indomethacin has been researched along with Necrosis in 80 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 7.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "Previous studies have shown that indomethacin administered during the early phase of experimental myocarditis may exacerbate the disease process." | 7.67 | Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model. ( Khatib, G; Khatib, R; Kloner, R; Rezkalla, S; Smith, F; Sowers, J; Walsh, M, 1988) |
| "The possible role of thromboxane A2 (TXA2) in acute necrotizing pancreatitis (ANP) was investigated in rats." | 7.67 | Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin. ( Kort, WJ; Ouwendijk, RJ; van Ooijen, B; Vincent, JE; Westbroek, DL; Wilson, JH; Zijlstra, FJ, 1988) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 5.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| " We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to induce necrosis and apoptosis in gastric mucosal cells) due to their membrane permeabilizing activities, which is involved in NSAID-induced gastric lesions." | 3.76 | Low direct cytotoxicity of loxoprofen on gastric mucosal cells. ( Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K, 2010) |
| "Indomethacin diminished cell death by necrosis and apoptosis, release of prostaglandin E2, induction of I/R-induced protein, dedifferentiation or induction of inducible nitric oxide synthase." | 3.76 | Indomethacin corrects alterations associated with ischemia/reperfusion in an in vitro proximal tubular model. ( Gekle, M; Holzinger, H; Renker, S; Sauvant, C; Schneider, R; Wanner, C, 2010) |
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 3.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "Oral indomethacin causes villous shortening, microvascular damage, and distortion, which might induce mucosal ischaemia and necrosis." | 3.70 | Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat. ( Anthony, A; Dhillon, AP; Kelly, DA; Piasecki, C; Pounder, RE; Wakefield, AJ, 1998) |
| "In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied." | 3.70 | [Celecoxib vs indomethacin and acute gastric lesions in rats]. ( Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS, 2000) |
| "Previous studies have shown that indomethacin administered during the early phase of experimental myocarditis may exacerbate the disease process." | 3.67 | Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model. ( Khatib, G; Khatib, R; Kloner, R; Rezkalla, S; Smith, F; Sowers, J; Walsh, M, 1988) |
| "This study addresses the question of whether the cyclooxygenase inhibitors indomethacin and diclofenac and the glucocorticosteroid dexamethasone ameliorate neuronal necrosis following cerebral ischemia." | 3.67 | Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. ( Koide, T; Siesjö, BK; Wieloch, TW, 1986) |
| "The effects of anti-inflammatory steroids and BW-755C (both of which inhibit the formation of prostaglandins and leukotrienes) were studied in ischemia-induced edema and necrosis of the rabbit ear utilizing an occlusion reperfusion model." | 3.67 | Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin. ( Chaudhuri, G; Hayden, B; Soderberg, R; Zarem, H, 1987) |
