salinomycin profile

salinomycin: from Streptomyces albus; RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	23703990
CHEMBL ID	1077120
MeSH ID	M0055726
PubMed CID	3085092
CHEMBL ID	1208572
CHEBI ID	80025
SCHEMBL ID	36890
MeSH ID	M0055726

Synonym
NCGC00095055-01
salinomycin sodium salt
sodium salinomycin
salinomycin, monosodium salt
CHEMBL1077120
salinomycin sodium
dtxcid9025902
tox21_111407
dtxsid1045902 ,
cas-55721-31-8
nsc-751548
92uod3bmek ,
nsc 751548
unii-92uod3bmek
salinomycin, sodium salt (1:1)
sacox
salinomycin sodium salt [mi]
salinomycin sodium [green book]
salinopharm-premix
bdbm50442913
HY-17439
CS-1493
salinomycin (sodium salt)
YPZYGIQXBGHDBH-UZHRAPRISA-M
(2r)-2-[(2r,5s,6r)-6-[(3s,5s,7r,9s,10s,12r,15r)-3-[(2r,5r,6s)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid soldium sa
Q27271530
salinomycin sodium 100 microg/ml in acetonitrile
F84956
sodium;(2r)-2-[(2r,5s,6r)-6-[(2s,3s,4s,6r)-6-[(3s,5s,7r,9s,10s,12r,15r)-3-[(2r,5r,6s)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-y
sodium salinomycinsalinomycin sodium
bio-cox type a medicated article
savalan 60
bio-cox 60type a medicated article
sacox 60
salinomycine [inn-french]
salinomicina [inn-spanish]
coxistac
bio-cox
einecs 258-290-1
salinomycinum [inn-latin]
k 364
hsdb 7032
ahr 3096
salinomycin
procoxacin (tn)
D08502
salinomycin (inn)
e716
CHEMBL1208572
chebi:80025 ,
procoxacin
A829344
sodium 2-[6-[5-[3-(5-ethyl-5-hydroxy-6-methyl-tetrahydropyran-2-yl)-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxo-heptyl]-5-methyl-tetrahydropyran-2-yl]butanoate
62uxs86t64 ,
salinomicina
unii-62uxs86t64
salinomycin [inn:ban]
salinomycinum
salinomycine
HY-15597
CS-1299
salinomycin [inn]
salinomycin [jan]
salinomycin [mi]
salinomycin [hsdb]
S2352
S8129
CCG-208535
SCHEMBL36890
DTXSID4048486 ,
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
(2r)-2-[(2r,5s,6r)-6-[(2s,3s,4s,6r)-6-[(3s,5s,7r,9s,10s,12r,15r)-3-[(2r,5r,6s)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butan
J-524236
AKOS030526154
SR-05000002207-3
gtpl11088
salinomycin, from streptomyces albus, >=98% (hplc)
(2r)-2-[(2r,5s,6r)-6-[(2s,3s,4s,6r)-6-[(2s,5s,7r,9s,10s,12r,15r)-2-[(2r,5r,6s)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5?.3?]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butan
Q411909
(r)-2-((2r,5s,6r)-6-((2s,3s,4s,6r)-6-((2s,5s,7r,9s,10s,12r,15r)-2-((2r,5r,6s)-5-ethyl-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methylt
salinomycin (from streptomyces albus)
DB11544
BS-17023
nsc757437
nsc-757437
bdbm430647
(alphar,2r,5s,6r)-alpha-ethyl-6-((1s,2s,3s,5r)-5-((2s,5s,7r,9s,10s,12r,15r)-2-((2r,5r,6s)-5-ethyltetrahydro-5-hydroxy-6-methyl-2h-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxydispiro(4.1.5.3)-pentadec-13-en-9-yl)-2-hydroxy-1,3-dimethyl-4-oxoheptyl
salinomycinum (inn-latin)
salinomycine (inn-french)
salinomycin mycelia
dtxcid4028460
salinomycinum (latin)
salinomicina (inn-spanish)

Excerpt	Reference	Relevance
"Salinomycin is a polyether organic anion that is extensively used as a coccidiostatic antibiotic in poultry and commonly fed to ruminant animals to improve feed efficiency. "	( P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin. Beijnen, JH; Lagas, JS; Schinkel, AH; Sparidans, RW; van Waterschoot, RA; Wagenaar, E, 2008)	2
"Salinomycin is a selective inhibitor against CSCs and shows promise in combination applications."	( The synergistic anticancer effect of salinomycin combined with cabazitaxel in CD44+ prostate cancer cells by downregulating wnt, NF-κB and AKT signaling. Dibirdik, I; Erdogan, S; Serttas, R; Turkekul, K, 2022)	1.72
"Salinomycin is a polyether ionophore antibiotic that selectively eliminates cancer stem cells by inhibiting the Wnt/β-catenin signal pathway."	( Potent salinomycin C20-O-alkyl oxime derivative SAL-98 efficiently inhibits tumor growth and metastasis by affecting Wnt/β-catenin signal pathway. Duan, W; Lei, K; Shi, Y; Tang, L; Tu, W; Wu, S; Zhang, C; Zhang, J; Zhang, W, 2023)	2.09
"Salinomycin (Sal) is a potent veterinary antibiotic known to offer significant toxicity to the variety of neoplastic cells. "	( F3 peptide functionalized liquid crystalline nanoparticles for delivering Salinomycin against breast cancer. Babu, S; Dey, S; Gupta, NV; Jain, R; Jain, V; Kumar, H; Madhunapantula, SV; Soni, AG, 2023)	2.58
"Salinomycin is a well-known cancer stem cell killer, and dichloroacetate is a pyruvate dehydrogenase kinase inhibitor that exclusively targets cells with altered mitochondrial activity, a characteristic being common to most of the cancer cells."	( Salinomycin and dichloroacetate synergistically inhibit Lewis lung carcinoma cell proliferation, tumor growth and metastasis. Barakauskienė, A; Bukelskienė, V; Jarmalaitė, S; Krasko, JA; Prokarenkaitė, R; Sarapinienė, I; Skeberdytė, A; Sužiedėlis, K; Žilionytė, K, 2020)	2.72
"Salinomycin is a polyether antibiotic showing anticancer activity. "	( Primary Human Hepatocytes, but Not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity. Olejnik, M; Posyniak, A; Radko, L, 2020)	2.22
"Salinomycin (Sal) is an agent used for the elimination of cancer stem cells (CSCs); however, the occurrence of several side effects hinders its application."	( Enhanced and Prolonged Antitumor Effect of Salinomycin-Loaded Gelatinase-Responsive Nanoparticles via Targeted Drug Delivery and Inhibition of Cervical Cancer Stem Cells. Du, S; Li, R; Liu, B; Liu, F; Liu, Q; Sun, Z; Wang, L; Wang, Q; Wu, P; Xie, C; Yu, L; Zhou, S, 2020)	1.54
"Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections."	( Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent. K, SC; Kumar Golla, VS; Kumar, CSP; P, L; Pindiprolu, SKSS; R K, R; S K, EB, 2020)	1.51
"Salinomycin (Sal) is a recently identified anti-tumor drug for treating several types of solid tumor; however, its effects on the migratory and invasive properties of non-small cell lung cancer (NSCLC) remain unclear. "	( Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the AMPK/SIRT1 pathway in non-small cell lung cancer. Hwang, KE; Jung, JW; Kim, HJ; Kim, HR; Kim, YS; Oh, SH; Park, C; Park, DS; Song, IS, 2021)	3.51
"Salinomycin is an attractive candidate, and has demonstrated selective anti-cancer properties in different cancer types."	( Pre-clinical evidence that salinomycin is active against retinoblastoma via inducing mitochondrial dysfunction, oxidative damage and AMPK activation. Li, J; Min, Y, 2021)	1.64
"Salinomycin is a promising anticancer drug for chemotherapy. "	( Establishing an efficient salinomycin biosynthetic pathway in three heterologous Streptomyces hosts by constructing a 106-kb multioperon artificial gene cluster. Cui, T; Fu, J; He, R; Jiang, C; Jiao, N; Luan, J; Song, C; Sun, H; Wang, H; Zhang, Y; Zhou, H, 2021)	2.36
"Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell apoptosis in human cancer cells displaying multiple mechanisms of drug resistance. "	( Salinomycin induces endoplasmic reticulum stress‑mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Ahn, SC; Ji, JH; Kim, KY; Kim, SH; Seo, YK; Yu, HS; Yu, SN, 2017)	3.34
"Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus. "	( Salinomycin overcomes acquired tamoxifen resistance through AIB1 and inhibits cancer cell invasion in endocrine resistant breast cancer. Ketchart, W; Manmuan, S; Sakunrangsit, N, 2017)	3.34
"Salinomycin is a monocarboxylic acid polyether antibiotics produced by Streptomyces albus. "	( [Enhancement of salinomycin production and its activity optimization - A review]. Tan, C; Tan, H; Zhang, J, 2016)	2.22
"Salinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. "	( Salinomycin-loaded Nanofibers for Glioblastoma Therapy. Abdali, Z; Liu, S; Miller, DW; Norouzi, M, 2018)	3.37
"Salinomycin is an antibiotic isolated from Streptomyces albus bacteria."	( Ovarian cancer stem cells: A target for oncological therapy. Huczyński, A; Markowska, A; Markowska, J; Rehlis, S; Sajdak, S, 2018)	1.2
"Salinomycin (SAL) is a polyether antibiotic, which is commonly used as a coccidiostat and has recently shown to exhibit anticancer activity. "	( Cytotoxicity of anticancer candidate salinomycin and identification of its metabolites in rat cell cultures. Olejnik, M; Radko, L, 2018)	2.2
"Salinomycin sodium (SS) is an antibacterial therapeutic agent that exerts potent activity against CICs in various types of cancer, including lung cancer."	( Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. Chen, H; Peng, Q; Sun, J; Zhou, J, 2018)	1.52
"Salinomycin is a monocarboxylic polyether antibiotic, which has been proved to possess anti-tumor activities in multiple types of cancer cells."	( Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells. Han, Y; Li, L; Li, Q; Liu, L; Mao, J; Qin, T; Sun, Y; Wang, Q; Yang, J, 2018)	2.64
"Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. "	( Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. Ball, C; Dieter, SM; Glimm, H; Klose, J; Preißendörfer Charrier, A; Radhakrishnan, P; Schmidt, T; Schneider, M; Steffen, L; Trefz, S; Ulrich, A; Volz, C; Wagner, T, 2019)	3.4
"Salinomycin is a polyether ionophore antibiotic having anti-tumorigenic property in various types of cancer. "	( Inhibition of thymidine phosphorylase expression by Hsp90 inhibitor potentiates the cytotoxic effect of salinomycin in human non-small-cell lung cancer cells. Chen, JC; Chen, TY; Ko, JC; Lin, YC; Lin, YW; Ma, PF; Peng, YS; Wu, CH; Yen, TC; Zheng, HY, 2019)	2.17
"Salinomycin (SAL) is a polyether compound that exhibits strong antimicrobial as well as anticancer activity. "	( Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin. Dube, A; Gouveia, LF; Kreutzer, B; Maphasa, RE; Silva-Lima, B; Sousa, C; Videira, M, 2019)	2.18
"Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. "	( Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells. Cao, J; Du, X; Ge, X; Hu, H; Jiang, H; Li, F; Liu, L; Wang, Y; Zhang, Y, 2019)	3.4
"Salinomycin is a well-known inhibitor of human cancer stem cells (CSCs). "	( Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. Carson, DA; Fan, J; Guo, F; Huang, P; Li, F; Li, H; Li, S; Liu, SS; Lu, D; Song, J; Su, Z; Sun, Q; Wang, Z; Xia, Y; Xiong, Y; Yu, S; Zhao, L; Zhou, L, 2019)	3.4
"Salinomycin is a polyether antibiotic used to kill gram-positive bacteria including mycobacteria, protozoans such as plasmodium falciparum, and the parasites responsible for the poultry disease coccidiosis."	( Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1. Adrian, TE; Al Dhaheri, Y; Arafat, K; Attoub, S; Iratni, R; Parekh, K; Takahashi, T, 2013)	1.43
"Salinomycin (Sal) is a polyether ionophore antibiotic that has recently been shown to induce cell death in various human cancer cells. "	( Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo. Fan, Z; Huang, J; Shi, F; Wang, S; Wu, D; Zhang, Y, 2014)	3.29
"Salinomycin is a polyether antibiotic which effectively eliminates a variety of cancer stem cells and chemotherapy-resistant tumor cells in vitro and in vivo. "	( Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. Boehmerle, W; Endres, M; Huehnchen, P; Muenzfeld, H; Springer, A, 2014)	2.06
"Salinomycin is a novel small molecule inhibitor of LRP6."	( Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells. Li, Y; Lu, W, 2014)	2.57
"Salinomycin (Sal) is a novel identified cancer stem cells (CSCs) killer, however, the molecular basis for its anticancer effects is not yet clear."	( Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling. Fan, S; Hou, Z; Kang, L; Li, J; Li, L; Liu, P; Liu, Q; Lu, Y; Ma, W; Mao, J; Song, B; Wang, H; Yu, X, 2015)	2.58
"Salinomycin is a promising compound eliminating cancer stem cells and retarding cancer cell migration."	( Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity. Aykut, B; Giese, NA; Schenk, M; Teske, C; Weitz, J; Welsch, T, 2015)	2.58
"Salinomycin is a monocarboxylic polyether antibiotic, which is widely used as an anticoccidial agent. "	( Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin. Ahn, SC; Choi, HD; Ji, JH; Kim, KY; Kim, SH; Park, SK; Seo, YK; Yu, HS; Yu, SN, 2015)	3.3
"Salinomycin is a widely used polyether coccidiostat and was recently found to have antitumor activities. "	( Formation of the Δ(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase-like Enzyme. Bai, L; Jiang, C; Jiang, M; Kang, Q; Liu, J; Qi, Z, 2015)	2.1
"Salinomycin is a monocarboxylic polyether antibiotic that has been reported to induce apoptosis in various types of cancer cells with specificity for cancer stem cells. "	( Salinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells. Fu, C; Han, B; Song, F; Tian, Y; Wang, Y; Zhang, C, 2015)	3.3
"Salinomycin is an antibiotic that has been shown to target cancer stem cells (CSC); however, the mechanisms of action involved have not been well characterized."	( Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells. An, H; Cho, Y; Kim, JY; Lee, N; Oh, E; Seo, JH, 2015)	2.58
"Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. "	( Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells. Bo, S; Chen, M; Chen, S; Cong, H; Deng, H; Ding, H; Jiang, ZX; Li, X; Li, Y; Liu, Q; Shi, Q; Yang, Z; Zhao, P; Zhou, X, 2016)	2.15
"Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. "	( Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways. Kim, SJ; Yu, SM, 2016)	3.32
"Salinomycin is a polyether antibiotic isolated from Streptomyces albus that acts in different biological membranes as a ionophore with a preference for potassium. "	( Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Daniel, V; Fuchs, D; Heinold, A; Naujokat, C; Opelz, G, 2009)	3.24
"Salinomycin is a polyether ionophore antibiotic that is widely used in poultry and livestock. "	( Identification and quantification of salinomycin in intoxicated human plasma by liquid chromatography-electrospray tandem mass spectrometry. Dong, F; Fang, J; Li, H; Li, Y; Ma, K; Wu, S; Yan, X, 2010)	2.08
"Salinomycin is a polyether antibiotic with properties of an ionophore, which is commonly used as cocciodiostatic drug and has been shown to be highly effective in the elimination of cancer stem cells (CSCs) both in vitro and in vivo. "	( Salinomycin induces calpain and cytochrome c-mediated neuronal cell death. Boehmerle, W; Endres, M, 2011)	3.25
"Salinomycin is a novel identified cancer stem cells (CSCs) killer. "	( Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer. Cai, Q; Chen, XH; Gu, QL; Ji, J; Li, JF; Liu, BY; Yu, YY; Zhang, JN; Zhi, QM; Zhu, ZG, 2011)	3.25
"Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance. "	( Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species. Liffers, ST; Mirmohammadsadegh, A; Schmitz, I; Tannapfel, A; Verdoodt, B; Vogt, M, 2012)	3.26
"Salinomycin is a polyether antibiotic used to promote growth in cattle and poultry. "	( HPLC analysis of salinomycin in human plasma using pre-column oxidation and automated heart cut column switching. Dimenna, GP; Karnes, HT; Wei, AT, 1993)	2.07

Excerpt	Reference	Relevance
"Salinomycin (Sal) has an extensive effect on a variety of cancer stem cells (CSCs); however, its poor water solubility and toxicity to healthy tissues at high doses limit further research into its potential as an anti-cancer drug."	( Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial-Mesenchymal Transition. Niu, X; Su, M; Wang, Y; Yin, X; Zhou, X; Zou, M, 2022)	2.89
"Salinomycin has a narrow therapeutic index; a dose of 5 mg/kg is tolerated in mice. "	( Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. Boehmerle, W; Endres, M; Huehnchen, P; Muenzfeld, H; Springer, A, 2014)	2.06
"Salinomycin (Sal) has been proved to be an effective anticancer drug in many studies, especially for cancer stem cells (CSCs)."	( Synthesis and Characterization of Salinomycin-Loaded High-Density Lipoprotein and Its Effects on Cervical Cancer Cells and Cervical Cancer Stem Cells. Lu, Y; Su, M; Wang, L; Yin, X; Zhang, Y; Zhou, X; Zou, M, 2021)	1.62
"Salinomycin (Sal) has an extensive effect on a variety of cancer stem cells (CSCs); however, its poor water solubility and toxicity to healthy tissues at high doses limit further research into its potential as an anti-cancer drug."	( Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial-Mesenchymal Transition. Niu, X; Su, M; Wang, Y; Yin, X; Zhou, X; Zou, M, 2022)	2.89
"Salinomycin (SAL) has potential to specifically target and kill CSCs through blocking their multiple pathways simultaneously."	( Polylactic acid based biodegradable hybrid block copolymeric nanoparticle mediated co-delivery of salinomycin and doxorubicin for cancer therapy. Anees, M; Kharbanda, S; Kumar, D; Mehrotra, N; Singh, H; Tiwari, S, 2023)	1.85
"Salinomycin (SAL) has caused widespread pollution as a feed additive and growth promoter in livestock such as pigs, exerting a negative impact on public health. "	( Exposure to salinomycin dysregulates interplay between mitophagy and oxidative response to damage the porcine jejunal cells. Fang, L; Lian, X; Liao, X; Liu, Y; Ren, H; Sun, J; Tian, X; Wang, X; Xu, D; Yan, H; Yu, Y; Zhao, D; Zhou, Y; Zhu, T, 2023)	2.73
"Salinomycin, which has been identified as a selective inhibitor of CSCs in multiple types of cancer, may be an attractive agent against CSCs thereby restrain hepatic metastasis in UM."	( Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma. Dai, W; Liu, S; Pan, J; Wang, S; Wang, Y; Zhang, J; Zhou, J; Zou, H, 2019)	2.68
"Salinomycin has positive effects towards retinoblastoma cells regardless of heterogeneity through suppressing growth and inducing apoptosis."	( Pre-clinical evidence that salinomycin is active against retinoblastoma via inducing mitochondrial dysfunction, oxidative damage and AMPK activation. Li, J; Min, Y, 2021)	1.64
"Salinomycin has recently been identified as an antitumour drug for several types of cancer stem cell (CSC) treatments. "	( Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway. Liu, L; Luo, Q; Song, G; Sun, J; Yang, X; Zhu, S, 2017)	3.34
"Salinomycin (SAL) has been identified as a promising anticancer drug during chemical screening, but it is unclear whether SAL plays a role in radioresistance."	( Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation. Han, M; Ren, J; Wang, W; Yao, C; Zhang, G; Zhang, S, 2017)	2.62
"Salinomycin has cytotoxic effects on various types of malignancy and induces autophagy. "	( Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells. Abe, T; Ando, Y; Endo, S; Kibe, S; Koikawa, K; Miyasaka, Y; Mizumoto, K; Moriyama, T; Nakamura, M; Nakata, K; Nakayama, H; Ohtsuka, T; Ohuchida, K; Okumura, T; Sagara, A; Takesue, S, )	1.82
"Salinomycin (SAL) has been reported to exhibit anticancer response on various types of cancer."	( Salinomycin inhibits breast cancer progression via targeting HIF-1α/VEGF mediated tumor angiogenesis in vitro and in vivo. Dewangan, J; Divakar, A; Kumar, S; Mishra, S; Rath, SK; Srivastava, S, 2019)	2.68
"Salinomycin has been shown to be highly effective in the elimination of cancer stem cells both in vitro and in vivo."	( Salinomycin inhibits Akt/NF-κB and induces apoptosis in cisplatin resistant ovarian cancer cells. Bae, I; Cha, SD; Cho, CH; Kwon, SH; Lee, GH; Lee, HG; Parajuli, B; Shin, SJ, 2013)	2.55
"Salinomycin has been shown to control breast cancer stem cells, although the mechanisms underlying its anticancer effects are not clear. "	( Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Bae, YK; Kim, H; Kim, K; Kim, YN; Koo, KH; Lee, CH; Park, BK, 2013)	3.28
"Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. "	( Synthetic modification of salinomycin: selective O-acylation and biological evaluation. Borgström, B; Hegardt, C; Huang, X; Oredsson, S; Pošta, M; Strand, D, 2013)	2.13
"Salinomycin has a narrow therapeutic index; a dose of 5 mg/kg is tolerated in mice. "	( Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. Boehmerle, W; Endres, M; Huehnchen, P; Muenzfeld, H; Springer, A, 2014)	2.06
"Salinomycin (Sali) has selective toxicity to cancer stem cells (CSCs), a subpopulation of cancer cells that have been recently linked with tumor multidrug resistance (MDR). "	( iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors. Bhattacharyya, J; Chen, M; Dong, S; Zhao, P, 2014)	2.14
"Salinomycin has shown strong inhibition activity against the proliferation process of many different cancer cells, including multi-drug resistance (MDR) cancer cells, as well as cancer stem cells (CSCs), i.e."	( Anticancer Activity of Polyether Ionophore-Salinomycin. Antoszczak, M; Huczyński, A, 2015)	1.4
"Salinomycin has been used as treatment for malignant tumors in a small number of humans, causing far less side effects than standard chemotherapy. "	( Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death. Hallbeck, AL; Jain, MV; Jangamreddy, JR; Lotfi, K; Roberg, K; Łos, MJ, 2015)	2.12
"Salinomycin has been demonstrated to be >100‑fold more effective than paclitaxel at causing cancer stem cell death, therefore, it may offer an important improvement in cancer therapy."	( Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Froelich, K; Ginzkey, C; Hackenberg, S; Hagen, R; Kleinsasser, N; Rak, K; Schendzielorz, P; Scherzed, A, 2015)	1.53
"Salinomycin has received recent attention for its ability to target breast cancer stem cells (BCSCs), but the mechanisms of action involved are not fully understood."	( Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway. An, H; Cho, Y; Kim, JY; Lee, N; Oh, E; Seo, JH, 2015)	2.58
"Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs. "	( Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells. Gümüşderelioğlu, M; Kaynak, G; Tığlı Aydın, RS, 2016)	3.32
"Salinomycin (Sal) has been found as an effective chemical compound to kill breast cancer stem cells."	( Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymal transition in MCF-7 human breast cancer cells. Fan, S; Gao, T; Hou, Z; Li, J; Li, L; Li, Q; Lu, Y; Mao, J; Song, B; Wang, B; Yan, B; Yu, X; Zhang, C, 2016)	2.6
"Salinomycin has recently been shown to selectively deplete human breast cancer stem cells from tumorspheres and to inhibit breast cancer growth and metastasis in mice."	( Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Daniel, V; Fuchs, D; Heinold, A; Naujokat, C; Opelz, G, 2009)	2.52
"Salinomycin (Sal) has recently been shown to inhibit various cancer stem cells. "	( Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein. Chae, M; Kang, HS; Kim, HS; Kim, JH; Kim, WK; Kim, YJ; Yoon, S, 2011)	3.25
"Salinomycin has been demonstrated to significantly rupture the in vitro lung cancer tumorospheres from ALDH positive A549 lung cells using flow cytometry."	( Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells. Wang, Y, 2011)	1.48

