Neuronal acetylcholine receptor subunit beta-2

A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17787]

Synonyms

Research

Bioassay Publications (86)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (6.98)	18.2507
2000's	27 (31.40)	29.6817
2010's	49 (56.98)	24.3611
2020's	4 (4.65)	2.80

Compounds (57)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nornicotine	Homo sapiens (human)	Ki	0.0290	1	1
bupropion	Homo sapiens (human)	IC50	6.4687	6	6
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	Ki	0.0010	1	1
epibatidine	Homo sapiens (human)	IC50	0.0011	1	1
epibatidine	Homo sapiens (human)	Ki	0.0000	8	9
anabasine	Homo sapiens (human)	Ki	0.0920	1	1
carbamylcholine	Homo sapiens (human)	Ki	0.7500	1	1
granisetron	Homo sapiens (human)	Ki	38.0000	1	1
isoflurane	Homo sapiens (human)	IC50	11.7000	1	1
mecamylamine	Homo sapiens (human)	IC50	0.4400	2	2
n-methylcarbamylcholine	Homo sapiens (human)	Ki	0.0230	1	1
ondansetron	Homo sapiens (human)	IC50	66.0000	1	1
ondansetron	Homo sapiens (human)	Ki	46.0000	1	1
tetramethylammonium	Homo sapiens (human)	Ki	0.0240	1	1
indopan	Homo sapiens (human)	Ki	10.0000	4	4
boldine	Homo sapiens (human)	IC50	10.0000	1	1
boldine	Homo sapiens (human)	Ki	3.0000	1	1
cytisine	Homo sapiens (human)	IC50	14.0250	2	2
cytisine	Homo sapiens (human)	Ki	0.0011	5	5
dihydro-beta-erythroidine	Homo sapiens (human)	IC50	0.1470	3	3
dihydro-beta-erythroidine	Homo sapiens (human)	Ki	0.0980	1	1
polygodial	Homo sapiens (human)	IC50	62.5000	1	1
N-methyl-N-(3-pyridylmethyl)amine	Homo sapiens (human)	Ki	10.0000	1	1
nicotine	Homo sapiens (human)	IC50	0.3256	11	13
nicotine	Homo sapiens (human)	Ki	0.3399	30	30
lobeline	Homo sapiens (human)	Ki	0.0050	1	1
philanthotoxin 343	Homo sapiens (human)	IC50	0.0802	1	1
erysodine	Homo sapiens (human)	Ki	0.0500	1	1
varenicline	Homo sapiens (human)	IC50	8.3893	5	6
varenicline	Homo sapiens (human)	Ki	0.5497	8	8
pozanicline	Homo sapiens (human)	Ki	0.0260	1	1
anatoxin a	Homo sapiens (human)	Ki	0.0011	1	1
deformylflustrabromine	Homo sapiens (human)	IC50	150.0000	1	1
tropacocaine	Homo sapiens (human)	Ki	31.6228	1	1
tropisetron	Homo sapiens (human)	IC50	170.0000	1	1
tropisetron	Homo sapiens (human)	Ki	55.0000	1	1
lobeline	Homo sapiens (human)	Ki	0.0047	2	3
anatoxin a	Homo sapiens (human)	Ki	0.0003	1	1
abt 594	Homo sapiens (human)	Ki	0.0000	1	2
5-(6-chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-4-ene	Homo sapiens (human)	Ki	0.0023	3	3
trans-metanicotine	Homo sapiens (human)	Ki	0.0255	2	2
a 85380	Homo sapiens (human)	IC50	0.0015	1	1
a 85380	Homo sapiens (human)	Ki	0.0000	3	3
ar-r 17779	Homo sapiens (human)	IC50	2,000.0000	1	1
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	0.0510	1	1
mg 624	Homo sapiens (human)	Ki	1.5028	2	2
a 84543	Homo sapiens (human)	Ki	0.0077	1	1
azd 0328	Homo sapiens (human)	Ki	0.1400	1	1
radafaxine	Homo sapiens (human)	IC50	25.5000	2	2
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride	Homo sapiens (human)	Ki	1.0000	1	1
desnitroimidacloprid	Homo sapiens (human)	Ki	0.0022	1	1
n-methylepibatidine	Homo sapiens (human)	Ki	0.0001	2	2
sazetidine-a	Homo sapiens (human)	IC50	0.0079	4	4
sazetidine-a	Homo sapiens (human)	Ki	0.0001	1	1
a-582941	Homo sapiens (human)	Ki	100.0000	1	1
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	Ki	10.0000	4	4
imidacloprid	Homo sapiens (human)	Ki	0.7200	1	1
3-(4-hydroxy-2-methoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	0.0190	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
epibatidine	Homo sapiens (human)	EC50	0.0356	7	9
epibatidine	Homo sapiens (human)	Kd	0.0000	1	1
dimethylphenylpiperazinium iodide	Homo sapiens (human)	EC50	29.2500	2	2
tilorone	Homo sapiens (human)	EC50	10.0000	2	2
cytisine	Homo sapiens (human)	EC50	26.7501	4	4
anatabine	Homo sapiens (human)	EC50	2.6500	1	1
nicotine	Homo sapiens (human)	EC50	9.3127	23	27
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole	Homo sapiens (human)	EC50	10.6000	1	1
varenicline	Homo sapiens (human)	EC50	0.9619	7	8
epibatidine	Homo sapiens (human)	Kd	0.0000	1	1
abt 594	Homo sapiens (human)	EC50	0.0200	1	1
trans-metanicotine	Homo sapiens (human)	EC50	4.3000	1	1
a 85380	Homo sapiens (human)	EC50	0.7016	4	5
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	EC50	10.0000	1	1
5-ia-85380	Homo sapiens (human)	EC50	0.7000	1	1
a 84543	Homo sapiens (human)	EC50	6.9667	3	3
ispronicline	Homo sapiens (human)	EC50	0.1060	1	1
dianicline	Homo sapiens (human)	EC50	100.0000	2	2
sazetidine-a	Homo sapiens (human)	EC50	0.0120	5	5
ns 9283	Homo sapiens (human)	EC50	0.8900	2	2
a-582941	Homo sapiens (human)	EC50	100.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bupropion	Homo sapiens (human)	Concentration	11.0000	1	2
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	ED50	4.0000	1	1
epibatidine	Homo sapiens (human)	Activity	0.0050	1	1
epibatidine	Homo sapiens (human)	ED50	0.0170	1	1
epibatidine	Homo sapiens (human)	INH	0.0001	1	1
mecamylamine	Homo sapiens (human)	Concentration	0.7800	1	1
cytisine	Homo sapiens (human)	Rmax	23.0000	1	1
abt 594	Homo sapiens (human)	Rmax	130.0000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ligand-gated monoatomic ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]
acetylcholine receptor activity	molecular function	Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]
acetylcholine-gated monoatomic cation-selective channel activity	molecular function	Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]
acetylcholine binding	molecular function	Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
quaternary ammonium group binding	molecular function	Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai]
heterocyclic compound binding	molecular function	Binding to heterocyclic compound. [GOC:TermGenie]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
presynaptic membrane	cellular component	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
plasma membrane raft	cellular component	A membrane raft that is part of the plasma membrane. [GOC:jl]
cholinergic synapse	cellular component	A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos]
postsynaptic specialization membrane	cellular component	The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
acetylcholine-gated channel complex	cellular component	A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]