| "The possible role of thromboxane A2 (TXA2) in acute necrotizing pancreatitis (ANP) was investigated in rats." | 3.67 | Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin. ( Kort, WJ; Ouwendijk, RJ; van Ooijen, B; Vincent, JE; Westbroek, DL; Wilson, JH; Zijlstra, FJ, 1988) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 1.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "Fatty necrosis was especially prominent in the zafirlukast-treated acute pancreatitis group compared with the untreated group (2." | 1.32 | Leukotriene receptor antagonism in experimental acute pancreatitis in rats. ( Batur, Y; Celik, HA; Musoglu, A; Oruc, N; Ozutemiz, AO; Yuce, G; Yukselen, V, 2004) |
| "Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid." | 1.31 | Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. ( Ajuebor, MN; Singh, A; Wallace, JL, 2000) |
| " In this study, we tested inhibitors of arachidonate metabolism for possible protection against the toxic effects of the cytokine combination of tumor necrosis factor (TNF, 100 U/ml) and interferon-gamma (IFN-gamma, 100 U/ml) in rat islet cell monolayer cultures, using a 51Cr release cytotoxicity assay to measure islet cell lysis (% 51Cr release)." | 1.28 | Cytotoxic effects of cytokines on islet beta-cells: evidence for involvement of eicosanoids. ( Baquerizo, H; Rabinovitch, A; Sumoski, W, 1990) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| "Pretreatment with ebselen at oral doses from 10 to 100 mg/kg significantly inhibited such lesion formation induced by either necrotizing agent in a dose-related manner, and the inhibition at the highest dose (100 mg/kg p." | 1.28 | Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats. ( Akasaki, M; Kurebayashi, Y; Tabuchi, Y, 1989) |
| "Pretreatment with indomethacin abolished the protection afforded by chronic mild restraint, suggesting a mechanism involving endogenous prostaglandin synthesis." | 1.27 | Chronic mild restraint protects the rat gastric mucosa from injury by ethanol or cold restraint. ( Cohen, MM; Track, NS; Wallace, JL, 1983) |
| "Indomethacin has been most effective but not free of significant complications." | 1.26 | Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ( Altmiller, DH; Altshuler, G; Krous, HF; Sharpe, GL, 1979) |
| "Every form of glomerulonephritis has in all probability its individual course and prognosis, which can only be very slightly influenced by therapy." | 1.26 | The morphological and clinical course of the different forms of glomerulonephritis. ( Bohle, A; Edel, HH; Fishbach, H; Frotscher, U; Kluthe, R; Meyer, D; Renner, D; Rinsche, K; Scheler, F, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (52.50) | 18.7374 |
| 1990's | 18 (22.50) | 18.2507 |
| 2000's | 16 (20.00) | 29.6817 |
| 2010's | 4 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chioua, M | 1 |
| Sucunza, D | 1 |
| Soriano, E | 1 |
| Hadjipavlou-Litina, D | 1 |
| Alcázar, A | 1 |
| Ayuso, I | 1 |
| Oset-Gasque, MJ | 1 |
| González, MP | 1 |
| Monjas, L | 1 |
| Rodríguez-Franco, MI | 1 |
| Marco-Contelles, J | 1 |
| Samadi, A | 1 |
| Pastoris, O | 1 |
| Verri, M | 1 |
| Boschi, F | 1 |
| Kastsiuchenka, O | 1 |
| Balestra, B | 1 |
| Pace, F | 1 |
| Tonini, M | 1 |
| Natale, G | 1 |
| Gordon, PV | 1 |
| Chiou, SK | 1 |
| Hoa, N | 1 |
| Yamakawa, N | 1 |
| Suemasu, S | 1 |
| Kimoto, A | 1 |
| Arai, Y | 1 |
| Ishihara, T | 1 |
| Yokomizo, K | 1 |
| Okamoto, Y | 1 |
| Otsuka, M | 1 |
| Tanaka, K | 1 |
| Mizushima, T | 3 |
| Sauvant, C | 1 |
| Schneider, R | 1 |
| Holzinger, H | 1 |
| Renker, S | 1 |
| Wanner, C | 1 |
| Gekle, M | 1 |
| Loh, AH | 1 |
| Ong, LY | 1 |
| Liew, WK | 1 |
| Arkachaisri, T | 1 |
| Lee, VK | 1 |
| Narasimhan, KL | 1 |
| Jacobsen, AS | 1 |
| Begay, CK | 1 |