Excerpt	Reference	Relevance
"Salinomycin could suppress stemness properties and induce differentiation of LCSCs through the Wnt/β-catenin signaling pathway, which provides evidence that salinomycin may serve as a potential drug for liver cancer therapy targeting LCSCs in the clinic."	( Salinomycin Suppresses Tumorigenicity of Liver Cancer Stem Cells and Wnt/Beta-catenin Signaling. Ju, Y; Liu, Q; Luo, Q; Song, G; Sun, J, 2021)	3.51
"Salinomycin was able to inhibit the growth of the three cell lines in time- and concentration-dependent manners. "	( Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation. Abuqamar, S; Al Dhaheri, Y; Al Faresi, N; Arafat, K; Attoub, S; Eid, A; Iratni, R, 2013)	3.28

Excerpt	Reference	Relevance
"Salinomycin treatment also showed similar results to the above DMT1 silencing."	( Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin. Lee, J; Roh, JL, 2023)	1.85
"Salinomycin and AZD3463 treatments, either alone or in combination, resulted in the downregulation or upregulation of mRNA expression levels of genes in the Wntsignaling pathway."	( Combination of Salinomycin and AZD3463 Reveals Synergistic Effect on Reducing the Viability of T98G Glioblastoma Cells. Asik, A; Avci, CB; Ay, NPO; Bagca, BG; Caglar, HO; Gunduz, C, 2020)	1.63
"Salinomycin treatment increased the motility of cells, however, this motility did not result in an increased distant migration i.e."	( Influence of salinomycin treatment on division and movement of individual cancer cells cultured in normoxia or hypoxia evaluated with time-lapse digital holographic microscopy. Alm, K; Janicke, B; Kamlund, S; Oredsson, S; Strand, D, 2017)	1.55
"Salinomycin treatment elevated the permeability of the cell membrane and leaded to the efflux of enzymes, including creatine kinase (CK) and lactate dehydrogenase (LDH)."	( Salinomycin induces primary chicken cardiomyocytes death via mitochondria mediated apoptosis. Gao, X; Guo, D; Ji, H; Jiang, S; Peng, L; Ruan, X; Zheng, Y, 2018)	2.64
"salinomycin treatment also suppressed the sphere formation ability of RCC cells and decreased the expressions of CD105, ALDH1 and CD44, biomarkers for reflecting the stemness of RCC cells."	( Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells. Han, Y; Li, L; Li, Q; Liu, L; Mao, J; Qin, T; Sun, Y; Wang, Q; Yang, J, 2018)	2.64
"Salinomycin treatment was lethal to few mice and retarded body growth in others with decreased weight of testes and seminal vesicles in a dose dependent manner."	( Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice. Bhadauria, S; Ojo, OO; Rath, SK, 2013)	1.39
"Salinomycin treatment was well tolerated by the mice and significantly reduced tumor growth after 19 days compared to the control group (each n = 16)."	( Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity. Aykut, B; Giese, NA; Schenk, M; Teske, C; Weitz, J; Welsch, T, 2015)	2.58
"Salinomycin treatment was shown to induce apoptosis, as evidenced by nuclear fragmentation, an increase in the proportion of acridine orange/ethidium bromide-positive cells and an increase in the percentage of Annexin V-positive cells."	( Salinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells. Fu, C; Han, B; Song, F; Tian, Y; Wang, Y; Zhang, C, 2015)	2.58
"Salinomycin treatment also caused a marked suppression of cell migration and invasion with concomitant downregulation of MMP-9 and MMP-2 mRNA levels."	( Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells. An, H; Cho, Y; Kim, JY; Lee, N; Oh, E; Seo, JH, 2015)	2.58
"Salinomycin at all treatment levels showed definite anticoccidial activity resulting in improved weights, feed conversion ratios, lesion scores, and mortality compared with unmedicated controls."	( Anticoccidial activity of salinomycin in floor-pen experiments with broilers. Danforth, HD; Johnson, J; Reid, WM; Ruff, MD, 1977)	1.28
"Co-treatment with salinomycin significantly potentiated the anti-cancer effects of resveratrol, whereas HLY78 co-treatment had minimal effect."	( A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis. Azad, N; Iyer, AKV; Kaushik, V; Venkatadri, R, 2017)	1.1
"Mice treated with salinomycin develop a painful sensory polyneuropathy."	( Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. Boehmerle, W; Endres, M; Huehnchen, P; Muenzfeld, H; Springer, A, 2014)	0.94
"Treatment with salinomycin alone reduced the stemness marker expression and spheroid-forming ability of OCSCs. "	( Salinomycin reduces stemness and induces apoptosis on human ovarian cancer stem cell. Cha, SD; Cho, CH; Chung, HW; Kwon, SH; Lee, HG; Lee, JE; Shin, SJ, 2017)	2.25
"Treatment with salinomycin had a cubic effect (P < .05) on coccidia oocyst excretion, and no oocysts were detected beyond d 28."	( Effect of salinomycin on giardiasis and coccidiosis in growing lambs. Annett, CB; Cheng, KJ; McAllister, TA; Morck, DW; Olson, ME, 1996)	1.04

Excerpt	Reference	Relevance
"Five 7-day trials using 336, 24, 24, 40, and 40 Large White male turkeys when 7, 11, 15, 27, and 32 weeks of age, respectively, were conducted to determine the toxic effects of salinomycin."	( Salinomycin toxicity in turkeys. Blair, ME; Blake, JP; Bliss, BA; Denbow, DM; Potter, LM, 1986)	1.91
" In addition the efficacy of a safe dose for prophylactic treatment of dysentery was controlled."	( [Toxicity of the combination of salinomycin and tiamulin in swine]. Bollwahn, W; Büsing, S; Wendt, M, 1997)	0.58
" Group 1, 2 and 3 were maintained as control, therapeutic dose control (60 mg/kg feed) and toxic dose control (120 mg/kg feed), respectively."	( Evaluation of zinc against salinomycin toxicity in broilers. Kamashi, K; Reddy, AG; Reddy, KS; Reddy, VR, 2004)	0.62
" Present study evaluated the toxic effects of Salinomycin on male reproductive system of mice."	( Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice. Bhadauria, S; Ojo, OO; Rath, SK, 2013)	0.93
" In the present study, we thus aimed to elucidate pharmacokinetic properties of salinomycin and to assess the side effect profile of chronic treatment with this compound in C57Bl/6 mice."	( Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. Boehmerle, W; Endres, M; Huehnchen, P; Muenzfeld, H; Springer, A, 2014)	0.84
" Concurrent to the evaluation of salinomycin application in experimental oncology, adverse effects in non-malignant cells need to be monitored and reduced as much as possible."	( Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes. Froelich, K; Ginzkey, C; Hackenberg, S; Hagen, R; Kleinsasser, N; Scherzad, A; Schramm, C, 2015)	1
" Treatment of Cd-exposed mice with DMSA or Sal restored the levels of the renal and hepatic functional markers and significantly decreased the concentration of the toxic metal ion in both organs."	( Ameliorative effect of the anticancer agent salinomycin on cadmium-induced hepatotoxicity and renal dysfunction in mice. Gluhcheva, Y; Ivanova, J; Kamenova, K; Stoykova, S; Vladov, I, 2018)	0.74
" The toxic action of the drug may be connected with the extent and routes of its biotransformation."	( Cytotoxicity of anticancer candidate salinomycin and identification of its metabolites in rat cell cultures. Olejnik, M; Radko, L, 2018)	0.75
" There are many reports of its toxicity to animals but little is known about the potential adverse effects in humans."	( Primary Human Hepatocytes, but Not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity. Olejnik, M; Posyniak, A; Radko, L, 2020)	0.78

Excerpt	Reference	Relevance
" In this study, we studied the in vitro drug metabolism and pharmacokinetic parameters of SAL."	( Preclinical drug metabolism and pharmacokinetics of salinomycin, a potential candidate for targeting human cancer stem cells. Bambal, RB; Guntuku, L; Naidu, VG; Patel, PN; Resham, K; Shah, V; Thummuri, D, 2015)	0.67
" The in-vivo trial with rats showed that the Cmax, AUC(0-t), and Tmax for orally administered SLN were all significantly higher than those for SS (P<0."	( Effects of D-α-tocopherol polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles on the absorption, pharmacokinetics, and pharmacodynamics of salinomycin sodium. Gao, J; Li, J; Xie, F; Xue, J; Zhai, L; Zhang, H, 2019)	0.71

Excerpt	Reference	Relevance
" The purpose of our study was to determine if salinomycin could decrease cancer cell viability when combined with doxorubicin in feline sarcoma and carcinoma cells."	( Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin. Borlle, L; Dergham, A; Hume, KR; Southard, T; Wund, Z; Zumbo, B, 2019)	2.21

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
"Salinomycin was administered to chickens orally and intravenously to determine blood concentration, kinetic behaviour, bioavailability and tissue residues."	( Kinetic disposition, systemic bioavailability and tissue distribution of salinomycin in chickens. Abo el-Sooud, K; Atef, M; Ramadan, A; Youssef, SA, 1993)	1.96
" The simultaneous administration of coccidiostats and/or antimicrobials with mycotoxin binders might lead to a reduced oral bioavailability of these veterinary medicinal products."	( Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens. Croubels, S; De Backer, P; De Mil, T; De Saeger, S; Devreese, M; Maes, A, 2017)	0.67
" To improve the bioavailability of SS, SS was encapsulated here using D-α-tocopherol polyethylene glycol succinate (TPGS)-emulsified poly(lactic-co-glycolic acid) (PLGA) nanoparticles and compared with its parent SS in terms of absorption, pharmacokinetics, and efficacy in suppressing nasopharyngeal carcinomas stem cells."	( Effects of D-α-tocopherol polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles on the absorption, pharmacokinetics, and pharmacodynamics of salinomycin sodium. Gao, J; Li, J; Xie, F; Xue, J; Zhai, L; Zhang, H, 2019)	0.71
" However, the poor bioavailability and catastrophic side effects brought about limitations to clinical practice."	( Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells. Li, R; Liu, B; Liu, F; Liu, Q; Meng, F; Wang, L; Wang, Q; Wei, J; Xie, C; Yen, YT; Yu, L, 2021)	0.94
"5%) and the pharmacokinetics and bioavailability of Sal was improved with F3-Sal-NPs."	( F3 peptide functionalized liquid crystalline nanoparticles for delivering Salinomycin against breast cancer. Babu, S; Dey, S; Gupta, NV; Jain, R; Jain, V; Kumar, H; Madhunapantula, SV; Soni, AG, 2023)	1.14

Excerpt	Relevance	Reference
" A total dosage per quail of 10(6) sporulated oocysts was chosen because this dosage gave a good (77%) depression of weight gain from Day 18 to Day 24."	( Prevention of coccidiosis in bobwhites by medication. Chute, MB; Ruff, MD; Wilkins, GC, 1987)	0.27
" Rumen and blood samples were obtained before and at 6, 12, and 24 hours after each carbohydrate-antibiotic dosing to monitor acid-base status."	( Effect of ionophore antibiotics on experimentally induced lactic acidosis in cattle. Avery, TB; Galitzer, SJ; Harmon, DL; Nagaraja, TG, 1985)	0.27
" The highest serum concentrations of salinomycin were reached half an hour after oral dosage with an absorption half-life (t0."	( Kinetic disposition, systemic bioavailability and tissue distribution of salinomycin in chickens. Abo el-Sooud, K; Atef, M; Ramadan, A; Youssef, SA, 1993)	0.79
") was investigated in dependence upon dosage and feeding method."	( [Toxicity of the combination of salinomycin and tiamulin in swine]. Bollwahn, W; Büsing, S; Wendt, M, 1997)	0.58
" The control diet, containing only SAL at 60 mg/kg, was fed to all birds throughout the 35-d trial, including the period during the gaps between dosing (i."	( Compatibility of a combination of tiamulin and chlortetracycline with salinomycin in feed during a pulsed medication program coadministration in broilers. Afrin, S; Burch, DG; Das, PM; Hassan, MM; Islam, KM; Kemppainen, BW; Klein, U; Valks, M, 2008)	0.58
" Monensin, salinomycin and maduramycin at the dosage of 120, 60, and 5 mg/kg were administered in feed for 14 days."	( Effects of ionophores on liver CYP1A and 3A in male broilers. Jiang, SX; Mo, F; Yu, ZG; Zhang, JR; Zhang, LL; Zhao, J, 2010)	0.75
" An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin."	( Synthetic modification of salinomycin: selective O-acylation and biological evaluation. Borgström, B; Hegardt, C; Huang, X; Oredsson, S; Pošta, M; Strand, D, 2013)	0.88
" The 4 medicinal products were dosed using a single bolus administration directly in the crop."	( Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens. Croubels, S; De Backer, P; De Mil, T; De Saeger, S; Devreese, M; Maes, A, 2017)	0.67
" Due to their strong cytotoxicity, strict control over their dosage and residue in animal food is necessary."	( One-Step Platform for Maduramicin and Salinomycin Detection Based on Bispecific Monoclonal Antibody and Interpretation of Molecular Recognition Mechanism. Chen, Y; Gu, Y; Huang, J; Li, J; Sun, Z, 2023)	1.18

Role	Description
animal growth promotant	Substances that are administered to farmed animals to improve productivity by promoting weight gain, increasing muscle mass, limiting fat deposition, reducing feed consumption, and reducing waste production.
potassium ionophore	Any ionophore capable of transportation of potassium ions across membranes.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
polyketide	Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides.
spiroketal	A cyclic ketal in which the ketal carbon is the only common atom of two rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
TDP1 protein	Homo sapiens (human)	Potency	1.5511	0.0008	11.3822	44.6684	AID686978; AID686979
AR protein	Homo sapiens (human)	Potency	3.0019	0.0002	21.2231	8,912.5098	AID743035; AID743042; AID743054; AID743063
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	4.4668	0.0123	7.9835	43.2770	AID1346984
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	2.0456	0.0002	14.3764	60.0339	AID720691; AID720692
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	9.8558	0.0002	29.3054	16,493.5996	AID743069; AID743075; AID743080; AID743091
67.9K protein	Vaccinia virus	Potency	10.2175	0.0001	8.4406	100.0000	AID720579; AID720580
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	10.1014	0.0010	19.4141	70.9645	AID743094; AID743140
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	0.6319	0.0003	23.4451	159.6830	AID743065; AID743067
Cellular tumor antigen p53	Homo sapiens (human)	Potency	27.1236	0.0023	19.5956	74.0614	AID651631; AID720552
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	0.5956	0.0119	17.9420	71.5630	AID651632
Ataxin-2	Homo sapiens (human)	Potency	0.5956	0.0119	12.2221	68.7989	AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	3.3100	0.0800	2.4688	9.8000	AID977604
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	2.0300	0.0440	1.3630	5.0000	AID977601
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50 (µMol)	0.2400	0.0002	2.4585	9.9600	AID1804171
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle G2/M phase transition	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
ER overload response	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
in utero embryonic development	Cellular tumor antigen p53	Homo sapiens (human)
somitogenesis	Cellular tumor antigen p53	Homo sapiens (human)
release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
T cell proliferation involved in immune response	Cellular tumor antigen p53	Homo sapiens (human)
B cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
T cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
response to ischemia	Cellular tumor antigen p53	Homo sapiens (human)
nucleotide-excision repair	Cellular tumor antigen p53	Homo sapiens (human)
double-strand break repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
protein import into nucleus	Cellular tumor antigen p53	Homo sapiens (human)
autophagy	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
Ras protein signal transduction	Cellular tumor antigen p53	Homo sapiens (human)
gastrulation	Cellular tumor antigen p53	Homo sapiens (human)
neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
protein localization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA replication	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
determination of adult lifespan	Cellular tumor antigen p53	Homo sapiens (human)
mRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
rRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
response to salt stress	Cellular tumor antigen p53	Homo sapiens (human)
response to inorganic substance	Cellular tumor antigen p53	Homo sapiens (human)
response to X-ray	Cellular tumor antigen p53	Homo sapiens (human)
response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of gene expression	Cellular tumor antigen p53	Homo sapiens (human)
cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
viral process	Cellular tumor antigen p53	Homo sapiens (human)
glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
cerebellum development	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell growth	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
mitotic G1 DNA damage checkpoint signaling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	Cellular tumor antigen p53	Homo sapiens (human)
T cell differentiation in thymus	Cellular tumor antigen p53	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
regulation of tissue remodeling	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV	Cellular tumor antigen p53	Homo sapiens (human)
multicellular organism growth	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of mitochondrial membrane permeability	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
entrainment of circadian clock by photoperiod	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial DNA repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
transcription initiation-coupled chromatin remodeling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of proteolysis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
response to antibiotic	Cellular tumor antigen p53	Homo sapiens (human)
fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
circadian behavior	Cellular tumor antigen p53	Homo sapiens (human)
bone marrow development	Cellular tumor antigen p53	Homo sapiens (human)
embryonic organ development	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Cellular tumor antigen p53	Homo sapiens (human)
protein stabilization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of helicase activity	Cellular tumor antigen p53	Homo sapiens (human)
protein tetramerization	Cellular tumor antigen p53	Homo sapiens (human)
chromosome organization	Cellular tumor antigen p53	Homo sapiens (human)
neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic stem cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
type II interferon-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cardiac septum morphogenesis	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of programmed necrotic cell death	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Cellular tumor antigen p53	Homo sapiens (human)
thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
necroptotic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to xenobiotic stimulus	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to ionizing radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV-C	Cellular tumor antigen p53	Homo sapiens (human)
stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to actinomycin D	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
replicative senescence	Cellular tumor antigen p53	Homo sapiens (human)
oxidative stress-induced premature senescence	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
oligodendrocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of execution phase of apoptosis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of G1 to G0 transition	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of miRNA processing	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of pentose-phosphate shunt	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
regulation of fibroblast apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cell population proliferation	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of B cell proliferation	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
nuclear DNA replication	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
signal transduction in response to DNA damage	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
isotype switching	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of DNA replication	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of isotype switching to IgG isotypes	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA clamp unloading	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
regulation of mitotic cell cycle phase transition	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of cell cycle G2/M phase transition	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
negative regulation of receptor internalization	Ataxin-2	Homo sapiens (human)
regulation of translation	Ataxin-2	Homo sapiens (human)
RNA metabolic process	Ataxin-2	Homo sapiens (human)
P-body assembly	Ataxin-2	Homo sapiens (human)
stress granule assembly	Ataxin-2	Homo sapiens (human)
RNA transport	Ataxin-2	Homo sapiens (human)
xenobiotic metabolic process	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
monoatomic ion transport	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
organic anion transport	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
bile acid and bile salt transport	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
heme catabolic process	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
sodium-independent organic anion transport	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
transmembrane transport	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
xenobiotic metabolic process	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
monoatomic ion transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
organic anion transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
bile acid and bile salt transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
prostaglandin transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
heme catabolic process	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
sodium-independent organic anion transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
transmembrane transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
thyroid hormone transport	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
core promoter sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
TFIID-class transcription factor complex binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
protease binding	Cellular tumor antigen p53	Homo sapiens (human)
p53 binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity	Cellular tumor antigen p53	Homo sapiens (human)
mRNA 3'-UTR binding	Cellular tumor antigen p53	Homo sapiens (human)
copper ion binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	Cellular tumor antigen p53	Homo sapiens (human)
zinc ion binding	Cellular tumor antigen p53	Homo sapiens (human)
enzyme binding	Cellular tumor antigen p53	Homo sapiens (human)
receptor tyrosine kinase binding	Cellular tumor antigen p53	Homo sapiens (human)
ubiquitin protein ligase binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase regulator activity	Cellular tumor antigen p53	Homo sapiens (human)
ATP-dependent DNA/DNA annealing activity	Cellular tumor antigen p53	Homo sapiens (human)
identical protein binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase binding	Cellular tumor antigen p53	Homo sapiens (human)
protein heterodimerization activity	Cellular tumor antigen p53	Homo sapiens (human)
protein-folding chaperone binding	Cellular tumor antigen p53	Homo sapiens (human)
protein phosphatase 2A binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Cellular tumor antigen p53	Homo sapiens (human)
14-3-3 protein binding	Cellular tumor antigen p53	Homo sapiens (human)
MDM2/MDM4 family protein binding	Cellular tumor antigen p53	Homo sapiens (human)
disordered domain specific binding	Cellular tumor antigen p53	Homo sapiens (human)
general transcription initiation factor binding	Cellular tumor antigen p53	Homo sapiens (human)
molecular function activator activity	Cellular tumor antigen p53	Homo sapiens (human)
promoter-specific chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
ATP binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
ATP hydrolysis activity	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA clamp unloader activity	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
RNA binding	Ataxin-2	Homo sapiens (human)
epidermal growth factor receptor binding	Ataxin-2	Homo sapiens (human)
protein binding	Ataxin-2	Homo sapiens (human)
mRNA binding	Ataxin-2	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
organic anion transmembrane transporter activity	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
bile acid transmembrane transporter activity	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
sodium-independent organic anion transmembrane transporter activity	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
organic anion transmembrane transporter activity	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
bile acid transmembrane transporter activity	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
prostaglandin transmembrane transporter activity	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
sodium-independent organic anion transmembrane transporter activity	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
thyroid hormone transmembrane transporter activity	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
3'-5'-RNA exonuclease activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoesters	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
protein guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nuclear body	Cellular tumor antigen p53	Homo sapiens (human)
nucleus	Cellular tumor antigen p53	Homo sapiens (human)
nucleoplasm	Cellular tumor antigen p53	Homo sapiens (human)
replication fork	Cellular tumor antigen p53	Homo sapiens (human)
nucleolus	Cellular tumor antigen p53	Homo sapiens (human)
cytoplasm	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrion	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial matrix	Cellular tumor antigen p53	Homo sapiens (human)
endoplasmic reticulum	Cellular tumor antigen p53	Homo sapiens (human)
centrosome	Cellular tumor antigen p53	Homo sapiens (human)
cytosol	Cellular tumor antigen p53	Homo sapiens (human)
nuclear matrix	Cellular tumor antigen p53	Homo sapiens (human)
PML body	Cellular tumor antigen p53	Homo sapiens (human)
transcription repressor complex	Cellular tumor antigen p53	Homo sapiens (human)
site of double-strand break	Cellular tumor antigen p53	Homo sapiens (human)
germ cell nucleus	Cellular tumor antigen p53	Homo sapiens (human)
chromatin	Cellular tumor antigen p53	Homo sapiens (human)
transcription regulator complex	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex	Cellular tumor antigen p53	Homo sapiens (human)
Elg1 RFC-like complex	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
nucleus	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
cytoplasm	Ataxin-2	Homo sapiens (human)
Golgi apparatus	Ataxin-2	Homo sapiens (human)
trans-Golgi network	Ataxin-2	Homo sapiens (human)
cytosol	Ataxin-2	Homo sapiens (human)
cytoplasmic stress granule	Ataxin-2	Homo sapiens (human)
membrane	Ataxin-2	Homo sapiens (human)
perinuclear region of cytoplasm	Ataxin-2	Homo sapiens (human)
ribonucleoprotein complex	Ataxin-2	Homo sapiens (human)
cytoplasmic stress granule	Ataxin-2	Homo sapiens (human)
plasma membrane	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
basal plasma membrane	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
basolateral plasma membrane	Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)
plasma membrane	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
basal plasma membrane	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
membrane	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
basolateral plasma membrane	Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (363)

