Metronidazole is a synthetic nitroimidazole antibiotic used to treat a variety of bacterial and parasitic infections. It is typically administered orally or intravenously. The mechanism of action of metronidazole involves the reduction of its nitro group to a nitro radical anion by bacterial and parasitic enzymes. This radical anion then interacts with the DNA of the microorganism, leading to strand breaks and inhibition of DNA synthesis. Metronidazole is particularly effective against anaerobic bacteria, including Bacteroides fragilis, Clostridium difficile, and Helicobacter pylori. It is also used to treat protozoal infections, such as giardiasis and trichomoniasis. The synthesis of metronidazole involves several steps, including the reaction of 2-nitro-5-chloroimidazole with 2-diethylaminoethanol. Metronidazole is widely studied due to its effectiveness against a range of infections and its relatively low cost. Researchers are investigating potential new uses for metronidazole, such as its potential to treat cancer and inflammatory bowel disease.'
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 4173 |
| CHEMBL ID | 137 |
| CHEBI ID | 6909 |
| SCHEMBL ID | 23042 |
| MeSH ID | M0013695 |
| Synonym |
|---|
| BIDD:GT0107 |
| HMS3393G07 |
| BB 0218386 |
| BRD-K52020312-001-05-2 |
| clont |
| 1-(.beta.-ethylol)-2-methyl-5-nitro-3-azapyrrole |
| 1h-imidazole-1-ethanol, 2-methyl-5-nitro- |
| orvagil |
| flagesol |
| sc 10295 |
| nalox |
| 1-(.beta.-hydroxyethyl)-2-methyl-5-nitroimidazole |
| trikacide |
| takimetol |
| trichomol |
| wagitran |
| flagyl |
| giatricol |
| trichomonacid 'pharmachim' |
| nsc50364 |
| sanatrichom |
| bayer 5360 |
| anagiardil |
| trikozol |
| tricocet |
| deflamon-wirkstoff |
| 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole |
| deflamon |
| 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole |
| danizol |
| metronidaz |
| monagyl |
| trichex |
| mexibol |
| tricowas b |
| neo-tric |
| cont |
| trichopal |
| trichocide |
| trivazol |
| trichazol |
| vagimid |
| flagil |
| wln: t6ntj dq anu1- et5n cnj a1 bnw |
| efloran |
| metronidazol |
| klion |
| gineflavir |
| 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole |
| acromona |
| arilin |
| flagemona |
| 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole |
| imidazole-1-ethanol, 2-methyl-5-nitro- |
| nsc-50364 |
| 2-methyl-5-nitroimidazole-1-ethanol |
| 1-hydroxyethyl-2-methyl-5-nitroimidazole |
| wln: t5n cnj a2q b1 enw |
| smr000058175 |
| DIVK1C_000007 |
| KBIO1_000007 |
| NCIOPEN2_000337 |
| nsc-69587 |
| SPECTRUM_001035 |
| PRESTWICK_334 |
| NCGC00016446-01 |
| cas-443-48-1 |
| BPBIO1_000004 |
| BSPBIO_000002 |
| PRESTWICK2_000081 |
| 2-(2-methyl-5-nitro-imidazol-1-yl)ethanol |
| metric 21 |
| rp 8823 |
| nida |
| nsc69587 |
| tricom |
| klont |
| vagilen |
| flegyl |
| elyzol |
| methronidazole |
| trikamon |
| vertisal |
| meronidal |
| protostat |
| trimeks |
| entizol |
| eumin |
| monasin |
| bexon |
| trikojol |
| trichopol |
| novonidazol |
| atrivyl |
| IDI1_000007 |
| SMP1_000189 |
| BCBCMAP01_000184 |
| PRESTWICK3_000081 |
| SPECTRUM5_001289 |
| BSPBIO_002031 |
| NCGC00022059-03 |
| AB00052046 |
| ccris 410 |
| metronidazolum [inn-latin] |
| nsc 69587 |
| hsdb 3129 |
| metromidol |
| satric |
| fossyol |
| mexibol 'silanes' |
| giniflavir |
| noritate |
| metronidazole in plastic container |
| metro i.v. in plastic container |
| metronidazol [inn-spanish] |
| nsc 50364 |
| epa pesticide chemical code 120401 |
| metronidazolo |
| flagyl i.v. rtu |
| metronidazolo [dcit] |
| caswell no. 579aa |
| metro gel |
| flagyl i.v. rtu in plastic container |
| einecs 207-136-1 |
| flagyl 375 |
| flagyl er |
| brn 0611683 |
| metronidazole |
| C07203 |
| 443-48-1 |
| metronidazole, bioxtra |
| MLS000758286 |
| 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole |
| 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole |
| DB00916 |
| 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole |
| noritate (tn) |
| D00409 |
| flagyl (tn) |
| nuvessa (tn) |
| metronidazole (jp17/usp/inn) |
| vandazole (tn) |
| 2-(2-methyl-5-nitro-1h-imidazol-1-yl)ethanol |
| metrolotion |
| rosased |
| metrogel-vaginal |
| florazole |
| metrocream |
| metrogel |
| cb-01-14 mmx |
| fp-250 |
| idr-90105 |
| zidoval |
| NCGC00022059-05 |
| NCGC00022059-04 |
| STK177359 |
| MLS000028590 , |
| KBIOGR_000559 |
| KBIO2_006651 |
| MAYBRIDGE1_001999 |
| KBIO2_001515 |
| KBIOSS_001515 |
| KBIO3_001531 |
| KBIO2_004083 |
| NINDS_000007 |
| PRESTWICK1_000081 |
| SPBIO_001941 |
| PRESTWICK0_000081 |
| SPBIO_000666 |
| SPECTRUM3_000506 |
| SPECTRUM2_000883 |
| SPECTRUM4_000060 |
| SPECTRUM1500412 |
| NCGC00016446-02 |
| metronidazolum |
| CHEBI:6909 , |
| 2 methyl 5 nitroimidazole 1 ethanol |
| HMS2091F14 |
| HMS2090B19 |
| HMS2051G07 |
| CHEMBL137 |
| bayer-5360 |
| bay-5360 |
| rp-8823 |
| AKOS000269646 |
| HMS547C19 |
| HMS500A09 |
| M0924 , |
| HMS1568A04 |
| HMS1920N19 |
| 2-(2-methyl-5-nitroimidazol-1-yl)ethanol |
| NCGC00016446-06 |
| HMS2095A04 |
| NCGC00256513-01 |
| tox21_302794 |
| dtxcid20892 |
| dtxsid2020892 , |
| NCGC00259962-01 |
| tox21_202413 |
| 2-(2-methyl-5-nitro-1-imidazolyl)ethanol |
| A826552 |
| BBL005452 |
| nsc-757118 |
| nsc757118 |
| pharmakon1600-01500412 |
| MLS001424018 |
| tox21_110441 |
| HMS2231E11 |
| CCG-40016 |
| NCGC00016446-05 |
| NCGC00016446-08 |
| NCGC00016446-03 |
| NCGC00016446-09 |
| NCGC00016446-04 |
| NCGC00016446-07 |
| AKOS005169650 |
| 2-(2-methyl-5-nitroimidazolyl)ethan-1-ol |
| bdbm50375309 |
| metrolyl |
| metro iv |
| tricho cordes |
| metrotop |
| zadstat |
| metrolag |
| nidagyl |
| tricho-gynaedron |
| mepagyl |
| rathimed |
| metronidazole [usan:usp:inn:ban:jan] |
| unii-140qmo216e |
| 140qmo216e , |
| vandazole |
| 5-23-05-00063 (beilstein handbook reference) |
| metro i.v. |
| FT-0603394 |
| NCGC00016446-12 |
| S1907 |
| 2-(2-methyl-5-nitro-1h-imidazol-1-yl)ethan-1-ol |
| HMS3373O05 |
| metronidazole [mi] |
| metronidazole [ep impurity] |
| metronidazole [usp-rs] |
| metronidazole [vandf] |
| pylera component metronidazole |
| metronidazole component of helidac |
| metronidazole [mart.] |
| metronidazole [usan] |
| metronidazole component of pylera |
| metronidazole [who-dd] |
| metronidazole [ep monograph] |
| metronidazole [orange book] |
| metronidazole [usp impurity] |
| helidac component metronidazole |
| metronidazole [hsdb] |
| metronidazole [who-ip] |
| metronidazole [iarc] |
| metronidazole [inn] |
| metronidazole [usp monograph] |
| metronidazole [jan] |
| metronidazole benzoate impurity a [ep impurity] |
| HY-B0318 |
| NC00020 |
| SCHEMBL23042 |
| NCGC00016446-11 |
| tox21_110441_1 |
| KS-5140 |
| AB00052046-17 |
| flazol |
| cimetrol 500lpci |
| helidac (salt/mix) |
| 2-(2-methyl-5-nitro-1h-imidazol-1-yl)ethanol # |
| flagyl i.v. rtu (salt/mix) |
| metro cream & gel |
| trikhopol |
| polibiotic |
| trichobrol |
| Q-201403 |
| metronidazole, antibiotic for culture media use only |
| metronidazole, british pharmacopoeia (bp) reference standard |
| AC-23968 |
| AB00052046_19 |
| OPERA_ID_1585 |
| AB00052046_18 |
| mfcd00009750 |
| F1773-0073 |
| metronidazole, united states pharmacopeia (usp) reference standard |
| metronidazole, certified reference material, tracecert(r) |
| metronidazole, saj first grade, >=99.0% |
| metronidazole, vetranal(tm), analytical standard |
| HMS3655E22 |
| EN300-16851 |
| metronidazole, european pharmacopoeia (ep) reference standard |
| metronidazole, analytical standard |
| metronidazole, pharmaceutical secondary standard; certified reference material |
| metronidazole 2.0 mg/ml in methanol |
| sr-01000000244 |
| SR-01000000244-5 |
| SR-01000000244-4 |
| SBI-0051447.P003 |
| HMS3712A04 |
| Z87001124 |
| SY002821 |
| SW196613-4 |
| metronidazole (flagyl) |
| metronidazole,(s) |
| BCP13757 |
| Q169569 |
| BRD-K52020312-001-15-1 |
| NCGC00016446-17 |
| gtpl10914 |
| donnan |
| metronidazole (ep impurity) |
| rosaced |
| mexibol'silanes' |
| metronidazole (usp impurity) |
| metronidazole500 mg |
| givagil |
| metronidazole (usp-rs) |
| metronidazole vaginal |
| metronidazole (mart.) |
| metronidazole topical gel |
| metronidazole (ep monograph) |
| a01ab17 |
| metronidazol (inn-spanish) |
| metronidazolum (inn-latin) |
| metronidazole (usp monograph) |
| usepa/opp pesticide code: 120401 |
| metronidazole vaginal gel, 0.75% |
| metrocleanse |
| nuvessa |
| metronidazole500 mg500 mg |
| metronidazole (usan:usp:inn:ban:jan) |
| metronidazole250 mg |
| j01xd01 |
| metroplex |
| trichomonacid'pharmachim' |
| metronidazole topical cream |
| p01ab01 |
| rosaclear system |
| d06bx01 |
| metronidazole (iarc) |
| metronidazole250 mg250 mg |
| g01af01 |
Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. It has been associated with serious neurologic disturbances which in some cases were irreversible.
Metronidazole has a substantial impact on the gut microbiome. It has a broad-spectrum antibacterial activity.
Metronidazole has been widely used in the treatment of trichomoniasis urogenitalis. It is the most active agent available against obligate anaerobes.
Oral metronidazole, however, may cause unpleasant side effects and is contraindicated during the first trimester of pregnancy. Metronidzole was shown to inhibit the repair of potentially lethal radiation damages.
Treatment with metronidazole and erythromycin reduced rates of premature delivery in women with bacterial vaginosis and an increased risk for preterm delivery.
Metronidazole rarely encountered in clinical practice despite its wide use as an antibacterial or antiparasitic agent. Both hepatotoxicity and acute neurologic deficit have been reported previously as extremely rare adverse events after metronidzole administration.
The pharmacokinetic interaction between metronidazole, an antibiotic-antiparasitic drug used to treat anaerobic bacterial and protozoal infections, and imatinib, a CYP3A4, P-glycoprotein substrate kinase inhibitor anticancer drug, was evaluated. Metronodazole mean+/-SD half-life was 196+/-39, 212+/-30 and 240+/-65 min after i.d.
NFJI investigated the effect of blue light combined with metronidazole in the treatment of acne. The same high concentrations, as well as lower therapeutically achievable concentration (2 mg/l or 5mg/l) were slightly more potent for the tested clostridia.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The inhibitory activity of five beta-lactam agents, alone and in combination with a beta-lactamase inhibitor, was compared with that of cefoxitin and metronidazole against 300 beta-lactamase producing Bacteroides fragilis group isolates." | ( Inhibitory and bactericidal activity of selected beta-lactam agents alone and in combination with beta-lactamase inhibitors compared with that of cefoxitin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides Aldridge, KE; Stratton, CW; Weeks, LS, ) | 0.53 |
| "In a randomised and coordinated multicentre study, 143 patients with severe infections received treatment with either imipenem/cilastatin (72; I/C group) or cefotaxime combined with metronidazole and optional cloxacillin (71; CX/M/CL group)." | ( Imipenem/cilastatin as monotherapy in severe infections: comparison with cefotaxime in combination with metronidazole and cloxacillin. Report from a Norwegian Study Group. , 1987) | 0.68 |
| " The same high concentrations, as well as lower therapeutically achievable concentration (2 mg/l or 5 mg/l) of metronidazole in combination with ciprofloxacin were slightly more potent for the tested clostridia than ciprofloxacin or metronidazole alone." | ( Ciprofloxacin in combination with metronidazole. Schneider, L; Werk, R, ) | 0.62 |
| "One hundred and one isolates representing five species of the Bacteroides fragilis group were examined for their susceptibility to amoxycillin and ticarcillin alone or in combination with clavulanic acid, as well as to cefoxitin, latamoxef (moxalactam), ceftizoxime, imipenem, chloramphenicol, clindamycin and metronidazole by the proposed NCCLS agar dilution method." | ( In-vitro activity of amoxycillin and ticarcillin in combination with clavulanic acid compared with that of new beta-lactam agents against species of the Bacteroides fragilis group. Bourgault, AM; Lamothe, F, 1986) | 0.45 |
| "The effect of 1-day mechanical bowel preparation with 10% mannitol combined with oral neomycin and short-term perioperative intravenous Flagyl (group I) was studied in a prospective, randomized, double-blind study and was compared with oral neomycin and an intravenous placebo (Group II)." | ( A prospective, randomized, double-blind study of 10% mannitol mechanical bowel preparation combined with oral neomycin and short-term, perioperative, intravenous Flagyl as prophylaxis in elective colorectal resections. Fazio, VW; Jagelman, DG; Lavery, IC; Weakley, FL, 1985) | 0.27 |
| "The authors described clinicomorphological correlations in the evaluation of the efficacy of preoperative radiotherapy combined with metronidazole (MZ) in laryngeal cancer patients." | ( [Morphology of laryngeal cancer in radiotherapy combined with the use of metronidazole]. Andreev, VG; Lushnikov, EF; Solov'eva, LP, 1985) | 0.7 |
| " Phenytoin in combination with other drugs (anticonvulsives, antibiotics etc." | ( [Effects of drug interaction in infancy (author's transl)]. Alterthum, K; Bauer, P; Stünkel, S; Windorfer, A, 1980) | 0.26 |
| " This study demonstrated the efficacy of penicillin and clavulanic acid in the treatment of infections caused by Bacteroides fragilis alone or in combination with beta-lactamase-producing aerobic bacteria." | ( Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria. Brook, I; Coolbaugh, JC; Walker, RI, 1983) | 0.27 |
| "A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix." | ( Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. Arvilommi, H; Saario, I; Silvola, H, 1983) | 0.71 |
| " Patients in Group 1 received either a single intravenous dose of 1500 mg metronidazole or this dose was combined with a single, intravenous dose of 6 g ampicillin." | ( Prophylactic regimens in colorectal surgery. Comparison between metronidazole used alone or in combination with either ampicillin or doxycycline. Andenaes, K; Bergan, T; Bjerkeset, T; Brabrand, G; Erichsen, H; Flørenes, T; Garberg, O; Glauer, H; Holter, O; Roland, M, 1984) | 0.74 |
| "The paper summarizes the results of dynamic dose-fractionation combined with oxygen breathing at ambient pressure and metronidazole in head and neck, and uterine cervix cancer." | ( Dynamic dose-fractionation combined with oxygen breathing at ambient pressure and high-dose metronidazole in head and neck, and uterine cervix cancer. Boljesíková, E; Durkovský, J; Jancina, J; Kubovcáková, N; Siracká, E, 1983) | 0.69 |
| "In vitro activity against 100 strains of Bacteroides fragilis of ticarcillin alone and combined with 4 or 8 mg of clavulanic acid was compared with those of cefoxitin, cefotaxime, ceftazidime, lamoxactam , ceftriaxone and metronidazole." | ( [Comparative bacteriostatic activity of ticarcillin, alone and combined with clavulanic acid, 5 cephalosporins and metronidazole against 100 strains of Bacteroides fragilis]. Bebear, C; de Barbeyrac, B; Quentin, C, 1984) | 0.66 |
| "6 mg/g, were used either alone or in combination with 900 rads of gamma-radiation in a fractionated dose schedule of twice a week for 3 weeks." | ( Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. Grdina, DJ; Mian, TA; Theiss, JC, 1983) | 0.27 |
| "Proceeding from the clinical observation of 11 patients with cancer of the tongue, oral mucosa and stomatopharynx who received gamma-beam therapy according to the scheme of dynamic fractionation combined with metronidazole, it has been concluded that the drug enhances the degree of radiation injury of the above tumors." | ( [Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole]. Dar'ialova, SL; Karakulov, RK; Kiseleva, ES; Pelevina, II; Poliakov, PIu, 1983) | 0.67 |
| "To establish the efficacy of omeprazole combined with two antibiotics for Helicobacter pylori eradication and duodenal ulcer relapse." | ( Efficacy of omeprazole combined with antibiotics for Helicobacter pylori eradication and duodenal ulcer recurrence. Bargiggia, S; Bianchi Porro, G; Lazzaroni, M; Maconi, G; Minguzzi, M, 1995) | 0.29 |
| "To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4." | ( Activity of fleroxacin alone and in combination with clindamycin or metronidazole in experimental intra-abdominal abscesses. Eliopoulos, GM; Ferraro, MJ; Holden, J; Moellering, RC; Pefanis, A; Thauvin-Eliopoulos, C, 1994) | 0.75 |
| " INTERVENTION--Treatment with oral S boulardii (1 g/d for 4 weeks) or placebo in combination with a standard antibiotic." | ( A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. Bowen, KE; Cox, JL; Elmer, GW; Fekety, R; Greenberg, RN; McFarland, LV; Melcher, SA; Moyer, KA; Noorani, Z; Surawicz, CM, ) | 0.13 |
| "The efficacy of hyperbaric oxygen (HBO) alone and in combination with several antimicrobial agents was evaluated in a lethal model of gas gangrene in mice." | ( Evaluation of antimicrobials combined with hyperbaric oxygen in a mouse model of clostridial myonecrosis. Anderson, LH; Mehm, WJ; Muhvich, KH, 1994) | 0.29 |
| " This article aims to review the "additional" effect of a subgingival irrigation with chlorhexidine, or a local or systemic application of tetracycline or metronidazole, performed in combination with a single course of scaling and root planing in patients with chronic adult periodontitis." | ( Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. Bollen, CM; Quirynen, M, 1996) | 0.49 |
| "This double-blind, randomized, phase III clinical trial was carried out in two parallel groups to assess the efficacy of ebrotidine (N-[(E)-[[2-[[[2-[(diaminomethylene) amino]-4-thiazolyl]methyl]thio]ethyl]amino] methylene]-4-bromo-benzenesulfonamide, CAS 100981-43-9, FI-3542) 400 mg and ranitidine 300 mg given in single evening dose, combined with amoxicillin 750 mg and metronidazole 500 mg three times daily for 14 days, in the eradication of Helicobacter pylori in patients with duodenal ulcer." | ( Efficacy of ebrotidine and ranitidine combined with amoxicillin and metronidazole in the eradication of Helicobacter pylori in patients with duodenal ulcer. Fillat, O; Herrero, E; Karcz, D; Kulig, J; Márquez, M; Ortiz, JA; Popiela, T; Tabor, J; Torres, J, 1997) | 0.7 |
| "In this random study, the efficacy of either colloidal bismuth subcitrate (CBS) or metronidazole in combination with an H2-antagonist in the treatment of various gastric pathologies was evaluated, along with the trends in antibody levels." | ( Comparison of colloidal bismuth subcitrate and metronidazole, both in combination with an H2-antagonist as therapy for Helicobacter pylori. Albano, A; Baffone, W; Barbieri, E; Belbusti, F; Bruscolini, F; Fabi, MT; Pianetti, A; Salvaggio, L, 1997) | 0.78 |
| " pylori than ranitidine when given with amoxicillin plus metronidazole for the treatment of duodenal ulcer, as both early reinfection and ulcer recurrence are diminished." | ( Ranitidine versus colloidal bismuth subcitrate in combination with amoxicillin and metronidazole for eradicating Helicobacter pylori in patients with duodenal ulcer. Blanco, M; Carpintero, P; Pajares, JM, 1997) | 0.77 |