| Gandolfi, AJ | 1 |
| Hoshino, T | 1 |
| Takano, T | 1 |
| Tomisato, W | 2 |
| Tsutsumi, S | 2 |
| Hwang, HJ | 1 |
| Koura, Y | 1 |
| Nishimoto, K | 1 |
| Tsuchiya, T | 2 |
| Sato, Y | 1 |
| Yoneda, M | 1 |
| Nakamura, K | 1 |
| Makino, I | 1 |
| Terano, A | 1 |
| Darmon, D | 1 |
| Goldfarb, M | 1 |
| Shina, A | 1 |
| Rosen, S | 1 |
| Heyman, SN | 1 |
| Tímár, J | 1 |
| Forster-Horváth, C | 1 |
| Lukits, J | 1 |
| Döme, B | 1 |
| Ladányi, A | 1 |
| Remenár, E | 1 |
| Kásler, M | 1 |
| Bencsik, M | 1 |
| Répássy, G | 1 |
| Szabó, G | 1 |
| Velich, N | 1 |
| Suba, Z | 1 |
| Elõ, J | 1 |
| Balatoni, Z | 1 |
| Bajtai, A | 1 |
| Chretien, P | 1 |
| Talor, E | 1 |
| Oruc, N | 1 |
| Yukselen, V | 1 |
| Ozutemiz, AO | 1 |
| Yuce, G | 1 |
| Celik, HA | 1 |
| Musoglu, A | 1 |
| Batur, Y | 1 |
| Tanglertsampan, C | 1 |
| Tantikun, N | 1 |
| Noppakun, N | 1 |
| Pinyopornpanit, V | 1 |
| Lovy, J | 1 |
| Speare, DJ | 1 |
| Wright, GM | 1 |
| Rubio, CA | 2 |
| Johansson, B | 1 |
| Kollberg, B | 2 |
| Kock, Y | 1 |
| Barr, RD | 1 |
| Sertic, J | 1 |
| Johansson, C | 1 |
| Rodensjö, M | 1 |
| Konturek, SJ | 2 |
| Brzozowski, T | 2 |
| Piastucki, I | 1 |
| Radecki, T | 2 |
| Dembińska-Kieć, A | 1 |
| Olazábal, A | 1 |
| Dobrzańska, M | 1 |
| Topalian, SL | 1 |
| Ziegler, MM | 1 |
| Robert, A | 2 |
| Eberle, D | 1 |
| Kaplowitz, N | 1 |
| Saziki, R | 1 |
| Arai, I | 1 |
| Isobe, Y | 1 |
| Hirose, H | 1 |
| Aihara, H | 2 |
| Hollander, D | 1 |
| Tarnawski, A | 1 |
| Gergely, H | 1 |
| Zipser, RD | 2 |
| Wallace, JL | 2 |
| Track, NS | 1 |
| Cohen, MM | 1 |
| Niada, R | 1 |
| Malandrino, S | 1 |
| Nardi, GF | 1 |
| Mantovani, M | 1 |
| Prino, G | 1 |
| Omini, C | 1 |
| Berti, F | 1 |
| Dietz, AJ | 1 |
| de Kraker-Sangster, M | 1 |
| Bronkhorst, FB | 1 |
| Brandt, KH | 1 |
| Boersma, JW | 1 |
| Spodick, DH | 1 |
| Watson, PG | 1 |
| Closa, D | 1 |
| Roselló-Catafau, J | 1 |
| Fernández-Cruz, L | 1 |
| Gelpí, E | 1 |
| Finstad, HS | 1 |
| Kolset, SO | 1 |
| Holme, JA | 1 |
| Wiger, R | 1 |
| Farrants, AK | 1 |
| Blomhoff, R | 1 |
| Drevon, CA | 1 |
| Guth, L | 1 |
| Zhang, Z | 1 |
| DiProspero, NA | 1 |
| Joubin, K | 1 |
| Fitch, MT | 1 |
| Bulbena, O | 1 |
| Escolar, G | 1 |
| Navarro, C | 1 |
| Bravo, L | 1 |
| Pfeiffer, CJ | 1 |
| Kelly, DA | 1 |
| Piasecki, C | 1 |
| Anthony, A | 1 |
| Dhillon, AP | 1 |
| Pounder, RE | 1 |
| Wakefield, AJ | 1 |
| Ko, JK | 1 |
| Cho, CH | 1 |
| Ajuebor, MN | 1 |
| Singh, A | 1 |
| Laudanno, OM | 3 |
| Esnarriaga, JM | 1 |
| Cesolari, JA | 3 |
| Maglione, CB | 1 |
| Aramberry, LJ | 1 |
| Sambrano, JS | 1 |
| Piombo, G | 1 |
| Rista, L | 1 |
| Bolisetty, S | 1 |
| Patole, S | 1 |
| Koh, G | 1 |
| Stalewski, H | 1 |
| Whitehall, J | 1 |
| Rokutan, K | 1 |
| Szabó, IL | 1 |
| Pai, R | 1 |
| Jones, MK | 1 |
| Ehring, GR | 1 |
| Kawanaka, H | 1 |
| Tarnawski, AS | 1 |
| Altshuler, G | 1 |
| Krous, HF | 1 |
| Altmiller, DH | 1 |
| Sharpe, GL | 1 |
| Jugdutt, BI | 1 |
| Hutchins, GM | 1 |
| Bulkley, BH | 1 |
| Pitt, B | 1 |
| Becker, LC | 1 |
| Fishbach, H | 1 |
| Bohle, A | 1 |
| Meyer, D | 1 |
| Edel, HH | 1 |
| Frotscher, U | 1 |
| Kluthe, R | 1 |
| Renner, D | 1 |
| Rinsche, K | 1 |
| Scheler, F | 1 |
| Romano, M | 1 |
| Polk, WH | 1 |
| Awad, JA | 1 |
| Arteaga, CL | 1 |
| Nanney, LB | 1 |
| Wargovich, MJ | 1 |
| Kraus, ER | 1 |
| Boland, CR | 1 |
| Coffey, RJ | 1 |
| Salerno, GM | 1 |
| McBride, DM | 1 |
| Bleicher, JN | 1 |
| Watson, P | 1 |
| Stromberg, BV | 1 |
| Whittle, BJ | 2 |
| Lopez-Belmonte, J | 1 |