Assay ID	Title	Year	Journal	Article
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID977599	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID977604	Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID1195543	Antimicrobial activity against Bacillus anthracis 34F2 after 18 hrs by twofold serial broth dilution method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID471234	Inhibition of bovine spleen PDE2 by surface plasmon resonance assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Surface plasmon resonance-based detection of ladder-shaped polyethers by inhibition detection method.
AID977601	Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID977602	Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID685500	HARVARD: Cytotoxicity in HepG2 cell line	2012	Proceedings of the National Academy of Sciences of the United States of America, May-29, Volume: 109, Issue:22	Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.
AID685501	HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells	2012	Proceedings of the National Academy of Sciences of the United States of America, May-29, Volume: 109, Issue:22	Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.
AID1520375	Antiproliferative activity against human MCF7 cells	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519369	Drug uptake in mdr1a/1b double knockout mouse brain at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670788	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 451/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1555488	Antimycobacterial activity against Mycobacterium avium IFO 315 by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1520367	Antiproliferative activity against human MCF7 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1406095	Antiproliferative activity against human MCF10A cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1667676	Genotoxicity in rec negative Bacillus subtilis M45 assessed as diameter of inhibition zone at 256 ug measured after 24 hrs by rec-assay	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID519350	Plasma clearance in wild-type mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1667677	Genotoxicity in rec-positive Bacillus subtilis H17 assessed as diameter of inhibition zone at 256 ug measured after 24 hrs by rec-assay	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1377756	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Design and synthesis of conformationally constrained salinomycin derivatives.
AID1240092	Antiproliferative activity against human MV4-11 cells after 72 hrs	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1439826	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological activity of salinomycin-hydroxamic acid conjugates.
AID1199988	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo/DX cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1439825	Cytotoxicity against human HGC27 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological activity of salinomycin-hydroxamic acid conjugates.
AID519360	Ratio of AUC (0 to 6 hrs) in mdr1a/1b double knockout mouse to AUC (0 to 6 hrs) in wild-type mouse at 1 mg/kg, IV	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519375	Ratio of drug uptake in liver in mdr1a/1b double knockout mouse to drug uptake in liver in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1520373	Antiproliferative activity against HMLER cells by MTT assay Breast cancer stem cell	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1520369	Antiproliferative activity against human HeLa cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1195588	Inhibition of Staphylococcus epidermidis ATCC 35984 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1406091	Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1199997	Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670775	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1524915	Inhibition of Wnt/beta-catenin signaling pathway in human HepG2 cells assessed as reduction in TCF-dependent beta-catenin mediated transcription incubated for 24 hrs by Topflash reporter assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain.
AID1406129	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human MCF7 cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1667661	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 602 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1520374	Antiproliferative activity against human JIMT1 cells	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1393186	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1439824	Cytotoxicity against human HT-29 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological activity of salinomycin-hydroxamic acid conjugates.
AID670754	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1601780	Antileishmanial activity against Leishmania donovani MHOM/SD/00/1S-2D promastigotes by luminescence assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Anti-parasitic activity of polyether ionophores.
AID670770	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1199978	Antiproliferative activity against human vincristine-resistant HL60/Vinc cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670773	Antibacterial activity against Staphylococcus epidermidis ATCC 35984 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1124882	Resistance index, ratio of IC50 for human HL60/Vinc cells to IC50 for human HL60 cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID670751	Antibacterial activity against Staphylococcus aureus NCTC 4163 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1393195	Cytotoxicity against human A2780cis cells assessed as cell viability at 8 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1200016	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 469/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1393188	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID697853	Inhibition of horse BChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID1199990	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LS180 cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670787	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 450/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID519357	Ratio of AUC (0 to 6 hrs) in mdr1a/1b double knockout mouse to AUC (0 to 6 hrs) in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1382642	Cytotoxicity against human SMMC7721 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID670774	Antibacterial activity against Escherichia coli ATCC 10538 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1393191	Cytotoxicity against human A2780/DX cells assessed as cell viability at 4 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID519367	Ratio of drug uptake in brain to drug uptake in plasma in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1667671	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 621 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1195543	Antimicrobial activity against Bacillus anthracis 34F2 after 18 hrs by twofold serial broth dilution method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1200007	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 573/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670752	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1382650	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human SMMC7721 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1555491	Antimycobacterial activity against Xanthomonas oryzae by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1227857	Decrease in ALDH activity in human SKBR3 cells overexpressing HER2 assessed as ALDH-positive population by flow cytometry in absence of ALDH inhibitor DEAB (Rvb = 20%)	2015	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1	Targeting HER-2 over expressed breast cancer cells with 2-cyclohexyl-N-[(Z)-(substituted phenyl/furan-2-yl/thiophene-2-yl)methylidene]hydrazinecarbothioamide.
AID1393190	Growth inhibition of human ovarian cancer stem cells at 0.5 uM in presence of 20 nM PTX	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1200015	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 468/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1200002	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 462/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1199986	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HL60/Vinc cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1195593	Inhibition of Staphylococcus epidermidis isolate 469/11 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1667660	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 574 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1382645	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human HL60 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1240094	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo cells	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID519343	AUC (0 to infinity) in mdr1a/1b double knockout mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519363	Drug uptake in wild-type mouse plasma at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670796	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 444/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1313592	Ionophoric activity in large unilamellar POPC/POPG (3:1) vesicles assessed as relaxation of potassium coupled-proton gradient by measuring decrease in internal pH at 1 pM after 300 secs by ratiometric pH reporter pyranin based spectroscopic analysis	2016	ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6	Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.
AID519352	Toxicity in mdr1a/1b double knockout mouse assessed as decrease in respiratory frequency at 10 mg/kg, po after 15 to 30 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID250727	Anticoccidial activity (percent reduction in oocyst production) against Eimeria tenella in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1200010	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 459/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1124900	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 488/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID250781	Anticoccidial activity (percent reduction in oocyst production) against Eimeria acervulina in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1393192	Cytotoxicity against human NCI-ADR-RES cells assessed as cell viability at 4 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID670778	Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1382636	Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1124881	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HL60/Vinc cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1124888	Antibacterial activity against Staphylococcus aureus ATCC 6538	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID519341	Tmax in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1555485	Antimycobacterial activity against Mycobacterium abscessus ATCC 19977	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID51258	The compound was tested for anti-coccidial activity in chicken against Eimeria mitis (LS-84) measured at dose 60 (ppm in diet)	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID670800	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 448/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1441104	Cytotoxicity against human MIAPaCa2 cells assessed as decrease in cell viability after 48 hrs by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1200017	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 470/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1124873	Antiproliferative activity against human HL60 cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1727715	Antitrypanosomal activity against Trypanosoma brucei brucei assessed as cell swelling	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
AID1520386	Antiproliferative activity against human JIMT1 cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519342	AUC (0 to 6 hrs) in mdr1a/1b double knockout mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1200005	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 537/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1667667	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 583 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1727713	Cytotoxicity against human HL-60 cells by resazurin dye based fluorescence assay	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
AID719327	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1382651	N-octanol/water partition co-efficient, log P of the compound by shake-flask method	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1124889	Antibacterial activity against Staphylococcus aureus ATCC 29213	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID250698	Anticoccidial activity (percent reduction in oocyst production) against Eimeria maxima in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID51238	The compound was tested for anti-coccidial activity in chicken against Eimeria brunetti (FS-103) measured at dose 60 (ppm in diet)	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID519355	Toxicity in mdr1a/1b double knockout mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1199985	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HL60 cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1667670	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 620 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID670772	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1393194	Cytotoxicity against human NCI-ADR-RES cells assessed as cell viability at 8 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1195591	Inhibition of Staphylococcus epidermidis isolate 409/10 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID519366	Drug uptake in wild-type mouse small intestinal content at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID719329	Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1124876	Antiproliferative activity against human LoVo/DX cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1124897	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 468/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID519358	Ratio of Cmax in mdr1a/1b double knockout mouse to Cmax in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519335	AUC (0 to 6 hrs) in wild-type mouse at 10 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1124887	Antibacterial activity against Staphylococcus aureus ATCC 25923	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1313588	Reduction in aldehyde dehydrogenase levels in human JIMT1 cells at 0.52 uM by ALDEFLUOR assay (Rvb = 30 to 60%)	2016	ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6	Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.
AID1200019	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 489/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1555486	Antimicrobial activity against Alternaria kikuchiana NIAS by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1200000	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 452/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1406089	Antiproliferative activity against human ALL5 cells after 120 hrs by MTT assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1441107	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1406090	Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID519372	Ratio of drug uptake in brain to drug uptake in plasma in mdr1a/1b double knockout mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1667668	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 584 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1393187	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1406125	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human ALL5 cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID670781	Antibacterial activity against Bordetella bronchiseptica ATCC 4617 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID670779	Antibacterial activity against Pseudomonas aeruginosa NCTC 6749 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1727714	Selectivity index, ratio of GI50 for human HL-60 cells to GI50 for antitrypanosomal activity against Trypanosoma brucei brucei S427	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
AID670802	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1199984	Antiproliferative activity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID719331	Resistance index, ratio of IC50 for doxorubicin-resistant human LoVo/DX cells to IC50 for parental human LoVo cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1200004	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 522/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1124885	Resistance index, ratio of IC50 for human LoVo/DX cells to IC50 for human LoVo cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1555494	Antiviral activity against HIV1 infected in U937 cells	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1406092	Antiproliferative activity against human JIMT1 cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID719326	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 doxorubicin-resistant human LoVo/DX cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1382640	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1199983	Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1382653	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID519376	Ratio of drug uptake in small intestinal content in mdr1a/1b double knockout mouse to drug uptake in small intestinal content in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670776	Antibacterial activity against Escherichia coli NCTC 8196 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID670767	Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID719336	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1520384	Antiproliferative activity against human LoVo cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID670769	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID250700	Anticoccidial activity (percent reduction in oocyst production) against Eimeria mivati in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID250725	Anticoccidial activity (percent reduction in oocyst production) against Eimeria praecox in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1555499	Antibacterial activity against Sarcina lutea	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1393193	Cytotoxicity against human A2780/DX cells assessed as cell viability at 8 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1195601	Genotoxicity in rec-negative Bacillus subtilis M45 at 2 ug/9 mm disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1200001	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 456/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID519337	Tmax in wild-type mouse at 10 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1195592	Inhibition of Staphylococcus epidermidis isolate 461/11 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID519347	AUC (0 to infinity) in wild-type mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519356	Ratio of AUC (0 to infinity) in mdr1a/1b double knockout mouse to AUC (0 to infinity) in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID716397	Antiproliferative activity against human VCaP cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Polyether ionophores-promising bioactive molecules for cancer therapy.
AID1555503	Antibacterial activity against Bacillus anthracis	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1124894	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 461/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1520363	Antiproliferative activity against human HT-29 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1124877	Antiproliferative activity mouse BALB/3T3 cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID519368	Drug uptake in mdr1a/1b double knockout mouse plasma at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519362	Ratio of plasma clearance in mdr1a/1b double knockout mouse to plasma clearance in wild-type mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1601791	Antiparasitic activity against Schistosoma mansoni Puerto Rico PR-1 after 48 hrs by fluorescence based lactate release assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Anti-parasitic activity of polyether ionophores.
AID51244	The compound was tested for anti-coccidial activity in chicken against Eimeria hagani (DP-786) measured at dose 60 (ppm in diet)	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID519374	Ratio of drug uptake in brain in mdr1a/1b double knockout mouse to drug uptake in brain in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1124895	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 466/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1667659	Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID250682	Anticoccidial activity (percent reduction in oocyst production) against Eimeria mitis in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1393185	Cytotoxicity against human OVCAR8 cells assessed as cell viability level at 8 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID670785	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 400/10 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID670784	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 399/10 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1382647	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human HeLa cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID670765	Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID519373	Ratio of drug uptake in plasma in mdr1a/1b double knockout mouse to drug uptake in plasma in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID51412	Anticoccidial activity in chicken against E. tenella	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1406127	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human JIMT1 cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID519348	AUC (0 to 6 hrs) in mdr1a/1b double knockout mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1124901	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 489/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1200012	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 461/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID519338	AUC (0 to 6 hrs) in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670753	Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1524906	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain.
AID1520371	Antiproliferative activity against mouse 4T1 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519365	Drug uptake in wild-type mouse liver at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1667669	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 612 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1520388	Antiproliferative activity against human MCF10A cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1124890	Antibacterial activity against Staphylococcus epidermidis ATCC 12228	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1124899	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 470/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1195600	Genotoxicity in rec-positive Bacillus subtilis H17 at 2 ug/9 mm disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1382649	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human SW480 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1520372	Antiproliferative activity against human A549 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1555501	Antibacterial activity against methicillin-resistant Staphylococcus aureus	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1520368	Antiproliferative activity against human U87 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1382637	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1199993	Resistance index, ratio of IC50 for human LoVo/DX cells to IC50 for human LoVo cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1520387	Antiproliferative activity against human SKBR3 cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1555489	Antimycobacterial activity against Mycobacterium phlei IPCR by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1551539	Selectivity index, ratio of GI50 for human HL60 cells to GI50 for bloodstream form of Trypanosoma brucei 427-221a	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Anti-trypanosomal activity of doubly modified salinomycin derivatives.
AID1200006	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 572/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID53003	Inhibitory activity against second generation merozoids of Eimeria tenella in chick hepatocyte assay in the presence of iproniazid; Value given as 0.08-0.016	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	8-Aminoquinolines as anticoccidials--II.
AID1199992	Resistance index, ratio of IC50 for human HL60/Vinc cells to IC50 for human HL60 cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1520365	Antiproliferative activity against human MDA-MB-231 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519346	AUC (0 to 6 hrs) in wild-type mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670771	Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1124883	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID670756	Antibacterial activity against Staphylococcus epidermidis ATCC 35984 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID670797	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 445/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1124880	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HL60 cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1667665	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 654 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1426138	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents.
AID1240095	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo/DX cells	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1200009	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 586/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID719334	Cytotoxicity against human LoVo cells incubated for 72 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID548272	Cytotoxicity against african green monkey COS1 cells assessed as reduction in cell viability after 32 hrs by luminescent assay	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription.
AID1382646	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human A549 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1124892	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 459/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID716396	Antiproliferative activity against human PC3 cells after 48 hrs	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Polyether ionophores-promising bioactive molecules for cancer therapy.
AID1551541	Cytotoxicity against human HL60 cells assessed as growth inhibition after 24 hrs by resazurin dye based assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Anti-trypanosomal activity of doubly modified salinomycin derivatives.
AID519353	Toxicity in mdr1a/1b double knockout mouse assessed as paralyzed fore limb and hind limb at 10 mg/kg, po after 15 to 30 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670798	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 446/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID670792	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 440/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1240097	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human MV4-11 cells	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1426137	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents.
AID1520380	Antiproliferative activity against human HGC27 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519359	Ratio of Tmax in mdr1a/1b double knockout mouse to Tmax in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1199995	Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1406128	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human SK-BR-3 cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID52997	Inhibitory activity against second generation merozoids of Eimeria tenella in chick hepatocyte assay in the absence of inhibitor; Value given as 0.08-0.016	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	8-Aminoquinolines as anticoccidials--II.
AID1520382	Antiproliferative activity against human MCF7 cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1382644	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against mouse 4T1 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1393184	Cytotoxicity against human OVCAR8 cells assessed as cell viability level at 4 uM incubated for 72 hrs by MTT assay	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID670782	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 393/10 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1555497	Antibacterial activity against Mycobacterium phlei	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID670799	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 447/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1520364	Antiproliferative activity against human HGC27 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1441125	Cytotoxicity against cancer stem cells derived from human BT474 cells assessed as cancer stem cell death at 20 uM after 3 days by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1555490	Antimycobacterial activity against Pyricularia oryzae by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID697852	Inhibition of electric eel AChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID519371	Drug uptake in mdr1a/1b double knockout mouse small intestinal content at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1406126	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human LoVo cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID670766	Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1667664	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 610 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID519344	Cmax in mdr1a/1b double knockout mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1199987	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1555498	Antibacterial activity against Staphylococcus aureus	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1551540	Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427-221a assessed as growth inhibition measured after 24 hrs by resazurin dye based assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Anti-trypanosomal activity of doubly modified salinomycin derivatives.