| " The aim of this study was to evaluate rabeprazole in combination with antibiotics for the eradication of Helicobacter pylori (H." | ( Safety and efficacy of rabeprazole in combination with four antibiotic regimens for the eradication of Helicobacter pylori in patients with chronic gastritis with or without peptic ulceration. Atherton, JC; Cockayne, A; Hawkey, CJ; Jenkins, D; Knifton, A; Stack, WA; Thirlwell, D, 1998) | 0.3 |
| " These findings suggest that metronidazole, given with bactericidal drugs such as rifampicin and isoniazid may be of value in eliminating persisting tubercle bacilli, but further studies are warranted." | ( Action of metronidazole in combination with isoniazid & rifampicin on persisting organisms in experimental murine tuberculosis. Herbert, D; Kubendiran, G; Paramasivan, CN, 1998) | 0.99 |
| "To test eradication and adverse events of ranitidine bismuth citrate (RBC) when given with metronidazole and either oxytetracycline or spiramycin." | ( Spiramycin is comparable to oxytetracycline in eradicating H. pylori when given with ranitidine bismuth citrate and metronidazole. Bang, CJ; Berstad, A; Coll, P; Hatlebakk, JG; Hausken, T; Nysaeter, G; Olafsson, S; Olafsson, T; Tefera, S, 1999) | 0.73 |
| " The aim of this study was to determine the optimal dose and duration of lansoprazole (LA) administration in combination with amoxicillin (AMPC) and metronidazole (MNZ)." | ( Eradication of Helicobacter pylori using 30 mg or 60 mg lansoprazole combined with amoxicillin and metronidazole: one and two weeks of a new triple therapy. Asaka, M; Ishizuka, J; Kagaya, H; Katagiri, M; Kato, M; Komatsu, Y; Kudo, M; Kudo, T; Nishikawa, K; Sugiyama, T; Sukegawa, M; Takeda, H; Toyota, J, 1999) | 0.72 |
| " pylori eradication rate in both metronidazole-sensitive and -resistant strains following quadruple therapy using single-triple capsules of bismuth biskalcitrate, metronidazole and tetracycline, given with omeprazole." | ( Efficacy and safety of single-triple capsules of bismuth biskalcitrate, metronidazole and tetracycline, given with omeprazole, for the eradication of Helicobacter pylori: an international multicentre study. Borody, T; Dallaire, C; De Boer, WA; Fallone, CA; Farley, A; Mégraud, F; O'Morain, C; Piotrowski, J; Schuman, R; Spénard, J; Tytgat, G, 2003) | 0.83 |
| "Between 1982 and 1988, MRRC RAMS carried out a prospective clinical trial of preoperative radiotherapy (20 Gy/5 days) in combination with metronidazole (given orally, 3 times, 5 gms per metre(2))." | ( Preoperative radiotherapy in combination with metronidazole for resectable gastric cancer: long-term results of a phase 2 study. Berdov, BA; Skoropad, VY; Zagrebin, VM, 2003) | 0.78 |
| " This finding, along with the abscess sterilization results, indicates that cefotaxime in combination with metronidazole is a highly effective treatment but is associated with a high frequency of reversible side effects." | ( Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases. Enblad, P; Jansson, AK; Sjölin, J, 2004) | 0.79 |
| "We evaluated the efficacy of enrofloxacin, alone or combined with metronidazole, against Leishmania infantum." | ( The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis. Bianciardi, P; Fasanella, A; Foglia Manzillo, V; Gradoni, L; Oliva, G; Pagano, A; Sorino, S; Trotta, T, 2004) | 0.81 |
| "The aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients." | ( Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study. Corbet, EF; Lee, DH; Zee, KY, 2006) | 0.77 |
| " Rosacea is most commonly managed with topical metronidazole, sometimes in combination with oral antibiotics." | ( Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. Balkrishnan, R; Conde, JF; Feldman, SR; Fleischer, AB; Yelverton, CB, 2007) | 0.86 |
| "75% lotion is more effective when used in combination with doxycycline 20 mg dosed twice daily." | ( Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. Balkrishnan, R; Conde, JF; Feldman, SR; Fleischer, AB; Yelverton, CB, 2007) | 0.61 |
| " Therefore, the selection of the antibiotic for combination with G-CSF in sepsis treatment should be guided not only by the bacteria to be eliminated, but also by the effects on antimicrobial functions of PMNs and the cytokine response." | ( Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats. Bauhofer, A; Huttel, M; Lorenz, W; Sessler, DI; Torossian, A, 2008) | 0.35 |
| " Isolated and combined with EMR effects of nicotine (10(-4)-10(-15) mol/l) and antimicrobial drug metronidazole (10(-5), 10(-8), 10(-9) mol/l) were investigated." | ( [Biological effects of electromagnetic radiation of extremely high frequencies combined with physiologically active compounds]. Denisova, SA; Kuznetsov, PE; Rogacheva, SM; Shul'gin, SV; Somov, AIu, ) | 0.35 |
| "By research, it was found that the Amsacrine (AMSA) can interact with bovine serum albumin (BSA)." | ( Assisted sonodynamic damage of bovine serum albumin by metronidazole under ultrasonic irradiation combined with photosensitive antitumor drug-Amsacrine. Guo, Y; Han, G; Ou, W; Wang, J; Wang, X; Xu, Y; Zhang, L; Zhang, X, 2010) | 0.61 |
| "To compare the effects of systemic amoxicillin (AMX) plus metronidazole (MET) or placebos combined with anti-infective mechanical debridement on the sub-gingival microbiota of generalized aggressive periodontitis (GAP)." | ( Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. Colombo, AP; Feres-Filho, EJ; Heller, D; Silva-Senem, MX; Torres, MC; Varela, VM, 2011) | 0.61 |
| " Patients were divided into 3 groups and received FRP alone, FRP combined with metronidazole and amoxicillin, or FRP combined with doxycycline." | ( Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. Aslan, M; Baltacioglu, E; Saraç, Ö; Saybak, A; Yuva, P, 2011) | 0.6 |
| "Treatment of generalized aggressive periodontitis with FRP alone or FRP combined with systemic antibiotics provided significant clinical benefits that reduced the need for periodontal surgery." | ( Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. Aslan, M; Baltacioglu, E; Saraç, Ö; Saybak, A; Yuva, P, 2011) | 0.37 |
| "The study shows that aggressive treatment of the patient with antibiotics combined with specific Lactobacillus strain administration and partner treatment can provide long lasting cure." | ( Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses. Andersen, KK; Brandsborg, E; Forsum, U; Hammarström, L; Larsson, PG; Marcotte, H; Nasic, S; Pendharkar, S, 2011) | 0.37 |
| " In this study, the activity of NXL104 in combination with the third-generation cephalosporins ceftazidime (CAZ) and ceftriaxone (CRO) or with piperacillin (PIP) was evaluated against 316 anaerobic bacteria." | ( Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole. Dubreuil, LJ; Mahieux, S; Miossec, C; Neut, C; Pace, J, 2012) | 0.6 |
| " This study aims to determine the comparative efficacy of a single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post caesarean infection." | ( Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial. Kidenya, BR; Konje, E; Lyimo, FM; Massinde, AN; Mshana, SE, 2012) | 0.84 |
| " Candidates in "A" will receive a single dose of gentamicin in combination with metronidazole 30 to 60 minutes prior to the operation and candidates in "B" will receive the same drugs prior to the operation and continue with gentamicin and metronidazole for 24 hours." | ( Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial. Kidenya, BR; Konje, E; Lyimo, FM; Massinde, AN; Mshana, SE, 2012) | 0.85 |
| "To determine the most common drug-drug interaction (DDI) pairs contributing to QTc prolongation in cardiac intensive care units (ICUs)." | ( Drug-drug interactions contributing to QT prolongation in cardiac intensive care units. Armahizer, MJ; Kane-Gill, SL; Seybert, AL; Smithburger, PL, 2013) | 0.39 |
| "The purpose of this study is to evaluate and compare the clinical and radiographic effectiveness of Ciprofloxacin, Minocycline, Metronidazole combination with Ciprofloxacin, Minocycline and Tinidazole combination when used for Lesion Sterilization and Tissue Repair in primary teeth." | ( In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations. Anantharaj, A; Jaya, AR; Praveen, P; Rani, PS; Venkataraghavan, K, 2012) | 0.58 |
| " This study aimed to determine the comparative efficacy of a single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection." | ( Single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: a randomized, equivalence, controlled trial. Kidenya, BR; Konje, ET; Lyimo, FM; Massinde, AN; Mshana, SE, 2013) | 0.86 |
| " Participants in "A" received a single dose of gentamicin in combination with metronidazole 30 to 60 minutes prior to the operation, and participants in "B" received the same drugs prior to the operation but continued with for 24 hours." | ( Single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: a randomized, equivalence, controlled trial. Kidenya, BR; Konje, ET; Lyimo, FM; Massinde, AN; Mshana, SE, 2013) | 0.88 |
| "To evaluate efficacy and side effects of glycididazole sodium (CMNa) combined with chemotherapy (cisplatin plus 5-FU/folic acid, PLF) and radiotherapy in treating patients with locally advanced nasopharyngeal carcinoma." | ( Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma. Chen, DP; Li, MY; Liang, YY; Liu, JQ; Qi, B; Yin, WJ, 2014) | 0.4 |
| "SUMMARY Eradikacion therapy at patients with chronic pancreatitis and combined with Helicobacter associated erosive gastropathy in a month after treatment appeared successful at 75% patients which accepted therapy of the first line--pantoprazol, amoksicillin, klaritromicin." | ( [Estimation of efficiency of anti-helicobacter therapy in patients with a chronic pancreatitis combined with an erosive gastropathy]. Kotsiubniak, LA; Koval', VIu; Moskal', OM, 2014) | 0.4 |
| "5-4) results against the bacterium in combination with ampicillin, ciprofloxacin, tetracycline or metronidazole." | ( In vitro effects of N-acetyl cysteine alone and in combination with antibiotics on Prevotella intermedia. Jang, EY; Lee, JY; Moon, JH; Shim, KS, 2015) | 0.63 |
| "We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma." | ( Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) | 2.12 |
| " The prospective, randomized, controlled trials of metronidazole amino acidum natrium combined with radiation versus radiotherapy alone in the treatment of nasopharyngeal carcinoma were included in this meta-analysis." | ( Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) | 2.11 |
| "Metronidazole amino acidum natrium combined with radiation can improve the objective RR and long-term survival compared to radiation therapy alone in the treatment of nasopharyngeal carcinoma." | ( Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) | 3.3 |
| " The model drug combination was metronidazole-pantoprazole-clarithromycin (MET-PAN-CLAR), which is widely used in clinic to treat ulcers caused by Helicobacter pylori." | ( The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans. Xing, J; Zang, M; Zhang, H; Zhu, M, 2015) | 0.7 |
| " Recently, a new treatment strategy has been developed to overcome the problem by using natural products in combination with antibiotics to enhance the treatment efficacy." | ( In vitro synergistic effect of Hibiscus sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates. Berchová, K; Hassan, ST; Majerová, M; Pokorná, M; Švajdlenka, E, 2016) | 0.43 |
| " Triple therapy group in combination with Curcumin significantly decreased all active, chronic and endoscopic inflammation scores of patients compared to the baseline and triple therapy group (P<0." | ( CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION. Asadollahi, K; Feizi, J; Hafezi Ahmadi, MR; Judaki, A; Rahmani, A, ) | 0.13 |
| "To assess the efficacy and safety of omeprazole given with the new single capsule of bismuth, metronidazole and tetracycline (OBMT) compared with quadruple treatment consisting of omeprazole, bismuth, amoxicillin and clarithromycin (OBAC) for Helicobacter pylori eradication in duodenal ulcer patients." | ( New single capsule of bismuth, metronidazole and tetracycline given with omeprazole versus quadruple therapy consisting of bismuth, omeprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a Chinese pro Chen, Y; Du, Y; Li, Y; Liu, D; Lv, N; Pan, X; Wang, H; Wang, J; Wu, K; Xie, Y; Xu, J; Zeng, Z; Zhang, G, 2018) | 0.99 |
| "gov Identifier: NCT02739997) to investigate the efficacy and safety of tazobactam/ceftolozane used in combination with metronidazole in Japanese patients with cIAI was conducted." | ( The efficacy and safety of tazobactam/ceftolozane in combination with metronidazole in Japanese patients with complicated intra-abdominal infections. Fujimoto, G; Fukuhara, T; Horiuchi, T; Mikamo, H; Miyasaka, Y; Monden, K; Rhee, EG; Shizuya, T; Yoshinari, T, 2019) | 0.96 |
| "To investigate the effect of Fuyanshu Capsules combined with Western medicine antibiotics on symptoms and inflammatory factors IL-10 and IL-1β in patients with pelvic inflammatory disease and its possible mechanism." | ( [Effect of Fuyanshu Capsules combined with antibiotics on inflammatory factors in patients with pelvic inflammatory disease]. Chen, J; Chen, L; Feng, XL; Jiang, S; Liu, X; Zhang, Y, 2019) | 0.51 |
| "To explore the effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor." | ( Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. Dai, Y; Peng, L, 2020) | 1.26 |
| " The observation group was treated with metronidazole combined with debridement gel while the control group received wet dressing therapy combined with silver sulfadiazine." | ( Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. Dai, Y; Peng, L, 2020) | 1.23 |
| "Metronidazole combined with autolytic debridement can effectively reduce the malodor of cancerous wounds while controlling infection, and alleviate patient stigma caused by malodor." | ( Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. Dai, Y; Peng, L, 2020) | 2.4 |
| "Ceftriaxone combined with metronidazole is superior to cefoxitin alone in preventing SSIs in children with uncomplicated appendicitis." | ( Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children: Results from a Multicenter Collaborative Comparative Effectiveness Study. Anandalwar, SP; Cameron, DB; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2021) | 1.22 |
| "To explore the efficacy and safety of ornidazole combined with periodontal tissue regeneration in the treatment of periodontitis." | ( [Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis]. DA, Y; Wang, MJ; Zheng, LC, 2020) | 0.83 |
| "Ornidazole combined with periodontal tissue regeneration can improve the level of periodontal index, alleviate oxidative stress injury, improve immune function, inhibit inflammation, and has a significant therapeutic effect with high safety." | ( [Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis]. DA, Y; Wang, MJ; Zheng, LC, 2020) | 0.83 |
| " She was administered cefoperazone and sulbactam sodium + metronidazole sodium chloride combined with morphine hydrochloride perioperatively, which caused a rash as an adverse side effect." | ( A case report of rash induced by cefoperazone sodium and sulbactam sodium plus metronidazole sodium chloride combined with morphine hydrochloride. Huang, J; Jiang, C; Liu, Z; Zhu, X, 2020) | 1.03 |
| " Clarithromycin combined with tinidazole can effectively improve the clinical effect of Helicobacter pylori-related gastritis and reduce the expression level of COX-2." | ( Clinical Effect of Clarithromycin Combined with Tinidazole on Helicobacter pylori-Related Gastritis and Its Influence on COX-2 Expression. He, C; Kong, F; Liu, Y; Wang, K; Zhao, W; Zhu, X, 2021) | 0.62 |
| " A total of 83 patients with PID were randomly divided into two groups: Western medicine group (control group, n=41) received oral antibiotics (azithromycin + metronidazole) alone and the traditional Chinese medicine combined with Western medicine group (experimental group, n=42) received Kangfuyan capsule based on Western medicine therapy." | ( Curative effect of kangfuyan capsule combined with antibiotic treatment on pelvic inflammatory disease. Chen, X; Chen, Y; Ouyang, YL; Wang, FW; Wang, L; Zhang, RJ, 2021) | 0.82 |
| " In this study, high doses of Bifidobacterium breve YH68 were used alone or in combination with vancomycin (VAN) and metronidazole (MTR) to treat pCDI mice." | ( Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model. Meng, L; Yang, H; Yang, J, 2022) | 1.15 |
| "For the treatment of trichomonas vaginitis, a combination therapy of metronidazole vaginal effervescent tablet combined with Flavescentis Sophora suppository is proposed." | ( Clinical Effect of Metronidazole Vaginal Effervescent Tablet Combined with Flavescentis Sophora Suppository in the Treatment of Trichomonas Vaginitis. Shi, L; Wang, X; Yang, D, 2022) | 1.28 |
| "In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ + blue light group, and then received 6-weeks' treatment." | ( Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris. Chen, F; Gao, L; Huang, X; Jiang, L; Lao, Y; Li, N; Lu, J; Lv, L; Yan, W; Yang, F; Yi, L; Zhang, B, 2023) | 1.46 |
| " The extraction procedure was combined with dispersive liquid-liquid microextraction for further preconcentration of the analytes for sensitive determination of the analytes followed by high performance liquid chromatography-diode array detector." | ( Determination of metronidazole and clarithromycin in plasma samples using surfactant-modified amorphous carbon-based DSPE combined with DLLME followed by HPLC. Abbasalizadeh, A; Afshar Mogaddam, MR; Farajzadeh, MA; Javanbakht, F; Nemati, M, 2023) | 1.25 |
| "This single-center study evaluated the efficacy and safety of tazobactam/ceftolozane (TAZ/CTLZ) in combination with metronidazole for intraabdominal infection in a hepato-biliary-pancreatic field in clinical practice." | ( Efficacy and safety of tazobactam/ceftolozane in combination with metronidazole for intraabdominal infection in a hepato-biliary-pancreatic field in clinical practice. Ishizawa, T; Kimura, K; Kinoshita, M; Kubo, S; Nishio, K; Ohira, G; Okada, T; Shinkawa, H; Shirai, D; Tanaka, S; Tani, N; Tauchi, J, 2023) | 1.36 |
| "This observational study demonstrated that TAZ/CTLZ in combination with metronidazole has a favorable effect without major drug-related adverse events for intraabdominal infection in the hepato-biliary-pancreatic field in clinical practice although the efficacy of TAZ/CTLZ may decrease in compromised patients." | ( Efficacy and safety of tazobactam/ceftolozane in combination with metronidazole for intraabdominal infection in a hepato-biliary-pancreatic field in clinical practice. Ishizawa, T; Kimura, K; Kinoshita, M; Kubo, S; Nishio, K; Ohira, G; Okada, T; Shinkawa, H; Shirai, D; Tanaka, S; Tani, N; Tauchi, J, 2023) | 1.38 |
The effect of food on the bioavailability of metronidazole from three commercial sugar-coated tablets varying markedly in drug dissolution behavior relative to pH was determined after oral administration in healthy male subjects with low gastric acidity. The authors evaluated the effect of cigarette smoking on the Bioavailability of Metronidzole in plasma and saliva.