| Morris, GP | 1 |
| Williamson, TE | 1 |
| Abonyi, S | 1 |
| Slomiany, A | 1 |
| Mizuta, K | 1 |
| Piotrowski, J | 1 |
| Nishikawa, H | 1 |
| Slomiany, BL | 1 |
| Peskar, BM | 1 |
| Saperas, E | 1 |
| Zhang, WR | 1 |
| Olafsson, AS | 1 |
| Lancaster, C | 1 |
| Tracey, DE | 1 |
| Chosay, JG | 1 |
| Taché, Y | 1 |
| Yonei, Y | 1 |
| Guth, PH | 1 |
| Takeuchi, K | 2 |
| Okada, M | 1 |
| Niida, H | 1 |
| Okabe, S | 1 |
| Rabinovitch, A | 1 |
| Baquerizo, H | 1 |
| Sumoski, W | 1 |
| Haridas, V | 1 |
| Rath, S | 1 |
| Bal, V | 1 |
| Kulkarni, AP | 1 |
| Plumber, ST | 1 |
| Naik, SR | 1 |
| Kamat, RS | 1 |
| Ben-Zvi, Z | 1 |
| Weissman-Teitellman, B | 1 |
| Katz, S | 1 |
| Danon, A | 1 |
| Goldberg, RI | 1 |
| Kurebayashi, Y | 2 |
| Tabuchi, Y | 1 |
| Akasaki, M | 1 |
| Koyama, Y | 1 |
| Imoto, M | 1 |
| Tanaka, M | 1 |
| Fukuda, Y | 1 |
| Satake, T | 1 |
| Ozawa, T | 1 |
| San Miguel, P | 2 |
| Bedini, OA | 1 |
| Rezkalla, S | 1 |
| Khatib, R | 1 |
| Khatib, G | 1 |
| Smith, F | 1 |
| Walsh, M | 1 |
| Sowers, J | 1 |
| Kloner, R | 1 |
| Schumert, R | 1 |
| Nast, CC | 1 |
| Cominelli, F | 1 |
| Hsueh, W | 1 |
| Gonzalez-Crussi, F | 1 |
| Arroyave, JL | 1 |
| Koide, T | 1 |
| Wieloch, TW | 1 |
| Siesjö, BK | 1 |
| Hayden, B | 1 |
| Soderberg, R | 1 |
| Zarem, H | 1 |
| Chaudhuri, G | 1 |
| Ohishi, M | 1 |
| Oobu, K | 1 |
| Miyanoshita, Y | 1 |
| Yamaguchi, K | 1 |
| Mesereau, WA | 1 |
| Lough, JO | 1 |
| Hinchey, EJ | 1 |
| van Ooijen, B | 1 |
| Ouwendijk, RJ | 1 |
| Kort, WJ | 1 |
| Zijlstra, FJ | 1 |
| Vincent, JE | 1 |
| Wilson, JH | 1 |
| Westbroek, DL | 1 |
| Ikeda, T | 1 |
| Osada, Y | 1 |
| Salminen, A | 1 |
| Kihlström, M | 1 |
| Bodini, OA | 1 |
| Capdopon, E | 1 |
| Higuchi, S | 1 |
| Shioiri, Y | 1 |
| Tanaka, N | 1 |
| Otomo, S | 1 |
| Steel, G | 1 |
| Nobuhara, Y | 1 |
| Marsh, FP | 1 |
| Almeyda, JR | 1 |
| Levy, IS | 1 |
| Houck, JC | 1 |
| Johnston, J | 1 |
| Jacob, RA | 1 |
| Lombardino, JG | 1 |
| Wiseman, EH | 1 |
| Arnold, L | 1 |
| Collins, C | 1 |
| Starmer, GA | 1 |
| Desproges-Gotteron, R | 1 |
| Loubet, R | 1 |
| Dunoyer, J | 1 |
| Laures, JC | 1 |
2 reviews available for indomethacin and Necrosis
| Article | Year |
|---|---|
Understanding intestinal vulnerability to perforation in the extremely low birth weight infant.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Communicable Diseases; Disease Models, Animal; Fem | 2009 |
Necrotizing enterocolitis: a review of animal models.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Bacterial Physiological Phenomena; Blood Volume; Bre | 1984 |
1 trial available for indomethacin and Necrosis
| Article | Year |
|---|---|
The effect of leukocyte interleukin injection (Multikine) treatment on the peritumoral and intratumoral subpopulation of mononuclear cells and on tumor epithelia: a possible new approach to augmenting sensitivity to radiation therapy and chemotherapy in o
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chem | 2003 |
77 other studies available for indomethacin and Necrosis
| Article | Year |
|---|---|
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood-Brain Barrier; Cell Hypoxia; C | 2012 |
Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 2008 |
Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Cell Cycle Proteins; Colonic Neopl | 2009 |
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; | 2010 |
Indomethacin corrects alterations associated with ischemia/reperfusion in an in vitro proximal tubular model.
