Page last updated: 2024-11-13

gluma

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Gluma: bonding agent; aqueous solution of hydroxyethylmethacrylate & glutaral [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56841985
SCHEMBL ID5792189
MeSH IDM0129690

Synonyms (4)

Synonym
gluma
95918-03-9
SCHEMBL5792189
DTXSID40242028

Research Excerpts

Overview

Gluma Dentin Bond is an adhesive system, where the primer contains 5% glutaraldehyde and 35% hydroxyethyl methacrylate.

ExcerptReferenceRelevance
"Gluma Dentin Bond is an adhesive system, where the primer contains 5% glutaraldehyde and 35% hydroxyethyl methacrylate. "( Closing of dentinal tubules by Gluma desensitizer.
Finger, WJ; Lutz, F; Schüpbach, P, 1997
)
2.03

Actions

ExcerptReferenceRelevance
"Gluma appears to enhance the bond at the post/tooth interface, resulting in decreased variability and increased strength."( Post and core retention with different cements.
Holmes, DC; Johnson, WT; Leary, JM,
)
0.85

Treatment

Gluma treatment inhibited total MMP activity of acid-etched dentin by 44, 50, 84, 86% after 5, 15, 30 or 60 s of exposure. Gluma-treated dentin was covered with various resins before a microfilled composite was applied.

ExcerptReferenceRelevance
"Gluma treatment inhibited total MMP activity of acid-etched dentin by 44, 50, 84, 86% after 5, 15, 30 or 60 s of exposure, respectively. "( Inhibition of endogenous human dentin MMPs by Gluma.
Agee, KA; Breschi, L; Mazzoni, A; Pashley, DH; Rouch, K; Sabatini, C; Scheffel, DL; Scheffel, RH; Takahashi, M; Tay, FR; Tjäderhane, L, 2014
)
2.1
"Gluma-treated dentin was covered with various resins before a microfilled composite was applied. "( Dentin-polymer bond promoted by Gluma and various resins.
Asmussen, E; Irie, M; Munksgaard, EC, 1985
)
2
"Treatment with Gluma increased retention of inlays, resulting in retentive strengths of the same magnitude for all three inlay systems."( Retention of composite inlays in enamel dentin cavities.
Asmussen, E; Peutzfeldt, A, 1991
)
0.62

Toxicity

ExcerptReferenceRelevance
" The ICI Dental experimental material was the least toxic through 100 microns slices (68."( In vitro cytotoxicity of three dentine bonding agents.
Brook, AM; Meryon, SD, 1989
)
0.28
" The toxic reactions to Gluma Bond were far more pronounced compared with the toxic reactions to 3M Etching Liquid in both models."( Toxic effects of two dental materials on human buccal epithelium in vitro and monkey buccal mucosa in vivo.
Arenholt-Bindslev, D; Hörsted-Bindslev, P; Philipsen, HP, 1987
)
0.58

Dosage Studied

ExcerptRelevanceReference
" The Tenure, Fuji, and Gluma materials were initially screened at 2 mg (solids) or 2 microL (liquids) per plate, without S9 (Aroclor 1254-induced rat liver microsomes), and dose-response studies were conducted for those materials showing potential mutagenicity."( Evaluation of mutagenicity of restorative dental materials using the Ames Salmonella/microsome test.
Dunipace, AJ; Li, Y; Noblitt, TW; Stookey, GK, 1990
)
0.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (270)

TimeframeStudies, This Drug (%)All Drugs %
pre-199065 (24.07)18.7374
1990's158 (58.52)18.2507
2000's25 (9.26)29.6817
2010's13 (4.81)24.3611
2020's9 (3.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 79.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index79.35 (24.57)
Research Supply Index5.83 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index149.84 (26.88)
Search Engine Supply Index2.15 (0.95)

This Compound (79.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials31 (10.10%)5.53%
Reviews7 (2.28%)6.00%
Case Studies2 (0.65%)4.05%
Observational0 (0.00%)0.25%
Other267 (86.97%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]