Clinical trials are needed to assess the efficacy and cost-benefit ratio of a 12 h dosing regimen of ceftizoxime in combination with metronidazole. We prospectively evaluated this enteric phase in 50 patients with ALA.
| Role | Description |
|---|---|
| antitrichomonal drug | A drug used to treat trichomonas infections. |
| prodrug | A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. |
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| antimicrobial agent | A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. |
| antiparasitic agent | A substance used to treat or prevent parasitic infections. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| radiosensitizing agent | A drug that makes increases the sensitivity of tumour cells to radiation therapy. |
| antiamoebic agent | An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| imidazoles | A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. |
| C-nitro compound | A nitro compound having the nitro group (-NO2) attached to a carbon atom. |
| primary alcohol | A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| TDP1 protein | Homo sapiens (human) | Potency | 9.4411 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 7.9433 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.8489 | 0.0013 | 18.0743 | 39.8107 | AID926; AID938 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1049 | 0.0013 | 10.1577 | 42.8575 | AID1259256 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 70.6875 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0898 | 0.0002 | 29.3054 | 16,493.5996 | AID743075 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 130.6660 | 0.0391 | 47.5451 | 146.8240 | AID1224845 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 63.0957 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 7.0795 | 0.0100 | 39.5371 | 1,122.0200 | AID1479 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 12.3807 | 0.0398 | 16.7842 | 39.8107 | AID1454 |
| geminin | Homo sapiens (human) | Potency | 0.6310 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 52.2759 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.5119 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 32.2399 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 7.9433 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thioredoxin reductase | Entamoeba histolytica | Ki | 3.3000 | 3.3000 | 3.3000 | 3.3000 | AID1331809 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 (µMol) | 177.9000 | 0.0003 | 2.6311 | 9.0000 | AID1207750 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.1100 | 7.1903 | 10.0000 | AID1473738 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 (µMol) | 177.9000 | 0.0003 | 2.5955 | 9.0000 | AID1207750 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 (µMol) | 177.9000 | 0.0003 | 2.6311 | 9.0000 | AID1207750 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 (µMol) | 177.9000 | 0.0003 | 2.2545 | 9.6000 | AID1207750 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 (µMol) | 200.0000 | 0.0500 | 1.4390 | 4.0000 | AID322753 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Flavodoxin | Helicobacter pylori 26695 | MIC | 67.3000 | 2.9000 | 2.9000 | 2.9000 | AID1568972; AID1568973; AID1568974 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1510772 | Antibacterial activity against metronidazole-resistant Helicobacter pylori | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID533635 | Antimicrobial activity against Propionibacterium sp. by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID341089 | Antimicrobial activity against Clostridium difficile clinical isolates by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004. |
| AID573799 | Antibacterial activity against Prevotella buccae assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID425083 | Antimicrobial activity against beta lactamase-positive Prevotella nigrescens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522170 | Antimicrobial activity against Anaerococcus sp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID697913 | Antimicrobial activity against Helicobacter pylori 26695 ATCC 700392 at pH 5 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1348800 | Selectivity ratio of MIC for metronidazole-resistant Trichomonas vaginalis CDC085 ATCC 50143 to MIC for metronidazole-susceptible Trichomonas vaginalis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID534453 | Antimicrobial activity against Lactobacillus acidophilus JCM 1132 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID386926 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID522155 | Antimicrobial activity against Fusobacterium necrophorum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1486947 | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to IC50 for Leishmania mexicana MHOM/MX/ISETGS | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID498584 | Antimicrobial activity against Prevotella buccae LBN 465 deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID572014 | Antibacterial activity against Prevotella P denticola by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522207 | Antimicrobial activity against Clostridium difficile under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1755855 | Antileishmanial activity against promastigote form of Leishmania mexicana MHOM/BZ/82/Bel21 measured for 7 days by cell counting method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID498309 | Antimicrobial activity against Prevotella baroniae LBN 430 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID433149 | Antibacterial activity against Bacteroides thetaiotaomicron isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID433358 | Antibacterial activity against Clostridium perfringens isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID360611 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites after 48 hrs by MTT/PMS assay | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Antiprotozoal activity of the constituents of Conyza filaginoides. |
| AID572010 | Antibacterial activity against Fusobacterium varium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID498568 | Antimicrobial activity against Prevotella bivia LBN 332 deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID522202 | Antimicrobial activity against Clostridium baratii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1335754 | Antiparasitic activity against Trichomonas vaginalis in po dosed mouse assessed as size of abscess at 100 mg/kg, po administered daily for 5 days measured 5 days post last dose (Rvb = 120 mm'2) | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID574969 | Antimicrobial activity against Actinomyces israelii after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID285526 | Antibacterial activity against Propionibacterium acnes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID533631 | Antimicrobial activity against Propionibacterium acnes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID557968 | Antimicrobial activity in Clostridium sp. by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID571830 | Antibacterial activity against Ruminococcus gnavus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1434536 | Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. |
| AID561097 | Antibacterial activity against Porphyromonas asaccharolytica by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1461559 | Displacement of [3H]U-69,593 from human kappa opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysis | 2017 | Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16 | Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. |
| AID147159 | Compound was evaluated for antimicrobial activity against Neisseria meningitidis | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID574726 | Antimicrobial activity against Prevotella oralis assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID386923 | Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID23442 | Partition coefficient (logP) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity. |
| AID534460 | Antimicrobial activity against Bacteroides fragilis GAI 5562 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1676971 | Antimicrobial activity against Clostridioides difficile ATCC BAA 1801 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID172621 | The amount of unchanged compound in urine collected at 0-54 hr after treatment | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID424324 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1697413 | Antibacterial activity against Helicobacter pylori 51 assessed as reduction in microbial growth after 24 hrs by two-fold serial dilution method | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10 | Polyhalogenation of Isoflavonoids by the Termite-Associated |
| AID1879543 | Antibacterial activity against rifampicin/fluoroquinolone-resistant Clostridioides difficile CB1942 harboring rpoBQ489K/gyrAD71Y/T82A mutant measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID571792 | Antibacterial activity against Clostridium hathewayi by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285551 | Bactericidal activity against 5-day old actively replicating Mycobacterium tuberculosis H37Rv in aerobic condition at 8 ug/ml by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID573784 | Antibacterial activity against Prevotella bivia by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID571804 | Antibacterial activity against Clostridium hypermegas by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1743063 | Antigiardial activity against metronidazole-resistant Giardia duodenalis BRIS/83/HEPU/106-2ID10 incubated for 3 days followed by compound wash-out and measured after 4 days | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID557464 | Antimicrobial activity in Prevotella disiens by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID533388 | Antimicrobial activity against Clostridium difficile assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1761175 | Giardicidal activity against Giardia intestinalis WB ATCC 30957 incubated for 48 hrs by hemocytometric counting method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. |
| AID1225674 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 150 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID1879530 | Antibacterial activity against rifampicin-resistant Clostridioides difficile CB1934 harboring rpoBQ489K mutant measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID69329 | Minimum inhibitory concentration measured against Escherichia coli EE349 strain (UvrB- Rec+) | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID521818 | Antimicrobial activity against Prevotella nigrescens isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID534691 | Antimicrobial activity against Prevotella intermedia by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID172622 | The amount of unchanged compound in urine collected at 0-72 h after treatment | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID433170 | Antibacterial activity against Peptostreptococcus micros isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID562224 | Antimicrobial activity against Desulfovibrio piger by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID498336 | Antimicrobial activity against Prevotella bivia LBP 52 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID574780 | Antimicrobial activity against Clostridium difficile assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1204233 | Toxicity in albino mouse assessed as mortality at 50 to 100 mg/kg indomethacin mol equivalent, ip measured after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID424331 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID366965 | Cytotoxicity against human KB cells after 44 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | New Pd(II) complexes of the synthesized 1-N-substituted thiosemicarbazones of 3-indole carboxaldehyde: characterization and antiamoebic assessment against E. histolytica. |
| AID498323 | Antimicrobial activity against Prevotella bivia LBN 346 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID433198 | Antibacterial activity against Bacteroides fragilis isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID375870 | Antigiardial activity against metronidazole-sensitive Giardia lamblia isolate 713 trophozoite after 2 days by bactiter-glo viability assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID433017 | Antibacterial activity against Bacteroides fragilis isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID531522 | Antibacterial activity against Bacteroides merdae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID561090 | Antibacterial activity against Bacteroides fragilis by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID572017 | Antibacterial activity against Prevotella intermedia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID498322 | Antimicrobial activity against Prevotella bivia LBN 343 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID534695 | Antimicrobial activity against Porphyromonas gingivalis by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID573823 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1917493 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID521810 | Antimicrobial activity against Porphyromonas salivosa isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID573835 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID425075 | Antimicrobial activity against beta lactamase-positive Bacteroides fragilis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID521819 | Antimicrobial activity against Prevotella oralis isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID534706 | Antimicrobial activity against Peptoniphilus asaccharolyticus by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID341722 | Antibacterial activity against Helicobacter pylori SS1 after 96 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antimicrobial diterpenes from Trigonostemon chinensis. |
| AID1585774 | Antiparasitic activity against bloodstream form of Trypanosoma brucei brucei strain 427 after 48 hrs by resazurin dye-based assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID1365695 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days under aerobic condition | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | The antitubercular activity of various nitro(triazole/imidazole)-based compounds. |
| AID574985 | Antimicrobial activity against Actinomyces naeslundii assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID573601 | Antibacterial activity against Fusobacterium necrophorum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1755866 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites incubated for 2 days under anaerobic condition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID575275 | Antimicrobial activity against Clostridium difficile by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID572007 | Antibacterial activity against Bacteroides splanchnicus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID557456 | Antimicrobial activity in Prevotella nigrescens by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID490821 | Antitrichinellosis activity against Trichinella spiralis ML assessed as reduction of parasites viability at 0 37 uM after 3 days by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID522188 | Antimicrobial activity against Eubacterium saburreum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID433356 | Antibacterial activity against Porphyromonas somerae isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID557714 | Antimicrobial activity in Fusobacterium necrophorum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID557440 | Antimicrobial activity in Prevotella buccae by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID574979 | Antimicrobial activity against Actinomyces meyeri assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID571811 | Antibacterial activity against Clostridium sporogenes by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425079 | Antimicrobial activity against beta lactamase-positive Bacteroides distasonis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID571802 | Antibacterial activity against Clostridium disporicum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID531529 | Antibacterial activity against Bacteroides uniformis isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1367036 | Antibacterial activity against drug-resistant Escherichia coli after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID521806 | Antimicrobial activity against Porphyromonas circumdentaria isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID433363 | Antibacterial activity against Clostridium malenominatum isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID490816 | Antiprotozoal activity against Giardia intestinalis IMSS:0989:1 after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID533397 | Antimicrobial activity against Clostridium paraputrificum by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID557742 | Antimicrobial activity in Anaerococcus tetradius by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID574051 | Antibacterial activity against beta-lactamase producing Finegoldia magna assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1331806 | Cytotoxicity against CHO cells assessed as reduction in cell viability at 2.5 to 25 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID1755865 | Antigiardial activity against Giardia intestinalis WB incubated for 2 days under anaerobic condition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID533401 | Antimicrobial activity against Clostridium subterminale by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1731671 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Trichomonas vaginalis IR78 trophozoites | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. |
| AID157257 | Minimum inhibitory concentration against Peptostreptococcus anaerobius(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID522133 | Antimicrobial activity against Bacteroides fragilis spp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID698048 | Inhibition of Helicobacter pylori adhesion to human AGS cells at 20 ug/ml after 6 hrs by gentamicin assay relative to control | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID534470 | Antimicrobial activity against Bacteroides ovatus ATCC 8483 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID522173 | Antimicrobial activity against Peptoniphilus harei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573825 | Antibacterial activity against beta-lactamase producing Clostridium tertium by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID571803 | Antibacterial activity against Clostridium glycolicum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID666990 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
| AID522181 | Antimicrobial activity against Propionibacterium avidum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID472376 | Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates. |
| AID574762 | Antimicrobial activity against Peptoniphilus asaccharolyticus assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1066689 | Antiprotozoal activity against Giardia lamblia IMSS:1090:1 | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Structure, absolute configuration, and antidiarrheal activity of a thymol derivative from Ageratina cylindrica. |
| AID425080 | Antimicrobial activity against beta lactamase-positive Prevotella bivia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID498307 | Antimicrobial activity against Prevotella baroniae DSM 16972T expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID522196 | Antimicrobial activity against Clostridium inoculum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID561094 | Antibacterial activity against Clostridium perfringens by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID536460 | Antimicrobial activity against Microsporum gypseum at 50 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID574050 | Antibacterial activity against beta-lactamase producing Finegoldia magna by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID533409 | Antimicrobial activity against Finegoldia magna by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID433162 | Antibacterial activity against Clostridium malenominatum isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID559488 | Antibacterial activity against Peptostreptococcus sp. by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID75267 | Inhibitory concentration against G. Lamblia (IMSS-0989) for antigiardial activity | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives. |
| AID625278 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID416728 | Specificity index, ratio of IC50 for human THP1 cells to IC50 for Trichomonas vaginalis TVR87 | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID1585768 | Antibacterial activity against Clostridium difficile 630 ATCC BAA-1382 by broth microdilution assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID1367034 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID534472 | Antimicrobial activity against Bacteroides uniformis ATCC 8492 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID573785 | Antibacterial activity against Prevotella intermedia by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID531719 | Antibacterial activity against Bacteroides fragilis isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID554697 | Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica NTR2 after 16 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID1510717 | Antibacterial activity against drug-resistant Helicobacter pylori assessed as zone of inhibition at 8 ug/disc | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID656873 | Cytotoxicity against human MCF7 cells assessed as cell viability at 2.5 to 100 uM after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica. |
| AID572015 | Antibacterial activity against Prevotella P disiens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879559 | Antibacterial activity against Fusobacterium nucleatum ATCC 10953 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498327 | Antimicrobial activity against Prevotella bivia LBN 371 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID571831 | Antibacterial activity against Ruminococcus obeum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID386925 | Antifungal activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID554699 | Ratio of EC50 for Escherichia coli JM109 transformed with empty vector PQE30 to EC50 for Escherichia coli JM109 transformed with Entamoeba histolytica NTR2 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID557420 | Antimicrobial activity in Bacteroides vulgatus by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID26811 | Partition coefficient (logP) | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. |
| AID533425 | Antimicrobial activity against Peptostreptococcus sp. by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID757805 | Antiprotozoal activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs by haemocytometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives. |
| AID574504 | Antimicrobial activity against Bacteroides caccae assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1755863 | Antigiardial activity against Giardia intestinalis MSS:0696:1 incubated for 48 hrs | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID322753 | Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay | 2007 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 35, Issue:3 | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. |
| AID574740 | Antimicrobial activity against Peptostreptococcus anaerobius after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID571819 | Antibacterial activity against Bifidobacterium dentium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1731669 | Cytotoxicity against African green monkey Vero cells | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. |
| AID1743084 | Antigiardial activity against Giardia intestinalis incubated for 48 hrs | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID522204 | Antimicrobial activity against Clostridium butyricum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID559487 | Antibacterial activity against Fusobacterium sp. by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1599240 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as reduction in body weight at 50 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID417443 | Cytotoxicity against HEK cells after 44 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | New derivatives of 3,5-substituted-1,4,2-dioxazoles: synthesis and activity against Entamoeba histolytica. |
| AID425084 | Antimicrobial activity against beta lactamase-positive Prevotella melaninogenica isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID498581 | Antimicrobial activity against Prevotella bivia LBN 332 deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1743093 | Half-life of the compound | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1676999 | Antibacterial activity against Bacteroides dorei HM-719 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID561091 | Antibacterial activity against Bacteroides vulgatus by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1317946 | Antiparasitic activity against metronidazole sensitive Giardia lamblia WB trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID572018 | Antibacterial activity against Prevotella nigrescens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1317951 | Antiparasitic activity against Clostridium difficile NAP1/027 ATCC BAA-1803 after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID380458 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID490817 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID433165 | Antibacterial activity against Anaerococcus prevotii isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID575005 | Antimicrobial activity against Eubacterium sp. after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1244341 | Anti-trichomonas activity against MTZ-resistant Trichomonas vaginalis incubated for 3 to 48 hrs by trypan blue exclusion assay | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID557412 | Antimicrobial activity in Bacteroides thetaiotaomicron by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID522158 | Antimicrobial activity against Veillonella spp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1135604 | Antimicrobial activity against Entamoeba histolytica NIH 200-mu cecal forms infected in Wistar albino rat assessed as cure rate administered qd for 5 days by microscopic analysis | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents. |
| AID1599200 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes harboring luciferase reporter gene at 25 uM after 48 hrs by Steady-Glo luminescence assay relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID554618 | Prodrug activation in Helicobacter pylori CAS 015 J0 lysate assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID75265 | In vitro antiprotozoal activity against Giardia lamblia | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2 | Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives. |
| AID319572 | Antibacterial activity against metronidazole-sensitive Helicobacter pylori assessed as inhibition zone diameter at 8 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID574738 | Antimicrobial activity against Fusobacterium mortiferum after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1545441 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as diameter of zone inhibition at 30 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID44956 | Antifungal activity against Candida albicans, activity expressed as minimum inhibitory concentration (ug/mL) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1683300 | Induction of apoptosis in Entamoeba histolytica HM1:MMS trophozoites assessed as viable cells at IC50 concentration after 48 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 98%) | |||
| AID554616 | Prodrug activation in Helicobacter pylori RIG 117 J0 lysate assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID533393 | Antimicrobial activity against Clostridium innocuum by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID425078 | Antimicrobial activity against beta lactamase-positive Bacteroides vulgatus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID440729 | Antimycobacterial activity against 30 day old non-replicating dormant cultures of Mycobacterium tuberculosis H37Rv assessed as reduction of bacterial viability measured after 11 days by resazurin reduction assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. |
| AID1879554 | Antibacterial activity against metronidazole-resistant Bacteroides ovatus MMX 3504 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID477786 | Cytotoxicity against african green monkey Vero cells after 72 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | New dioxazole derivatives: Synthesis and effects on the growth of Entamoeba histolytica and Giardia intestinalis. |
| AID377875 | Antifungal activity against Giardia intestinalis ATCC 30888 after 48 hrs by XTT assay | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Antigiardial activity of isoflavones from Dalbergia frutescens bark. |
| AID484210 | Antiprotozoal activity against Entamoeba invadens after 24 hrs by trypan blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates. |
| AID1760139 | Antibacterial activity against gut Veillonella sp HM-49 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID572005 | Antibacterial activity against Bacteroides thetaiotaomicron by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID521815 | Antimicrobial activity against Bacteroides heparinolyticus isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID571805 | Antibacterial activity against Clostridium leptum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID572021 | Antibacterial activity against Prevotella oralis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574987 | Antimicrobial activity against Bifidobacterium adolescentis after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1274890 | Antiparasitic activity against Trichomonas vaginalis 162 after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents. |
| AID572008 | Antibacterial activity against Bilophila wadsworthia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574776 | Antimicrobial activity against Clostridium difficile after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID87942 | Compound was evaluated for antimicrobial activity against Helicobacter pylori | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID554606 | Antimicrobial activity against compound-resistant Helicobacter pylori 10593a/2 harboring rdxA C177stop mutant gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID498560 | Antimicrobial activity against Prevotella buccae LBN 465 deficient in nimI gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID571993 | Antibacterial activity against Anaerococcus tetradius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID598286 | Antimalarial activity against Plasmodium berghei schizonts isolated from parasitized erythrocytes infected Wistar rat measured 16 hrs post compound exposure | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID572001 | Antibacterial activity against Parabacteroides distasonis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425094 | Antimicrobial activity against beta lactamase-positive Fusobacterium mortiferum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID557424 | Antimicrobial activity in Bacteroides distasonis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID534698 | Antimicrobial activity against Fusobacterium necrophorum by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID533420 | Antimicrobial activity against Micromonas micros assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID533412 | Antimicrobial activity against Finegoldia magna assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID522142 | Antimicrobial activity against Prevotella melaninogenica under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522137 | Antimicrobial activity against Bacteroides ovatus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID698055 | Antimicrobial activity against Helicobacter pylori 26695 ATCC 700392 at 800 ug/ml by disk agar diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1317947 | Antiparasitic activity against metronidazole resistant Giardia lamblia 713M3 trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID533413 | Antimicrobial activity against Peptoniphilus asaccharolyticus by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1294236 | Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for metronidazole-sensitive Trichomonas vaginalis JH31A#4 trophozoites | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles. |
| AID571797 | Antibacterial activity against Clostridium bartlettii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1420362 | Antibacterial activity against Helicobacter pylori after 48 hrs | 2018 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 28, Issue:19 | Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study. |
| AID531530 | Antibacterial activity against Bacteroides thetaiotaomicron isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID557972 | Antimicrobial activity in Clostridium tertium by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID425076 | Antimicrobial activity against beta lactamase-positive Bacteroides thetaiotaomicron isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522190 | Antimicrobial activity against Slackia exigua under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1683293 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as total bilirubin level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 0.8 +/- 0.2 mg/dl) | |||