AID1667662	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 603 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1382638	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID670777	Antibacterial activity against Proteus vulgaris NCTC 4635 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID519351	Plasma clearance in mdr1a/1b double knockout mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1406121	Ex vivo antitumor activity against patient derived breast cancer tissue assessed as decrease in tumor cell proliferation at 6.2 uM by Ki-67 staining based immunohistochemical analysis	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1555502	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1199998	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID519336	Cmax in wild-type mouse at 10 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1520385	Antiproliferative activity against human LoVo/DX cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1124884	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human LoVo/DX cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1240091	Antiproliferative activity against doxorubicin-resistant human LoVo/DX cells after 72 hrs	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1555493	Antiviral activity against HIV1	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1240093	Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID670793	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 441/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1382648	Selectivity index, ratio of IC50 for cytotoxicity against human BEAS2B cells to IC50 for cytotoxicity against human MCF7 cells	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID719330	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HL60 cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID1520381	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID250757	Anticoccidial activity (percent reduction in oocyst production) against Eimeria necatrix in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1200003	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 514/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1124886	Antibacterial activity against Staphylococcus aureus NCTC 4163	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1199996	Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1441123	Disruption of cancer stem cells spheroids derived from human BT474 cells at 7.5 uM after 3 days by microscopic analysis	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1667657	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1489324	Induction of disintegration of human BT474 cancer stem cell spheroids at 7.5 uM after 3 days by microscopic method	2017	Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23	Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells.
AID1200011	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 460/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID719328	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human vincristine-resistant human HL60/Vinc cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID519345	Tmax in mdr1a/1b double knockout mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1727712	Antitrypanosomal activity against Trypanosoma brucei brucei S427 by resazurin dye based fluorescence assay	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
AID53006	Inhibitory activity against second generation merozoids of Eimeria tenella in chick hepatocyte assay in the presence of Tranylcypromine; Value given as 0.08-0.016	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	8-Aminoquinolines as anticoccidials--II.
AID51408	The compound was tested for anti-coccidial activity in chicken against Eimeria praecox (DP-785) measured at dose 60 (ppm in diet)	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1406124	Resistance index, ratio of IC50 for human LoVo/DX cells to IC50 for human LoVo cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID670794	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 442/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1195589	Inhibition of Staphylococcus epidermidis ATCC 12228 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID519339	AUC (0 to infinity) in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID519349	AUC (0 to infinity) in mdr1a/1b double knockout mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID670768	Antibacterial activity against Staphylococcus aureus NCTC 4163 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1393196	Antitumor activity against human C13 cells xenografted in mouse assessed as tumor volume at 5 mg/kg, ip dosed every other day for 3 weeks and measured every two days (Rvb = 252.5 +/- 63.4 mm3)	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID670795	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 443/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1199979	Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1124874	Antiproliferative activity against human HL60/Vinc cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1520370	Antiproliferative activity against human Caco2 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID670786	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 401/10 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1124898	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 469/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1406093	Antiproliferative activity against human SK-BR-3 cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1555500	Antibacterial activity against methicillin-sensitive Staphylococcus aureus	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1199999	Antimicrobial activity against Staphylococcus epidermidis ATCC 35984 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670780	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1555487	Antimicrobial activity against Alternaria kikuchiana A-14 by agar diffusion method	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1382652	Cytotoxicity against doxycycline inducible T-Rex/K-Ras G12V HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1124896	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 467/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1382641	Cytotoxicity against human SW480 cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1441106	Cytotoxicity against human BT474 cells assessed as decrease in cell viability after 48 hrs by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID670755	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 400 ug/disc after 18 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1406123	Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human LoVo/DX cells	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1441105	Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 48 hrs by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1124893	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 460/11	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1393189	Growth inhibition of human ovarian epithelial cancer cells at 0.5 uM in presence of 20 nM PTX	2017	European journal of medicinal chemistry, Dec-15, Volume: 142	Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer.
AID1439832	Chemical stability in RPMI1640 medium at 10 mg after 72 hrs by 1H NMR method	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological activity of salinomycin-hydroxamic acid conjugates.
AID1199977	Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1200008	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 585/12 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670790	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 481/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID519370	Drug uptake in mdr1a/1b double knockout mouse liver at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID548271	Antiviral activity against Ebolavirus infected in african green monkey COS1 cells assessed as inhibition of viral replication after 32 hrs by luciferase reporter gene assay	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription.
AID719333	Resistance index, ratio of IC50 for vincristine-resistant human HL60/Vinc cells to IC50 for parental human HL60 cells	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID250755	Anticoccidial activity (percent reduction in oocyst production) against Eimeria brunetti in chickens at 66 ppm; Range = 50-79 %	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
AID1667672	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 750 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1520383	Antiproliferative activity against human MDA-MB-231 cells by SRB assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID519377	Ratio of drug uptake in brain to plasma in mdr1a/1b double knockout mouse to drug uptake in brain to plasma in wild-type mouse at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1124875	Antiproliferative activity against human LoVo cells	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1199989	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human HT-29 cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670789	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 452/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1382639	Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1441124	Cytotoxicity against cancer stem cells derived from human BT474 cells assessed as cancer stem cell death at 7.5 uM after 3 days by MTS assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5	Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.
AID1520379	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1199981	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1406094	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1200014	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 467/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1199982	Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID670791	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 482/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1124891	Antibacterial activity against Staphylococcus epidermidis ATCC 35984	2014	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7	Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.
AID1199994	Antimicrobial activity against Staphylococcus aureus ACTC 4163 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1667666	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 660 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1227856	Decrease in ALDH activity in human SKBR3 cells overexpressing HER2 assessed as ALDH-positive population by flow cytometry in presence of ALDH inhibitor DEAB (Rvb = 0.7%)	2015	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1	Targeting HER-2 over expressed breast cancer cells with 2-cyclohexyl-N-[(Z)-(substituted phenyl/furan-2-yl/thiophene-2-yl)methylidene]hydrazinecarbothioamide.
AID1199980	Antiproliferative activity against human doxorubicin-resistant LoVo/DX cells assessed as growth inhibition after 72 hrs by SRB method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID519340	Cmax in wild-type mouse at 1 mg/kg, po	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1313591	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	2016	ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6	Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.
AID1555496	Antibacterial activity against Bacillus subtilis	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1667658	Antibacterial activity against Escherichia coli NCTC 8196 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1195590	Inhibition of Staphylococcus epidermidis isolate 407/10 biofilm formation at 4 ug/ml after 24 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
AID1520366	Antiproliferative activity against human JIMT1 cells by MTT assay	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
AID1200018	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 488/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1555495	Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) infected in MDCK cells after 3 days by MTT assay	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID1667663	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate 609 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1489325	Induction of disintegration of human BT474 cancer stem cell spheroids at 20 uM after 3 days by microscopic method	2017	Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23	Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells.
AID519364	Drug uptake in wild-type mouse brain at 1 mg/kg, iv after 180 mins by LC-MS/MS analysis	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1555504	Trypanocidal activity against bloodstream forms of Trypanosoma brucei infected in human HL-60 cells incubated for 24 hrs followed by compound wash out after 72 hrs	2019	European journal of medicinal chemistry, Aug-15, Volume: 176	Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets".
AID670801	Antibacterial activity against hospital-acquired methicillin-sensitive Staphylococcus aureus 449/11 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1667673	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 770 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1240090	Antiproliferative activity against human LoVo cells after 72 hrs	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1313590	Cytotoxicity against human JIMT1 cells after 72 hrs by MTT assay	2016	ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6	Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.
AID519354	Toxicity in wild-type mouse at 10 mg/kg, po after 15 to 30 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID51252	The compound was tested for anti-coccidial activity in chicken against Eimeria maxima (DP-776) measured at dose 60 (ppm in diet)	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	Benzylated 1,2,3-triazoles as anticoccidiostats.
AID519361	Ratio of AUC (0 to infinity) in mdr1a/1b double knockout mouse to AUC (0 to infinity) in wild-type mouse at 1 mg/kg, iv	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
AID1377755	Antiproliferative activity against human HT-29 cells at 10 uM after 48 hrs by MTT assay relative to control	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Design and synthesis of conformationally constrained salinomycin derivatives.
AID719335	Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID719332	Cytotoxicity against doxorubicin-resistant human LoVo/DX cells incubated for 72 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antiproliferative activity of salinomycin and its derivatives.
AID670783	Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 394/10 after 18 hrs by twofold serial agar dilution technique	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
AID1667656	Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as bacterial growth inhibition measured after 18 hrs by CLSI protocol based two-fold serial microdilution method	2020	Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9	Antibacterial activity of singly and doubly modified salinomycin derivatives.
AID1199991	Selectivity index, ratio of IC50 for mouse BALB/3T3 cells to IC50 for human SW707 cells	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1406120	Ex vivo antitumor activity against patient derived breast cancer tissue assessed as increase in number of dead tumor cells at 6.2 uM by H and E staining based immunohistochemical analysis	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
AID1240096	Resistant index, ratio of IC50 for human LoVo/DX cells to IC50 for LoVo cells	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
AID1382643	Cytotoxicity against human BEAS2B cells assessed as cell growth inhibition after 48 hrs by MTS assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
AID1200013	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis 466/11 after 18 hrs by two-fold serial microdilution method	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and biological activity of salinomycin conjugates with floxuridine.
AID1804171	DRC analysis by immunofluorescence from Article 10.1128/AAC.00819-20: \\Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.\\	2020	Antimicrobial agents and chemotherapy, 06-23, Volume: 64, Issue:7	Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	83 (12.87)	18.7374
1990's	66 (10.23)	18.2507
2000's	72 (11.16)	29.6817
2010's	326 (50.54)	24.3611
2020's	98 (15.19)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	30 (4.46%)	5.53%
Reviews	1 (14.29%)	6.00%
Reviews	27 (4.02%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	8 (1.19%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
Other	607 (90.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
astemizole Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.. astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.	2.07	1	0	benzimidazoles; piperidines	anti-allergic agent; anticoronaviral agent; H1-receptor antagonist
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.11	1	0	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
clomiphene [no description available]	2.07	1	0	tertiary amine	estrogen antagonist; estrogen receptor modulator
omeprazole Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.	2.07	1	0	aromatic ether; benzimidazoles; pyridines; sulfoxide
pyrimethamine Maloprim: contains above 2 cpds	2.07	1	0	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	2.11	1	0	C-nitro compound; quinoline N-oxide	carcinogenic agent
primaquine phosphate [no description available]	2.07	1	0
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.07	1	0	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
dequalinium chloride dequalinium chloride : An organic chloride salt that is the dichloride salt of dequalinium.	2.07	1	0	organic chloride salt	antifungal agent; antineoplastic agent; antiseptic drug; mitochondrial NADH:ubiquinone reductase inhibitor
antimycin a [no description available]	2.07	1	0	benzamides; formamides; macrodiolide; phenols	antifungal agent; mitochondrial respiratory-chain inhibitor; piscicide
decoquinate Decoquinate: A coccidiostat for poultry.	2.07	1	0
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	2.07	1	0	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
ciclopirox olamine ciclopirox olamine : The ethanolamine salt of ciclopirox. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.	2.07	1	0
idarubicin Idarubicin: An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.	2.07	1	0	anthracycline antibiotic; deoxy hexoside; monosaccharide derivative
proadifen hydrochloride [no description available]	2.07	1	0
telmisartan Telmisartan: A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.. telmisartan : A member of the class of benzimidazoles used widely in the treatment of hypertension.	2.07	1	0	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic
nonoxynol-9 tergitol NP-9 : A tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4.	2.07	1	0	tergitol	contraceptive drug; nonionic surfactant
atovaquone Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.. atovaquone : A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.	2.07	1	0	hydroxy-1,2-naphthoquinone
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2.07	1	0	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
shikonin shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities	2.07	1	0	hydroxy-1,4-naphthoquinone
evp 4593 EVP 4593: an NF-kappaB pathway inhibitor; structure in first source	2.07	1	0
tenatoprazole Tenatoprazole: structure in first source	2.07	1	0	imidazopyridine
emetine dihydrochloride emetine dihydrochloride : The dihydrochloride salt of emetine.. emetine dihydrochloride hydrate : A hydrate that is the monohydrate of the dihydrochloride salt of emetine.	2.07	1	0	hydrochloride	anticoronaviral agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; protein synthesis inhibitor
clemastine fumarate clemastine fumarate : The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.	2.07	1	0	fumarate salt	anti-allergic agent; antipruritic drug; H1-receptor antagonist; muscarinic antagonist
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	2.07	1	0	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
lasalocid sodium lasalocid sodium : The sodium salt of lasalocid. It is a veterinary ionophore antibiotic used for prevention and treatment of coccidiosis in poultry.	2.07	1	0	benzoates; organic sodium salt	coccidiostat; ionophore
1-methyl-d-lysergic acid butanolamide [no description available]	2.07	1	0	ergot alkaloid; monocarboxylic acid amide	serotonergic antagonist; sympatholytic agent; vasoconstrictor agent
gedunin [no description available]	2.07	1	0	acetate ester; enone; epoxide; furans; lactone; limonoid; organic heteropentacyclic compound; pentacyclic triterpenoid	antimalarial; antineoplastic agent; Hsp90 inhibitor; plant metabolite
monensin [no description available]	2.49	2	0
zaprinast zaprinast: anaphylaxis inhibitor; structure	2.07	1	0	triazolopyrimidines
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.71	3	0	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2.02	1	0	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
adenine [no description available]	2.37	2	0	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	3.33	2	0	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	2.13	1	0	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
betaine glycine betaine : The amino acid betaine derived from glycine.	2.43	2	0	amino-acid betaine; glycine derivative	fundamental metabolite
butyric acid Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.. butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.. butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.	1.98	1	0	fatty acid 4:0; straight-chain saturated fatty acid	human urinary metabolite; Mycoplasma genitalium metabolite
formic acid formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	6.97	1	0	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.8	3	0	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.39	2	0	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
hydrochloric acid Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.. hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.	2.08	1	0	chlorine molecular entity; gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite
4-aminophenol 4-aminophenol: RN given refers to parent cpd. 4-aminophenol : An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.	2.07	1	0	aminophenol	allergen; metabolite
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	3.6	8	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.01	1	0	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.4	2	0	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	2.07	1	0	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.47	2	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	2.25	1	0	cyclitol; hexol
melatonin [no description available]	2.07	1	0	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2.8	3	0	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
propionic acid propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.	1.98	1	0	saturated fatty acid; short-chain fatty acid	antifungal drug
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	2.02	1	0	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.31	1	0	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
vanillin Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).	2.02	1	0	benzaldehydes; monomethoxybenzene; phenols	anti-inflammatory agent; anticonvulsant; antioxidant; flavouring agent; plant metabolite
epibatidine [no description available]	2.07	1	0	alkaloid
1,10-phenanthroline 1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases	2.17	1	0	phenanthroline	EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.7	3	0	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.25	1	0	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
am 251 AM 251: an analog of SR141716A; structure given in first source. AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.	2.13	1	0	amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles	antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist
amodiaquine Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.	3.57	2	0	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug
amprolium Amprolium: A veterinary coccidiostat that interferes with THIAMINE metabolism.. amprolium : An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.. amprolium(1+) : A pyridinium ion that is the cationic portion of amprolium, a veterinary drug which is used for prevention of coccidiosis in poultry and cattle.	3.1	5	0	pyridinium ion	coccidiostat
aristolochic acid i aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.	2.07	1	0	aristolochic acids; aromatic ether; C-nitro compound; cyclic acetal; monocarboxylic acid; organic heterotetracyclic compound	carcinogenic agent; metabolite; mutagen; nephrotoxin; toxin
berberine [no description available]	3.31	1	0	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
5-methoxypsoralen 5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.	2.07	1	0	5-methoxyfurocoumarin; organic heterotricyclic compound; psoralens	hepatoprotective agent; plant metabolite
bromhexine Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744). bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).	2.13	1	0	organobromine compound; substituted aniline; tertiary amino compound	mucolytic
caffeine [no description available]	2.05	1	0	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.07	1	0	aromatic ether; nitrile; polyether; tertiary amino compound
camostat camostat : A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients.	3.17	1	0	benzoate ester; carboxylic ester; diester; guanidines; tertiary carboxamide	anti-inflammatory agent; anticoronaviral agent; antifibrinolytic drug; antihypertensive agent; antineoplastic agent; antiviral agent; serine protease inhibitor
cannabinol Cannabinol: A physiologically inactive constituent of Cannabis sativa L.	2.21	1	0	dibenzopyran
celecoxib [no description available]	2.11	1	0	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug
cgp 37157 CGP 37157: benzothiazepine derivative of clonazepam; inhibits the in vitro activity of mitochondrial sodium-calcium exchange	2.11	1	0	benzothiazepine
chlorambucil Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.	2.15	1	0	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	3.64	3	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	3.21	5	0	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
clonazepam Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.. clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.	2.11	1	0	1,4-benzodiazepinone; monochlorobenzenes	anticonvulsant; anxiolytic drug; GABA modulator
dapsone [no description available]	2.05	1	0	substituted aniline; sulfone	anti-inflammatory drug; antiinfective agent; antimalarial; leprostatic drug
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone: ubiquinol analog. 6-decylubiquinone : A member of the class of 1,4-benzoquinones that is 2,3-dimethoxybenzoquinone which has been substituted at positions 5 and 6 by decyl and methyl groups.	2.07	1	0	1,4-benzoquinones	cofactor
deferiprone Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.	7.6	1	0	4-pyridones	iron chelator; protective agent
3,3'-diindolylmethane 3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist	2.07	1	0	indoles	antineoplastic agent; P450 inhibitor
valproic acid Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.. valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.	2.1	1	0	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent
ebastine [no description available]	3.17	1	0	organic molecular entity
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	2.47	2	0	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
embelin embelin: from Embelia fruit (Myrsinaceae). embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.	2.07	1	0	dihydroxy-1,4-benzoquinones	antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.07	1	0	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.98	1	0
ether Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.	2.81	3	0	ether; volatile organic compound	inhalation anaesthetic; non-polar solvent; refrigerant
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	8.01	4	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	2.01	1	0
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	2.07	1	0
hexachlorophene Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.	3.17	1	0	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
hexestrol [no description available]	2.42	2	0	stilbenoid
hypericin [no description available]	2.07	1	0
indole-3-carbinol indole-3-carbinol: occurs in edible cruciferous vegetables. indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.	2.07	1	0	indolyl alcohol	antineoplastic agent; plant metabolite
isoproterenol Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.	1.96	1	0	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent
juglone juglone: structure. juglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.	2.1	1	0	hydroxy-1,4-naphthoquinone	geroprotector; herbicide; reactive oxygen species generator
nsc 664704 kenpaullone: inhibits CDK1/cyclin B; structure in first source. kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).	2.07	1	0	indolobenzazepine; lactam; organobromine compound	cardioprotective agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; geroprotector
ketamine Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.. ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.	1.99	1	0	cyclohexanones; monochlorobenzenes; secondary amino compound	analgesic; environmental contaminant; intravenous anaesthetic; neurotoxin; NMDA receptor antagonist; xenobiotic
khellin Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024). khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.	2.07	1	0	furanochromone; organic heterotricyclic compound; oxacycle	anti-asthmatic agent; bronchodilator agent; cardiovascular drug; vasodilator agent
kinetin Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.. cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.	2.07	1	0	6-aminopurines; furans	cytokinin; geroprotector
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.07	1	0	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
lavendustin a lavendustin A: from Streptomyces griseolavendus; structure given in first source	2.07	1	0	aromatic amine
lavendustin b [no description available]	2.07	1	0
loperamide Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.. loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.	3.17	1	0	monocarboxylic acid amide; monochlorobenzenes; piperidines; tertiary alcohol	anticoronaviral agent; antidiarrhoeal drug; mu-opioid receptor agonist