Involved In

This protein is involved in 42 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
smooth muscle contraction	biological process	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
synaptic transmission, cholinergic	biological process	The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic]
visual perception	biological process	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]
sensory perception of sound	biological process	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai]
learning	biological process	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544]
memory	biological process	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
associative learning	biological process	Learning by associating a stimulus (the cause) with a particular outcome (the effect). [ISBN:0582227089]
visual learning	biological process	Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. [GOC:jid, ISBN:0582227089]
regulation of dopamine secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef]
sensory perception of pain	biological process	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
vestibulocochlear nerve development	biological process	The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
optic nerve morphogenesis	biological process	The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
lateral geniculate nucleus development	biological process	The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
central nervous system projection neuron axonogenesis	biological process	Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
positive regulation of B cell proliferation	biological process	Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah]
regulation of synaptic transmission, dopaminergic	biological process	Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah]
positive regulation of dopamine secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine. [GOC:sl]
monoatomic ion transmembrane transport	biological process	A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
response to nicotine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
behavioral response to nicotine	biological process	Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. [GOC:bf, ISBN:0198506732]
social behavior	biological process	Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
regulation of dopamine metabolic process	biological process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators]
B cell activation	biological process	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
response to cocaine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]
regulation of circadian sleep/wake cycle, REM sleep	biological process	Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. [GOC:jl, PMID:11506998]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
negative regulation of action potential	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]
regulation of dendrite morphogenesis	biological process	Any process that modulates the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
nervous system process	biological process	A organ system process carried out by any of the organs or tissues of neurological system. [GOC:ai, GOC:mtg_cardio]
cognition	biological process	The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908]
membrane depolarization	biological process	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]
regulation of synapse assembly	biological process	Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
synaptic transmission involved in micturition	biological process	The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. [GOC:dph, PMID:15827347]
acetylcholine receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah]
response to acetylcholine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]