| AID522171 | Antimicrobial activity against Gemella morbillorum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1879527 | Antibacterial activity against Clostridioides difficile CB1921 ATCC BAA1382 measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498574 | Antimicrobial activity against Bacteroides fragilis ATCC 25285T deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534679 | Antimicrobial activity against Desulfovibrio piger DSM 749 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID425091 | Antimicrobial activity against beta lactamase-positive Fusobacterium nucleatum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID425112 | Antimicrobial activity against beta lactamase-positive Prevotella intermedia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534703 | Antimicrobial activity against Finegoldia magna by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1867247 | Antibacterial activity against multidrug resistant Helicobacter pylori HP159 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method | |||
| AID522193 | Antimicrobial activity against Lactobacillus rhamnosus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID502777 | Antibacterial activity against Helicobacter pylori ATCC 700392 at 0.8 ug/ml by disk agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID534684 | Antimicrobial activity against Bacteroides thetaiotaomicron by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID757806 | Antiprotozoal activity against trophozoite stage of Giardia intestinalis IMSS:0981:1 assessed as growth inhibition after 48 hrs by haemocytometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives. |
| AID1146201 | Therapeutic index, ratio of LD50 for po dosed mouse to ED50 for Trichomonas vaginalis infected in po dosed mouse | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID574991 | Antimicrobial activity against Bifidobacterium adolescentis assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID252979 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 1 mg/mL after 24 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID571800 | Antibacterial activity against Clostridium butyricum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID554813 | Prodrug activation in compound-resistant Helicobacter pylori HER 126 V4 lysate assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID498541 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 365 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1879566 | Antibacterial activity against Peptoniphilus asaccharolyticus ATCC 29743 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID531785 | Antibacterial activity against Prevotella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1879564 | Antibacterial activity against Mobiluncus mulieris ATCC 35243 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID285564 | Bactericidal activity against 26-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 1 day by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID571798 | Antibacterial activity against Clostridium beijerinckii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID534431 | Antimicrobial activity against Peptoniphilus asaccharolyticus WAL 3218 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571173 | Antimicrobial activity against Clostridium difficile harboring ribotype 001 by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. |
| AID572019 | Antibacterial activity against Prevotella loescheii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574973 | Antimicrobial activity against Actinomyces israelii assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID574983 | Antimicrobial activity against Actinomyces naeslundii assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1147715 | Antibacterial activity against Trichomonas vaginalis ATCC 30001 after 48 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID522150 | Antimicrobial activity against Prevotella oris under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1676979 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID534462 | Antimicrobial activity against Bacteroides fragilis NCTC 10581 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID574752 | Antimicrobial activity against Anaerococcus prevotii after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID369334 | Antimicrobial activity against log phase recombinant Mycobacterium tuberculosis H37Rv-lux with plasmid MV361 at 10 ug/ml incubated for 7 days assessed as bacterial count | 2000 | Nature, Jun-22, Volume: 405, Issue:6789 | A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. |
| AID1225679 | Cytotoxicity against African green monkey Vero cells at 300 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID433169 | Antibacterial activity against Peptostreptococcus anaerobius isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID498320 | Antimicrobial activity against Prevotella bivia LBN 336 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID571821 | Antibacterial activity against Bifidobacterium longum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571172 | Antimicrobial activity against Clostridium difficile harboring ribotype 027 by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. |
| AID574999 | Antimicrobial activity against Eubacterium lentum after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1146227 | Toxicity in CF1 mouse assessed as cyanosis at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID534690 | Antimicrobial activity against Odoribacter splanchnicus by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID574482 | Antimicrobial activity against Bacteroides fragilis after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID598287 | Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID200314 | Antifungal activity against Saccharomyces cerevisiae, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1146200 | Acute toxicity in po dosed mouse | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID571832 | Antibacterial activity against Ruminococcus albus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522169 | Antimicrobial activity against Anaerococcus vaginalis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573592 | Antibacterial activity against Fusobacterium mortiferum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1879519 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1771 harboring rpoBL525I/D530N/rdxAE75stop mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID484209 | Antiprotozoal activity against Entamoeba histolytica after 24 hrs by trypan blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates. |
| AID433152 | Antibacterial activity against Parabacteroides distasonis isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID9473 | Average intracellular compound concentration where the hypoxia sensitizer enhancement ratio (SER)=1.6 | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID67524 | In vitro antiprotozoal activity against Entamoeba histolytica | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2 | Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives. |
| AID554691 | Activity of Entamoeba histolytica NTR2 at 50 uM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID531519 | Antibacterial activity against Bacteroides thetaiotaomicron assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID522161 | Antimicrobial activity against Finegoldia magna under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574742 | Antimicrobial activity against Peptostreptococcus micros after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID249328 | Minimal inhibitory concentration against 17 strains of Helicobacter pylori | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID750272 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID433368 | Antibacterial activity against Finegoldia magna isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID574026 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID571813 | Antibacterial activity against Clostridium tertium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425103 | Antimicrobial activity against Clostridium innocuum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID574975 | Antimicrobial activity against Actinomyces meyeri after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID574486 | Antimicrobial activity against Bacteroides caccae after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1055955 | Antimycobacterial activity against cycloserine-resistant Mycobacterium tuberculosis ATCC 35826 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1676980 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 51299 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID1067254 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 2 ug/ml after 24 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID1147712 | Antibacterial activity against Clostridium perfringens ATCC 13124 after 24 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID67523 | In vitro antiamnesic activity was evaluated against HK-9 strain of Entamoeba histolytica | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20 | Synthesis, characterisation and antiamoebic activity of new thiophene-2-carboxaldehyde thiosemicarbazone derivatives and their cyclooctadiene Ru(II) complexes. |
| AID341723 | Antibacterial activity against metronidazole-resistant Helicobacter pylori ATCC 43504 after 96 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antimicrobial diterpenes from Trigonostemon chinensis. |
| AID433018 | Antibacterial activity against Bacteroides caccae isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID557436 | Antimicrobial activity in Prevotella bivia by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID210972 | Percentage viability reduction of Trichinella spiralis muscle larvae after 3 days of incubation; Not determined | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Synthesis and antiparasitic activity of 1H-benzimidazole derivatives. |
| AID1067252 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 1 ug/ml after 24 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID433156 | Antibacterial activity against Prevotella bivia isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID574993 | Antimicrobial activity against Bifidobacterium sp. after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID522180 | Antimicrobial activity against Propionibacterium acnes under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID571994 | Antibacterial activity against Finegoldia magna by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID393131 | Antiprotozoal activity against Giardia intestinalis IMSS:0981:1 trophozoites after 48 hrs | 2009 | Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4 | Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives. |
| AID1055966 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X001354 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID534480 | Antimicrobial activity against Prevotella heparinolytica ATCC 35895 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID562220 | Antimicrobial activity against Desulfovibrio sp. by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID1125376 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 150 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1335739 | Antiparasitic activity against metronidazole resistant Trichomonas vaginalis ATCC 50143 after 48 hrs by trypan blue exclusion assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID1416870 | Antiparasitic activity against Giardia lamblia WB trophozoites assessed as parasite growth inhibition after 48 hrs by ATP bioluminescence-based CellTiter-Glo luminescent cell viability assay | 2017 | MedChemComm, , Volume: 8, Issue:10 | Design, Synthesis and Preliminary Antimicrobial Evaluation of |
| AID1515378 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2 | Metronidazole aryloxy, carboxy and azole derivatives: Synthesis, anti-tumor activity, QSAR, molecular docking and dynamics studies. |
| AID490822 | Antitrichinellosis activity against Trichinella spiralis ML assessed as reduction of parasites viability at 1.8 uM after 3 days by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID521814 | Antimicrobial activity against Prevotella disiens isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID194146 | The total 72 hr urinary excretion of unchanged compound reported as log (percent X 10) of the administered dose | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID559486 | Antibacterial activity against Clostridium perfringens by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID425100 | Antimicrobial activity against Peptoniphilus asaccharolyticus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID498338 | Antimicrobial activity against Prevotella bivia LBP 69 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID79590 | Minimum bactericidal concentration against Helicobacter pylori ATCC 43504; range 2-4 ug/mL | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 1. |
| AID386924 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID425081 | Antimicrobial activity against beta lactamase-positive Prevotella disiens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID324729 | Antimicrobial activity against Fusobacterium nucleatum biofilms assessed as decrease in viable cell count at 2 uM after 30 mins | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria. |
| AID554603 | Antimicrobial activity against Helicobacter pylori RIG 117 J0 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID522164 | Antimicrobial activity against Peptostreptococcus anaerobius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574034 | Antibacterial activity against beta-lactamase producing Micromonas micros assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID574512 | Antimicrobial activity against Bacteroides vulgatus assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID522160 | Antimicrobial activity against Anaerococcus tetradius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425085 | Antimicrobial activity against beta lactamase-positive Prevotella denticola isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID573822 | Antibacterial activity against beta-lactamase producing Clostridium perfringens by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID477787 | Safety index, ratio of IC50 for african green monkey Vero cells to IC50 for Entamoeba histolytica HM-1:IMSS | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | New dioxazole derivatives: Synthesis and effects on the growth of Entamoeba histolytica and Giardia intestinalis. |
| AID1067349 | Antimicrobial activity against Trichomonas vaginalis GT3 incubated for 48 hrs followed by compound washout measured after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | 2-acylamino-5-nitro-1,3-thiazoles: preparation and in vitro bioevaluation against four neglected protozoan parasites. |
| AID675034 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors. |
| AID1147714 | Antibacterial activity against Neisseria gonorrhoeae ATCC 19424 after 48 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID557738 | Antimicrobial activity in Peptoniphilus asaccharolyticus by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID498544 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 445 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID323659 | Antibacterial activity against Peptostreptococcus anaerobius | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. |
| AID572012 | Antibacterial activity against Prevotella buccae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID521812 | Antimicrobial activity against Prevotella corporis isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID1676994 | Antibacterial activity against Lactobacillus gasseri HM-400 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID534455 | Antimicrobial activity against Lactobacillus casei subsp. casei JCM 1134 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID252980 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 1 mg/mL after 48 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID644764 | Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold. |
| AID1879499 | Antibacterial activity against rifampicin-resistant Clostridioides difficile harboring rpoBQ489K mutant | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID386920 | Spermicidal activity in liquefied human semen assessed as drug level required to kill 100% sperm in 20 seconds | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID522178 | Antimicrobial activity against Actinomyces odontolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID498565 | Antimicrobial activity against Prevotella baroniae LBN 432 expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID571810 | Antibacterial activity against Clostridium spiroforme by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879515 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1614 harboring rpoBL525I/D530N mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID557718 | Antimicrobial activity in Fusobacterium mortiferum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID588220 | Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset | 2008 | Toxicology mechanisms and methods, , Volume: 18, Issue:2-3 | Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. |
| AID534707 | Antimicrobial activity against Eggerthella lenta by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID40360 | Stability towards beta-lactamase was determined in penicillinase; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID502039 | Antimicrobial activity against Trichomonas vaginalis GT3 after 48 hrs | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas. |
| AID1055958 | Antimycobacterial activity against moxifloxacin-resistant Mycobacterium tuberculosis under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1367035 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID522184 | Antimicrobial activity against Colinsella aerofaciens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1294235 | Trichomonacidal activity against metronidazole-resistant Trichomonas vaginalis IR78 trophozoites after 24 hrs by resazurin dye based fluorescence assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles. |
| AID571793 | Antibacterial activity against Clostridium innocuum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522136 | Antimicrobial activity against Bacteroides merdae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425077 | Antimicrobial activity against beta lactamase-positive Bacteroides ovatus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID425109 | Antimicrobial activity against Clostridium cadaveris isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID521817 | Antimicrobial activity against Prevotella loescheii isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID433020 | Antibacterial activity against Bacteroides stercoris isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID433353 | Antibacterial activity against Parabacteroides distasonis isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID572003 | Antibacterial activity against Bacteroides fragilis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID572002 | Antibacterial activity against Parabacteroides merdae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID598283 | Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID531524 | Antibacterial activity against Bacteroides spp. isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1225678 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 9.37 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID571829 | Antibacterial activity against Propionibacterium propionicus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID666991 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
| AID87945 | Evaluated for antimicrobial activity against Helicobacter pylori | 1997 | Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16 | Anti-Helicobacter pylori agents. 1. 2-(Alkylguanidino)-4-furylthiazoles and related compounds. |
| AID522183 | Antimicrobial activity against Atopobium parvulum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID433159 | Antibacterial activity against Clostridium cadaveris isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1599201 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes harboring luciferase reporter gene infected in mouse J774 cells at 50 uM after 48 hrs by Steady-Glo luminescence assay relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID1755822 | Antibacterial activity against Clostridium perfringens ATCC 13124 incubated for 48 hrs under anaerobic condition by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID522132 | Antimicrobial activity against Bacteroides thetaiotaomicron under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534693 | Antimicrobial activity against Prevotella melaninogenica by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID522162 | Antimicrobial activity against Parvimonas micra under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID557710 | Antimicrobial activity in Fusobacterium nucleatum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1063472 | Antibacterial activity against Lactobacillus reuteri ATCC 23272 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1879528 | Antibacterial activity against Clostridioides difficile CB1921 ATCC BAA1382 at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID531784 | Antibacterial activity against Bacteroides fragilis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID285515 | Antibacterial activity against Clostridium difficile by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1917492 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID534708 | Antimicrobial activity against Eubacterium limosum by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID498319 | Antimicrobial activity against Prevotella bivia LBN 334 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1461557 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysis | 2017 | Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16 | Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. |
| AID1135253 | Trichomonastatic activity against Trichomonas vaginalis by tube dilution method | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. |
| AID424329 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID377878 | Antifungal activity against Giardia intestinalis ATCC 30888 assessed as impairment of parasite motility after 4 hrs | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Antigiardial activity of isoflavones from Dalbergia frutescens bark. |
| AID67525 | In vitro growth inhibition against Entamoeba histolytica | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. |
| AID1225680 | Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID380455 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID43006 | Antimicrobial activity was measured against Clostridium perfringens organism; Value ranges from 0.78-3.13 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID573597 | Antibacterial activity against Fusobacterium necrophorum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID557448 | Antimicrobial activity in Prevotella denticola by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID522182 | Antimicrobial activity against Eggerthella lenta under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID433371 | Antibacterial activity against Peptostreptococcus micros isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID561096 | Antibacterial activity against Peptostreptococcus micros by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID319575 | Antibacterial activity against metronidazole-resistant Helicobacter pylori assessed as inhibition zone diameter at 8 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID571996 | Antibacterial activity against Peptostreptococcus anaerobius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID557452 | Antimicrobial activity in Prevotella intermedia by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID534680 | Antimicrobial activity against Capnocytophaga ochracea GAI 5586 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571794 | Antibacterial activity against Clostridium perfringens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522208 | Antimicrobial activity against Clostridium glycolicum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID557730 | Antimicrobial activity in Micromonas micros by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1146197 | Antimicrobial activity against Trichomonas vaginalis by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID571999 | Antibacterial activity against Streptococcus constellatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574770 | Antimicrobial activity against Clostridium perfringens after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID534433 | Antimicrobial activity against Peptostreptococcus anaerobius ATCC 27337 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID573572 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1599234 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as reduction in body weight at 12.5 to 200 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID346842 | Antimycobacterial activity against Mycobacterium tuberculosis with deazaflavin-dependent nitroreductase mutant | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles. |
| AID1327936 | Antifungal activity against Aspergillus niger at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID554796 | Prodrug activation in Helicobacter pylori HER 126 V1 lysate assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID571988 | Antibacterial activity against Ruminococcus lactaris by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID573801 | Antibacterial activity against Prevotella intermedia assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1879502 | Antibacterial activity against Helicobacter pylori ATCC 700392 at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID433359 | Antibacterial activity against Clostridium aminovalericum isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID571834 | Antibacterial activity against Ruminococcus luti by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1540922 | Antibacterial activity against Clostridium difficile VPI 10463 ATCC 43255 assessed as bacterial growth inhibition incubated for 48 hrs under anaerobic condition by CLSI protocol based assay | |||
| AID531527 | Antibacterial activity against Bacteroides vulgatus isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID502657 | Cytotoxicity against BALB/c mouse splenocyte by [3H]thymidine incorporation assay | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Structure-activity relationships of mononuclear metal-thiosemicarbazone complexes endowed with potent antiplasmodial and antiamoebic activities. |
| AID522165 | Antimicrobial activity against Peptostreptococcus stomatis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1194389 | Trichomonicidal activity against Trichomonas vaginalis GT3 compound treated for 48 hrs followed by incubation for 48 hrs in compound-free medium by cell counting | 2015 | Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9 | Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis. |
| AID522176 | Antimicrobial activity against Actinomyces meyeri under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1545437 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as diameter of zone inhibition at 30 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID574516 | Antimicrobial activity against Bacteroides ovatus assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID531517 | Antibacterial activity against Bacteroides vulgatus assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID534692 | Antimicrobial activity against Prevotella sp. by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID548282 | Antimicrobial activity against Trypanosoma brucei NfxR2 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. |
| AID1146161 | Antibacterial activity against Escherichia coli SKF 12140 assessed as growth inhibition | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID1879573 | Antibacterial activity against Prevotella disiens MMX 3457 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID618300 | Cytotoxicity against rat H9c2 cells assessed as cell viability at 200 uM after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID1585766 | Antiparasitic activity against Giardia lamblia WB trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID534447 | Antimicrobial activity against Bifidobacterium breve ATCC 15700 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID245320 | Minimal inhibitory concentration against metronidazole resistant Helicobacter pylori NCTC 11637 strain | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID433369 | Antibacterial activity against Peptoniphilus asaccharolyticus isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID698051 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v633 at pH 5 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID252982 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 2 mg/ml after 48 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID1510718 | Antibacterial activity against drug-sensitive Helicobacter pylori assessed as zone of inhibition at 8 ug/disc | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID571799 | Antibacterial activity against Clostridium bifermentans by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1755857 | Antigiardial activity against Giardia intestinalis WB ATCC 30957 incubated for 72 hrs by trypan blue staining based assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID433164 | Antibacterial activity against Propionibacterium acnes isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID425092 | Antimicrobial activity against Fusobacterium necrophorum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID574041 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID534475 | Antimicrobial activity against Campylobacter gracilis JCM 8538 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID380460 | Antibacterial activity against Bacteroides thetaiotaomicron DSM 2255 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID557952 | Antimicrobial activity in Actinomyces by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1683315 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as creatinine level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 0.9 +/- 0.06 mg/dl) | |||
| AID554690 | Activity of Entamoeba histolytica NTR1 at 50 uM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID502656 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microplate method | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Structure-activity relationships of mononuclear metal-thiosemicarbazone complexes endowed with potent antiplasmodial and antiamoebic activities. |
| AID1731668 | Antimicrobial activity against Trichomonas vaginalis IR78 trophozoites assessed as reduction in parasitic growth incubated for 24 hrs by resazurin dye based fluorescence assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. |
| AID498558 | Antimicrobial activity against slow growing colonies of Prevotella nanceiensis LBN 410 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1317949 | Antiparasitic activity against metronidazole sensitive Trichomonas vaginalis F1623 trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID1599235 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as death at 25 mg/kg, po administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID522175 | Antimicrobial activity against Actinomyces israelii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID417444 | Safety index, ratio of IC50 for HEK cells to IC50 for Entamoeba histolytica HM-1:IMSS | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | New derivatives of 3,5-substituted-1,4,2-dioxazoles: synthesis and activity against Entamoeba histolytica. |
| AID522198 | Antimicrobial activity against Clostridium aldenense under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1500579 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days measured under aerobic conditions by fluorescence-based assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. |
| AID534697 | Antimicrobial activity against Fusobacterium nucleatum by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID572013 | Antibacterial activity against Prevotella corporis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571812 | Antibacterial activity against Clostridium sporosphaeroides by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID16036 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-1 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID536462 | Antimicrobial activity against Aspergillus flavus at 50 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID1317955 | Selectivity index, ratio of CC50 for HEK293 cells to EC50 for metronidazole sensitive Giardia lamblia WB trophozoites | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID510492 | Antimicrobial activity against Porphyromonas gingivalis assessed as reduction in average number of microcolonies at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID561095 | Antibacterial activity against Peptostreptococcus anaerobius by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID557746 | Antimicrobial activity in Anaerococcus prevotii by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID19424 | Partition coefficient (logD7.4) | 2001 | Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15 | ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. |