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source	2.08	1	0	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector
mefloquine hydrochloride [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.	3.17	1	0	organofluorine compound; piperidines; quinolines; secondary alcohol
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.07	1	0	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
mequitazine mequitazine: RN given refers to parent cpd without isomeric designation; structure	3.17	1	0	phenothiazines
metformin Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.	9.98	4	0	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic
methoxsalen Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.	2.07	1	0	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite
entinostat [no description available]	2.11	1	0	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
myristicin myristicin: asaricin is an isomer; structure; a methylene dioxy version of elemicin;	2.07	1	0	organic molecular entity	metabolite
nalidixic acid [no description available]	2.07	1	0	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
niclosamide Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.	8.77	3	0	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one [no description available]	2.07	1	0	isoquinolines
patulin Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.	2.47	2	0	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	2.15	1	0	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
perhexiline Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.	3.17	1	0	piperidines	cardiovascular drug
phenazopyridine Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.. phenazopyridine : A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.	3.17	1	0	diaminopyridine; monoazo compound	anticoronaviral agent; carcinogenic agent; local anaesthetic; non-narcotic analgesic
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.13	1	0	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
phloretin [no description available]	2.07	1	0	dihydrochalcones	antineoplastic agent; plant metabolite
propidium Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.	1.98	1	0	phenanthridines; quaternary ammonium ion	fluorochrome; intercalator
pyrimethamine Maloprim: contains above 2 cpds	2.01	1	0	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
roxarsone Roxarsone: An arsenic derivative which has anticoccidial action and promotes growth in animals.. roxarsone : An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.	3.07	5	0	2-nitrophenols; organoarsonic acid	agrochemical; animal growth promotant; antibacterial drug; coccidiostat
sanguinarine benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.	2.07	1	0	alkaloid antibiotic; benzophenanthridine alkaloid; botanical anti-fungal agent
streptonigrin [no description available]	2.07	1	0	pyridines; quinolone	antimicrobial agent; antineoplastic agent
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	2.1	1	0	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
temozolomide [no description available]	3.92	3	0	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug
terfenadine Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.	2.07	1	0	diarylmethane
tetrahydropapaverine tetrahydropapaverine: RN given refers to parent cpd. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline : A benzylisoquinoline alkaloid that is norlaudanosoline in which the four phenolic hydrogens have been replaced by methyl groups.	2.07	1	0	aromatic ether; benzylisoquinoline alkaloid; benzyltetrahydroisoquinoline; polyether; secondary amino compound
theobromine Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9). theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.	2.07	1	0	dimethylxanthine	adenosine receptor antagonist; bronchodilator agent; food component; human blood serum metabolite; mouse metabolite; plant metabolite; vasodilator agent
thioridazine Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.. thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.	3.45	2	0	phenothiazines; piperidines	alpha-adrenergic antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist
tilorone Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.. tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.	3.17	1	0	aromatic ether; diether; fluoren-9-ones; tertiary amino compound	anti-inflammatory agent; antineoplastic agent; antiviral agent; interferon inducer; nicotinic acetylcholine receptor agonist
triclosan [no description available]	2.15	1	0	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic
trioxsalen Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.. lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.. antipsoriatic : A drug used to treat psoriasis.. trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.	2.07	1	0	psoralens	dermatologic drug; photosensitizing agent
xylazine Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.. xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.	1.99	1	0	1,3-thiazine; methylbenzene; secondary amino compound	alpha-adrenergic agonist; analgesic; emetic; muscle relaxant; sedative
zinc chloride zinc chloride: RN given refers to parent cpd. zinc dichloride : A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.	2.02	1	0	inorganic chloride; zinc molecular entity	astringent; disinfectant; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; Lewis acid
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.07	1	0	mitomycin	alkylating agent; antineoplastic agent
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	2.61	2	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
reserpine Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	2.07	1	0	alkaloid ester; methyl ester; yohimban alkaloid	adrenergic uptake inhibitor; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; first generation antipsychotic; plant metabolite; xenobiotic
phentolamine Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.. phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.	1.96	1	0	imidazoles; phenols; substituted aniline; tertiary amino compound	alpha-adrenergic antagonist; vasodilator agent
floxuridine Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.	7.11	1	0	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent
pilocarpine hydrochloride pilocarpine hydrochloride : The hydrochloride salt of (+)-pilocarpine, a medication used to treat increased pressure inside the eye and dry mouth.	2.07	1	0	hydrochloride
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	2.17	1	0	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
cantharidin Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.. cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.	2.07	1	0	cyclic dicarboxylic anhydride; monoterpenoid	EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; herbicide
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2.13	1	0	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	2.57	2	0	C-nitro compound; quinoline N-oxide	carcinogenic agent
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	3.68	2	0	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
physostigmine Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	2.07	1	0	carbamate ester; indole alkaloid	antidote to curare poisoning; EC 3.1.1.8 (cholinesterase) inhibitor; miotic
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.5	2	0	kanamycins	bacterial metabolite
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.68	3	0	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
veratramine veratramine: structure. veratramine : A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.	2.07	1	0	piperidine alkaloid
phlorhizin [no description available]	2.07	1	0	aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative	antioxidant; plant metabolite
papaverine hydrochloride [no description available]	2.07	1	0
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.48	2	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
yohimbine hydrochloride [no description available]	2.07	1	0
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.07	1	0	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
gliotoxin Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.	2.07	1	0	dipeptide; organic disulfide; organic heterotetracyclic compound; pyrazinoindole	antifungal agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; immunosuppressive agent; mycotoxin; proteasome inhibitor
17-alpha-hydroxyprogesterone 17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.	3.17	1	0	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; tertiary alpha-hydroxy ketone	human metabolite; metabolite; mouse metabolite; progestin
tubercidin Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.	2.07	1	0	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite
cytarabine [no description available]	2.07	1	0	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
veratridine [no description available]	2.07	1	0	steroid	sodium channel modulator
gibberellic acid gibberellic acid: RN given refers to (1alpha,2beta,4aalpha,4bbeta,10beta)-isomer; structure. gibberellin A3 : A C19-gibberellin that is a pentacyclic diterpenoid responsible for promoting growth and elongation of cells in plants. Initially identified in Gibberella fujikuroi,it differs from gibberellin A1 in the presence of a double bond between C-3 and C-4.	2.07	1	0	C19-gibberellin; gibberellin monocarboxylic acid; lactone; organic heteropentacyclic compound	mouse metabolite; plant metabolite
triparanol Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.	3.17	1	0	stilbenoid	anticoronaviral agent
dichloroacetic acid [no description available]	2.61	2	0	monocarboxylic acid; organochlorine compound	astringent; marine metabolite
visnagin visnagin: from Musineon divaricatum. visnagin : A furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga.	2.07	1	0	aromatic ether; furanochromone; polyketide	anti-inflammatory agent; antihypertensive agent; EC 1.1.1.37 (malate dehydrogenase) inhibitor; phytotoxin; plant metabolite; vasodilator agent
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	2.07	1	0	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
skimmianine skimmianine: furanoquinoline alkaloid from Teclea (RUTACEAE)	2.07	1	0	alkaloid antibiotic; organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
syrosingopine syrosingopine: was heading 1963-94; SYRINGOPINE was see SYROSINGOPINE 1977-94; use RESERPINE to search SYROSINGOPINE 1966-94	2.07	1	0	yohimban alkaloid
gramine gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.	2.07	1	0	aminoalkylindole; indole alkaloid; tertiary amino compound	antibacterial agent; antiviral agent; plant metabolite; serotonergic antagonist
benzotriazole benzotriazole: inhibitor of atmospheric metal corrosion; also component of motion picture film & Neva brake fluid. benzotriazole : The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring.	2.07	1	0	benzotriazoles	environmental contaminant; xenobiotic
acrolein [no description available]	2.25	1	0	enal	herbicide; human xenobiotic metabolite; toxin
3-hydroxybutanal [no description available]	2.03	1	0
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	4.08	4	0	pyrrole; secondary amine
methylergonovine Methylergonovine: A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)	2.07	1	0	ergoline alkaloid
2,2'-methylenebis(4-methyl-6-tert-butylphenol) [no description available]	2.07	1	0	diarylmethane
indolebutyric acid indolebutyric acid: RN given refers to parent cpd. indole-3-butyric acid : A indol-3-yl carboxylic acid that is butanoic acid carrying a 1H-indol-3-yl substituent at position 1.	2.07	1	0	indol-3-yl carboxylic acid	auxin; plant hormone; plant metabolite
shikimic acid Shikimic Acid: A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.. shikimic acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.	2.07	1	0	alpha,beta-unsaturated monocarboxylic acid; cyclohexenecarboxylic acid; hydroxy monocarboxylic acid	Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	4.96	12	0	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	2.49	2	0	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.11	1	0	diazine; pyrazines	Daphnia magna metabolite
monocrotaline Monocrotaline: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.	2.07	1	0	pyrrolizidine alkaloid
nicarbazin Nicarbazin: An equimolar complex of 4,4'-Dinitrocarbanilide and 2-Hydroxy-4,6-dimethylpyrimidine. A coccidiostat for poultry.	5.82	12	2	organic molecular entity
jervine jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure	2.07	1	0	piperidines
glycyrrhetinic acid [no description available]	2.07	1	0	cyclic terpene ketone; hydroxy monocarboxylic acid; pentacyclic triterpenoid	immunomodulator; plant metabolite
boldine [no description available]	2.07	1	0	aporphine alkaloid
indirubin [no description available]	2.07	1	0
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	2.07	1	0	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
cepharanthine cepharanthine: isoquinoline alkaloid from tubers of STEPHANIA; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. cepharanthine : A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.	2.07	1	0	bisbenzylisoquinoline alkaloid; isoquinolines
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.07	1	0	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
emetine Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.	2.25	1	0	isoquinoline alkaloid; pyridoisoquinoline	antiamoebic agent; anticoronaviral agent; antiinfective agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; expectorant; plant metabolite; protein synthesis inhibitor
osthol osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source	2.07	1	0	botanical anti-fungal agent; coumarins	metabolite
cytisine [no description available]	2.07	1	0	alkaloid; bridged compound; lactam; organic heterotricyclic compound; secondary amino compound	nicotinic acetylcholine receptor agonist; phytotoxin; plant metabolite
bicuculline Bicuculline: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.. bicuculline : A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.	2.07	1	0	benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines	agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin
kainic acid Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.	2.07	1	0	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist
thymoquinone thymoquinone: constituent of cedarwood; can cause dermatitis; structure. thymoquinone : A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.	2.07	1	0	1,4-benzoquinones	adjuvant; anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; cardioprotective agent; plant metabolite
benzohydroxamic acid [no description available]	2.15	1	0
carvacrol carvacrol : A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).	2.08	1	0	botanical anti-fungal agent; p-menthane monoterpenoid; phenols	agrochemical; antimicrobial agent; flavouring agent; TRPA1 channel agonist; volatile oil component
oxetane oxetane: structure. oxetane : A saturated organic heteromonocyclic parent that is a four-membered ring comprising of three carbon atoms and an oxygen atom.	7.1	1	0	oxetanes; saturated organic heteromonocyclic parent
oleanolic acid [no description available]	2.07	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	2.07	1	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
hesperidin Hesperidin: A flavanone glycoside found in CITRUS fruit peels.. hesperidin : A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	0	3'-hydroxyflavanones; 4'-methoxyflavanones; dihydroxyflavanone; disaccharide derivative; flavanone glycoside; monomethoxyflavanone; rutinoside	mutagen
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	2.07	1	0	C-nitro compound; imidazoles	antitubercular agent
cadmium acetate cadmium acetate: RN given refers to parent cpd	2.21	1	0
Berberine chloride (TN) [no description available]	2.07	1	0	organic molecular entity
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	4.04	4	0	cyclic ketone; erythromycin
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	2.05	1	0	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
deoxycytidine [no description available]	3.04	4	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
arsenic trioxide Arsenic Trioxide: An inorganic compound with the chemical formula As2O3 that is used for the treatment of ACUTE PROMYELOCYTIC LEUKEMIA in patients who have relapsed from, or are resistant to, conventional drug therapy.	2.17	1	0
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	3.32	6	0	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
tocopherols [no description available]	2.02	1	0
vincamine Vincamine: A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.	2.07	1	0	alkaloid ester; hemiaminal; methyl ester; organic heteropentacyclic compound; vinca alkaloid	antihypertensive agent; metabolite; vasodilator agent
dronabinol Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.. Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.	2.21	1	0	benzochromene; diterpenoid; phytocannabinoid; polyketide	cannabinoid receptor agonist; epitope; hallucinogen; metabolite; non-narcotic analgesic
n-tetradecylamine N-tetradecylamine: RN given refers to parent cpd	2.15	1	0	alkylamine
oxyclozanide Oxyclozanide: Anthelmintic used in grazing animals for fasciola and cestode infestations.	3.17	1	0
muscarine [no description available]	2.07	1	0
clopidol pharmcoccide: Russian drug; no other info available 1/1/79	7.68	3	0	chloropyridine
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.52	2	0	fluorescein isothiocyanate
ecdysone [no description available]	2.07	1	0	14alpha-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; 6-oxo steroid; ecdysteroid	prohormone
streptomycin [no description available]	3.88	3	0	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
pentaquine pentaquine: RN given refers to parent cpd	1.99	1	0
n-deacetyl-n-formylcolchicine N-deacetyl-N-formylcolchicine: structure given in first source	2.07	1	0	cyclic ketone
lanthanum [no description available]	7.25	1	0	f-block element atom; lanthanoid atom; scandium group element atom
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.21	1	0	elemental platinum; nickel group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.55	2	0	copper group element atom; elemental silver	Escherichia coli metabolite
cadmium Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.	2.88	3	0	cadmium molecular entity; zinc group element atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.1	1	0	copper group element atom; elemental gold
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	2.25	1	0	titanium group element atom
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.49	2	0	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
nequinate nequinate: minor descriptor (75-88); on line & & INDEX MEDICUS search QUINOLINES (75-88)	2.38	2	0	quinolines
levamisole Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.	3.43	1	1	6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole	antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator
thiamphenicol [no description available]	2.08	1	0	monocarboxylic acid amide; sulfone	antimicrobial agent; immunosuppressive agent
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.07	1	0	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
decoquinate Decoquinate: A coccidiostat for poultry.	2.41	2	0
cannabichromene [no description available]	2.21	1	0	1-benzopyran
2-bromoergocryptine mesylate [no description available]	2.07	1	0	methanesulfonate salt	antiparkinson drug
zingerone zingerone: pungent principle of ginger; structure. zingerone : A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.	2.07	1	0	methyl ketone; monomethoxybenzene; phenols	anti-inflammatory agent; antiemetic; antioxidant; flavouring agent; fragrance; plant metabolite; radiation protective agent
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.75	3	0	benzenes; phenyl acetates
triamcinolone Triamcinolone: A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739). triamcinolone : A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.	1.99	1	0	11beta-hydroxy steroid; 16alpha-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug
penfluridol Penfluridol: One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.	3.17	1	0	diarylmethane
nigericin Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.	7.09	14	2	polycyclic ether	antibacterial agent; antimicrobial agent; bacterial metabolite; potassium ionophore
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	2.15	1	0	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	2.13	1	0	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	4.43	19	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	7.47	2	0	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
phorbol 12,13-dibutyrate Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.	2.07	1	0	butyrate ester; phorbol ester; tertiary alpha-hydroxy ketone
cephradine Cephradine: A semi-synthetic cephalosporin antibiotic.. cephradine : A first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton.	2.07	1	0	beta-lactam antibiotic allergen; cephalosporin	antibacterial drug
sq-11725 Nadolol: A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.. nadolol : Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol.	2.37	2	0
deoxynivalenol deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.	6.97	1	0	cyclic ketone; enone; primary alcohol; secondary alpha-hydroxy ketone; trichothecene; triol	mycotoxin
quisqualic acid Quisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.	2.07	1	0	non-proteinogenic alpha-amino acid
arprinocid arprinocid: structure	2.66	3	0	6-aminopurines
colforsin Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.	2.07	1	0	acetate ester; cyclic ketone; labdane diterpenoid; organic heterotricyclic compound; tertiary alpha-hydroxy ketone; triol	adenylate cyclase agonist; anti-HIV agent; antihypertensive agent; plant metabolite; platelet aggregation inhibitor; protein kinase A agonist
swainsonine Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.. swainsonine : An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.	2.07	1	0	indolizidine alkaloid	antineoplastic agent; EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor; immunological adjuvant; plant metabolite
castanospermine castanospermine: indolizidine alkaloid from seeds of Australian legume, Castanospermum australe. castanospermine : A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).	2.07	1	0	indolizidine alkaloid	anti-HIV-1 agent; anti-inflammatory agent; EC 3.2.1.* (glycosidase) inhibitor; metabolite
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	3.04	4	0	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
aripiprazole Aripiprazole: A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.. aripiprazole : An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.	2.13	1	0	aromatic ether; delta-lactam; dichlorobenzene; N-alkylpiperazine; N-arylpiperazine; quinolone	drug metabolite; H1-receptor antagonist; second generation antipsychotic; serotonergic agonist
irinotecan [no description available]	2.57	2	0	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug
acridine orange Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.	2.08	1	0	aminoacridines; aromatic amine; tertiary amino compound	fluorochrome; histological dye
daunorubicin hydrochloride [no description available]	2.07	1	0	anthracycline
halofuginone [no description available]	3.78	11	0	quinazolines
nelfinavir Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.	7.83	3	0	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor
mevastatin mevastatin: antifungal metabolite from Penicillium brevicopactum; potent inhibitory activity to sterol synthesis; structure. mevastatin : A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.	2.07	1	0	2-pyranones; carboxylic ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	antifungal agent; apoptosis inducer; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; fungal metabolite; Penicillium metabolite
ursolic acid [no description available]	2.07	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
norharman norharman: RN given refers to parent cpd. beta-carboline : The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.	2.07	1	0	beta-carbolines; mancude organic heterotricyclic parent	fungal metabolite; marine metabolite
betulinic acid [no description available]	2.53	2	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
oseltamivir Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.	2.17	1	0	acetamides; amino acid ester; cyclohexenecarboxylate ester; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; environmental contaminant; prodrug; xenobiotic
diacetylfluorescein [no description available]	1.98	1	0
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.07	1	0	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
baccatin iii [no description available]	2.07	1	0	acetate ester; benzoate ester; tetracyclic diterpenoid	plant metabolite
taleranol taleranol: a metabolite of ZEARALENONE which is a non-steroidal estrogenic lactone used as an anabolic compound in animal feed; a stereoisomer of ZERANOL (alpha-zearalanol)	2.07	1	0	macrolide
narasin [no description available]	3.62	2	0	diterpene glycoside
quassin quassin: article discusses quassinoid principle; structure	2.07	1	0	triterpenoid
tomatidine tomatidine: RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure. tomatidine : A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.	2.07	1	0	3beta-hydroxy steroid; azaspiro compound; oxaspiro compound
aloxistatin aloxistatin: a membrane-permeable cysteine protease inhibitor. aloxistatin : An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide.	2.07	1	0	epoxide; ethyl ester; L-leucine derivative; monocarboxylic acid amide	anticoronaviral agent; cathepsin B inhibitor
rutecarpine rutacarpine: from Evodia rutaecarpa; an ingredient in zhuyu hewei zhitong capsules	2.07	1	0	beta-carbolines
bergenin bergenin: RN refers to (2R-(2alpha,3beta,4alpha,4aalpha,10bbeta))-isomer; structure	2.07	1	0	trihydroxybenzoic acid	metabolite
1,7-phenanthroline [no description available]	2.17	1	0	phenanthroline
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	3.05	4	0	1,2,3-triazole
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.07	1	0	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
toltrazuril toltrazuril: structure in first source	2.91	4	0	aromatic ether
isoscopoletin isoscopoletin : A hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone.	2.07	1	0	aromatic ether; hydroxycoumarin	plant metabolite
enrofloxacin Enrofloxacin: A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice.. enrofloxacin : A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.	2.02	1	0	cyclopropanes; N-alkylpiperazine; N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone	antibacterial agent; antimicrobial agent; antineoplastic agent
vinburnine [no description available]	2.07	1	0	alkaloid
tocophersolan tocophersolan: RN given refers to parent cpd	2.21	1	0	tocol
avilamycin avilamycin: similar to Hygromycin B but lacking amino groups	2.7	3	0
epicatechin (-)-epicatechin : A catechin with (2R,3R)-configuration.	2.07	1	0	catechin; polyphenol	antioxidant
hesperetin [no description available]	2.07	1	0	3'-hydroxyflavanones; 4'-methoxyflavanones; monomethoxyflavanone; trihydroxyflavanone	antineoplastic agent; antioxidant; plant metabolite
magnolol [no description available]	2.07	1	0	biphenyls
honokiol [no description available]	2.07	1	0	biphenyls
chelerythrine chloride [no description available]	2.07	1	0
betulin betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.	2.07	1	0	diol; pentacyclic triterpenoid	analgesic; anti-inflammatory agent; antineoplastic agent; antiviral agent; metabolite
tetrahydroalstonine tetrahydroalstonine : A heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species.	2.07	1	0	methyl ester; organic heteropentacyclic compound; yohimban alkaloid	plant metabolite
hernandezine hernandezine: from Thalictrum glandulosissimum; structure given in first source; RN given refers to (1beta)-isomer; RN for cpd without isomeric designation not avail 3/91	2.07	1	0	bisbenzylisoquinoline alkaloid; isoquinolines
picropodophyllin picropodophyllin: isolated from American May apple (Podophyllum); inhibits IGF-I autophosphorylation without interfering with tyrosine kinase activity. picropodophyllotoxin : An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.	2.07	1	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antineoplastic agent; insulin-like growth factor receptor 1 antagonist; plant metabolite; tyrosine kinase inhibitor
tetrandrine tetrandrine: a bisbenzylisoquinoline that exhibits antifibrogenic activity	3.45	2	0	bisbenzylisoquinoline alkaloid; isoquinolines
dehydrocostus lactone dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.	2.07	1	0	gamma-lactone; guaiane sesquiterpenoid; organic heterotricyclic compound; sesquiterpene lactone	antimycobacterial drug; antineoplastic agent; apoptosis inducer; cyclooxygenase 2 inhibitor; metabolite; trypanocidal drug
alborixin alborixin: polycyclic, polyether, acidic, ionophore antibiotic; RN given refers to cpd with stereoisomeric designation; structure in sixth source. alborixin : A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus.	1.97	1	0	cyclic hemiketal; monocarboxylic acid; oxolanes; polyether antibiotic	ionophore
madecassic acid [no description available]	2.07	1	0	monocarboxylic acid; pentacyclic triterpenoid; tetrol	antioxidant; plant metabolite
panaxadiol panaxadiol: a protopanaxadiol with the side chain cyclized into a pyran which is an artifact of acidic hydrolysis; RN refers to (3 beta,12 beta,20R)-isomer	2.07	1	0	triterpenoid saponin
tryptanthrine tryptanthrine: minor constituent of traditional Chinese medicine qing dai	2.07	1	0	alkaloid antibiotic; organic heterotetracyclic compound; organonitrogen heterocyclic compound
homoeriodictyol homoeriodictyol: structure in first source. homoeriodictyol : A trihydroxyflavanone that consists of 3'-methoxyflavanone in which the three hydroxy substituents are located at positions 4', 5, and 7.	2.07	1	0	3'-methoxyflavanones; 4'-hydroxyflavanones; monomethoxyflavanone; trihydroxyflavanone	flavouring agent; metabolite
maslinic acid (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria	2.05	1	0	dihydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; plant metabolite
4-hydroxyindole hydroxyindoles : Any member of the class of indoles carrying at least one hydroxy group.	2.07	1	0	hydroxyindoles; phenols
eriocitrin eriocitrin: structure in first source. eriocitrin : A disaccharide derivative that consists of eriodictyol substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	0	3'-hydroxyflavanones; 4'-hydroxyflavanones; disaccharide derivative; flavanone glycoside; rutinoside; trihydroxyflavanone	antioxidant
7,8-dihydromethysticin [no description available]	2.07	1	0	2-pyranones; aromatic ether
