A transmembrane protease serine 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15393]
EC 3.4.21.-;
Serine protease 10
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| camostat | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| camostat | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| carmofur | Homo sapiens (human) | IC50 | 1.8200 | 1 | 1 |
| chloroquine | Homo sapiens (human) | IC50 | 5.4700 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 11.2400 | 1 | 2 |
| disulfiram | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| ebselen | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| emodin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| fluphenazine | Homo sapiens (human) | IC50 | 11.8000 | 1 | 2 |
| niclosamide | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| promethazine | Homo sapiens (human) | IC50 | 13.6450 | 1 | 2 |
| tanshinone ii a | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| 1-methylpropyl-2-imidazolyl disulfide | Homo sapiens (human) | IC50 | 21.0000 | 1 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Homo sapiens (human) | IC50 | 0.3700 | 1 | 1 |
| hirsutanone | Homo sapiens (human) | IC50 | 4.1000 | 1 | 1 |
| S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide | Homo sapiens (human) | IC50 | 18.1000 | 1 | 2 |
| amentoflavone | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| savinin | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| broussochalcone a | Homo sapiens (human) | IC50 | 25.6500 | 1 | 2 |
| rupintrivir | Homo sapiens (human) | IC50 | 410.0000 | 1 | 2 |
| rupintrivir | Homo sapiens (human) | Ki | 10.0000 | 1 | 2 |
| 5-Chloro-3-pyridinyl 2-furoate | Homo sapiens (human) | IC50 | 0.0600 | 1 | 1 |
| np 031112 | Homo sapiens (human) | IC50 | 1.5500 | 1 | 1 |
| Benzotriazol-1-yl 1H-indole-5-carboxylate | Homo sapiens (human) | Ki | 0.0075 | 1 | 1 |
| 5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate | Homo sapiens (human) | IC50 | 0.0630 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | Homo sapiens (human) | IC50 | 0.3100 | 1 | 1 |
| 5-Chloropyridin-3-yl 1H-indole-2-carboxylate | Homo sapiens (human) | IC50 | 0.0650 | 1 | 1 |
| GRL-0617 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| KOM70144 | Homo sapiens (human) | IC50 | 0.5600 | 1 | 1 |
| N-[(1R)-2-(tert-butylamino)-2-oxo-1-(3-pyridinyl)ethyl]-N-(4-tert-butylphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amodiaquine | Homo sapiens (human) | EC50 | 3.1933 | 1 | 3 |
| astemizole | Homo sapiens (human) | EC50 | 5.2350 | 1 | 2 |
| camostat | Homo sapiens (human) | EC50 | 7.0000 | 2 | 3 |
| chloroquine | Homo sapiens (human) | EC50 | 5.3333 | 1 | 6 |
| chlorpromazine | Homo sapiens (human) | EC50 | 7.7360 | 1 | 5 |
| clomipramine | Homo sapiens (human) | EC50 | 11.2800 | 1 | 2 |
| ebselen | Homo sapiens (human) | EC50 | 4.6700 | 1 | 1 |
| emodin | Homo sapiens (human) | EC50 | 200.0000 | 1 | 2 |
| fluphenazine | Homo sapiens (human) | EC50 | 16.2400 | 1 | 3 |
| fluspirilene | Homo sapiens (human) | EC50 | 6.7150 | 1 | 2 |
| hydroxychloroquine | Homo sapiens (human) | EC50 | 5.6567 | 1 | 3 |
| hydroxyzine | Homo sapiens (human) | EC50 | 14.4000 | 1 | 1 |
| loperamide | Homo sapiens (human) | EC50 | 5.0800 | 1 | 5 |
| mefloquine hydrochloride | Homo sapiens (human) | EC50 | 11.4800 | 1 | 2 |
| promethazine | Homo sapiens (human) | EC50 | 9.6700 | 1 | 2 |
| imatinib | Homo sapiens (human) | EC50 | 12.5000 | 1 | 3 |
| thiethylperazine | Homo sapiens (human) | EC50 | 7.8600 | 1 | 1 |
| triflupromazine | Homo sapiens (human) | EC50 | 6.0700 | 1 | 2 |
| cycloheximide | Homo sapiens (human) | EC50 | 0.1145 | 1 | 2 |
| chlorphenoxamine | Homo sapiens (human) | EC50 | 16.3350 | 1 | 2 |
| triparanol | Homo sapiens (human) | EC50 | 5.2800 | 1 | 1 |
| emetine | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| acetophenazine | Homo sapiens (human) | EC50 | 23.6000 | 1 | 1 |
| ribavirin | Homo sapiens (human) | EC50 | 109.5000 | 1 | 1 |
| gemcitabine | Homo sapiens (human) | EC50 | 3.0800 | 1 | 2 |
| methotrimeprazine | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| lopinavir | Homo sapiens (human) | EC50 | 12.8200 | 1 | 5 |
| nutlin 3 | Homo sapiens (human) | EC50 | 36.9000 | 1 | 1 |
| anisomycin | Homo sapiens (human) | EC50 | 0.0965 | 1 | 2 |
| homoharringtonine | Homo sapiens (human) | EC50 | 0.0710 | 1 | 1 |
| terconazole | Homo sapiens (human) | EC50 | 13.7600 | 1 | 2 |
| thiothixene | Homo sapiens (human) | EC50 | 7.3000 | 1 | 2 |
| benztropine | Homo sapiens (human) | EC50 | 19.1150 | 1 | 2 |
| tamoxifen | Homo sapiens (human) | EC50 | 51.4950 | 1 | 2 |
| toremifene | Homo sapiens (human) | EC50 | 12.4350 | 1 | 2 |
| dasatinib | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| quercetin | Homo sapiens (human) | EC50 | 83.4000 | 1 | 1 |
| luteolin | Homo sapiens (human) | EC50 | 10.6000 | 1 | 1 |
| dothiepin hydrochloride | Homo sapiens (human) | EC50 | 3.4000 | 1 | 1 |
| sotrastaurin | Homo sapiens (human) | EC50 | 9.7000 | 1 | 1 |
| saracatinib | Homo sapiens (human) | EC50 | 2.9000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | Homo sapiens (human) | EC50 | 24.0000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | Homo sapiens (human) | EC50 | 6.9000 | 1 | 1 |
| s 8932 | Homo sapiens (human) | EC50 | 0.7700 | 1 | 1 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Homo sapiens (human) | EC50 | 0.4200 | 1 | 1 |
| molnupiravir | Homo sapiens (human) | EC50 | 0.1540 | 1 | 1 |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | Homo sapiens (human) | EC50 | 0.3300 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| serine-type peptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| protein autoprocessing | biological process | Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337] |
| positive regulation of viral entry into host cell | biological process | Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. [GOC:jl] |