| AID534448 | Antimicrobial activity against Bifidobacterium longum subsp. longum ATCC 15707 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571823 | Antibacterial activity against Catenibacterium mitsuokai by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522206 | Antimicrobial activity against Clostridium celerecrescens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID496823 | Antimicrobial activity against Trichomonas vaginalis | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID533389 | Antimicrobial activity against Clostridium perfringens by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID322093 | Antimicrobial activity against Trichomonas vaginalis G3 assessed as parasite death at 1 uM after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. |
| AID285560 | Bactericidal activity against 19-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 11 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID1367038 | Antibacterial activity against drug-resistant Pseudomonas aeruginosa after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID574027 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID498313 | Antimicrobial activity against Prevotella baroniae LBP 9 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1053268 | Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21 | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. |
| AID656870 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica. |
| AID522166 | Antimicrobial activity against Anaerococcus lactolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID557976 | Antimicrobial activity in Clostridium ramosum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID522148 | Antimicrobial activity against Prevotella loescheii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID557960 | Antimicrobial activity in Clostridium perfringens by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1683292 | Induction of ROS generation in Entamoeba histolytica HM1:MMS trophozoites at IC50 concentration incubated for 1 hr in presence of trolox by DCFDA staining based assay relative to control | |||
| AID522145 | Antimicrobial activity against Prevotella corporis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID533417 | Antimicrobial activity against Micromonas micros by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID573796 | Antibacterial activity against Prevotella bivia assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1879562 | Antibacterial activity against Gardnerella vaginalis ATCC 49145 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID285566 | Bactericidal activity against 26-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 11 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID534696 | Antimicrobial activity against Porphyromonas uenonis by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1755883 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for antigiardial activity against Trichomonas vaginalis GT3 | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID534452 | Antimicrobial activity against Propionibacterium granulosum ATCC 25564 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID425104 | Antimicrobial activity against Clostridium ramosum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534667 | Antimicrobial activity against Prevotella intermedia ATCC 25611 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID554794 | Prodrug activation in Helicobacter pylori HER 126 V1 lysate assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID571825 | Antibacterial activity against Coprobacillus cateniformis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID87946 | Inhibitory activity was determined against 102R strain of Helicobacter pylori | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | Anti-Helicobacter pylori agents endowed with H2-antagonist properties. |
| AID573802 | Antibacterial activity against Prevotella melaninogenica assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID211137 | Antiprotozoal activity measured as the conc for <25% inhibition of Trichomonas foetus | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID375867 | Antigiardial activity against Giardia lamblia GS/M trophozoites infected in C57BL/6 mouse assessed as reduction in live trophozoite number in small intestine at 2 mg/kg, po administered as 5 doses for 3 days | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID1456718 | Drug excretion in po dosed human watery feces | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID28236 | Unbound fraction (tissues) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID521816 | Antimicrobial activity against Prevotella intermedia isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID47570 | Antifungal activity against Candida albicans, activity expressed as minimum inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID534700 | Antimicrobial activity against Fusobacterium mortiferum by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID379775 | Antiprotozoal activity against axenically grown trophozoites of Entamoeba histolytica HM1-IMSS after 48 hrs by MTT method | 1999 | Journal of natural products, May, Volume: 62, Issue:5 | Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum. |
| AID534427 | Antimicrobial activity against Anaerococcus prevotii ATCC 9321 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID534676 | Antimicrobial activity against Fusobacterium necrophorum ATCC 25286 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID425086 | Antimicrobial activity against beta lactamase-positive Prevotella corporis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID557956 | Antimicrobial activity in Eggerthella lenta by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID554617 | Prodrug activation in Helicobacter pylori RIG 117 J0 lysate assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID498586 | Antimicrobial activity against Prevotella nanceiensis LBN 410 deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID425099 | Antimicrobial activity against Anaerococcus tetradius isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID1743061 | Antigiardial activity against Giardia duodenalis BRIS/91/HEPU/1279 incubated for 3 days followed by compound wash-out and measured after 4 days | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID534702 | Antimicrobial activity against Desulfovibrio desulfuricans by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID557408 | Antimicrobial activity in Bacteroides fragilis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1879492 | Antibacterial activity against Clostridioides difficile clinical isolate China | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID572020 | Antibacterial activity against Prevotella melaninogenica by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID424322 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID433167 | Antibacterial activity against Finegoldia magna isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID571827 | Antibacterial activity against Eggerthella lenta by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID573563 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558004 | Antimicrobial activity in Clostridium hastiforme by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1755862 | Anti-trichomonas activity against Trichomonas vaginalis CDC 085 incubated for 48 hrs by hemocytometer based eosin exclusion assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID522210 | Antimicrobial activity against Clostridium paraputrificum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1486945 | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to IC50 for Giardia intestinalis Giardia intestinalis IMSS:0696:1 (genotype A) | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID1879518 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1614 harboring rpoBL525I/D530N at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1456721 | Antibacterial activity against resistant Helicobacter pylori | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID70074 | Antifungal activity against Epidermophyton floccosum, activity expressed as minimum inhibitory concentration (ug/mL) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID572004 | Antibacterial activity against Bacteroides ovatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522177 | Antimicrobial activity against Actinomyces neuii subsp. anitratus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID571789 | Antibacterial activity against Clostridium bolteae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879577 | Antibacterial activity against Veillonella parvula ATCC 17745 MMX 1272 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1125399 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 75 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID571815 | Antibacterial activity against Actinomyces naeslundii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID698053 | Antimicrobial activity against Helicobacter pylori 26695 ATCC 700392 at pH 8 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID319583 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 16 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID574758 | Antimicrobial activity against Peptoniphilus asaccharolyticus after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID573397 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522189 | Antimicrobial activity against Mogibacterium timidum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534450 | Antimicrobial activity against Eggerthella lenta ATCC 25559 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID172616 | The amount of the unchanged form of compound detected in the urine samples collected at 0-18 hr after the treatment by HPLC technique | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID425114 | Antimicrobial activity against beta lactamase-positive Fusobacterium nucleatum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522211 | Antimicrobial activity against Clostridium sordellii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573594 | Antibacterial activity against Fusobacterium varium assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1879496 | Antibacterial activity against Clostridioides difficile ATCC 9689 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID285565 | Bactericidal activity against 26-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 4 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID554812 | Prodrug activation in compound-resistant Helicobacter pylori HER 126 V4 lysate assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID498324 | Antimicrobial activity against Prevotella bivia LBN 350 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534439 | Antimicrobial activity against Clostridium difficile GAI 10029 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1585771 | Antibacterial activity against non-replicating Mycobacterium tuberculosis H37Rv after 5 days under hypoxic condition by resazurin dye-based fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID1486937 | Antiprotozoal activity against Trypanosoma cruzi MHOM/MX/1994/Ninoa incubated for 72 hrs by Neubauer chamber based cell counting method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID21136 | Solubility in mMol was measured by UV spectrophotometry. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID531521 | Antibacterial activity against Bacteroides stercoris isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID373105 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microdilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives. |
| AID521808 | Antimicrobial activity against Porphyromonas levii isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID572000 | Antibacterial activity against Streptococcus intermedius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID534704 | Antimicrobial activity against Parvimonas micra by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID557948 | Antimicrobial activity in Propionibacterium acnes by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID531526 | Antibacterial activity against Bacteroides distasonis isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID534465 | Antimicrobial activity against Bacteroides fragilis GAI 10150 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID424327 | Antimicrobial activity against Dialister propionicifaciens by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID522131 | Antimicrobial activity against Bacteroides fragilis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1683303 | Induction of apoptosis in Entamoeba histolytica HM1:MMS trophozoites assessed as necrotic cells at IC50 concentration after 48 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.4%) | |||
| AID233802 | The ratio of aerobic CT10 to hypoxic CT10 | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID573590 | Antibacterial activity against Fusobacterium varium by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID573800 | Antibacterial activity against Prevotella bivia assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID534461 | Antimicrobial activity against Bacteroides fragilis ATCC 25285 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID502520 | Inhibition of Helicobacter pylori invasion into human AGS cells at 2.5 uM after 6 hrs | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID521820 | Antimicrobial activity against Prevotella oris isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID157249 | Minimum inhibitory concentration against Peptococcus magnus(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID522197 | Antimicrobial activity against Clostridium clostridioforme under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID323660 | Antibacterial activity against Peptostreptococcus stomatis | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. |
| AID538979 | Antitrypanosomal activity against Trichomonas vaginalis T1 | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | AdoHcy hydrolase of Trichomonas vaginalis: studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives. |
| AID425097 | Antimicrobial activity against Peptostreptococcus anaerobius isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID211133 | Antiprotozoal activity measured as the conc for >95% inhibition of Trichomonas foetus; ND denotes no data | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID554702 | Ratio of EC50 for Escherichia coli JM109 transformed with empty vector PQE30 to EC50 for Escherichia coli JM109 transformed with Entamoeba histolytica nim1 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID689771 | Antitubercular activity against Mycobacterium tuberculosis H37Rv isolate ITR after 7 days by luminescence spectrometry | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13 | Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. |
| AID1377041 | Antiparasitic activity against trophozoite stage of Trichomonas vaginalis CNCD 147 after 48 hrs | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds. |
| AID573786 | Antibacterial activity against Prevotella melaninogenica by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522151 | Antimicrobial activity against Prevotella tannerae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573394 | Antibacterial activity against Bacteroides fragilis by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1879572 | Antibacterial activity against metronidazole-resistant Prevotella bivia MMX 3454 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID311534 | Antibacterial activity against Helicobacter pylori ATCC 43504 by agar dilution method | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. |
| AID535831 | Toxicity in Hartley guinea pig lung assessed as formation of TB lesions by histological analysis | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID325505 | Inhibition of Giardia lamblia recombinant nitroreductase 1 (EAA43030.1) expressed in Escherichia coli at 5 uM | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. |
| AID522156 | Antimicrobial activity against Fusobacterium mortiferum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID285514 | Antibacterial activity against Bacteroides fragilis by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID522195 | Antimicrobial activity against Clostridium ramosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID522147 | Antimicrobial activity against Prevotella disiens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1879547 | Antibacterial activity against Bacteroides fragilis ATCC 25285 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID425102 | Antimicrobial activity against Clostridium difficile isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID200690 | Mutagenic activity in an Ames test on Salmonella Typhimurium TA98; Activity is log of revertants/nmol | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity. |
| AID561098 | Antibacterial activity against Prevotella sp. by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1428231 | Anti-parasitic activity against Tritrichomonas foetus measured after 48 hrs by microscopic analysis | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID1335740 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID574774 | Antimicrobial activity against Clostridium perfringens assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID498347 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 332 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID245231 | Minimal inhibitory concentration against metronidazole resistant Helicobacter pylori 8 strain | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID498579 | Antimicrobial activity against Prevotella baroniae LBN 475 expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID574782 | Antimicrobial activity against Actinomyces odontolyticus after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1879523 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1893 harboring rpoBL525I/D530N/rdxAR16S mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID510489 | Antimicrobial activity against Porphyromonas gingivalis assessed as reduction in thickness of biofilm at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID531528 | Antibacterial activity against Bacteroides caccae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID571833 | Antibacterial activity against Ruminococcus flavefaciens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID433168 | Antibacterial activity against Peptoniphilus asaccharolyticus isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1225681 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Trichomonas vaginalis JH31A#4 trophozite | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID571796 | Antibacterial activity against Clostridium subterminale by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571790 | Antibacterial activity against Clostridium clostridioforme by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID618298 | Cytotoxicity against rat H9c2 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID574510 | Antimicrobial activity against Bacteroides vulgatus assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID433352 | Antibacterial activity against Bacteroides vulgatus isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID574520 | Antimicrobial activity against Prevotella bivia after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID534683 | Antimicrobial activity against Bacteroides fragilis by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID319582 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 8 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID774912 | Antimicrobial activity against Trichomonas vaginalis G3 assessed as growth inhibition at 10 uM after 24 hrs by hemocytometry | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds. |
| AID1456719 | Antibacterial activity against Clostridium difficile | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID557444 | Antimicrobial activity in Prevotella melaninogenica by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID573783 | Antibacterial activity against Prevotella buccae by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID1076164 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. |
| AID1335741 | Selectivity index, ratio of IC50 for human HeLa cells to MIC for metronidazole sensitive Trichomonas vaginalis ATCC 33592 | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID1568976 | Therapeutic index, ratio of MCC50 for human HeLa cells to MIC for inhibition of flavodoxin in Mnz-resistant Helicobacter pylori NCTC 11637 ATCC 43504 assessed as reduction in bacterial growth | |||
| AID571995 | Antibacterial activity against Peptoniphilus asaccharolyticus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID575001 | Antimicrobial activity against Eubacterium lentum assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID498566 | Antimicrobial activity against Prevotella baroniae LBN 475 expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID745656 | Antibacterial activity against Trichomonas vaginalis G3 after 24 hrs by hemocytometry | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis of 1H-1,2,3-triazole linked β-lactam-isatin bi-functional hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalis. |
| AID561093 | Antibacterial activity against Bacteroides ovatus by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID571991 | Antibacterial activity against Ruminococcus sp. by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425089 | Antimicrobial activity against Porphyromonas gingivalis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID1317948 | Antiparasitic activity against metronidazole sensitive Entamoeba histolytica HM-1:IMSS trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID1295349 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis in sc dosed mouse assessed as pustule formation at 5 ug administered daily measured after 7 days (Rvb = 190 mm'2) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID521823 | Antimicrobial activity against Prevotella sp. isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID9641 | Concentration required to reduce AA8 cell numbers to 50% of controls in a growth inhibition microassay | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID574730 | Antimicrobial activity against Porphyromonas asaccharolytica after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID211139 | In vitro anti-trichomonal activity against Trichomonas foetus-Ortho strain-2. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1 | Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles. |
| AID534479 | Antimicrobial activity against Prevotella corporis GAI 91000 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571801 | Antibacterial activity against Clostridium celerecrescens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425095 | Antimicrobial activity against Finegoldia magna isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID375873 | Resistance ratio of EC50 for metronidazole-resistant Giardia lamblia isolate 713 to EC50 for metronidazole-sensitive Giardia lamblia isolate 713 | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID1055962 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X005282 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID472379 | Antitrichomonal activity against Trichomonas vaginalis TVR79 after 48 hrs by optical microscopy | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates. |
| AID494131 | Antibacterial activity against metronidazole-resistant Helicobacter pylori isolate 1 after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID534687 | Antimicrobial activity against Bacteroides vulgatus by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571824 | Antibacterial activity against Colinsella aerofaciens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID557706 | Antimicrobial activity in Porphyromonas asaccharolytica by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID572006 | Antibacterial activity against Bacteroides vulgatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571998 | Antibacterial activity against Streptococcus anginosus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID498557 | Antimicrobial activity against slow growing colonies of Prevotella nanceiensis LBN 298 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1879560 | Antibacterial activity against Fusobacterium nucleatum ATCC 25586 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1403743 | Inhibition of Bacillus pasteurii urease using urea as substrate measured after 20 mins by phenol reagent based assay relative to control | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID557944 | Antimicrobial activity in Bifidobacterium by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID574532 | Antimicrobial activity against Prevotella bivia assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID554797 | Prodrug activation in Helicobacter pylori HER 126 V1 lysate assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID573558 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1879508 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1902 harboring rpoBV149F mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID522144 | Antimicrobial activity against Prevotella bergensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1054551 | Trichomonacidal activity against Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID571990 | Antibacterial activity against Ruminococcus torques by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID433370 | Antibacterial activity against Peptostreptococcus anaerobius isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID698047 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v633 at pH 8 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1676997 | Antibacterial activity against Bacteroides fragilis HM-711 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID498545 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 464 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID574492 | Antimicrobial activity against Bacteroides ovatus after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1743042 | Antigiardial activity against Giardia duodenalis Ah1 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID554602 | Antimicrobial activity against Helicobacter pylori 10593/2 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID433200 | Antibacterial activity against Bacteroides ovatus isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID533634 | Antimicrobial activity against Propionibacterium acnes assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1146213 | Toxicity in CF1 mouse assessed as reduction in heart rate at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID425116 | Antimicrobial activity against Clostridium difficile isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID521809 | Antimicrobial activity against Porphyromonas macacae isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID1683287 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites assessed as decrease in size of cells at IC50 concentration after 48 hrs by uranyl acetate staining based TEM analysis | |||
| AID534430 | Antimicrobial activity against Parvimonas micra VPI 5464-1 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID557988 | Antimicrobial activity in Clostridium innocuum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID571806 | Antibacterial activity against Clostridium orbiscindens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID698052 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v633 at pH 7 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID318681 | Anticarcinogenic activity in rat assessed as induction of tumors per day | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | QSAR modeling of the rodent carcinogenicity of nitrocompounds. |
| AID531516 | Antibacterial activity against Bacteroides caccae assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID656871 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica. |
| AID425082 | Antimicrobial activity against beta lactamase-positive Prevotella intermedia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID1515376 | Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2 | Metronidazole aryloxy, carboxy and azole derivatives: Synthesis, anti-tumor activity, QSAR, molecular docking and dynamics studies. |
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| AID1331810 | Inhibition of Entamoeba histolytica O-acetyl-L-serine sulfohydrolase preincubated with enzyme followed by TNB substrate addition measured after 30 mins by UV-Visible spectrophotometric method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID498564 | Antimicrobial activity against Prevotella baroniae LBN 430 expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentrations of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
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| AID522201 | Antimicrobial activity against Clostridium hathewayi under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574522 | Antimicrobial activity against Prevotella buccae after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID554798 | Prodrug activation in Helicobacter pylori 10593a/2 lysate harboring rdxA C177stop mutant gene assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
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| AID558000 | Antimicrobial activity in Clostridium clostridioforme by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1529186 | Binding affinity to human serum albumin assessed as change in dissociation constant pKa1 of compound in aqueous medium to presence of human serum albumin by UV-pH titration based spectrophotometric analysis | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. |
| AID1917501 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1586955 | Antiprotozoal activity against Trichomonas vaginalis TVR87 measured after 48 hrs by trypan blue assay | 2019 | ACS medicinal chemistry letters, Jan-10, Volume: 10, Issue:1 | Nongenotoxic 3-Nitroimidazo[1,2- |
| AID571820 | Antibacterial activity against Bifidobacterium infantis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574967 | Antimicrobial activity against Actinomyces odontolyticus assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID572011 | Antibacterial activity against Prevotella bivia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1331802 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by eosin staining based microdilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID521822 | Antimicrobial activity against Bacteroides zoogleoformans isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID425107 | Antimicrobial activity against Clostridium sordellii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID573591 | Antibacterial activity against Fusobacterium nucleatum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID557722 | Antimicrobial activity in Fusobacterium varium by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID521813 | Antimicrobial activity against Prevotella denticola isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID534701 | Antimicrobial activity against Fusobacterium sp. by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1146160 | Antibacterial activity against Clostridium perfringens ISS 30453 assessed as growth inhibition | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID417445 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by trypan blue exclusion assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | New derivatives of 3,5-substituted-1,4,2-dioxazoles: synthesis and activity against Entamoeba histolytica. |
| AID285162 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in anaerobic condition assessed as bacterial density after 10 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID572009 | Antibacterial activity against Fusobacterium mortiferum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID30563 | Antibacterial activity against Actinomyces israelii, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID675036 | Octanol-water partition coefficient, log P of the compound | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors. |
| AID1125369 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 300 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID557416 | Antimicrobial activity in Bacteroides ovatus by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID571818 | Antibacterial activity against Bifidobacterium breve by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID425105 | Antimicrobial activity against Clostridium bifermentans isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534429 | Antimicrobial activity against Finegoldia magna ATCC 29328 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID467900 | Sperimcidal activity against human spermatozoa assessed as sperm motility at 1 % drug solution% | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID1295337 | Selectivity ratio of MIC for metronidazole-resistant trophozoite stage of Trichomonas vaginalis ATCC 50143 to MIC for metronidazole-susceptible trophozoite stage of Trichomonas vaginalis | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID574032 | Antibacterial activity against beta-lactamase producing Micromonas micros by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID490820 | Antitrichinellosis activity against Trichinella spiralis ML assessed as reduction of parasites viability at 0.18 uM after 3 days by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID498539 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 350 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID522154 | Antimicrobial activity against Fusobacterium nucleatum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573552 | Antibacterial activity against Bacteroides fragilis assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID559490 | Antibacterial activity against Propionibacterium acnes by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1146159 | Antibacterial activity against Staphylococcus aureus Tour assessed as growth inhibition | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID494132 | Antibacterial activity against metronidazole-resistant Helicobacter pylori isolate 8 after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID1146194 | Antimicrobial activity against Streptococcus pyogenes C 203 by microtitre method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID1761178 | Giardicidal activity against albendazole-resistant Giardia intestinalis incubated for 48 hrs by hemocytometric counting method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. |
| AID1743046 | Antigiardial activity against Giardia duodenalis Ec1 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1403738 | Antibacterial activity against Bacillus subtilis ATCC 6633 after overnight incubation by microbroth dilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID1204231 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 3 hrs relative to indomethacin | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID160375 | Antibacterial activity against Propionibacterium acnes, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1403741 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after overnight incubation by microbroth dilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID522146 | Antimicrobial activity against Prevotella denticola under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID572016 | Antibacterial activity against Prevotella P intermedia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID289871 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Syntheses, characterization and in vitro antiamoebic activity of new Pd(II) complexes with 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives. |
| AID1297388 | Antitrichomonal activity against metronidazole-resistant Trichomonas vaginalis TV-LACM2R clinical isolate trophozoites | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis. |
| AID1540921 | Antibacterial activity against Clostridium difficile 4118 ATCC BAA 1870 assessed as bacterial growth inhibition incubated for 48 hrs under anaerobic condition by CLSI protocol-based assay | |||
| AID1879494 | Antibacterial activity against Helicobacter pylori clinical isolate China | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID774310 | Antiprotozoal activity against clinical isolates of Entamoeba histolytica HM-1:IMSS | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Hydroxyclerodanes from Salvia shannoni. |
| AID1879574 | Antibacterial activity against Prevotella disiens MMX 3446 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID573565 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID433202 | Antibacterial activity against Bacteroides thetaiotaomicron isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID571808 | Antibacterial activity against Clostridium scindens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID41273 | Minimum inhibitory concentration against Bacteroides fragilis(NCTC 10581)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID23240 | Partition coefficient (logP) | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID531520 | Antibacterial activity against Bacteroides fragilis assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID571826 | Antibacterial activity against Coriobacteriumecies by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID366966 | Safety index, IC50 for human KB cells to IC50 for Entamoeba histolytica HM1:IMSS | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | New Pd(II) complexes of the synthesized 1-N-substituted thiosemicarbazones of 3-indole carboxaldehyde: characterization and antiamoebic assessment against E. histolytica. |
| AID534477 | Antimicrobial activity against Prevotella bivia ATCC 29303 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1599199 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes harboring luciferase reporter gene at 50 uM after 48 hrs by Steady-Glo luminescence assay relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID554809 | Prodrug activation in compound-resistant Helicobacter pylori CAS 015 J56 lysate harboring rdxA L132stop and frxA L39stop mutant genes assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID573824 | Antibacterial activity against beta-lactamase producing Clostridium septicum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID380454 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID574006 | Antibacterial activity against beta-lactamase producing Clostridium tertium assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID87951 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 206 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID573795 | Antibacterial activity against Prevotella buccae assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1755803 | Antibacterial activity against Staphylococcus aureus ATCC 6538P incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID574490 | Antimicrobial activity against Bacteroides vulgatus after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID533408 | Antimicrobial activity against Clostridium tertium assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID498337 | Antimicrobial activity against Prevotella bivia LBP 65 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID522215 | Antimicrobial activity against Clostridium tertium under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID763547 | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs by microdilution method | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica. |
| AID698042 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v1254 at pH 7 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1063468 | Antibacterial activity against Enterococcus faecalis ATCC 47077 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID559485 | Antibacterial activity against Bacteroides fragilis by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID571809 | Antibacterial activity against Clostridium sordellii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879575 | Antibacterial activity against Prevotella intermedia ATCC 25611 MMX 3002 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1365696 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 10 days under low oxygen condition followed by incubation under aerobic condition for 28 hrs by LORA | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | The antitubercular activity of various nitro(triazole/imidazole)-based compounds. |
| AID1294720 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 24 hrs by pour plate method (Rvb = 12.64 +/- 0.224 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID380459 | Antibacterial activity against Bacteroides fragilis DSM 2151 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID1568972 | Inhibition of flavodoxin in Helicobacter pylori SS1 assessed as reduction in bacterial growth measured after 48 hrs by resazurin staining-based microdilution method | |||
| AID502782 | Inhibition of Helicobacter pylori-induced inflammation in human AGS cells assessed as reduction of IL-8 production at 10 uM by ELISA | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID1067348 | Antimicrobial activity against promastigote stage of Leishmania amazonensis IFLA/BR/67/PH-8 clinical isolate after 72 hrs by Neubauer chamber analysis | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | 2-acylamino-5-nitro-1,3-thiazoles: preparation and in vitro bioevaluation against four neglected protozoan parasites. |
| AID571828 | Antibacterial activity against Holdemania filiformis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879504 | Antibacterial activity against metronidazole-resistant Helicobacter pylori CB1573 harboring rdxAR16S mutant at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1435767 | Antiamoebic activity against Entamoeba histolytica assessed as growth inhibition at 200 ug/ml after 24 hrs by trypan blue dye-based hemocytometer relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Improved anticancer and antiparasitic activity of new lawsone Mannich bases. |
| AID572022 | Antibacterial activity against Prevotella oris by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID522153 | Antimicrobial activity against Porphyromonas somerae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID572023 | Antibacterial activity against Sutterella wadsworthensis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID574484 | Antimicrobial activity against Bacteroides thetaiotaomicron after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID574764 | Antimicrobial activity against Finegoldia magna after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID534669 | Antimicrobial activity against Prevotella denticola GAI 5490 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID522135 | Antimicrobial activity against Bacteroides distasonis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID554808 | Prodrug activation in compound-resistant Helicobacter pylori CAS 015 J56 lysate harboring rdxA L132stop and frxA L39stop mutant genes assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID571791 | Antibacterial activity against Clostridium difficile by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID433151 | Antibacterial activity against Bacteroides vulgatus isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID574981 | Antimicrobial activity against Actinomyces naeslundii after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1127196 | Antitrichomonal activity against metronidazole-resistant Trichomonas vaginalis ATCC 50143 by trypan blue staining-based cell counting | 2014 | European journal of medicinal chemistry, May-22, Volume: 79 | Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis. |
| AID1568975 | Therapeutic index, ratio of MCC50 for human HeLa cells to MIC for inhibition of flavodoxin in Helicobacter pylori SS1 assessed as reduction in bacterial growth | |||
| AID1456706 | Antiparasitic activity against Trichomonas vaginalis clinical isolate after 48 hrs under aerobic conditions by inverted phase contrast microscopic analysis | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID592683 | Apparent permeability from basolateral side to apical side of human Caco2 cells by LC/MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID1879516 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1614 harboring rpoBL525I/D530N at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID331193 | Antiprotozoal activity against Entamoeba histolytica | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids. |
| AID1403737 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after overnight incubation by microbroth dilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID522143 | Antimicrobial activity against Prevotella intermedia under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID9657 | In vitro therapeutic index (aerobic IC50 / hypoxic C1.6) | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID26535 | Capacity factor (log k') | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID534428 | Antimicrobial activity against Atopobium parvulum VPI 0546 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID557702 | Antimicrobial activity in Prevotella sp.by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID575007 | Antimicrobial activity against Eubacterium sp. assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID574500 | Antimicrobial activity against Bacteroides thetaiotaomicron assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1879503 | Antibacterial activity against metronidazole-resistant Helicobacter pylori CB1573 harboring rdxAR16S mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID571807 | Antibacterial activity against Clostridium paraputrificum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879489 | Antibacterial activity against Actinomyces naeslundii ATCC 1210 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID554806 | Prodrug activation in compound-resistant Helicobacter pylori CAS 015 J56 lysate harboring rdxA L132stop and frxA L39stop mutant genes assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1683327 | Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability after 24 hrs by MTT assay | |||
| AID522152 | Antimicrobial activity against Porphyromonas asaccharolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1879491 | Antibacterial activity against Clostridioides difficile clinical isolate USA | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1510750 | Antibacterial activity against Clostridium difficile ATCC 43603 assessed as zone of inhibition at 2.5 ug/disc after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID534670 | Antimicrobial activity against Prevotella oralis ATCC 33269 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID571817 | Antibacterial activity against Bifidobacterium bifidum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522212 | Antimicrobial activity against Clostridium sphenoides under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1545442 | Antifungal activity against Candida albicans ATCC 653/885 assessed as diameter of zone inhibition at 30 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID557996 | Antimicrobial activity in Clostridium butyricum by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1879524 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1893 harboring rpoBL525I/D530N/rdxAR16S mutant at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID425090 | Antimicrobial activity against Porphyromonas levii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522205 | Antimicrobial activity against Clostridium cadaveris under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID379778 | Cytotoxicity against human A549 cells after 7 days by MTT method | 1999 | Journal of natural products, May, Volume: 62, Issue:5 | Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum. |
| AID1760138 | Antibacterial activity against gut Lactobacillus gasseri HM-664 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID557980 | Antimicrobial activity in Clostridium cadaveris by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1063473 | Antibacterial activity against Lactobacillus casei ATCC 334 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID531514 | Antibacterial activity against Bacteroides ovatus assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID557460 | Antimicrobial activity in Prevotella corporis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID574508 | Antimicrobial activity against Bacteroides distasonis assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID9480 | Compound concentration required to reduce cell survival to 10% of control values under hypoxic condition | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID498335 | Antimicrobial activity against Prevotella bivia LBP 51 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID433163 | Antibacterial activity against Clostridium sphenoides isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID554694 | Activity of Trichomonas vaginalis NTR8 at 50 uM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID433201 | Antibacterial activity against Bacteroides stercoris isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID498310 | Antimicrobial activity against Prevotella baroniae LBN 432 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID522172 | Antimicrobial activity against Gemella sanguinis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID494135 | Antibacterial activity against metronidazole-resistant Helicobacter pylori isolate 20 after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID562221 | Antimicrobial activity against Desulfovibrio fairfieldensis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID1434535 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes measured after 48 hrs by Malstat/nitroblue tetrazolium/phenazine ethosulphate reagent based LDH assay | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. |
| AID490819 | Antileishmanial activity against Leishmania mexicana MHOM/MX92/UAY68 after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID618296 | Cytotoxicity against rat H9c2 cells assessed as cell viability at 3.13 uM after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID559494 | Antibacterial activity against Peptostreptococcus sp. assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID366941 | Antibacterial activity against metronidazole-resistant Helicobacter pylori at 8 ug/disk after 3 to 5 days by filter paper disk diffusion method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds. |
| AID1054553 | Spermicidal activity in human semen assessed as sperm immobilization at 1.0 % w/v up to 30 seconds by phase contrast microscopy | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID28235 | Unbound fraction (plasma) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID522375 | Antimicrobial activity against Eubacterium limosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1683290 | Induction of ROS generation in Entamoeba histolytica HM1:MMS trophozoites at IC50 concentration incubated for 1 hr by DCFDA staining based assay | |||
| AID522134 | Antimicrobial activity against Bacteroides caccae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID554605 | Antimicrobial activity against Helicobacter pylori HER 126 V1 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1146193 | Antimicrobial activity against Staphylococcus aureus Tour by microtitre method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID1540929 | Effect on growth of Lactobacillus crispatus JV-V01 HM 103 measured after 48 hrs in anaerobic conditions by CLSI method | |||
| AID1743048 | Antigiardial activity against Giardia lamblia WB (ATCC 30957) incubated for 3 days by [3H]thymidine incorporation based assay | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1867248 | Antibacterial activity against multidrug resistant Helicobacter pylori JRES00015 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method | |||
| AID534688 | Antimicrobial activity against Bacteroides caccae by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1917500 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID534440 | Antimicrobial activity against Clostridium perfringens ATCC 13124 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID194141 | The total 18 hr urinary excretion of the unchanged form of compound in urine was reported as log (percent X 10) of the administered dose by HPLC technique | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID1063463 | Cytotoxicity against human HepG2 cells assessed as concentration required to decrease cell viability incubated for 24 hrs followed by compound washout measured after 18 hrs by resazurin dye-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID424321 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1146223 | Inhibition of strychine sulfate/pentetrazole-induced death in CF1 mouse at 300 to 600 mg/kg, po administered 60 mins prior to strychine sulfate/pentetrazole challenge | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID394720 | Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Bis-pyrazolines: synthesis, characterization and antiamoebic activity as inhibitors of growth of Entamoeba histolytica. |
| AID498559 | Antimicrobial activity against slow growing colonies of Prevotella nanceiensis LBP 66 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1552221 | Antibacterial activity against Clostridium difficile by CLSI method | 2019 | Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15 | Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. |
| AID1879555 | Antibacterial activity against Bifidobacterium ATCC 15698 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID424320 | Antimicrobial activity against Dialister micraerophilus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID574488 | Antimicrobial activity against Bacteroides distasonis after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1207750 | Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits | 2013 | Scientific reports, , Volume: 3 | MICE models: superior to the HERG model in predicting Torsade de Pointes. |
| AID554615 | Prodrug activation in Helicobacter pylori RIG 117 J0 lysate assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID360612 | Antiprotozoal activity against Giardia lamblia IMSS:0989:1 after 48 hrs by MTT/PMS assay | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Antiprotozoal activity of the constituents of Conyza filaginoides. |
| AID531525 | Antibacterial activity against Bacteroides ovatus isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1510716 | Antibacterial activity against Helicobacter pylori clinical isolate assessed as zone of inhibition at 8 ug/disc | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1676982 | Antimicrobial activity against Escherichia coli BW25113 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID1683295 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as ALP level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 638 +/- 50 U/L) | |||
| AID125251 | Antibacterial activity against Morganella morganii was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID498342 | Antimicrobial activity against Prevotella nanceiensis LBN 298 deficient in nim gene assessed as inhibition of growth at 48 hrs by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID531523 | Antibacterial activity against Bacteroides eggerthii isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID393132 | Antiprotozoal activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs | 2009 | Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4 | Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives. |
| AID1070247 | Antiprotozoal activity against trophozoite stage of Giardia lamblia IMSS:8909:1 assessed as growth inhibition after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis. |
| AID382589 | Selectivity index, Ratio of IC50 for human KB cells to IC50 for Entamoeba histolytica HM1 IMSS | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID561092 | Antibacterial activity against Bacteroides thetaiotaomicron by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID202866 | Antifungal activity against Saccharomyces cerevisiae, activity expressed as minimum inhibitory concentration (ug/mL). | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID498341 | Antimicrobial activity against Prevotella nanceiensis LBN 297 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID87949 | Minimal concentration needed to inhibitH. pylori strain | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | Anti-Helicobacter pylori agents endowed with H2-antagonist properties. |
| AID662997 | Growth inhibition of Mycobacterium tuberculosis H37Rv at >256 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID1176978 | Antiprotozoal activity against Giardia lamblia assessed as growth inhibition | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites. |
| AID1917499 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1683314 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as urea level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 14 +/- 1 mg/dl) | |||
| AID40468 | Stability towards penicillinase was determined; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1879533 | Antibacterial activity against Atopobium vaginae BAA-55 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID521807 | Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID1879493 | Antibacterial activity against Helicobacter pylori clinical isolate USA | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1879497 | Antibacterial activity against Helicobacter pylori ATCC 700392 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574766 | Antimicrobial activity against Finegoldia magna assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID498349 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 334 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1322344 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21 | Recent progress on the discovery of antiamoebic agents. |
| AID543648 | Antimicrobial activity against Clostridium difficile | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection. |
| AID87809 | Antibacterial activity against Helicobacter pylori HP0017 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1456720 | Antibacterial activity against susceptible Helicobacter pylori | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID498352 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 343 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1676996 | Antibacterial activity against Lactobacillus crispatus HM-371 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID522213 | Antimicrobial activity against Clostridium subterminale under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID433199 | Antibacterial activity against Bacteroides caccae isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID467623 | Toxicity in rat H9c2 cells after 48 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives. |
| AID545983 | Cytotoxicity against human MCF7 cells assessed as cell viability up to 100 uM after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives). |
| AID557734 | Antimicrobial activity in Peptostreptococcus anaerobius by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1146215 | Toxicity in CF1 mouse assessed as reduction in opening of eyelid at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID433161 | Antibacterial activity against Clostridium innocuum isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID522157 | Antimicrobial activity against Fusobacterium varium under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID571997 | Antibacterial activity against Peptostreptococcus micros by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID28233 | Fraction ionized (pH 7.4) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID674906 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Metronidazole thiosalicylate conjugates: synthesis, crystal structure, docking studies and antiamoebic activity. |
| AID1731667 | Antimicrobial activity against Trichomonas vaginalis JH31A#4 trophozoites assessed as reduction in parasitic growth incubated for 24 hrs by resazurin dye based fluorescence assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. |
| AID534444 | Antimicrobial activity against Actinomyces odontolyticus GAI 91002 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID214096 | Antifungal activity against Trichophyton mentagrophytes, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1755860 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites measured after 72 hrs by microdilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1225676 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 37.5 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID1146214 | Toxicity in CF1 mouse assessed as reduction in respiratory rate at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID1879550 | Antibacterial activity against Bacteroides gracilis ATCC 33236 MMX 1270 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID571992 | Antibacterial activity against Anaerococcus prevotii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID522138 | Antimicrobial activity against Bacteroides uniformis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1585767 | Antiparasitic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID1879563 | Antibacterial activity against Mobiluncus curtisii subsp. curtisii ATCC 35241 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID87952 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 80 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID207179 | Antibacterial activity against Staphylococcus aureus 209P JC was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID548283 | Selectivity ratio of EC50 for Trypanosoma brucei NfxR1 to EC50 for Trypanosoma brucei | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. |
| AID1879488 | Antibacterial activity against Gardnerella vaginalis clinical isolate China | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574003 | Antibacterial activity against beta-lactamase producing Clostridium perfringens assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID425087 | Antimicrobial activity against beta lactamase-positive Prevotella buccae isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID433158 | Antibacterial activity against Clostridium aminovalericum isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID559489 | Antibacterial activity against Prevotella sp. by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID677471 | Antimicrobial activity against Trichomonas vaginalis ATCC 25258 | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. |
| AID522185 | Antimicrobial activity against Eubacterium contortum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID521811 | Antimicrobial activity against Prevotella buccae isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID571795 | Antibacterial activity against Clostridium ramosum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1879570 | Antibacterial activity against Prevotella bivia ATCC 29303/MMX 5718 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574518 | Antimicrobial activity against Prevotella intermedia after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID27167 | Delta logD (logD6.5 - logD7.4) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID522186 | Antimicrobial activity against Eubacterium cylindroides under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID498576 | Antimicrobial activity against Prevotella baroniae LBN 427 expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID574977 | Antimicrobial activity against Actinomyces meyeri assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID502779 | Antibacterial activity against Helicobacter pylori Hp 26695 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID1683284 | Antimicrobial activity against Entamoeba histolytica HM1:MMS assessed as reduction in amoeba growth | |||
| AID8002 | Observed volume of distribution | 2004 | Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5 | Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. |
| AID1760135 | Antibacterial activity against gut Corynebacterium HM-784 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID522159 | Antimicrobial activity against Anaerococcus prevotii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID498552 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 65 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID592682 | Apparent permeability from apical to basolateral side of human Caco2 cells after 2 hrs by LC/MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID498546 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 467 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534673 | Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1879674 | Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as mortality at 100 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment and measured upto 21 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID433155 | Antibacterial activity against Porphyromonas somerae isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID425101 | Antimicrobial activity against Clostridium perfringens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID644763 | Antiameobic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs using trypan blue staining method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold. |
| AID1569034 | Binding affinity to Helicobacter pylori flavodoxin by thermal upshift assay | |||
| AID1879511 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1902 harboring rpoBV149F mutant at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID285159 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed by relative light units after 7 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID498572 | Antimicrobial activity against Prevotella nanceiensis LBN 293b deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534434 | Antimicrobial activity against Gemella morbillorum ATCC 27824 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID386927 | Antitrichomonas activity against Trichomonas vaginalis after 48 hrs by trypan blue staining | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1755856 | Antiamoebic activity against Entamoeba histolytica HK9 ATCC 30015 incubated for 72 hrs by trypan blue staining based assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1755879 | Anti-trichomonas activity against Trichomonas vaginalis JT assessed as release of H2O2 at 0.229 uM preincubated for 3 hrs followed by DCFH-DA probe addition and measured after 30 mins by confocal microscopy | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1135254 | Trichomonacidal activity against Trichomonas vaginalis by tube dilution method | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. |
| AID375868 | Antigiardial activity against Giardia lamblia GS/M trophozoites infected in C57BL/6 mouse assessed as parasite eradication in small intestine at 10 mg/kg, po administered as 5 doses for 3 days | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID534709 | Antimicrobial activity against Clostridium difficile by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1055967 | Antimycobacterial activity against Mycobacterium tuberculosis harboring luxABCDE under hypoxic condition after 10 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1743064 | Antigiardial activity against metronidazole-resistant Giardia duodenalis WB1B-M3 incubated for 3 days followed by compound wash-out and measured after 4 days | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID533863 | Antibacterial activity against toxin-positive Clostridium difficile clinical isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. |
| AID574498 | Antimicrobial activity against Bacteroides thetaiotaomicron assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1317954 | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for metronidazole sensitive Giardia lamblia WB trophozoites | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID433150 | Antibacterial activity against Bacteroides uniformis isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID534469 | Antimicrobial activity against Parabacteroides distasonis ATCC 8503 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1599232 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as death at 12.5 to 200 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID425096 | Antimicrobial activity against Micromonas micros isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID260370 | Antiprotozoal activity against Trypanosoma brucei brucei GVR35 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines. |