Topics: Animals; Apoptosis; Biomarkers; Cardiovascular Agents; Cells, Cultured; Chemokine CCL2; Dinoprostone | 2010 |
Multiple indomethacin-induced colonic perforations in an adolescent.
Topics: Abdomen, Acute; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Colectomy | 2011 |
Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclooxygenase In | 2003 |
Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Ethanol; Gastric Mucosa; Guinea Pigs; Hydrogen P | 2003 |
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Che | 2003 |
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.
Topics: Acute Kidney Injury; Animals; Benzamides; Contrast Media; Disease Models, Animal; Disease Progressio | 2003 |
Leukotriene receptor antagonism in experimental acute pancreatitis in rats.
Topics: Acute Disease; Animals; Cyclooxygenase Inhibitors; Indoles; Indomethacin; Leukotriene Antagonists; M | 2004 |
Indomethacin for recurrent cutaneous necrotizing eosinophilic vasculitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Eosinophilia; Eosinophils; Humans; Indomethacin; Male; Midd | 2007 |
Pathological effects caused by chronic treatment of rainbow trout with indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Fish Diseases; I | 2007 |
Acute gastric erosions in the rat. II. Viability of the gastric mucosa.
Topics: Animals; Autoradiography; Cell Division; Cytidine; Gastric Mucosa; Indomethacin; Male; Necrosis; Rat | 1981 |
Soft-tissue necrosis induced by extravasated cancer chemotherapeutic agents: a study of active intervention.
Topics: Animals; Bicarbonates; Doxorubicin; Guinea Pigs; Hydrocortisone; Indomethacin; Necrosis; Skin; Sodiu | 1981 |
Acute gastric erosions in the rat. I. Microangiography.
Topics: Angiography; Animals; Gastric Mucosa; Indomethacin; Ischemia; Male; Microcirculation; Necrosis; Rats | 1981 |
Role of prostaglandin and thromboxane biosynthesis in gastric necrosis produced by taurocholate and ethanol.
Topics: Animals; Dinoprostone; Epoprostenol; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Methacryla | 1983 |
Effect of prostaglandins E2 and I2 and of indomethacin on deoxycholic acid-induced damage to the rat bile-pancreatic duct.
Topics: Animals; Deoxycholic Acid; Dinoprostone; Epithelium; Epoprostenol; Female; Indomethacin; Mucous Memb | 1983 |
Generation of endogenous prostaglandins and thromboxanes in taurocholate-induced gastric mucosal lesions.
Topics: Animals; Dinoprostone; Epoprostenol; Female; Gastric Mucosa; Indomethacin; Male; Methacrylates; Necr | 1984 |
Role of glutathione in gastric mucosal cytoprotection.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclohexanones; Dinoprost; Dinoprostone; Ethanol; Gastric Muc | 1984 |
Effects of sofalcone on necrotizing agents-induced gastric lesions and on endogenous prostaglandins in rats stomachs.
Topics: Animals; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Gastric Mucosa; Indomethacin; Male; N | 1984 |
Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process?
Topics: Aluminum; Animals; Anti-Ulcer Agents; Dinoprostone; Drug Synergism; Ethanol; Gastric Mucosa; Hydroge | 1984 |
Chronic mild restraint protects the rat gastric mucosa from injury by ethanol or cold restraint.