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.07	1	0	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
cinchonine [no description available]	2.07	1	0	(8xi)-cinchonan-9-ol; cinchona alkaloid	metabolite
aucubin [no description available]	2.07	1	0	organic molecular entity	metabolite
lupinine lupinine: RN given refers to parent cpd(1R-trans)-isomer; structure	2.07	1	0	quinolizidine alkaloid
matrine [no description available]	2.07	1	0	alkaloid
friedelin 3-friedelanone: from the stem bark of Irvingia gabonensis; structure in first source. friedelin : A pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork.	2.07	1	0	cyclic terpene ketone; pentacyclic triterpenoid	anti-inflammatory drug; antipyretic; non-narcotic analgesic; plant metabolite
catalpol [no description available]	2.07	1	0	organic molecular entity	metabolite
quinine hydrochloride [no description available]	2.07	1	0
sarsasapogenin [no description available]	2.07	1	0	sapogenin
lopinavir [no description available]	3.46	2	0	amphetamines; dicarboxylic acid diamide	anticoronaviral agent; antiviral drug; HIV protease inhibitor
corynanthine Corynanthine: A stereoisomer of yohimbine.	2.07	1	0	yohimban alkaloid
prunin protein, prunus prunin protein, Prunus: a legumin-like type of globulin; structure given in first source. naringenin 7-O-beta-D-glucoside : A flavanone 7-O-beta-D-glucoside that is (S)-naringenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	0	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; flavanone 7-O-beta-D-glucoside; monosaccharide derivative	antibacterial agent; antilipemic drug; hypoglycemic agent; metabolite
podocarpic acid podocarpic acid: structure. podocarpic acid : An abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position.	2.07	1	0	abietane diterpenoid
(6ar-trans)-isomer of tetrahydrocannabivarin 9 [no description available]	2.21	1	0
harmol hydrochloride [no description available]	2.07	1	0
5-Methoxyflavone 5-methoxyflavone: DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity; structure in first source	2.07	1	0	ether; flavonoids
osajin osajin: from Maclura pomifera	3.17	1	0	isoflavanones
10-hydroxycamptothecin [no description available]	2.07	1	0	pyranoindolizinoquinoline
corydaline [no description available]	2.07	1	0	isoquinoline alkaloid; isoquinolines
demissidine [no description available]	2.07	1	0	alkaloid; organic heteropolycyclic compound; steroid
cinchonidine cinchonidine: has antimalarial activity; diastereoisomer of cinchonine with distinct physiochemical properties; RN given refers to parent cpd(8alpha,9R)-isomer. cinchonidine : 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.	2.07	1	0	(8xi)-cinchonan-9-ol; cinchona alkaloid	metabolite
1,2-distearoylphosphatidylethanolamine 1,2-distearoylphosphatidylethanolamine: RN given refers to cpd without isomeric designation. 1,2-distearoylphosphatidylethanolamine : A phosphatidylethanolamine in which the phosphatidyl acyl group at C-1 and C-2 is stearoyl.	2.15	1	0	phosphatidylethanolamine zwitterion; phosphatidylethanolamine	human metabolite
arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system	2.11	1	0	oligopeptide
quin2 Quin2: fluorescent highly selective Ca indicator, binding Ca 1:1; structure given in first source	1.96	1	0
propidium iodide [no description available]	2.07	1	0	organic iodide salt
tryptoline tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure	2.07	1	0	beta-carbolines
deguelin deguelin: a natural product from Mundulea sericea; RN refers to (7aS-cis)-isomer; structure given in first source. deguelin : A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.	2.07	1	0	aromatic ether; diether; organic heteropentacyclic compound; rotenones	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; mitochondrial NADH:ubiquinone reductase inhibitor; plant metabolite
catechin (+)-catechin monohydrate : The monohydrate of (+)-catechin.	2.07	1	0	hydrate	geroprotector
daidzin daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase. daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).	2.07	1	0	7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative	plant metabolite
cafestol [no description available]	2.07	1	0	diterpenoid; furans; organic heteropentacyclic compound; primary alcohol; tertiary alcohol	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; plant metabolite
parthenolide [no description available]	2.07	1	0	germacranolide
carboxyamido-triazole carboxyamido-triazole: structure given in first source; coccidiostat; U.S. patent No. 4,590,201	1.97	1	0
homoorientin homoorientin: isolated from Swertia japonica; structure given in first source	2.07	1	0	flavone C-glycoside; tetrahydroxyflavone	antineoplastic agent; radical scavenger
florfenicol florfenicol: structure given in first source. florfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.	2.08	1	0	organochlorine compound; organofluorine compound; secondary alcohol; secondary carboxamide; sulfone	antimicrobial agent
asiatic acid [no description available]	2.07	1	0	monocarboxylic acid; pentacyclic triterpenoid; triol	angiogenesis modulating agent; metabolite
angustmycin a angustmycin A: structure; from Streptomyces hygroscopicus; inhibits GMP synthesis	2.07	1	0	6-aminopurines
razadyne Razadyne: Name of the FDA approved preparation from J&J.	2.07	1	0
phytosphingosine phytosphingosine: differ with an additional hydroxyl at C-4 & no double bond between C-4 & C-5	2.07	1	0	amino alcohol; sphingoid; triol	mouse metabolite; Saccharomyces cerevisiae metabolite
tetradecanoylphorbol acetate [no description available]	2.07	1	0
celastrol [no description available]	2.07	1	0	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
4'-demethylepipodophyllotoxin 4'-demethylepipodophyllotoxin: structure in first source. 4'-demethylepipodophyllotoxin : An organic heterotetracyclic compound that is the 9- epimer of 4'-demethylpodophyllotoxin.	2.07	1	0	furonaphthodioxole; organic heterotetracyclic compound; phenols	antineoplastic agent
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.05	1	0	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
gefitinib [no description available]	7.15	1	0	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine: inhibits calcium-activated neutral protease; see also record for E-64; RN given refers to (2-S-(2alpha,3beta)(R*)-isomer)	2.07	1	0	leucine derivative
e 64 E 64: cysteine protease inhibitor of microbial origin, which inhibits cathepsin B (EC 3.4.22.1) and cathepsin L (EC 3.4.22.-)	2.07	1	0	dicarboxylic acid monoamide; epoxy monocarboxylic acid; guanidines; L-leucine derivative; zwitterion	antimalarial; antiparasitic agent; protease inhibitor
methotrexate [no description available]	7.15	1	0	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
sinensetin sinensetin: isolated from citrus fruit; exhibit antiadhesive action on platelets. sinensetin : A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.	2.07	1	0	pentamethoxyflavone	plant metabolite
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	6.98	1	0	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
harmalol hydrochloride [no description available]	2.07	1	0
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	3.24	5	0	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
bazedoxifene [no description available]	3.17	1	0	phenylindole
hyoscyamine Hyoscyamine: The 3(S)-endo isomer of atropine.. (S)-atropine : An atropine with a 2S-configuration.	2.07	1	0	tropane alkaloid
schizandrin a schizandrin A: the major lignan, 2-9%, of Schisandra plant; has hepatoprotective, antioxidant, and antineoplastic activities	2.07	1	0
schizandrin b (+)-schisandrin B : An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis.	2.07	1	0	aromatic ether; cyclic acetal; organic heterotetracyclic compound; oxacycle; tannin	anti-asthmatic agent; anti-inflammatory agent; antilipemic drug; antioxidant; apoptosis inhibitor; hepatoprotective agent; nephroprotective agent; neuroprotective agent; plant metabolite
cryptotanshinone cryptotanshinone: from Salvia miltiorrhiza	2.07	1	0	abietane diterpenoid	anticoronaviral agent
isosakuranetin isosakuranetin: structure in first source. 4'-methoxy-5,7-dihydroxyflavanone : A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and a methoxy group at position 4' (the 2S stereoisomer).	2.07	1	0	(2S)-flavan-4-one; 4'-methoxyflavanones; dihydroxyflavanone; monomethoxyflavanone	plant metabolite
isovitexin [no description available]	2.07	1	0	C-glycosyl compound; trihydroxyflavone	EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite
sclareol sclareol: structure given in first source. sclareol : A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.	2.07	1	0	labdane diterpenoid	antifungal agent; antimicrobial agent; apoptosis inducer; fragrance; plant metabolite
tanshinone ii a tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source	2.07	1	0	abietane diterpenoid
anidulafungin Anidulafungin: Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.. anidulafungin : A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.	3.17	1	0	antibiotic antifungal drug; azamacrocycle; echinocandin; heterodetic cyclic peptide; semisynthetic derivative
leucodin leucodin: structure in first source	2.07	1	0	sesquiterpene lactone
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	2.31	1	0	amino acid zwitterion; angiotensin II	human metabolite
sb 203580 [no description available]	2.15	1	0	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent
erlotinib hydrochloride [no description available]	2.15	1	0	hydrochloride; terminal acetylenic compound	antineoplastic agent; protein kinase inhibitor
limonin [no description available]	2.07	1	0	epoxide; furans; hexacyclic triterpenoid; lactone; limonoid; organic heterohexacyclic compound	inhibitor; metabolite; volatile oil component
maduramicin maduramicin: isolated from Actinomadura rubra	3.98	13	0
chelidonine chelidonine: benzophenanthridine derived from scoulerine from Chelidonium majus; RN given refers to parent cpd (chelidonine, (5bR-(5balpha,6beta,12alpha))-isomer)	2.07	1	0	alkaloid antibiotic; alkaloid fundamental parent; benzophenanthridine alkaloid
troleandomycin Troleandomycin: A macrolide antibiotic that is similar to ERYTHROMYCIN.. troleandomycin : A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.	2.07	1	0	acetate ester; epoxide; macrolide antibiotic; monosaccharide derivative; polyketide; semisynthetic derivative	EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor; xenobiotic
dronedarone Dronedarone: A non-iodinated derivative of amiodarone that is used for the treatment of ARRHYTHMIA.. dronedarone : A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias.	3.17	1	0	1-benzofurans; aromatic ether; aromatic ketone; sulfonamide; tertiary amino compound	anti-arrhythmia drug; environmental contaminant; xenobiotic
N-hydroxy-2-phenylacetamide [no description available]	2.15	1	0	acetamides
santonin Santonin: Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)	2.07	1	0	botanical anti-fungal agent; santonin	plant metabolite
sitosterol, (3beta)-isomer Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.	2.07	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C29-steroid; phytosterols; stigmastane sterol	anticholesteremic drug; antioxidant; mouse metabolite; plant metabolite; sterol methyltransferase inhibitor
vincristine sulfate [no description available]	2.07	1	0	organic sulfate salt	antineoplastic agent; geroprotector
anisomycin Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.	2.07	1	0	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.05	1	0
acetylstrophanthidin acetylstrophanthidin: structure. acetylstrophanthidin : An acetate ester that is strophanidin acetylated at the 3beta-hydroxy group.	2.07	1	0	acetate ester	anti-arrhythmia drug
berbamine [no description available]	3.17	1	0	bisbenzylisoquinoline alkaloid; isoquinolines
Harringtonine harringtonin: alkaloid C from Caphalotaxus fortunei	2.07	1	0	alkaloid
homoharringtonine Homoharringtonine: Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.. omacetaxine mepesuccinate : A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.	2.25	1	0	alkaloid ester; enol ether; organic heteropentacyclic compound; tertiary alcohol	anticoronaviral agent; antineoplastic agent; apoptosis inducer; protein synthesis inhibitor
acivicin [no description available]	2.07	1	0	isoxazoles; non-proteinogenic L-alpha-amino acid; organochlorine compound	antileishmanial agent; antimetabolite; antimicrobial agent; antineoplastic agent; EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor; glutamine antagonist; metabolite
ketopinic acid ketopinic acid: structure in first source	2.07	1	0
wortmannin [no description available]	2.48	2	0	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent
gitoxigenin gitoxigenin: structure	2.07	1	0	14beta-hydroxy steroid; 16beta-hydroxy steroid; 3beta-hydroxy steroid
graveoline graveoline: structure in first source	2.07	1	0	quinolines
4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en: RN given for (3R-(3alpha,3abeta,4beta,8aalpha))-isomer; a natural benzyl ester of a carotyl type azulene sesquiterpenoid; structure in first source	2.07	1	0
carboplatin [no description available]	2.21	1	0
glycogen glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.	3.46	1	1
elastin [no description available]	2.52	2	0	oligopeptide
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.07	1	0	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
ouabain Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.	3.7	3	0	11alpha-hydroxy steroid; 14beta-hydroxy steroid; 5beta-hydroxy steroid; alpha-L-rhamnoside; cardenolide glycoside; steroid hormone	anti-arrhythmia drug; cardiotonic drug; EC 2.3.3.1 [citrate (Si)-synthase] inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; ion transport inhibitor; plant metabolite
puromycin [no description available]	2.07	1	0	puromycins	antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor
taxifolin (+)-taxifolin : A taxifolin that has (2R,3R)-configuration.	2.07	1	0	taxifolin	metabolite
mimosine L-mimosine : An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.	2.07	1	0	4-pyridones; amino acid zwitterion; non-proteinogenic L-alpha-amino acid	EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
eriodictyol eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.	2.07	1	0	3'-hydroxyflavanones; tetrahydroxyflavanone
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.07	1	0	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	2.07	1	0	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
conessine conessine : A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.	2.07	1	0	steroid alkaloid; tertiary amino compound	antibacterial agent; antimalarial; H3-receptor antagonist; plant metabolite
griseofulvin Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.	2.07	1	0	1-benzofurans; antibiotic antifungal drug; benzofuran antifungal drug; organochlorine compound; oxaspiro compound	antibacterial agent; Penicillium metabolite
actinorhodin actinorhodin: structure. actinorhodin : A member of the class of benzoisochromanequinone that is produced by Streptomyces coelicolor A3(2) and exhibits antibiotic activity.	2.55	2	0
monensin Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.. monensin A : A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.	10.42	99	4	cyclic hemiketal; monocarboxylic acid; polyether antibiotic; spiroketal	antifungal agent; coccidiostat; ionophore
digitoxin Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.	3.45	2	0	cardenolide glycoside	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
hyperforin hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;. hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.	2.07	1	0
deltaline [no description available]	2.07	1	0	acetate ester; cyclic acetal; diterpene alkaloid; organic polycyclic compound; tertiary alcohol; tertiary amino compound
ingenol [no description available]	2.07	1	0	cyclic terpene ketone; tetracyclic diterpenoid
picrotin picrotin: the less toxic component of PICROTOXIN lacking GABA activity. picrotin : An organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity.	2.07	1	0	diol; epoxide; gamma-lactone; organic heteropentacyclic compound; picrotoxane sesquiterpenoid; tertiary alcohol	plant metabolite
picrotoxinin [no description available]	2.07	1	0	epoxide; gamma-lactone; organic heteropentacyclic compound; picrotoxane sesquiterpenoid; tertiary alcohol	GABA antagonist; plant metabolite; serotonergic antagonist
naringin [no description available]	2.07	1	0	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; neohesperidoside	anti-inflammatory agent; antineoplastic agent; metabolite
isonaringin isonaringin: structure in first source. narirutin : A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	0	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; rutinoside	anti-inflammatory agent; antioxidant; metabolite
ochratoxin a ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.	2.07	1	0	isochromanes; monocarboxylic acid amide; N-acyl-L-phenylalanine; organochlorine compound; phenylalanine derivative	Aspergillus metabolite; calcium channel blocker; carcinogenic agent; mycotoxin; nephrotoxin; Penicillium metabolite; teratogenic agent
gingerol gingerol: an active ingredient in GINGER along with SHOGAOL. a nonvolatile methoxy phenyl decanone. gingerol : A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.	2.07	1	0	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite
securinine securinine: a quinolizine pseudoalkaloid (not from amino acid) from Securinega suffurutiosa or Securinini nitras	2.07	1	0	indolizines
Dubinidine [no description available]	2.07	1	0	organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
cyclopamine [no description available]	2.07	1	0	piperidines	glioma-associated oncogene inhibitor
doxorubicin hydrochloride [no description available]	2.78	3	0	anthracycline
vinpocetine vinpocetine: whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation	2.07	1	0	alkaloid	geroprotector
dihydroergocristine monomesylate dihydroergocristine mesylate : The methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia.	2.07	1	0	methanesulfonate salt	alpha-adrenergic antagonist; geroprotector; vasodilator agent
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	2.86	3	0	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.17	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.04	4	0	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
ferulic acid ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.	2.07	1	0	ferulic acids	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite
thapsigargin Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.	2.47	2	0	butyrate ester; organic heterotricyclic compound; sesquiterpene lactone	calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2.07	1	0	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
alitretinoin Alitretinoin: A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.	2.07	1	0	retinoic acid	antineoplastic agent; keratolytic drug; metabolite; retinoid X receptor agonist
L-cycloserine L-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.	2.07	1	0	4-amino-1,2-oxazolidin-3-one	anti-HIV agent; anticonvulsant; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
12-deoxyphorbol 13-acetate [no description available]	2.07	1	0	phorbol ester	metabolite
diclazuril [no description available]	10.48	8	2	nitrile
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.49	2	0	actinomycin	mutagen
aphidicolin Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.. aphidicolin : A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.	2.07	1	0	tetracyclic diterpenoid	antimicrobial agent; antimitotic; antineoplastic agent; antiviral drug; apoptosis inducer; Aspergillus metabolite; DNA synthesis inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; fungal metabolite
(+)-usnic acid [no description available]	2.07	1	0	usnic acid
beta, beta-dimethylacrylshikonin, (+)-isomer [no description available]	2.07	1	0	hydroxy-1,4-naphthoquinone
shikonin shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities	2.07	1	0	hydroxy-1,4-naphthoquinone
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	2.31	1	0	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
rhapontin rhapontin: constituent of rhubarb rhizome	2.07	1	0	rhaponticin	angiogenesis inhibitor; anti-allergic agent; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 2.3.1.85 (fatty acid synthase) inhibitor; hypoglycemic agent; neuroprotective agent; plant metabolite
cinnamaldehyde 3-phenylprop-2-enal : A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name "cinnamaldehyde" is widely used to refer to the E (trans) isomer.. (E)-cinnamaldehyde : The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.	2.25	1	0	3-phenylprop-2-enal; cinnamaldehydes	antifungal agent; EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor; flavouring agent; hypoglycemic agent; plant metabolite; sensitiser; vasodilator agent
glycosides [no description available]	2.39	2	0
piperine piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.	2.07	1	0	benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide	food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.84	3	0	stilbene
rauwolscine Rauwolscine: A stereoisomer of yohimbine.	2.07	1	0	methyl 17-hydroxy-20xi-yohimban-16-carboxylate
cannabidiol Cannabidiol: Compound isolated from Cannabis sativa extract.. cannabidiol : An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.	2.21	1	0	olefinic compound; phytocannabinoid; resorcinols	antimicrobial agent; plant metabolite
amygdalin (R)-amygdalin : An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.	2.07	1	0	amygdalin	antineoplastic agent; apoptosis inducer; plant metabolite
lanatoside c lanatoside C: RN given refers to (3beta,5beta,12beta)-isomer	3.17	1	0
hydrastine, (r-(r,s))-isomer [no description available]	2.07	1	0	isoquinolines
tiamulin tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer. tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.	6.03	15	2	carbotricyclic compound; carboxylic ester; cyclic ketone; organic sulfide; secondary alcohol; semisynthetic derivative; tertiary amino compound; tetracyclic diterpenoid	antibacterial drug
sesquiterpenes [no description available]	2.39	2	0
vasicine vasicine: RN given refers to (R)-isomer	2.07	1	0
3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.	2.07	1	0	catechols; polyphenol; resorcinols; stilbenol	antineoplastic agent; apoptosis inducer; geroprotector; hypoglycemic agent; plant metabolite; protein kinase inhibitor; tyrosine kinase inhibitor
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.07	1	0	caffeic acid	geroprotector; mouse metabolite
cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	2.07	1	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite
heliotrine [no description available]	2.07	1	0	pyrrolizines
sclareolide [no description available]	2.07	1	0	naphthofuran
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.08	1	0	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
hypocrellin b hypocrellin B: photosensitive pigments isolated from Hypocrella bambusae Sacc; structure given in first source	2.07	1	0
capsaicin ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.	2.07	1	0	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker
zuclomiphene Zuclomiphene: The cis or (Z)-isomer of clomiphene.	3.17	1	0	stilbenoid
aurapten aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.	2.07	1	0	coumarins; monoterpenoid	antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.07	1	0	cinnamate ester; tannin	food component; plant metabolite
succimer Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.. succimer : A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.	2.59	2	0	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	3.17	1	0	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
fumonisin b2 fumonisin B2: produced by Fusarium moniliforme MRC 826; structure given in first source; has cancer-promoting ability. fumonisin B2 : A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case).	2.07	1	0	diester; diol; fumonisin; primary amino compound	Aspergillus metabolite; carcinogenic agent
tamoxifen [no description available]	2.54	2	0	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator
4,6-dimorpholino-n-(4-nitrophenyl)-1,3,5-triazin-2-amine 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine: an mTOR activator; structure in first source	2.21	1	0
lincomycin Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.. lincomycin : A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.	2.81	3	0	carbohydrate-containing antibiotic; L-proline derivative; monocarboxylic acid amide; pyrrolidinecarboxamide; S-glycosyl compound	antimicrobial agent; bacterial metabolite
valinomycin Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.	7.93	4	0	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore
toremifene Toremifene: A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.	3.17	1	0	aromatic ether; organochlorine compound; tertiary amine	antineoplastic agent; bone density conservation agent; estrogen antagonist; estrogen receptor modulator
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	2.6	1	0	alkali metal atom
droloxifene [no description available]	3.17	1	0	stilbenoid
orlistat Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.	2.07	1	0	beta-lactone; carboxylic ester; formamides; L-leucine derivative	anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor
quinine [no description available]	7.01	1	0	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic
12-deoxyphorbolphenylacetate-20-acetate [no description available]	2.07	1	0
brassinin [no description available]	2.07	1	0	dithiocarbamic ester; indole phytoalexin
chaetomellic acid a chaetomellic acid A: structure given in first source; an inhibitor of farnesyl-protein transferase	2.07	1	0
hirsutine [no description available]	2.07	1	0
3-deoxyvasicine, hydrochloride [no description available]	2.07	1	0
dasatinib N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source. dasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).	7.25	1	0	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor
emetine dihydrochloride emetine dihydrochloride : The dihydrochloride salt of emetine.. emetine dihydrochloride hydrate : A hydrate that is the monohydrate of the dihydrochloride salt of emetine.	2.47	2	0	hydrochloride	anticoronaviral agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; protein synthesis inhibitor
apramycin apramycin : An aminoglycoside that is 2-deoxystreptamine that is substituted on the oxygen at position 4 by an (8R)-2-amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl) group.	2.13	1	0	2-deoxystreptamine derivative; aminoglycoside; organic heterobicyclic compound	antibacterial drug; antimicrobial agent
silybin [no description available]	2.07	1	0
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.05	1	0
2,4-dinitrophenylhydrazine 2,4-dinitrophenylhydrazine: structure. 2,4-dinitrophenylhydrazine : A C-nitro compound that is phenylhydrazine substituted at the 2- and 4-positions by nitro groups.	2	1	0	C-nitro compound; phenylhydrazines	reagent
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.1	1	0
5,6-dehydrokawain 5,6-dehydrokawain: from Alpinia speciosa rhizoma; RN given for cpd without isomeric designation; structure given in first source	2.07	1	0	2-pyranones; aromatic ether
9,10-dihydrolysergol 9,10-dihydrolysergol: RN given refers to cpd without isomeric designation	2.07	1	0
geranylgeranic acid geranylgeranic acid: RN given refers to cpd without isomeric designation. (2E,6E,10E)-geranylgeranic acid : A diterpenoid obtained by formal oxidation of the CH2OH group of (E,E,E)-geranylgeraniol to the corresponding carboxylic acid.	2.07	1	0	alpha,beta-unsaturated monocarboxylic acid; diterpenoid; methyl-branched fatty acid; trienoic fatty acid
quercetin [no description available]	2.07	1	0	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.07	1	0	prostaglandins E	human metabolite; mouse metabolite; oxytocic
dinoprost Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.	2.07	1	0	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite
biochanin a [no description available]	2.07	1	0	4'-methoxyisoflavones; 7-hydroxyisoflavones	antineoplastic agent; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
formononetin [no description available]	2.07	1	0	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
prostaglandin b1 prostaglandin Bx: phospholipase A2 inhibitor; polymeric derivative of diketo-PGB1; mean MW 2,200. prostaglandin B1 : A member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer).	2.07	1	0	prostaglandins B	human metabolite
sterigmatocystin [no description available]	2.07	1	0	sterigmatocystins	metabolite
vitexin [no description available]	2.07	1	0	C-glycosyl compound; trihydroxyflavone	antineoplastic agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite; platelet aggregation inhibitor
acacetin 5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.	2.07	1	0	dihydroxyflavone; monomethoxyflavone	anticonvulsant; plant metabolite
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.07	1	0	trihydroxyflavone	antineoplastic agent; metabolite
luteolin [no description available]	2.07	1	0	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
linoleic acid Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed). linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.	2.25	1	0	octadecadienoic acid; omega-6 fatty acid	algal metabolite; Daphnia galeata metabolite; plant metabolite
quercitrin [no description available]	2.07	1	0	alpha-L-rhamnoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	antileishmanial agent; antioxidant; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
scopoletin [no description available]	2.07	1	0	hydroxycoumarin	plant growth regulator; plant metabolite
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	2.07	1	0	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
alprostadil [no description available]	2.07	1	0	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	2.41	1	0	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
quercetin 3-o-glucopyranoside quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells	2.07	1	0	beta-D-glucoside; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antineoplastic agent; antioxidant; antipruritic drug; bone density conservation agent; geroprotector; histamine antagonist; osteogenesis regulator; plant metabolite
rutin Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.	2.07	1	0	disaccharide derivative; quercetin O-glucoside; rutinoside; tetrahydroxyflavone	antioxidant; metabolite
kaempferol [no description available]	2.07	1	0	7-hydroxyflavonol; flavonols; tetrahydroxyflavone	antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite
senecionine senecionine: RN given refers to parent cpd; structure. senecionine : A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.	2.07	1	0	lactone; pyrrolizidine alkaloid; tertiary alcohol	plant metabolite
genistein [no description available]	2.07	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.07	1	0	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
butein [no description available]	2.07	1	0	chalcones; polyphenol	antineoplastic agent; antioxidant; EC 1.1.1.21 (aldehyde reductase) inhibitor; geroprotector; hypoglycemic agent; plant metabolite; radiosensitizing agent; tyrosine kinase inhibitor
sulfuretin sulfuretin: the chalcone C ring closes into a 5 instead of the more typical 6 membered ring leaving a phenyl methane at the 2 position instead of the typical phenyl	2.07	1	0	1-benzofurans
genistin genistin: glycoside of soy bean isoflavone, gentistein	2.07	1	0	7-hydroxyisoflavones 7-O-beta-D-glucoside
ophiobolin a ophiobolin A: sesterterpene; phytotoxin produced by plant pathogen Helminthosporium maydis; natural product inhibitor of calmodulin; RN refers to (18R)-isomer; structure given in first source. ophiobolin A : A sesterterpenoid that is ophiobolane with a hydroxy group at position 3, oxo groups at positions 5 and 25, double bonds at positions 7-8 and 19-20, and an oxygen link between positions 14 and 18.	2.13	1	0	cyclic ketone; enal; oxaspiro compound; sesterterpenoid; tertiary alcohol
chartreusin chartreusin: structure	2.07	1	0	benzochromenone; glycoside
methysticin [no description available]	2.07	1	0	2-pyranones; aromatic ether
yangonin yangonin: structure in first source	2.07	1	0	2-pyranones; aromatic ether
zearalenone Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.	2.07	1	0	macrolide; resorcinols	fungal metabolite; mycoestrogen
baicalein [no description available]	2.07	1	0	trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger
chrysin chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.	2.07	1	0	7-hydroxyflavonol; dihydroxyflavone	anti-inflammatory agent; antineoplastic agent; antioxidant; EC 2.7.11.18 (myosin-light-chain kinase) inhibitor; hepatoprotective agent; plant metabolite
datiscetin datiscetin : A tetrahydroxyflavone that is 7-hydroxyflavonol bearing two additional hydroxy substituents at positions 2' and 5.	2.07	1	0	7-hydroxyflavonol; tetrahydroxyflavone
diosmetin [no description available]	2.07	1	0	3'-hydroxyflavonoid; monomethoxyflavone; trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; bone density conservation agent; cardioprotective agent; plant metabolite; tropomyosin-related kinase B receptor agonist; vasodilator agent
diosmin [no description available]	2.07	1	0	dihydroxyflavanone; disaccharide derivative; glycosyloxyflavone; monomethoxyflavone; rutinoside	anti-inflammatory agent; antioxidant
fisetin [no description available]	2.07	1	0	3'-hydroxyflavonoid; 7-hydroxyflavonol; tetrahydroxyflavone	anti-inflammatory agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; metabolite; plant metabolite
galangin 5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source. galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.	2.07	1	0	7-hydroxyflavonol; trihydroxyflavone	antimicrobial agent; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; plant metabolite
3-methylquercetin isorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.	2.07	1	0	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	anticoagulant; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite
morin morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	2.07	1	0	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent
myricetin [no description available]	2.07	1	0	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
rhamnetin rhamnetin: aglycone of xanthorhamnin; from Rhamnus. rhamnetin : A monomethoxyflavone that is quercetin methylated at position 7.	2.07	1	0	monomethoxyflavone; tetrahydroxyflavone	anti-inflammatory agent; antioxidant; metabolite
robinetin robinetin: structure given in first source. robinetin : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.	2.07	1	0	7-hydroxyflavonol; pentahydroxyflavone	plant metabolite
tamarixetin tamarixetin: isolated from Costsus spicatus. tamarixetin : A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.	2.07	1	0	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	antioxidant; metabolite
wogonin wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.	2.07	1	0	dihydroxyflavone; monomethoxyflavone	angiogenesis inhibitor; antineoplastic agent; cyclooxygenase 2 inhibitor; plant metabolite
coumestrol Coumestrol: A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.. coumestrol : A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.	2.07	1	0	coumestans; delta-lactone; polyphenol	anti-inflammatory agent; antioxidant; plant metabolite
daidzein [no description available]	2.07	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
caffeic acid phenethyl ester phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.	2.07	1	0	alkyl caffeate ester	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiviral agent; immunomodulator; metabolite; neuroprotective agent
rosmarinic acid rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.	2.07	1	0	rosmarinic acid	geroprotector; plant metabolite
wedelolactone wedelolactone: antihepatotoxic coumestan from Eclipta prostrata and Wedelia calendulacea (both Asteraceae); structure given in first source. wedelolactone : A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.	2.07	1	0	aromatic ether; coumestans; delta-lactone; polyphenol	antineoplastic agent; apoptosis inducer; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; hepatoprotective agent; metabolite
rottlerin rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.	2.07	1	0	aromatic ketone; benzenetriol; chromenol; enone; methyl ketone	anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite
ellagic acid [no description available]	2.07	1	0	catechols; cyclic ketone; lactone; organic heterotetracyclic compound; polyphenol	antioxidant; EC 1.14.18.1 (tyrosinase) inhibitor; EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor; EC 2.4.1.1 (glycogen phosphorylase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor; EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor; EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; food additive; fungal metabolite; geroprotector; plant metabolite; skin lightening agent
7-hydroxyflavone 7-hydroxyflavone : A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.	2.07	1	0	hydroxyflavonoid
prostaglandin a1 [no description available]	2.07	1	0	prostaglandins A
cerulenin Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.	2.07	1	0	epoxide; monocarboxylic acid amide	antifungal agent; antiinfective agent; antilipemic drug; antimetabolite; antimicrobial agent; fatty acid synthesis inhibitor
rhoifolin rhoifolin: from many plants. apigenin 7-O-neohesperidoside : An apigenin derivative having an alpha-(1->2)-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group.	2.07	1	0	dihydroxyflavone; glycosyloxyflavone; neohesperidoside	metabolite
vitexin rhamnoside 2''-O-rhamnopyranosylvitexin: has both analgesic and anti-inflammatory activities; isolated from Alternanthera maritima; structure in first source. vitexin 2''-O-alpha-L-rhamnoside : A derivative of vitexin having an alpha-L-rhamnosyl residue attached at the 2''-position of the glucitol moiety.	2.07	1	0	C-glycosyl compound; disaccharide derivative; trihydroxyflavone	plant metabolite
domoic acid domoic acid: kainic acid analog, heterocyclic amino acid from seaweed; RN given refers to parent cpd; structure. domoic acid : An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).	2.07	1	0	L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid; tricarboxylic acid	algal metabolite; hapten; marine metabolite; neuromuscular agent; neurotoxin
isotretinoin Isotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.. isotretinoin : A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.	2.07	1	0	retinoic acid	antineoplastic agent; keratolytic drug; teratogenic agent
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	3.45	2	0	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
natamycin [no description available]	2.07	1	0	antibiotic antifungal drug; dicarboxylic acid monoester; epoxide; macrolide antibiotic; monosaccharide derivative; polyene antibiotic	antifungal agrochemical; antimicrobial food preservative; apoptosis inducer; bacterial metabolite; ophthalmology drug
proscillaridin Proscillaridin: A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).	3.17	1	0	organic molecular entity
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	2.5	2	0	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
brefeldin a [no description available]	2.07	1	0	macrolide antibiotic	Penicillium metabolite
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	2.07	1	0	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor
ciguatoxins Ciguatoxins: Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.. ciguatoxin CTX1B : A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered rings and a spiro-fused five-membered ring. A commonly encountered fish toxin.. ciguatoxin : Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders.	2.05	1	0	ciguatoxin	metabolite
calyculin a calyculin A: RN given refers to (5S-(5alpha(2R(1S,3S,4S,5R,6R,7E,9E,11E,13Z),3R),7beta(E(S)),*beta,9alpha))-isomer	2.05	1	0
vinorelbine [no description available]	2.07	1	0	acetate ester; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; ring assembly; vinca alkaloid	antineoplastic agent; photosensitizing agent
bisdemethoxycurcumin curcumin III: structure in first source. bisdemethoxycurcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.	2.07	1	0	beta-diketone; diarylheptanoid; enone; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; metabolite
andrographolide [no description available]	2.07	1	0	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
isorhamnetin 3-o-glucoside isorhamnetin 3-O-glucoside: from the flowers of Persea gratissima; structure in first source. isorhamnetin 3-O-beta-D-glucopyranoside : A glycosyloxyflavone that is isorhamnetin substituted at position 3 by a beta-D-glucosyl residue.	2.07	1	0	beta-D-glucoside; glycosyloxyflavone; monomethoxyflavone; monosaccharide derivative; trihydroxyflavone	metabolite
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	2.63	2	0	carbon group element atom; elemental lead; metal atom	neurotoxin
6,7-dihydroxyflavone 6,7-dihydroxyflavone: intensifies effect of antibiotics on Staphylococcus aureus; structure in first source	2.07	1	0
cesium Cesium: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.	1.95	1	0	alkali metal atom
flavokawain a flavokawain A: from kava extract, induces apoptosis in bladder cancer cells; structure in first source	2.07	1	0	chalcones
cinnamoylhydroxamic acid cinnamoylhydroxamic acid: RN given refers to parent cpd	2.15	1	0
flavokawain b flavokawain B: from Piper methysticum Forst (Kava Kava) roots; structure in first source. flavokawain B : A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.	2.07	1	0	chalcones; dimethoxybenzene; phenols	anti-inflammatory agent; antileishmanial agent; antineoplastic agent; apoptosis inducer; metabolite
rubidium Rubidium: An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.	2.36	2	0	alkali metal atom
strontium Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.	1.95	1	0	alkaline earth metal atom
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	2.89	4	0	metalloid atom; pnictogen	micronutrient
lasalocid Lasalocid: Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry.. lasalocid : A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.	5.14	46	0	beta-hydroxy ketone; monocarboxylic acid; monohydroxybenzoic acid; oxanes; oxolanes; polyether antibiotic; secondary alcohol; tertiary alcohol	bacterial metabolite; coccidiostat; ionophore
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	7.31	1	0	chalcogen; nonmetal atom	macronutrient
kavain [no description available]	2.07	1	0	racemate	glycine receptor antagonist
abscisic acid, (+,-)-isomer 2-cis-abscisic acid : A member of the class of abscisic acids in which the double bond betweeen positions 2 and 3 has cis- (natural) geometry.	2.07	1	0	abscisic acids	abscisic acid receptor agonist
veratrine Veratrine: A voltage-gated sodium channel activator.	2.07	1	0	alkaloid
vinblastine sulfate [no description available]	2.07	1	0
catharanthine [no description available]	2.07	1	0	alkaloid ester; bridged compound; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound
cytochalasin e cytochalasin E: structure	2.07	1	0	cytochalasan alkaloid	metabolite
cytochalasin d [no description available]	2.07	1	0
sinomenine sinomenine: isolated from root of Sinomenium acutum; antirheumatic, antineuralgic	2.07	1	0	morphinane alkaloid
ecdysterone Ecdysterone: A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.. 20-hydroxyecdysone : An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20.	2.07	1	0	14alpha-hydroxy steroid; 20-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; ecdysteroid; phytoecdysteroid	animal metabolite; plant metabolite
bleomycin [no description available]	2.07	1	0	bleomycin	antineoplastic agent; metabolite
bakuchiol bakuchiol: chief component of Psoralea corylifolia Linn; structure	2.07	1	0
zerumbone zerumbone: RN given for (E,E,E)-isomer; structure in first source. zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.	2.07	1	0	cyclic ketone; sesquiterpenoid	anti-inflammatory agent; glioma-associated oncogene inhibitor; plant metabolite
solanesol solanesol : A nonaprenol that is hexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-ol substituted by 9 methyl groups at positions 3, 7, 11, 15, 19, 23, 27, 31 and 35 (the all-trans0stereoisomer).	2.07	1	0	nonaprenol; primary alcohol	plant metabolite
(1S,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid methyl ester [no description available]	2.07	1	0	yohimban alkaloid
n-caproylsphingosine N-(hexanoyl)sphing-4-enine : An N-acylsphingosine consisting of sphing-4-enine bearing a hexanoyl group on nitrogen.	2.07	1	0	N-acylsphingosine
monorden monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II	2.07	1	0	cyclic ketone; enone; epoxide; macrolide antibiotic; monochlorobenzenes; phenols	antifungal agent; metabolite; tyrosine kinase inhibitor
ginkgolide b [no description available]	2.07	1	0
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	7.43	2	0	chalcogen; nonmetal atom	micronutrient
clinoptilolite clinoptilolite: clinoptilolite was SY to zeolite (NM); use zeolites (NM) to search through 1993; RN is for cpd with unknown MF	2.02	1	0
homatropine hydrobromide, (endo-(+-)-isomer) [no description available]	2.07	1	0
hydrocotarnine hydrobromide [no description available]	2.07	1	0
salsolinol hydrobromide [no description available]	2.07	1	0
lasalocid sodium lasalocid sodium : The sodium salt of lasalocid. It is a veterinary ionophore antibiotic used for prevention and treatment of coccidiosis in poultry.	2.07	1	0	benzoates; organic sodium salt	coccidiostat; ionophore
bambermycins Bambermycins: Antibiotic complex obtained from Streptomyces bambergiensis containing mainly Moenomycins A and C. They are used as feed additives and growth promoters for poultry, swine, and cattle.	4.48	5	1
sclerotiorin sclerotiorin: isolated from monoverticillate Penicillia; RN given for (R-(R,S-(E,E)))-isomer; structure in first source	2.07	1	0	azaphilone
himbacine himbacine: muscarine receptor antagonist; RN given refers to (3S-(3alpha,3aalpha,4beta(1E,2(2R,6S)),4abeta,8aalpha,9aalpha))-isomer; structure given in first source. himbacine : A piperidine alkaloid that is decahydronaphtho[2,3-c]furan-1(3H)-one substituted by a methyl group at position 3 and a 2-[(2R,6S)-1,6-dimethylpiperidin-2-yl]ethenyl group at position 4. It has been isolated from the bark of Australian magnolias.	2.07	1	0	gamma-lactone; organic heterotricyclic compound; piperidine alkaloid	muscarinic antagonist
ebelactone b ebelactone B: esterase inhibitor; structure given in first source; see also ebelactone A	2.07	1	0
3-o-methylbutein 3-O-methylbutein: RN given refers to (E)-isomer; structure given in first source	2.07	1	0	chalcones
thermozymocidin thermozymocidin: a serine palmitoyltransferase inhibitor; FTY720 is an analog	2.07	1	0	alpha-amino fatty acid; hydroxy monocarboxylic acid; non-proteinogenic alpha-amino acid; sphingoid	antifungal agent; antimicrobial agent; antineoplastic agent; apoptosis inducer; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor; fungal metabolite; immunosuppressive agent
x 14547-a X 14547-A: structure. indanomycin : An indene that is (3aS,7aR)-2,3,3a,4,5,7a-hexahydro-1H-indene which is substituted at the 2-pro-R position by a 1H-pyrrol-2-ylcarbonyl group, at the 9-pro-S position by an ethyl group, and at the 5-pro-R position by a hexa-1,3-dineyl group in which position 4 has been substituted by a (2R,3S,6R)-6-[(1R)-1-carboxyethyl]-3-methyltetrahydropyran-2-yl group. It exhibits activity against Gram-positive bacteria as well as antihypertensive and antitumour. It also functions as an effective growth promoter for ruminants.	1.97	1	0
marein marein: hypoglycemic from Coreopsis tinctoria; structure in first source	2.07	1	0	flavonoids; glycoside
tanespimycin CP 127374: analog of herbimycin A	2.15	1	0	1,4-benzoquinones; ansamycin; carbamate ester; organic heterobicyclic compound; secondary amino compound	antineoplastic agent; apoptosis inducer; Hsp90 inhibitor
beta-escin [no description available]	3.73	2	0
hydroxyachillin hydroxyachillin: isolated from Tanacetum microphyllum; structure given in first source	2.07	1	0	gamma-lactone
butylscopolammonium bromide Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.	2.07	1	0
sq-23377 Ionomycin: A divalent calcium ionophore that is widely used as a tool to investigate the role of intracellular calcium in cellular processes.. ionomycin : A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.	3.17	1	0	cyclic ether; enol; polyunsaturated fatty acid; very long-chain fatty acid	calcium ionophore; metabolite
fumagillin [no description available]	2.45	2	0	antibiotic antifungal drug; carboxylic ester; dicarboxylic acid monoester; meroterpenoid; organooxygen heterocyclic antibiotic; spiro-epoxide	angiogenesis inhibitor; antibacterial drug; antimicrobial agent; antiprotozoal drug; fungal metabolite; methionine aminopeptidase 2 inhibitor
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.07	1	0	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
ciclesonide ciclesonide: nasal spray approved for seasonal and perennial allergic rhinitis	3.17	1	0	organic molecular entity
anisodamine [no description available]	2.07	1	0
panobinostat Panobinostat: An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.. panobinostat : A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.	2.11	1	0	cinnamamides; hydroxamic acid; methylindole; secondary amino compound	angiogenesis modulating agent; antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor
bufalin bufalin: cardiotonic; powerful anesthetic & one of the active constituents of the Chinese drug ch'an su(senso); in Japan prepared from skin of Bufo bufo garfarizans; RN given refers to (3beta,5beta)-isomer. bufalin : A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.	2.07	1	0	14beta-hydroxy steroid; 3beta-hydroxy steroid	animal metabolite; anti-inflammatory agent; antineoplastic agent; cardiotonic drug
alpha-solanine [no description available]	2.07	1	0	glycoalkaloid; organic heterohexacyclic compound; steroid saponin; trisaccharide derivative	antineoplastic agent; apoptosis inducer; phytotoxin; plant metabolite
robenidine [no description available]	1.97	1	0
apigenin-7-o-rutinoside [no description available]	2.07	1	0
gambogic acid gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer	2.07	1	0	pyranoxanthones	metabolite
cabazitaxel cabazitaxel: an antineoplastic agent; structure in first source. cabazitaxel : A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.	2.9	2	0	tetracyclic diterpenoid	antineoplastic agent; microtubule-stabilising agent
nu 7026 2-(morpholin-4-yl)benzo(h)chromen-4-one: a radiosensitizing agent that inhibits DNA-dependent protein kinase; structure in first source	2.13	1	0	organic heterotricyclic compound; organooxygen compound
bn 52020 [no description available]	2.07	1	0
zeolites [no description available]	2.02	1	0
carmine carminic acid : A tetrahydroxyanthraquinone that is that is 1,3,4,6-tetrahydroxy-9,10-anthraquinone substituted by a methyl group at position 8, a carboxy group at position 7 and a 1,5-anhydro-D-glucitol moiety at position 2 via a C-glycosidic linkage. It is a natural dye isolated from several insects such as Dactylopius coccus.	2.07	1	0	C-glycosyl compound; monocarboxylic acid; tetrahydroxyanthraquinone	animal metabolite; histological dye
sotrastaurin sotrastaurin: a potent protein kinase C-selective inhibitor; structure in first source. sotrastaurin : A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients.	3.31	1	0	indoles; maleimides; N-alkylpiperazine; N-arylpiperazine; quinazolines	anticoronaviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunosuppressive agent
bavachinin bavachinin: do not confuse with bavachin	2.07	1	0	flavanones
grayanotoxin iii grayanotoxin III: from leaves of Leucothoe grayana (Ericaceae); RN refers to (3beta,6beta,14R)-isomer; structure given in first source	2.07	1	0
bistramide c bistramide C: isolated from marine ascidian Lissoclinum bistratum; structure in first source	2.05	1	0
Dihydrotanshinone I dihydrotanshinone I: extracted from Radix Salviae	2.07	1	0	abietane diterpenoid	anticoronaviral agent
cannabidivarin cannabidivarin: from Cannabis sativa	2.21	1	0	monoterpenoid
zincophorin zincophorin: 25 carbon polypropionate from Streptomyces griseus; griseochelin and M 144255 are the same monocarboxylic acid ionophore	2.08	1	0	pyrans	bacterial metabolite; ionophore
portmicin portmicin: from Nocardiopsis; structure given in first source	1.98	1	0
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	2.4	2	0	benzoxazole
dextrothyroxine [no description available]	3.61	2	0
cinobufagin cinobufagin: isolated from Chinese medicinal preparation ch'an su; derived from toad venom	2.07	1	0	steroid lactone
virginiamycin Virginiamycin: A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.. virginiamycin : A mixture of cyclic polypeptide streptogramin antibiotics produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. The two major components are virginiamycin M1 (also known as pristinamycin IIA) and virginiamycin S1. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci.	7.88	4	0
bacitracin methylenedisalicylic acid bacitracin methylenedisalicylic acid: RN given refers to Bacitracin, methylenebis(2-hydroxybenzoate)	1.96	1	0
atropine sulfate [no description available]	2.07	1	0
cannogenin thevetoside cannogenin thevetoside: from Thevetia neriifolia; minor descriptor (75-84); on-line & Index Medicus search CARDENOLIDES (77-84), CARDANOLIDES (75-76); RN given refers to (3beta,5beta)-isomer	2.07	1	0	cardenolide glycoside
mefloquine Mefloquine: A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.. mefloquine : A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.	2.07	1	0
eriodictyol 7-O-beta-D-glucopyranoside [no description available]	2.07	1	0	beta-D-glucoside; flavanone glycoside; monosaccharide derivative; trihydroxyflavanone	plant metabolite; radical scavenger
hypocrellin a hypocrellin A: isolated from fungus Hypocrella bambusae sacc	2.07	1	0
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.47	2	0
avoparcin avoparcin: glycopeptide antibiotic from Streptomyces candidus; antibiotic growth promoter for improving growth rates & feed conversion efficiency of broiler chickens & pigs	7.67	3	0
tannins Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.	2.17	1	0
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.43	2	0	1,2-diacyl-sn-glycero-3-phosphocholine
vx-770 ivacaftor: a CFTR potentiator; structure in first source. ivacaftor : An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.	3.17	1	0	aromatic amide; monocarboxylic acid amide; phenols; quinolone	CFTR potentiator; orphan drug
dihydrorobinetin dihydrorobinetin: structure in first source	2.07	1	0
robenidine Robenidine: An anticoccidial agent mainly for poultry.	8.4	7	0
calpain Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.	7.06	1	0
monensin [no description available]	2.49	2	0
mk 2206 MK 2206: a protein kinase inhibitor and antineoplastic agent	2.1	1	0	organic heterotricyclic compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
navitoclax [no description available]	2.17	1	0	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
thiopeptin [no description available]	1.97	1	0
spirolide d spirolide D: structure in first source	2.05	1	0	azepine
piperidines Piperidines: A family of hexahydropyridines.	3.94	13	0
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.11	1	0
spirolide b spirolide B: structure in first source	2.05	1	0
gx 15-070 obatoclax: a pan-Bcl-2 inhibitor potentially useful in treating mantle cell lymphoma	2.25	1	0
tylosin [no description available]	7.92	4	0
abemaciclib [no description available]	3.17	1	0
lgk974 LGK974: a potent and specific small-molecule inhibitor of Porcupine (PORCN) acyltransferase. LGK974 : A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).	2.11	1	0	bipyridines; pyrazines; pyridines; secondary carboxamide	Wnt signalling inhibitor
gilteritinib gilteritinib: an FLT3/AXL protein tyrosine kinase inhibitor. gilteritinib : A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.	3.17	1	0	aromatic amine; monomethoxybenzene; N-methylpiperazine; oxanes; piperidines; primary carboxamide; pyrazines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
lusutrombopag lusutrombopag: a thrombopoietin receptor agonist; structure in first source	3.17	1	0	cinnamic acids
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	6.98	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	3.31	1	0
chlortetracycline Chlortetracycline: A TETRACYCLINE with a 7-chloro substitution.. chlortetracycline : A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens.	4.67	3	2
minocycline Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.	2.07	1	0
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	1.96	1	0	monohydroxybenzoate	plant metabolite
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	2.07	1	0	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
citrinin Citrinin: Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.	2.07	1	0
tetronasin tetronasin: RN refers to the Na-salt; from Streptomyces longisporoflavus	3.08	1	0	terpene glycoside
vulpinic acid vulpinic acid: RN given refers to cpd without isomeric designation; structure given in first source; vulpinic acid refers to (E)-isomer	2.07	1	0	butenolide
AZD3463 AZD3463 : A member of the class of indoles that is 1H-indole substituted by a 2-[4-(4-aminopiperidin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl group at position 3. It is an orally bioavailable dual inhibitor of ALK and IGF1R with Ki value of 0.75 nM for ALK.	7.25	1	0	aminopiperidine; aminopyrimidine; indoles; monomethoxybenzene; organochlorine compound; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
clay Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.	7.07	1	0
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.55	2	0
okadaic acid Okadaic Acid: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.. okadaic acid : A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.	2	1	0	ketal
ceritinib ceritinib: an anaplastic lymphoma kinase inhibitor. ceritinib : A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.	3.17	1	0	aminopyrimidine; aromatic ether; organochlorine compound; piperidines; secondary amino compound; sulfone	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
wnt-c59 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide: a PORCN acyltransferase inhibitor; structure in first source	2.11	1	0
g007-lk G007-LK: potent and specific small-molecule tankyrase inhibitor; structure in first source	2.58	2	0
ajmaline [no description available]	2.07	1	0
laidlomycin laidlomycin: polycyclic, polyether, monocarboxylic acid posessing inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii; structure	3.56	2	0
osimertinib osimertinib: an EGFR tyrosine kinase inhibitor. osimertinib : A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.	3.17	1	0	acrylamides; aminopyrimidine; biaryl; indoles; monomethoxybenzene; secondary amino compound; secondary carboxamide; substituted aniline; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	3.01	4	0
s 8932 [no description available]	3.17	1	0	aromatic amine; C-nucleoside; carboxylic ester; nitrile; phosphoramidate ester; pyrrolotriazine	anticoronaviral agent; antiviral drug; prodrug
validamycins validamycins: RN given refers to cpd with unknown MF; structure given in Merck Index, 9th ed, #9570 has been revised in fifth source; structure in fifth source; see also record for validamycin A. validamycins : Any of the inositol-derived beta-D-glucoside antibiotics produced by Streptomyces hygroscopicus.	2.25	1	0
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	3.43	1	1
silybin Silybin: The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.	2.52	2	0
monazomycin monazomycin: antibiotic produced by Streptomyces mashuensis; takacidn produced by S. griseoverticillatum; U-0412 produced by Streptoverticillium SP. KCC U-0142	1.95	1	0
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	2.02	1	0
narasin narasin: related to salinomycin & A28086B; structure; RN given refers to parent cpd	6.11	29	1
semduramicin semduramicin: structure given in first source; carboxylic acid ionophore for management of chicken coccidiosis	5.04	5	2
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.44	2	0	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	3.92	3	0	dacarbazine
xav939 XAV939: selectively inhibits beta-catenin-mediated transcription; structure in first source. XAV939 : A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.	2.11	1	0	(trifluoromethyl)benzenes; thiopyranopyrimidine	tankyrase inhibitor
amg531 [no description available]	3.17	1	0
alpha-cyclopiazonic acid [no description available]	2.07	1	0	alpha-cyclopiazonic acids
carbadox Carbadox: An antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p125)	1.96	1	0	quinoxaline derivative
avermectin avermectin: produced by actinomycete, Streptomyces avermitilis; structure; see also records for specific avermectins. avermectin : Any of the macrolides obtained as fermentation products from the bacterium Streptomyces avermitilis and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties.	2.05	1	0
conglobatin conglobatin: dimer consisting of 2 molecules of 7-hydroxy-8-oxazolyl-2,4,6-trimethyl-2-octenoic acid joined by 2 ester linkages; structure	2.13	1	0
frondoside a frondoside A: from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa	2.08	1	0

Condition	Relationship Strength	Studies	Trials
Infections, Plasmodium [description not available]	2.67	3	0
Plasmodium falciparum Malaria [description not available]	2.07	1	0
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	7.67	3	0
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.07	1	0
Cancer of Ovary [description not available]	5.43	13	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	5.43	13	0
Besnoitiasis [description not available]	10.02	71	11
Benign Neoplasms [description not available]	7.66	31	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	7.66	31	0
Breast Cancer [description not available]	6.94	61	0
Breast Neoplasms Tumors or cancer of the human BREAST.	6.94	61	0
Angiogenesis, Pathologic [description not available]	3.75	3	0
Nerve Pain [description not available]	2.21	1	0
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.21	1	0
African Sleeping Sickness [description not available]	3.1	4	0
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	3.1	4	0
Infections, Coronavirus [description not available]	4.1	4	0
2019 Novel Coronavirus Disease [description not available]	3.86	3	0
Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection.	3.86	3	0
Coronavirus Infections Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).	4.1	4	0
Cancer of Cervix [description not available]	2.98	3	0
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.98	3	0
Innate Inflammatory Response [description not available]	3.8	1	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	8.8	1	1
Bone Cancer [description not available]	3.4	6	0
Osteogenic Sarcoma [description not available]	3.53	7	0
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	3.4	6	0
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	3.53	7	0
Cancer of Prostate [description not available]	3.84	10	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	3.84	10	0
Bone Spur [description not available]	2.41	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.96	11	0
Arthritis, Degenerative [description not available]	2.41	1	0
Sclerosis A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.	2.41	1	0
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	7.41	1	0
Epithelial Ovarian Cancer [description not available]	2.41	1	0
Carcinoma, Ovarian Epithelial A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.	2.41	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	6.45	43	1
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	9.04	61	12
Colorectal Cancer [description not available]	4.38	17	0
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	4.38	17	0
Acute Myelogenous Leukemia [description not available]	3.23	5	0
Acute Promyelocytic Leukemia [description not available]	7.69	2	0
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	3.23	5	0
Leukemia, Promyelocytic, Acute An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.	2.69	2	0
Cancer of Head [description not available]	3.41	6	0
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	3.41	6	0
B-Cell Lymphoma [description not available]	7.6	1	0
Lymphoma, B-Cell A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.	2.6	1	0
Carcinoma, Small Cell Lung [description not available]	2.25	1	0
Cancer of Lung [description not available]	4.08	13	0
Cells, Neoplasm Circulating [description not available]	2.25	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	4.08	13	0
Small Cell Lung Carcinoma A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).	2.25	1	0
Benign Neoplasms, Brain [description not available]	3.26	5	0
Astrocytoma, Grade IV [description not available]	4.95	12	0
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	3.26	5	0
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	4.95	12	0
Proliferative Vitreoretinopathy [description not available]	2.63	2	0
Vitreoretinopathy, Proliferative Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.	2.63	2	0
Cancer of Liver [description not available]	5.19	16	0
Malignant Melanoma [description not available]	2.86	3	0
Liver Neoplasms Tumors or cancer of the LIVER.	5.19	16	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.86	3	0
Uveal Neoplasms Tumors or cancer of the UVEA.	2.21	1	0
Cancer of the Thyroid [description not available]	2.25	1	0
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2.25	1	0
Carcinoma, Neuroendocrine A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round blue cells, granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (oat) cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)	2.25	1	0
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	2.25	1	0
Metastase [description not available]	9.97	13	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	4.97	13	0
Local Neoplasm Recurrence [description not available]	3.76	3	0
Adenocystic Carcinoma [description not available]	2.25	1	0
Carcinoma, Adenoid Cystic Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)	2.25	1	0
Cancer of Esophagus [description not available]	2.25	1	0
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	2.25	1	0
Cancer of Endometrium [description not available]	4.5	7	0
Endometrial Neoplasms Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.	4.5	7	0
Nasopharyngeal Carcinoma A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.	3.09	4	0
Cancer of Nasopharynx [description not available]	3.25	5	0
Nasopharyngeal Neoplasms Tumors or cancer of the NASOPHARYNX.	3.25	5	0
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	4.07	4	0
Experimental Neoplasms [description not available]	3.11	4	0
Carcinoma, Squamous Cell of Head and Neck [description not available]	3.06	4	0
Squamous Cell Carcinoma of Head and Neck The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.	3.06	4	0
Avian Diseases [description not available]	2.42	2	0
Weight Gain Increase in BODY WEIGHT over existing weight.	7.15	17	6
Hepatocellular Carcinoma [description not available]	4.83	11	0
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	4.83	11	0
Carcinoma, Non-Small Cell Lung [description not available]	3.74	9	0
Invasiveness, Neoplasm [description not available]	4.43	7	0
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	3.74	9	0
Graft-Versus-Host Disease [description not available]	2.31	1	0
Sclerosis, Systemic [description not available]	2.31	1	0
Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	2.31	1	0
Scleroderma, Systemic A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.	2.31	1	0
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	6.5	13	4
Cardiac Remodeling, Ventricular [description not available]	2.31	1	0
Cirrhosis [description not available]	2.31	1	0
Cardiac Hypertrophy Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.	2.31	1	0
Cardiac Failure [description not available]	2.31	1	0
Cardiovascular Stroke [description not available]	2.31	1	0
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	7.31	1	0
Cardiomegaly Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.	2.31	1	0
Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	2.31	1	0
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	2.31	1	0
Cancer of Mouth [description not available]	2.41	1	0
Mouth Neoplasms Tumors or cancer of the MOUTH.	2.41	1	0
Adenomatous Polyposis Coli, Familial [description not available]	3.83	2	1
Adenomatous Polyposis Coli A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.	3.83	2	1
Eye Cancer, Retinoblastoma [description not available]	2.31	1	0
Retinoblastoma A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)	7.31	1	0
Salmonella Infections, Animal Infections in animals with bacteria of the genus SALMONELLA.	4.08	3	1
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	3.98	4	0
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	3.98	4	0
Glial Cell Tumors [description not available]	3.52	7	0
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	3.52	7	0
Carcinoma, Anaplastic [description not available]	2.85	3	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.85	3	0
Cancer of Stomach [description not available]	3.62	8	0
Stomach Neoplasms Tumors or cancer of the STOMACH.	3.62	8	0
Cholangiocellular Carcinoma [description not available]	2.51	2	0
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	2.51	2	0
Anoxemia [description not available]	2.15	1	0
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	7.15	1	0
Acute Liver Injury, Drug-Induced [description not available]	2.17	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.17	1	0
Acute Lymphoid Leukemia [description not available]	2.17	1	0
Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	2.17	1	0
Carcinoma, Epidermoid [description not available]	3.2	5	0
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	3.2	5	0
Cancer of Pancreas [description not available]	3.21	5	0
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	3.21	5	0
Mastitis, Bovine INFLAMMATION of the UDDER in cows.	2.17	1	0
Infections, Staphylococcal [description not available]	2.54	2	0
Group A Strep Infection [description not available]	2.17	1	0
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.54	2	0
Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS.	2.17	1	0
Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	5.07	5	2
Adenocarcinoma Of Kidney [description not available]	2.17	1	0
Cancer of Kidney [description not available]	2.17	1	0
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2.17	1	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.17	1	0
Infections, Orthomyxoviridae [description not available]	2.17	1	0
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	2.17	1	0
Liver Dysfunction [description not available]	2.17	1	0
Liver Diseases Pathological processes of the LIVER.	2.17	1	0
Ciliophora Infections Infections with protozoa of the phylum CILIOPHORA.	2.47	2	0
Fish Diseases Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	3.27	6	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	4.74	6	0
Sarcoma, Epithelioid [description not available]	2.79	3	0
Sarcoma A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.	2.79	3	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	7.55	2	0
Disease Exacerbation [description not available]	3.71	3	0
Neoplasms, Squamous Cell Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.	2.21	1	0
Cancer of the Tongue [description not available]	2.21	1	0
Tongue Neoplasms Tumors or cancer of the TONGUE.	2.21	1	0
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2.08	1	0
Adenocarcinoma, Basal Cell [description not available]	3.01	4	0
Cancer of Intestines [description not available]	2.08	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	8.01	4	0
Intestinal Neoplasms Tumors or cancer of the INTESTINES.	2.08	1	0
Diffuse Lymphocytic Lymphoma, Poorly-Differentiated [description not available]	2.1	1	0
Lymphoma, Mantle-Cell A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).	2.1	1	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	7.52	2	0
Giant Osteoid Osteoma [description not available]	2.08	1	0
Extravascular Hemolysis [description not available]	2.51	2	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.51	2	0
Peripheral Nerve Diseases [description not available]	2.44	2	0
Peripheral Nervous System Diseases Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.	2.44	2	0
Clostridioides difficile Infection [description not available]	4.65	3	2
Clostridium Infections Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species.	4.65	3	2
Carcinoma, Ductal, Pancreatic [description not available]	2.11	1	0
Carcinoma, Pancreatic Ductal Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.	2.11	1	0
Leukemia, Lymphoblastic, Acute, T Cell [description not available]	2.11	1	0
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.	2.11	1	0
Adenocarcinoma, Endometrioid [description not available]	3.03	1	0
Carcinoma, Endometrioid An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.	3.03	1	0
Arachnoidal Cerebellar Sarcoma, Circumscribed [description not available]	2.11	1	0
Medulloblastoma A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)	2.11	1	0
Health Care Associated Infection [description not available]	2.11	1	0
Cross Infection Any infection which a patient contracts in a health-care institution.	2.11	1	0
Poisoning, Lead [description not available]	2.13	1	0
Lead Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	2.13	1	0
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	7.13	1	0
Metabolic Acidosis [description not available]	2.41	2	0
Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	7.41	2	0
Androgen-Independent Prostatic Cancer [description not available]	2.13	1	0
Prostatic Neoplasms, Castration-Resistant Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.	2.13	1	0
Acute Biphenotypic Leukemia [description not available]	2.13	1	0
Leukemia, Biphenotypic, Acute An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.	2.13	1	0
Autosomal Dominant Striatonigral Degeneration [description not available]	2.13	1	0
Machado-Joseph Disease A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)	2.13	1	0
Chylopericardium [description not available]	3.43	1	1
Newcastle Disease An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.	8.43	1	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	4.66	3	2
Pericardial Effusion Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.	3.43	1	1
Experimental Mammary Neoplasms [description not available]	2.05	1	0
Gastrointestinal Stromal Neoplasm [description not available]	2.05	1	0
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	2.05	1	0
Gastrointestinal Stromal Tumors All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).	2.05	1	0
Cancer of the Uterus [description not available]	2.06	1	0
Uterine Neoplasms Tumors or cancer of the UTERUS.	2.06	1	0
Bovine Diseases [description not available]	3.24	6	0
Lung Adenocarcinoma [description not available]	7.06	1	0
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	2.06	1	0
B-Cell Chronic Lymphocytic Leukemia [description not available]	2.06	1	0
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	2.06	1	0
Animal Diseases Diseases that occur in VERTEBRATE animals.	3.36	2	0
Weight Reduction [description not available]	2.07	1	0
Weight Loss Decrease in existing BODY WEIGHT.	2.07	1	0
Cancer of Colon [description not available]	2.07	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.07	1	0
Bile Duct Cancer [description not available]	2.07	1	0
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	2.07	1	0
Atopic Hypersensitivity [description not available]	2.01	1	0
Experimental Leukemia [description not available]	2.01	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.93	4	0
Muscular Weakness [description not available]	2.02	1	0
Ache [description not available]	2.02	1	0
Tachyarrhythmia [description not available]	2.02	1	0
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.02	1	0
Rhabdomyolysis Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.	2.02	1	0
Tachycardia Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.	2.02	1	0
Muscle Weakness A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)	2.02	1	0
Protozoan Infections, Animal Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.	2.42	2	0
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.02	1	0
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	3.24	6	0
Equine Diseases [description not available]	2.68	3	0
Campylobacter Infection [description not available]	3.42	1	1
Addiction, Opioid [description not available]	2.04	1	0
Opioid-Related Disorders Disorders related to or resulting from abuse or misuse of OPIOIDS.	2.04	1	0
Ovine Diseases [description not available]	3.76	2	1
Sarcocystosis Infection of the striated muscle of mammals by parasites of the genus SARCOCYSTIS. Disease symptoms such as vomiting, diarrhea, muscle weakness, and paralysis are produced by sarcocystin, a toxin produced by the organism.	1.96	1	0
Food Poisoning [description not available]	2.38	2	0
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.96	1	0
Arrhythmia [description not available]	1.96	1	0
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	1.96	1	0
Liver Diseases, Parasitic Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).	1.96	1	0
Bile Duct Diseases Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.	1.95	1	0
Cryptosporidium Infection [description not available]	2.38	2	0
Cryptosporidiosis Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.	7.38	2	0
Bacterial Infections, Gram-Positive [description not available]	1.98	1	0
Gram-Positive Bacterial Infections Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	1.98	1	0
Cancer of ILEUM [description not available]	3.37	1	1
Cardiomyopathies, Primary [description not available]	1.99	1	0
Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	1.99	1	0
Giardia duodenalis Infection [description not available]	3.37	1	1
Giardiasis An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA. It is spread via contaminated food and water and by direct person-to-person contact.	8.37	1	1
Infections, Spirochaetales [description not available]	1.99	1	0
Anorexia The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.	1.99	1	0
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	1.99	1	0
Palsy [description not available]	1.99	1	0
Polyneuropathy, Acquired [description not available]	1.99	1	0
Cat Diseases Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.	2.4	2	0
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	1.99	1	0
Polyneuropathies Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.	1.99	1	0
Bacterial Disease [description not available]	1.99	1	0
Ileitis Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.	1.99	1	0
Bacterial Infections Infections by bacteria, general or unspecified.	1.99	1	0
Gait Disorders, Animal [description not available]	2	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	4.28	4	1
Stunted Growth [description not available]	1.97	1	0
Growth Disorders Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.	1.97	1	0
Cholera Infantum [description not available]	1.97	1	0
Dyskinesia Syndromes [description not available]	1.97	1	0
Complications, Pregnancy [description not available]	1.97	1	0
Movement Disorders Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.	1.97	1	0
Plasma Cell Tumor [description not available]	1.96	1	0
Plasmacytoma Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.	1.96	1	0

salinomycin

Description

Cross-References

Synonyms (93)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (2)

Drug Classes (2)

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Biological Processes (150)

Molecular Functions (56)

Ceullar Components (30)

Bioassays (363)

Research

Studies (645)

Market Indicators

Research Demand Index: 45.76

Study Types

salinomycin

Description

Cross-References

Synonyms (93)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (2)

Drug Classes (2)

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Biological Processes (150)

Molecular Functions (56)

Ceullar Components (30)

Bioassays (363)

Research

Studies (645)

Market Indicators

Research Demand Index: 45.76

Study Types

Related Drugs (697)

Related Conditions (270)