| AID1599202 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes harboring luciferase reporter gene infected in mouse J774 cells at 25 uM after 48 hrs by Steady-Glo luminescence assay relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID1317953 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 24 hrs by resazurin assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID1867246 | Antibacterial activity against multidrug resistant Helicobacter pylori G27 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method | |||
| AID522192 | Antimicrobial activity against Lactobacillus casei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1348797 | Antitrichomonas activity against metronidazole-resistant Trichomonas vaginalis CDC085 ATCC 50143 assessed as decrease in cell viability after 48 hrs by trypan blue exclusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID498350 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 336 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534682 | Antimicrobial activity against Veillonella dispar ATCC 17748 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID534689 | Antimicrobial activity against Bacteroides stercoris by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID662568 | Growth inhibition of mtronidazole-resistant Trichomonas vaginalis after 24 hrs by hemocytometry | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine. |
| AID534705 | Antimicrobial activity against Peptostreptococcus anaerobius by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID501584 | Antiparasitic activity against Trichomonas vaginalis G3 after 24 hrs by hemocytometric analysis | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis. |
| AID557726 | Antimicrobial activity in Finegoldia magna by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1348796 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1063477 | Antibacterial activity against Clostridium perfringens ATCC 13124 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1135605 | Antimicrobial activity against Entamoeba histolytica NIH 200-mu hepatic forms infected in golden hamster assessed as survival rate administered qd for 5 days measured up to 14 days by microscopic analysis | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents. |
| AID1136090 | Antimicrobial activity against Trichomonas vaginalis ATCC 30001 assessed as growth inhibition after 48 hrs under anaerobic conditions by microscopic analysis | 1978 | Journal of medicinal chemistry, Apr, Volume: 21, Issue:4 | Activity-electroreduction relationship of antimicrobial metronidazole analogues. |
| AID1348177 | Spermicidal activity in human semen assessed as induction of sperm immobilization | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Recent developments in anti-Trichomonas research: An update review. |
| AID1294233 | Cytotoxicity against african green monkey Vero cells assessed as inhibition of cell growth after 24 hrs by resazurin dye based fluorescence assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles. |
| AID194145 | The total 54 h urinary excretion of unchanged compound reported as log (percent X 10) of the administered dose | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID424319 | Antimicrobial activity against Dialister pneumosintes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID554807 | Prodrug activation in compound-resistant Helicobacter pylori CAS 015 J56 lysate harboring rdxA L132stop and frxA L39stop mutant genes assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID67513 | Antiprotozoal activity measured as the conc for <25% inhibition of Entamoeba histolytica; ND denotes no data | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID574524 | Antimicrobial activity against Prevotella oralis after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1683313 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as blood ureic nitrogen level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 7 +/- 0.6 g/dl) | |||
| AID1125391 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 100 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1743083 | Antigiardial activity against Giardia intestinalis IMSS:0696:1 incubated for 48 hrs followed by wash out by hemocytometric counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID562222 | Antimicrobial activity against Desulfovibrio desulfuricans Essex 6 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID16040 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-5 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID67515 | Antiprotozoal activity measured as the conc for 100% inhibition of Entamoeba histolytica | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1146166 | Acute toxicity in po dosed mouse | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID371504 | Antiamnesic activity against Entamoeba histolytica HMI:IMSS after 72 hrs by microdilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives. |
| AID1264943 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | ent-Kaurene Glycosides from Ageratina cylindrica. |
| AID283190 | Growth inhibition of Escherichia coli CC104 expressing rdxA after 16 hrs relative to Escherichia coli with pBSK | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni. |
| AID557964 | Antimicrobial activity in Clostridium difficile by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1244340 | Anti-trichomonas activity against MTZ-susceptible Trichomonas vaginalis incubated for 3 to 48 hrs by trypan blue exclusion assay | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID1515377 | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2 | Metronidazole aryloxy, carboxy and azole derivatives: Synthesis, anti-tumor activity, QSAR, molecular docking and dynamics studies. |
| AID515153 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail. |
| AID574965 | Antimicrobial activity against Actinomyces odontolyticus assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID548284 | Selectivity ratio of EC50 for Trypanosoma brucei NfxR2 to EC50 for Trypanosoma brucei | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. |
| AID522140 | Antimicrobial activity against Prevotella bivia under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID51006 | Minimum inhibitory concentration against Clostridium perfringens (NCTC 8237)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID571174 | Antimicrobial activity against Clostridium difficile harboring other ribotypes by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. |
| AID521821 | Antimicrobial activity against Prevotella oulorum isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID571822 | Antibacterial activity against Bifidobacterium pseudolongum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1377040 | Antiparasitic activity against trophozoite stage of Giardia intestinalis IMSS:0989:1 after 48 hrs | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds. |
| AID574530 | Antimicrobial activity against Prevotella bivia assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID69916 | Antibacterial activity against Escherichia coli K-12 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID380831 | Antigiardial activity against Giardia intestinalis | 1999 | Journal of natural products, Aug, Volume: 62, Issue:8 | Sesquiterpene lactones from neurolaena oaxacana |
| AID433160 | Antibacterial activity against Clostridium clostridioforme isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1879522 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1771 harboring rpoBL525I/D530N/rdxAE75stop mutant at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID16039 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-4 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID750271 | Safety index, ratio of IC50 for human HepG2 cells to IC50 for Entamoeba histolytica HM-1:IMSS trophozoites | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID498569 | Antimicrobial activity against Prevotella bivia LBN 371 deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1136089 | Antimicrobial activity against Clostridium pasteurianum ATCC 6013 assessed as growth inhibition after 24 hrs under anaerobic conditions by microscopic analysis | 1978 | Journal of medicinal chemistry, Apr, Volume: 21, Issue:4 | Activity-electroreduction relationship of antimicrobial metronidazole analogues. |
| AID211152 | Antiprotozoal activity measured as the conc for >95% inhibition of Trichomonas vaginalis | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID571814 | Antibacterial activity against Clostridium sp. by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1510751 | Antibacterial activity against Clostridium difficile 630 assessed as zone of inhibition at 2.5 ug/disc after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID573836 | Antibacterial activity against beta-lactamase producing Clostridium septicum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1225675 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 75 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID635850 | Antiprotozoal activity against Giardia intestinalis G1 after 70 hrs by resazurin-based spectrophotometric assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. |
| AID223214 | Inhibition of histamine-stimulated chronotropic response in isolated guinea pig right atrium at 1*10e-6 g/mL; ND is No Data. | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID534457 | Antimicrobial activity against Lactobacillus plantarum JCM 1149 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID510490 | Antimicrobial activity against Porphyromonas gingivalis assessed as surface area/biovolume ratio at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID498573 | Antimicrobial activity against Prevotella nanceiensis LBN 410 deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID26380 | Dissociation constant (pKa) | 2004 | Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5 | Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. |
| AID573583 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1194392 | Inhibition of Giardia intestinalis fructose 1,6-bisphosphate aldolase at 400 nM after 2 hrs by spectrophotometry | 2015 | Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9 | Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis. |
| AID189629 | The capillary permeability of radioligand was measured in Rat brain | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. |
| AID1225684 | Trichomonicidal activity against Trichomonas vaginalis C-1:NIH trophozoites infected in NMRI mouse assessed as reduction of pathogenicity at 25 mg/kg/day, po administered for 7 days from day 3 to day 10 post-infection measured at day 15 post-infection | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID1456707 | In vivo antiparasitic activity against Giardia lamblia infected in human at 250 mg administered 2 to 3 times per day daily for 5 to 10 days | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID574023 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID534699 | Antimicrobial activity against Fusobacterium varium by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1435775 | Antiamoebic activity against Entamoeba histolytica assessed as growth inhibition at 200 ug/ml after 72 hrs by trypan blue dye-based hemocytometer relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Improved anticancer and antiparasitic activity of new lawsone Mannich bases. |
| AID522194 | Antimicrobial activity against Clostridium perfringens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID535823 | Antibacterial activity against Mycobacterium tuberculosis infected in Hartley guinea pig lung assessed as reduction in bacterial load at 100 mg/kg | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID433019 | Antibacterial activity against Bacteroides ovatus isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1136091 | 1-Octanol-saturated McIlvaine buffer partition coefficient, log P of the compound at 80 uM at pH 6.01 by spectrophotometric analysis | 1978 | Journal of medicinal chemistry, Apr, Volume: 21, Issue:4 | Activity-electroreduction relationship of antimicrobial metronidazole analogues. |
| AID571816 | Antibacterial activity against Bifidobacterium adolescentis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID433153 | Antibacterial activity against Parabacteroides merdae isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID571989 | Antibacterial activity against Ruminococcus productus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1867110 | Antibacterial activity against Clostridioides difficile assessed as inhibition of bacterial growth by CLSI based agar dilution susceptibility analysis | |||
| AID172620 | The amount of unchanged compound in urine collected at 0-36 hr after treatment | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID23734 | Micelle/water partition coefficient (Pmic) of the compound was determined | 1996 | Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13 | Thermodynamic aspects of hydrophobicity and the blood-brain barrier permeability studied with a gel filtration chromatography. |
| AID375861 | Antigiardial activity against metronidazole-resistant Giardia lamblia isolate 713 trophozoite after 2 days by bactiter-glo viability assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID675035 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors. |
| AID1760136 | Antibacterial activity against gut Fusobacterium nucleatum HM-992 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID522141 | Antimicrobial activity against Prevotella buccae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1055969 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID573593 | Antibacterial activity against Fusobacterium necrophorum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID557432 | Antimicrobial activity in Bacteroides stercoris by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID498332 | Antimicrobial activity against Prevotella bivia LBN 478 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1254732 | Antitrichomonal activity against Trichomonas vaginalis after 48 hrs by invert microscope analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21 | Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound. |
| AID69327 | Minimum inhibitory concentration measured against Escherichia coli AB1885 strain (UvrB- Rec+) | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID87932 | Antibacterial activity against Helicobacter pylori HP021 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1196181 | Antimicrobial activity against Helicobacter pylori at 1 ug/disc | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold. |
| AID450072 | Antigiardial activity against Giardia lamblia WB (ATCC 30957) trophozoites after 24 hrs by trypan blue assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia. |
| AID1879487 | Antibacterial activity against Gardnerella vaginalis clinical isolate USA | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID522179 | Antimicrobial activity against Actinomyces turicensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1055938 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv under normoxic condition after 7 days by MABA assay in presence of 4% bovine serum albumin | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID573557 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID573834 | Antibacterial activity against beta-lactamase producing Clostridium perfringens assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID498345 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 330 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID502780 | Antibacterial activity against multidrug-resistant Helicobacter pylori v1254 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID557428 | Antimicrobial activity in Bacteroides uniformis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1879544 | Antibacterial activity against rifampicin/fluoroquinolone-resistant Clostridioides difficile CB1942 harboring rpoBQ489K/gyrAD71Y/T82A mutant at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID40466 | Stability towards beta-lactamase was determined in Bacillus fragilis FP784; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID522200 | Antimicrobial activity against Clostridium citroniae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1676976 | Antimicrobial activity against Clostridioides difficile NR-32895 P19 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID631764 | Antiprotozoan activity against Giardia intestinalis IMSS:0989:1 trophozoites compound treated for 48 hrs measured after 48 hrs washout period | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Antiprotozoal activity of proton-pump inhibitors. |
| AID533400 | Antimicrobial activity against Clostridium paraputrificum assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID534681 | Antimicrobial activity against Veillonella parvula ATCC 10790 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID535822 | AUC (0 to 24 hrs) in guinea pig at 100 mg/kg | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID573581 | Antibacterial activity against beta-lactamase producing Bacteroides caccae by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID380457 | Antibacterial activity against Escherichia coli ATCC 25922 by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID425115 | Antimicrobial activity against Clostridium perfringens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522214 | Antimicrobial activity against Clostridium symbiosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID498547 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 478 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID533421 | Antimicrobial activity against Anaerococcus prevotii by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1063466 | Antibacterial activity against stationary phase of Clostridium difficile CD196 assessed as cell killing at 1 to 20 X MIC after 3 to 6 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1879576 | Antibacterial activity against Treponema denticola ATCC 35405 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID521805 | Antimicrobial activity against Porphyromonas asaccharolyticus isolated from canine periodontal pockets after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study. |
| AID554698 | Ratio of EC50 for Escherichia coli JM109 transformed with empty vector PQE30 to EC50 for Escherichia coli JM109 transformed with Entamoeba histolytica NTR1 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID425093 | Antimicrobial activity against Fusobacterium varium isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID531512 | Antibacterial activity against Bacteroides eggerthii assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID664684 | Toxicity against Lactobacillus jensenii ATCC 25258 | 2012 | ACS medicinal chemistry letters, Feb-09, Volume: 3, Issue:2 | Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D-QSAR Analysis. |
| AID522174 | Antimicrobial activity against Peptoniphilus lacrimalis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522149 | Antimicrobial activity against Prevotella nanceiensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534710 | Antimicrobial activity against Clostridium perfringens by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID536461 | Antimicrobial activity against Aspergillus flavus at 100 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID498331 | Antimicrobial activity against Prevotella bivia LBN 467 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1879676 | Antibacterial activity against Clostridioides difficile BAA 1382 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID573573 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID23681 | Partition coefficient (logP) | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID1127195 | Antitrichomonal activity against metronidazole-susceptible Trichomonas vaginalis clinical isolate by trypan blue staining-based cell counting | 2014 | European journal of medicinal chemistry, May-22, Volume: 79 | Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis. |
| AID574005 | Antibacterial activity against beta-lactamase producing Clostridium septicum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID319584 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 32 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID1181511 | Antiprotozoal activity against Giardia lamblia IMSS: 8909:1 trophozoites assessed as growth inhibition compound treated for 48 hrs measured 48 hrs post wash-out by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs. |
| AID534685 | Antimicrobial activity against Parabacteroides distasonis by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1486948 | Antigiardial activity against Giardia intestinalis WB trophozoites infected in CD1 mouse dosed intragastrically 6 days after infection and measured 48 hrs post dose | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID67621 | Aerobic cytotoxicity against murine mammary carcinoma EMT6 cells in a growth inhibition microassay | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID533405 | Antimicrobial activity against Clostridium tertium by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1879567 | Antibacterial activity against Peptostreptococcus magnus ATCC 14956 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1461556 | Antimicrobial activity against Trichomonas vaginalis after 48 hrs by neutral red staining based invert microscopic analysis | 2017 | Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16 | Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. |
| AID369333 | Antimicrobial activity against log phase recombinant Mycobacterium tuberculosis H37Rv-lux with plasmid MV361 at 10 ug/ml incubated for 7 days assessed as bacterial count after 4 days | 2000 | Nature, Jun-22, Volume: 405, Issue:6789 | A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. |
| AID394721 | Selectivity index, ratio of IC50 for human kidney epithelial cells to IC50 for Entamoeba histolytica HM-1:IMSS trophozoites | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Bis-pyrazolines: synthesis, characterization and antiamoebic activity as inhibitors of growth of Entamoeba histolytica. |
| AID1067247 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 2 ug/ml after 48 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID598282 | Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID1525244 | Antiparasitic activity against Giardia intestinalis IMSS:0989:1 assessed as inhibition of parasitic growth treated for 48 hrs followed by compound washout and measured after 48 hrs by MTT/PMS dye based colorimetric method | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5 | Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities. |
| AID534438 | Antimicrobial activity against Clostridium clostridioforme NCTC 11224 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1743053 | Growth inhibition of Giardia duodenalis isolate 14-03/F7 measured after 24 hrs by resazurin based assay | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID531515 | Antibacterial activity against Bacteroides distasonis assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1204232 | Toxicity in albino mouse assessed as appearance of toxic symptoms at 50 to 100 mg/kg indomethacin mol equivalent, ip measured after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID534464 | Antimicrobial activity against Bacteroides fragilis GAI 7955 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1683318 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as glucose level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 126 +/- 18 mg/dl) | |||
| AID88249 | In vitro inhibitory activity evaluated against Helicobacter pylori (HP) | 1999 | Bioorganic & medicinal chemistry letters, Jan-18, Volume: 9, Issue:2 | In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1317958 | Antiparasitic activity against metronidazole sensitive Giardia lamblia WB trophozoites assessed as morphological alterations at 3 times EC50 after 48 hrs under anaerobic conditions by phase contrast microscopic analysis | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID1181510 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites assessed as growth inhibition compound treated for 48 hrs measured 48 hrs post wash-out by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs. |
| AID557750 | Antimicrobial activity in Lactobacillus by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID534458 | Antimicrobial activity against Lactobacillus reuteri JCM 1112 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID228170 | Inhibition of histamine-stimulated gastric acid secretion in lumen-perfused stomach of anesthetized rats after 1 mg/kg iv administration; ND is No Data. | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID1743047 | Antigiardial activity against Giardia duodenalis Ec2 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1569035 | Binding affinity to Helicobacter pylori flavodoxin by isothermal titration calorimetric method | |||
| AID1743062 | Antigiardial activity against Giardia duodenalis BRIS/83/HEPU/106 incubated for 3 days followed by compound wash-out and measured after 4 days | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID522168 | Antimicrobial activity against Anaerococcus octavius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1055957 | Antimycobacterial activity against kanamycin-resistant Mycobacterium tuberculosis ATCC 35827 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1879495 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1055935 | Antimycobacterial activity against Mycobacterium tuberculosis harboring luxABCDE under hypoxic condition after 10 days by MABA assay in presence of 10% fetal bovine serum | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1225677 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 18.75 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1461558 | Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysis | 2017 | Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16 | Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. |
| AID498542 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 371 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1294717 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 12 hrs by pour plate method (Rvb = 10.12 +/- 0.428 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID1063478 | Antibacterial activity against Clostridium difficile CD196 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID371505 | Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives. |
| AID396583 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines. |
| AID1146195 | Antimicrobial activity against Clostridium perfringens ISS 30543 by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID375864 | Cytotoxicity against human HeLa cells after 2 days by Alamar blue assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID554700 | Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica nim1 after 16 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID51004 | Minimum inhibitory concentration measured against Clostridium perfringens strain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID522209 | Antimicrobial activity against Clostridium hylemonae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1434534 | Anti-amoebic activity against trophozoites of Entamoeba histolytica HM-1:IMSS gassed with nitrogen for 10 mins measured after 72 hrs by eosin staining based micro dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. |
| AID1348807 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis infected in mouse assessed as growth of abscess at 50 mg/kg, po administered for 7 days measured on day 7 post last dose (Rvb = 96.5 mm'2) | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1683317 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as platelets at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 439 +/- 108 million/mm3) | |||
| AID502523 | Inhibition of Helicobacter pylori-induced inflammation in human AGS cells assessed as reduction of NF-kappaB activity at 2.5 uM after 6 hrs by luciferase reporter gene assay relative to control | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID574526 | Antimicrobial activity against Prevotella intermedia assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1147718 | Antifungal activity against Candida albicans | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID87806 | Antibacterial activity against Helicobacter pylori ATCC 43504 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1761176 | Giardicidal activity against metronidazole-resistant Giardia intestinalis incubated for 48 hrs by hemocytometric counting method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. |
| AID1244339 | Spermicidal activity in liquefied human semen assessed as reduction in motile spermatozoa incubated at 37 degC for 30 mins | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID534454 | Antimicrobial activity against Lactobacillus brevis subsp. brevis JCM 1059 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID319573 | Antibacterial activity against metronidazole-sensitive Helicobacter pylori assessed as inhibition zone diameter at 16 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID1660011 | Antimicrobial activity against Giardia lamblia GS/M assessed as reduction in trophozoites formation | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Triazoxins: Novel nucleosides with anti-Giardia activity. |
| AID331194 | Antiprotozoal activity against Leishmania mexicana | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids. |
| AID72251 | Minimum inhibitory concentration against Fusobacterium necrophorum (ATCC 11295)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID1879556 | Antibacterial activity against Bifidobacterium longum ATCC 15707 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1204226 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 3 hrs relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID215302 | Aerobic cytotoxicity against UV4 cells in a growth inhibition microassay | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID1204222 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 1 hr relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID351909 | Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity. |
| AID40337 | Compound was evaluated for antimicrobial activity against Bacteroides fragilis | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID1879541 | Antibacterial activity against rifampicin/fluoroquinolone-resistant Clostridioides difficile CB1940 harboring rpoBQ489K/gyrAA118S mutant at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID252985 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 0.5 mg/ml after 48 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID433376 | Antibacterial activity against Anaerococcus vaginalis isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1063471 | Antibacterial activity against Staphylococcus aureus 8325-4 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1070246 | Antiprotozoal activity against trophozoite stage of Trichomonas vaginalis GT3 assessed as growth inhibition | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis. |
| AID749415 | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 72 hrs by microdilution method | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents. |
| AID211134 | Antiprotozoal activity measured as the conc for 100% inhibition of Trichomonas foetus | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID664681 | Antitrichomonas activity against metronidazole-resistant Trichomonas vaginalis ATCC 50143 | 2012 | ACS medicinal chemistry letters, Feb-09, Volume: 3, Issue:2 | Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D-QSAR Analysis. |
| AID490818 | Antiprotozoal activity against Trichomonas vaginalis G3 after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. |
| AID574534 | Antimicrobial activity against Prevotella buccae assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID426309 | Antiparasitic activity against Giardia intestinalis IMSS:0696 trophozoites after 48 hrs by Hill culture method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles. |
| AID1755864 | Anti-trichomonas activity against Trichomonas vaginalis GT3 incubated for 48 hrs | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1067251 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 0.5 ug/ml after 24 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID1331809 | Inhibition of Entamoeba histolytica thioredoxin reductase | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID424323 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID285570 | Bactericidal activity against 12-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 1 day by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID573599 | Antibacterial activity against Fusobacterium nucleatum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID41121 | Antibacterial activity against Bacteroides fragilis, activity expressed as minimum inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1879548 | Antibacterial activity against metronidazole-resistant Bacteroides fragilis MMX 3387 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID88227 | The lowest drug concentration that inhibited macroscopic colonial growth against Helicobacter pylori; Value ranges from 1.56-25 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID87954 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 15069 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID322087 | Antimicrobial activity against Entamoeba histolytica HM1 IMSS trophozoites after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. |
