterine smooth muscle contraction	biological process	Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
female pregnancy	biological process	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
regulation of systemic arterial blood pressure by vasopressin	biological process	The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. [GOC:mtg_cardio, ISBN:0721643949]
positive regulation of vasoconstriction	biological process	Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators]
maternal process involved in parturition	biological process	A reproductive process occurring in the mother that results in birth. [GOC:dph]
cellular response to hormone stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah]