Asialoglycoprotein receptor 1

An asialoglycoprotein receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07306]

ASGP-R 1;
ASGPR 1;
C-type lectin domain family 4 member H1;
Hepatic lectin H1;
HL-1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glucose, (beta-d)-isomer	Homo sapiens (human)	IC50	30,000.0000	1	1
galactose	Homo sapiens (human)	IC50	1,049.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glucose, (beta-d)-isomer	Homo sapiens (human)	Kd	10,000.0000	1	1
galactose	Homo sapiens (human)	Kd	1,460.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
asialoglycoprotein receptor activity	molecular function	Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
fucose binding	molecular function	Binding to fucose, the pentose 6-deoxygalactose. [ISBN:0582227089]
mannose binding	molecular function	Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. [GOC:jl, ISBN:0192800981]

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

This protein is involved in 2 target(s):

Target	Category	Definition
receptor-mediated endocytosis	biological process	An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363]
biological process involved in interspecies interaction between organisms	biological process	Any process evolved to enable an interaction with an organism of a different species. [GOC:cc]