Topics: Animals; Cold Temperature; Electrophysiology; Ethanol; Gastric Mucosa; General Adaptation Syndrome; | 1983 |
Cytoprotection by sulglycotide: prevention of gastric necrosis in rat.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Necrosi | 1981 |
Necrotizing vasculitis.
Topics: Humans; Indomethacin; Male; Middle Aged; Necrosis; Prednisone; Vasculitis | 1982 |
[Massive liver cell necrosis following administration of indomethacin in combination with aminophenzone].
Topics: Adult; Aminopyrine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Hepatic Encep | 1981 |
Effects of indomethacin during experimental myocardial ischemia.
Topics: Animals; Coronary Disease; Dogs; Humans; Indomethacin; Necrosis | 1981 |
The diagnosis and management of scleritis.
Topics: Eye Diseases; Humans; Indomethacin; Inflammation; Necrosis; Oxyphenbutazone; Pain; Sclera | 1980 |
Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats.
Topics: Acute Disease; Alprostadil; Amylases; Animals; Dinoprost; Dinoprostone; Hemorrhage; Indomethacin; Li | 1994 |
Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells.
Topics: Apoptosis; Arachidonic Acid; Cell Differentiation; Cell Division; DNA Replication; DNA, Neoplasm; Do | 1994 |
Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Indomethacin; Lipopolysaccharide | 1994 |
Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1993 |
Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Jejunal Diseases; Jejunum; M | 1998 |
Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Gastri | 1999 |
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
Topics: Animals; Blotting, Western; Celecoxib; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2000 |
[Celecoxib vs indomethacin and acute gastric lesions in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive Sy | 2000 |
Neonatal acute haemorrhagic gastritis and antenatal exposure to indomethacin for tocolysis.
Topics: Adolescent; Fatal Outcome; Female; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; I | 2001 |
NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspiri | 2001 |
Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers.
Topics: Actins; Animals; Apoptosis; Caspase 3; Caspases; Cell Death; Cell Line; Cell Movement; Cyclooxygenas | 2002 |
Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem.
Topics: Animals; Brain Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arterio | 1979 |
Effect of indomethacin on collateral blood flow and infarct size in the conscious dog.
Topics: Animals; Arterial Occlusive Diseases; Collateral Circulation; Coronary Vessels; Dogs; Electrocardiog | 1979 |
The morphological and clinical course of the different forms of glomerulonephritis.
Topics: Acute Disease; Antimetabolites; Glomerulonephritis; Humans; Indomethacin; Male; Middle Aged; Necrosi | 1976 |
Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.
Topics: Animals; Aspirin; Dinoprostone; Ethanol; Ethylmaleimide; Gastric Mucins; Gastric Mucosa; Image Proce | 1992 |
Ciprostene and indomethacin partially reverse the mechanisms of distal end necrosis in the rat random skin flap.
Topics: Animals; Drug Synergism; Epoprostenol; Graft Survival; Indomethacin; Injections, Subcutaneous; Male; | 1992 |
Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Endothelins; Gastric Mucosa; Gastrointestinal H | 1991 |
The effects of sucralfate and luminal stasis on recovery of the chambered rat gastric mucosa from taurocholate-induced damage.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Ga | 1991 |
Gastric mucosal protection by sucralfate involves phosphoinositides participation.
Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; M | 1990 |
Role of leukotriene C4 in mucosal damage caused by necrotizing agents and indomethacin in the rat stomach.
Topics: Animals; Arachidonate 5-Lipoxygenase; Dinoprostone; Ethanol; Gastric Mucosa; Indoles; Indomethacin; | 1991 |
Gastric cytoprotection by intracisternal interleukin-1 beta in the rat.
Topics: Animals; Cell Survival; Ethanol; Female; Indomethacin; Injections; Injections, Spinal; Interleukin-1 | 1991 |
Ethanol-induced gastric injury. Role of submucosal venoconstriction and leukotrienes.
Topics: Animals; Arterioles; Ethanol; Gastric Mucosa; Indomethacin; Leukotrienes; Male; Necrosis; Parietal C | 1991 |
Dual effects of N-ethylmaleimide on ethanol-induced gastric lesions in rats.
Topics: Administration, Oral; Animals; Capillary Permeability; Dose-Response Relationship, Drug; Ethanol; Et | 1991 |
Cytotoxic effects of cytokines on islet beta-cells: evidence for involvement of eicosanoids.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Factors; Cytokines; Cytotoxicity, Immunolog | 1990 |
Immune response to hepatitis B viral antigens in chronic infection & its relationship with liver necrosis.
Topics: Chronic Disease; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Humans; Indomethacin; Li | 1990 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Protection of irradiated parotid by prostaglandin synthesis inhibitors.
Topics: Amylases; Animals; Aspirin; Female; Indomethacin; Necrosis; Parotid Gland; Prostaglandin Antagonists | 1986 |
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Or | 1989 |
Changes in endogenous prostaglandin levels during D-galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Galactosamine | 1989 |
[Drugs cytoprotective of the gastric mucosa against ethanol damage].
Topics: Acetaminophen; Aluminum Hydroxide; Animals; Bicarbonates; Drug Evaluation, Preclinical; Enprostil; E | 1988 |
Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model.
Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Coxsackievirus Infections; Disease Models, Anim | 1988 |
Effects of 16,16-dimethyl prostaglandin E2 and indomethacin on leukotriene B4 and inflammation in rabbit colitis.
Topics: Animals; Colitis; Colon; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Leukotriene B | 1988 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Anim | 1986 |
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; D | 1986 |
Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ear | 1987 |
Acute gingival necrosis caused by drug-induced agranulocytosis.
Topics: Agranulocytosis; Candidiasis, Oral; Cefmetazole; Dipyrone; Female; Gingivitis; Humans; Indomethacin; | 1988 |
Factors in formation and prevention of bandlike gastric lesions in the rat.
Topics: Animals; Ethanol; Female; Gastric Mucosa; Gentian Violet; Hydrochloric Acid; Indomethacin; Necrosis; | 1988 |
Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin.
Topics: Acute Disease; Animals; Flunarizine; Imidazoles; Indomethacin; Male; Necrosis; Pancreatitis; Rats; R | 1988 |
Cytoprotective action of cetraxate against HCl.ethanol-induced gastric lesion in rats.
Topics: Animals; Anti-Ulcer Agents; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Ethanol; Gastric | 1988 |
Protective effect of indomethacin against exercise-induced injuries in mouse skeletal muscle fibers.
Topics: Animals; Athletic Injuries; Glucosephosphate Dehydrogenase; Glucuronidase; Indomethacin; Inflammatio | 1987 |
[Cytoprotection of gastric mucosa induced by tripotassium-dicitrato bismuthate against ethanol stress. Dependent mechanisms of sulfhydryl, dopaminergic and endogenous prostaglandin].
Topics: Acetazolamide; Animals; Chlorpromazine; Domperidone; Ethanol; Female; Gastric Mucosa; Indomethacin; | 1986 |
[The modes of anti-inflammatory and analgesic actions of 2-[4-(3-methyl-2-butenyl) phenyl] propionic acid (TA-60) and 2-[4-(2,2-dichlorovinyl) phenyl] propionic acid (TA-668) and effect of TA-60 on the gastrointestinal tract].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Diarrhea | 1985 |
Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques.
Topics: 16,16-Dimethylprostaglandin E2; Acid Phosphatase; Animals; Cytoplasm; Ethanol; Gastric Mucosa; Glucu | 1985 |
Inhibition of gastric motor activity by 16,16-dimethyl prostaglandin E2. A possible explanation of cytoprotection.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Drug Interactions; Ethanol; Gastric Mucosa; Gastrointestina | 1985 |
Non-thrombocytopenic purpura and acute glomerulonephritis after indomethacin therapy.
Topics: Aged; Drug Hypersensitivity; Female; Glomerulonephritis; Humans; Indomethacin; Kidney; Male; Middle | 1971 |
Chemical biology of in vivo and in vitro wounds.
Topics: Animals; Burns; Collagen; Croton Oil; Fucose; Glucuronidase; Glycoproteins; Histamine; Hot Temperatu | 1968 |
Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles.
Topics: Administration, Oral; Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Carrageenan; | 1974 |
Renal and gastric lesions after phenylbutazone and indomethacin in the rat.
Topics: Animals; Ascites; Epithelium; Female; Gastrointestinal Hemorrhage; Indomethacin; Kidney; Kidney Papi | 1974 |
[Anatomopathological survey of femoral heads removed during hip arthroplasty].
Topics: Aged; Arthroplasty; Female; Femur Head; Hip; Hip Joint; Humans; Indomethacin; Male; Middle Aged; Nec | 1971 |