| AID477784 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution technique | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | New dioxazole derivatives: Synthesis and effects on the growth of Entamoeba histolytica and Giardia intestinalis. |
| AID1917498 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID425113 | Antimicrobial activity against beta lactamase-positive Finegoldia magna isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID477785 | Antigiardial activity against Giardia intestinalis Thai trophozoites after 24 hrs by inverted microscopic analysis | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | New dioxazole derivatives: Synthesis and effects on the growth of Entamoeba histolytica and Giardia intestinalis. |
| AID554804 | Prodrug activation in compound-resistant Helicobacter pylori RIG 117 J56 lysate harboring rdxA R16C and frxA A40stop mutant genes assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID467909 | Cytotoxicity against human HeLa cells at 200 ug/ml after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID433166 | Antibacterial activity against Anaerococcus tetradius isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID534435 | Antimicrobial activity against Staphylococcus saccharolyticus ATCC 14953 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID498308 | Antimicrobial activity against Prevotella baroniae LBN 427 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID559495 | Antibacterial activity against Prevotella sp. assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID382587 | Antiamnesic activity against Entamoeba histolytica HM1 IMSS after 72 hrs by serial dilution method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity. |
| AID157253 | Minimum inhibitory concentration against Peptococcus prevotti(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID1244338 | Inhibition of HIV1 reverse transcriptase at 100 ug/ml incubated for 1 hr by ELISA method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID534445 | Antimicrobial activity against Bifidobacterium adolescentis ATCC 15703 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID494129 | Antibacterial activity against Helicobacter pylori ATCC 43504 clinical isolates after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID375862 | Resistance ratio of EC50 for metronidazole-resistant Giardia lamblia isolate 106 to EC50 for metronidazole-sensitive Giardia lamblia isolate 106 | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID1755801 | Antimicrobial activity against Clostridium sporogenes ATCC 19404 incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID375871 | Antigiardial activity against metronidazole-resistant Giardia lamblia isolate 106 trophozoite after 2 days by bactiter-glo viability assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID366948 | Antibacterial activity against Helicobacter pylori clinical isolates at 8 ug/disk after 3 to 5 days by filter paper disk diffusion method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds. |
| AID1063475 | Antibacterial activity against Bacteroides thetaiotaomicron ATCC 29148 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID51005 | Minimum inhibitory concentration against Clostridium perfringens (NCTC 523)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID1146210 | Toxicity in CF1 mouse assessed as reduction in curiosity at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID574768 | Antimicrobial activity against Finegoldia magna assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1331804 | Cytotoxicity against CHO cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID498583 | Antimicrobial activity against Prevotella bivia LBN 467 deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID664682 | Spermicidal activity against human spermatozoa assessed as immobilization measured for 60 seconds | 2012 | ACS medicinal chemistry letters, Feb-09, Volume: 3, Issue:2 | Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D-QSAR Analysis. |
| AID1055963 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X004439 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID557992 | Antimicrobial activity in Clostridium sordellii by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID763545 | Selectivity index, ratio of IC50 for african green monkey Vero cells to IC50 for trophozoite stage of Entamoeba histolytica HM-1:IMSS | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica. |
| AID1676995 | Antibacterial activity against Lactobacillus crispatus HM-103 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID1599238 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as death at 50 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID554693 | Activity of Giardia lamblia NTR at 50 uM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID574496 | Antimicrobial activity against Bacteroides fragilis assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID763546 | Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by WST-1 assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID574043 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1879509 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1902 harboring rpoBV149F mutant at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID557984 | Antimicrobial activity in Clostridium bifermentans by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1294237 | Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for metronidazole-resistant Trichomonas vaginalis IR78 trophozoites | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles. |
| AID1504965 | Antitubercular activity against Mycobacterium tuberculosis H37Rv measured after 7 days under aerobic condition by alamar blue assay | 2017 | ACS medicinal chemistry letters, Dec-14, Volume: 8, Issue:12 | Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. |
| AID382588 | Cytotoxicity against human KB cells after 44 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity. |
| AID498326 | Antimicrobial activity against Prevotella bivia LBN 365 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID1697368 | Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 2.5 to 50 uM incubated for 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23 | Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents. |
| AID554692 | Activity of Entamoeba histolytica NTR3 at 50 uM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID498580 | Antimicrobial activity against Prevotella baroniae LBP19 expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1055954 | Antimycobacterial activity against capreomycin-resistant Mycobacterium tuberculosis under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID574506 | Antimicrobial activity against Bacteroides distasonis assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID27797 | Maximum plasma concentration (Cmax) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice; Not checked | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID534694 | Antimicrobial activity against Porphyromonas asaccharolyticus by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1879514 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1903 harboring rpoBD530V mutant at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID559491 | Antibacterial activity against Bacteroides fragilis assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1240190 | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies. |
| AID1917494 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID664683 | Cytotoxicity against human HeLa cells | 2012 | ACS medicinal chemistry letters, Feb-09, Volume: 3, Issue:2 | Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D-QSAR Analysis. |
| AID409946 | Inhibition of human recombinant MAOB at 100 uM by fluorimetric method | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID1760140 | Antibacterial activity against gut Eubacterium sp. HM-178 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID433157 | Antibacterial activity against Clostridium perfringens isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID260369 | Antiprotozoal activity against Leishmania donovani MHOM/ET/L82/LV9 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines. |
| AID510488 | Antimicrobial activity against Porphyromonas gingivalis assessed as reduction in biovolume at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID194143 | The total 18 hr urinary excretion of unchanged compound reported as log (percent X 10) of the administered dose | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID1599224 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes infected in BALB/c mouse assessed as reduction in parasite load in spleen at 50 mg/kg, ip administered once daily for 5 days measured 7 days post dose by giemsa staining-bas | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID1743041 | Antigiardial activity against Giardia duodenalis G1 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1525243 | Antiparasitic activity against Entamoeba histolytica HM1-IMSS trophozoites assessed as inhibition of parasitic growth treated for 48 hrs followed by compound washout and measured after 48 hrs by MTT/PMS dye based colorimetric method | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5 | Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities. |
| AID27795 | AUC (area under curve) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice; Not checked | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID1676998 | Antibacterial activity against Bacteroides fragilis HM-709 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID534671 | Antimicrobial activity against Prevotella oris ATCC 33573 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID433366 | Antibacterial activity against Anaerococcus prevotii isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID69328 | Minimum inhibitory concentration measured against Escherichia coli EE128 strain (Uvr+ RecA-) | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID554619 | Prodrug activation in Helicobacter pylori CAS 015 J0 lysate assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID573600 | Antibacterial activity against Fusobacterium mortiferum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID534449 | Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25526 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1297389 | Antitrichomonal activity against metronidazole-resistant Trichomonas vaginalis TV-LACM2R clinical isolate trophozoites assessed as reduction in parasite viability at 15 uM after 24 hrs by trypan blue dye based hemocytometry | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis. |
| AID534436 | Antimicrobial activity against Streptococcus constellatus ATCC 27923 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1076163 | Cytotoxicity against BALB/c mouse splenocytes assessed as [3H]-thymidine incorporation after 24 hrs by beta-radiation counting analysis relative to control | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. |
| AID1683312 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as triglycerides level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 395 +/- 41 mg/dl) | |||
| AID558014 | Antimicrobial activity in Porphyromonas gingivalis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1348794 | Selectivity index, ratio of IC50 for human HeLa cells to MIC for metronidazole-susceptible Trichomonas vaginalis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1063474 | Antibacterial activity against Bifidobacterium longum ATCC BAA-999 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID194144 | The total 36 hr urinary excretion of unchanged compound reported as log (percent X 10) of the administered dose | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID433351 | Antibacterial activity against Bacteroides uniformis isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID554795 | Prodrug activation in Helicobacter pylori HER 126 V1 lysate assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID677472 | Cytotoxicity against human HeLa cells by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. |
| AID1879552 | Antibacterial activity against Bacteroides vulgatus MMX 8348 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498315 | Antimicrobial activity against Prevotella bivia LBN 330 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1055961 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X005319 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID574750 | Antimicrobial activity against Peptostreptococcus micros assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID750268 | Cytotoxicity against human HepG2 cells assessed as cell viability up to 25 uM after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID1204234 | Ulcerogenic activity in Wistar rat assessed as ulcer index at 10 mg/kg indomethacin mol equivalent, po administered 3 days relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID285161 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in anaerobic condition assessed as relative light unit after 11 days by LORA assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID574748 | Antimicrobial activity against Peptostreptococcus micros assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1063464 | Cytotoxicity against human FADU cells assessed as concentration required to decrease cell viability incubated for 24 hrs followed by compound washout measured after 18 hrs by resazurin dye-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1755859 | Antigiardial activity against Giardia intestinalis WB ATCC 30957 by trypan blue staining based assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1879553 | Antibacterial activity against metronidazole-resistant Bacteroides vulgatus 3490 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1743039 | Antigiardial activity against Giardia duodenalis GS/M-83-H7 (ATCC 50581) incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID380452 | Antibacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 mg/ml | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID1879512 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1903 harboring rpoBD530V mutant at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID573797 | Antibacterial activity against Prevotella intermedia assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID147155 | Compound was evaluated for antimicrobial activity against Neisseria gonorrhoeae | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID573551 | Antibacterial activity against Bacteroides fragilis assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1367033 | Antibacterial activity against drug-resistant Staphylococcus aureus after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID1867252 | Antibiofilm activity against Helicobacter pylori G27 assessed as reduction in viable cells count at 4 times MIC | |||
| AID1204230 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 24 hrs relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID515156 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail. |
| AID46744 | Compound was evaluated for antimicrobial activity against Campylobacter jejuni | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID440732 | Antimycobacterial activity against 30 day old non-replicating dormant cultures of Mycobacterium tuberculosis H37Rv assessed as revival of bacterial viability exposed for 11 days measured after 30 days post exposure by resazurin reduction assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. |
| AID554610 | Prodrug activation in Helicobacter pylori 10593/2 lysate assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1879537 | Antibacterial activity against fluoroquinolone-resistant Clostridioides difficile CB1941 harboring gyrAD71Y/T82A mutant measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498548 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 4 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1486935 | Antiprotozoal activity against Leishmania mexicana MHOM/MX/ISETGS incubated for 72 hrs by Neubauer chamber based cell counting method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID260371 | Antiprotozoal activity against Trichomonas vaginalis CMP | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines. |
| AID467624 | Safety index, ratio of IC50 for rat H9c2 cells to IC50 for Entamoeba histolytica HM1:IMSS trophozoites | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives. |
| AID534437 | Antimicrobial activity against Streptococcus intermedius ATCC 27335 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1879571 | Antibacterial activity against Prevotella bivia MMX 3450 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID534686 | Antimicrobial activity against Bacteroides uniformis by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID534456 | Antimicrobial activity against Lactobacillus fermentum JCM 1173 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID618299 | Cytotoxicity against rat H9c2 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID1569037 | Effect on growth of Staphylococcus aureus ATCC 1228 after 48 hrs by resazurin-dye based microdilution assay | |||
| AID1146198 | Antimicrobial activity against Trichomonas vaginalis infected in po dosed mouse | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID510491 | Antimicrobial activity against Porphyromonas gingivalis assessed as reduction in surface area of substratum occupied by cells at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID498556 | Antimicrobial activity against slow growing colonies of Prevotella nanceiensis LBN 297 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID211142 | The Mutagenicity against Trichomonas foetus relative to Ronidazole. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1 | Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles. |
| AID319574 | Antibacterial activity against metronidazole-sensitive Helicobacter pylori assessed as inhibition zone diameter at 32 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID522203 | Antimicrobial activity against Clostridium bifermentans under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID467902 | Antitrichomonal activity against Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID1879540 | Antibacterial activity against rifampicin/fluoroquinolone-resistant Clostridioides difficile CB1940 harboring rpoBQ489K/gyrAA118S mutant measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1435771 | Antiamoebic activity against Entamoeba histolytica assessed as growth inhibition at 200 ug/ml after 48 hrs by trypan blue dye-based hemocytometer relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Improved anticancer and antiparasitic activity of new lawsone Mannich bases. |
| AID1540932 | Effect on growth of Enterobacter cloacae ATCC BAA 1143 assessed as bacterial growth inhibition measured after 16 to 18 hrs grown in tryptic soy medium by CLSI method | |||
| AID87958 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 16043 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID498346 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 331 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID554608 | Antimicrobial activity against compound-resistant Helicobacter pylori CAS 015 J56 harboring rdxA L132stop and frxA L39stop mutant genes by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID67511 | Antiprotozoal activity measured as the conc for 95-25% inhibition of Entamoeba histolytica; ND denotes no data | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID252984 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 0.5 mg/ml after 24 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID1456717 | Drug excretion in po dosed human feces | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID1335753 | Antiparasitic activity against Trichomonas vaginalis in po dosed mouse assessed as size of abscess at 50 mg/kg, po administered daily for 5 days measured 5 days post last dose (Rvb = 120 mm'2) | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID534478 | Antimicrobial activity against Prevotella buccae ATCC 33574 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID433362 | Antibacterial activity against Clostridium innocuum isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID498344 | Antimicrobial activity against Prevotella nanceiensis LBP 66 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1461560 | Antimicrobial activity against Tritrichomonas mobilensis after 48 hrs by neutral red staining based invert microscopic analysis | 2017 | Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16 | Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. |
| AID498577 | Antimicrobial activity against Prevotella baroniae LBN 430 expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1599239 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as effect on health at 50 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID498311 | Antimicrobial activity against Prevotella baroniae LBN 466 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID249262 | Minimal inhibitory concentration against 17 strains of Helicobacter pylori | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID1067357 | Cytotoxicity against African green monkey Vero cells assessed as cell viability after 48 hrs by SRB assay | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | 2-acylamino-5-nitro-1,3-thiazoles: preparation and in vitro bioevaluation against four neglected protozoan parasites. |
| AID1504966 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 incubated for 10 days under low oxygen condition followed by second incubation under aerobic condition for 28 hrs by LORA | 2017 | ACS medicinal chemistry letters, Dec-14, Volume: 8, Issue:12 | Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. |
| AID498567 | Antimicrobial activity against Prevotella baroniae LBP19 expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID562223 | Antimicrobial activity against Desulfovibrio desulfuricans MB by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID1486934 | Antiprotozoal activity against Leishmania amazonensis IFLA/BR/67/PH-8 incubated for 72 hrs by Neubauer chamber based cell counting method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID677470 | Antimicrobial activity against clinical isolate of Trichomonas vaginalis | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. |
| AID433365 | Antibacterial activity against Propionibacterium acnes isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1146164 | Antiprotozoal activity against Trichomonas vaginalis infected in po dosed mouse | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID380456 | Antibacterial activity against Enterococcus faecalis by standard broth microdilution technique | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. |
| AID1568977 | Therapeutic index, ratio of MCC50 for human HeLa cells to MIC for inhibition of flavodoxin in Helicobacter pylori ATCC 700392 26695 assessed as reduction in bacterial growth | |||
| AID1917491 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1683328 | Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability after 24 hrs by MTT assay | |||
| AID50859 | Antibacterial activity against Clostridium novyi, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1486932 | Antiprotozoal activity against Giardia intestinalis IMSS:0696:1 (genotype A) trophozoites incubated for 48 hrs | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID250189 | Viable Mycobacterium tuberculosis in lungs of infected Mice after an 8-day drug treatment; Dose is 150 mg/kg | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21 | Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. |
| AID573564 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1755880 | Anti-trichomonas activity against Trichomonas vaginalis JT assessed as release of superoxide radical at 0.229 uM preincubated for 3 hrs followed by Dihydroethidium probe addition and measured after 30 mins by confocal microscopy | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID656872 | Cytotoxicity against human MCF7 cells assessed as cell viability at 250 uM after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica. |
| AID1331805 | Cytotoxicity against CHO cells assessed as reduction in cell viability at 2.5 to 50 uM after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID498561 | Antimicrobial activity against Bacteroides fragilis ATCC 25285T deficient in nimI gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID534459 | Antimicrobial activity against Lactobacillus salivarius subsp. salivarius JCM 1231 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID548280 | Antimicrobial activity against Trypanosoma brucei | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. |
| AID367002 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and antiamoebic activity of metronidazole thiosemicarbazone analogues. |
| AID1348175 | Anti-Trichomonas activity against metronidazole-resistant Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Recent developments in anti-Trichomonas research: An update review. |
| AID41272 | Minimum inhibitory concentration against Bacteroides fragilis (MZ-R)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID600469 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Antiprotozoal activity of chloroquinoline based chalcones. |
| AID574494 | Antimicrobial activity against Bacteroides fragilis assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1683286 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites assessed as decrease in granularity at IC50 concentration after 48 hrs by uranyl acetate staining based TEM analysis | |||
| AID214101 | Antifungal activity against Trichophyton mentagrophytes, activity expressed as minimum inhibitory concentration (ug/mL). | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID534443 | Antimicrobial activity against Clostridium ramosum ATCC 25582 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1194391 | Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9 | Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis. |
| AID346843 | Antimycobacterial activity against Mycobacterium tuberculosis with deazaflavin-dependent nitroreductase mutant under anaerobic condition | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles. |
| AID1125400 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 50 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID598281 | Antiprotozoan activity against Giardia intestinalis IMSS:0696:1 trophozoites after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID666992 | Selectivity index, ratio of IC50 for human HepG2 cells to IC50 for Entamoeba histolytica HM1:IMSS | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
| AID750269 | Cytotoxicity against human HepG2 cells assessed as cell viability at 3.13 uM after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID522199 | Antimicrobial activity against Clostridium bolteae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID533385 | Antimicrobial activity against Clostridium difficile by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID375866 | Antigiardial activity against Giardia lamblia GS/M trophozoites infected in C57BL/6 mouse assessed as reduction in live trophozoite number in small intestine at 10 mg/kg, po administered as 5 doses for 3 days relative to control | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID87931 | Antibacterial activity against Helicobacter pylori HP020 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1067358 | Antimicrobial activity against epimastigote stage of Trypanosoma cruzi MHOM/MX/1994/Ninoa clinical isolate after 72 hrs by Neubauer chamber analysis | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | 2-acylamino-5-nitro-1,3-thiazoles: preparation and in vitro bioevaluation against four neglected protozoan parasites. |
| AID1486946 | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to IC50 for Trichomonas vaginalis GT3 | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID1761177 | Giardicidal activity against Giardia intestinalis IMSS isolate incubated for 48 hrs by hemocytometric counting method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID534451 | Antimicrobial activity against Propionibacterium acnes ATCC 11828 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1225671 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID87956 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 16021 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID534668 | Antimicrobial activity against Prevotella melaninogenica JCM 6325 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID319578 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 0.5 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID263999 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS | 2006 | Bioorganic & medicinal chemistry letters, May-15, Volume: 16, Issue:10 | Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives. |
| AID1146196 | Antimicrobial activity against Mycoplasma gallisepticum S6 Weybridge by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID498575 | Antimicrobial activity against Prevotella baroniae DSM 16972T expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID533428 | Antimicrobial activity against Peptostreptococcus sp. assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID536457 | Antimicrobial activity against Candida albicans at 100 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1297379 | Antitrichomonal activity against metronidazole-sensitive Trichomonas vaginalis ATCC 30236 clinical isolate trophozoites assessed as parasite viability at 100 uM after 24 hrs by trypan blue dye based hemocytometry | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis. |
| AID433154 | Antibacterial activity against Porphyromonas asaccharolyticus isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID574754 | Antimicrobial activity against Anaerococcus prevotii assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID550085 | Antitrichomonas activity against Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. |
| AID1348798 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis assessed as decrease in cell viability after 48 hrs by trypan blue exclusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID522167 | Antimicrobial activity against Anaerococcus murdochii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID637018 | Safety index, ratio of IC50 for human HepG2 cells to IC50 for Entamoeba histolytica HM-1:IMSS | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives. |
| AID1879568 | Antibacterial activity against Peptostreptococcus anaerobius ATCC 27337 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498551 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 52 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID635851 | Antiprotozoal activity against Entamoeba histolytica Hk-9 trophozoites after 70 hrs by resazurin-based spectrophotometric assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. |
| AID416736 | Ratio of number of revertant per nmol of drug for Salmonella Typhimurium YG1042 to number of revertant per nmol of drug for Salmonella Typhimurium TA100 | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID416733 | Induction of mutagenicity in Salmonella Typhimurium TA100 assessed as number of revertant per nmol after 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID534476 | Antimicrobial activity against Sutterella wadsworthensis ATCC 51579 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID574042 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID554614 | Prodrug activation in Helicobacter pylori RIG 117 J0 lysate assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1367039 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID1683316 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as total leukocytes at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 18 +/- 16 million/mm3) | |||
| AID698041 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v1254 at pH 8 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID386922 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1147713 | Antibacterial activity against Bacteroides fragilis ATCC 23745 after 24 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID534474 | Antimicrobial activity against Bacteroides ureolyticus NCTC 10941 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID534432 | Antimicrobial activity against Peptoniphilus indolicus GAI 0915 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID498554 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 78 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID689770 | Antitubercular activity against Mycobacterium tuberculosis H37Rv isolate SRI after 5 days by resazurin-based microplate assay | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13 | Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. |
| AID40356 | Relative stability towards penicillinase was determined; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID559496 | Antibacterial activity against Propionibacterium acnes assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1127198 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, May-22, Volume: 79 | Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis. |
| AID1204228 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 4 hrs relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID554621 | Prodrug activation in Helicobacter pylori CAS 015 J0 lysate assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID371506 | Safety index, ratio of IC50 for human kidney epithelial cells to IC50 for Entamoeba histolytica HMI:IMSS | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives. |
| AID531511 | Antibacterial activity against Bacteroides merdae assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID535829 | Antibacterial activity against Mycobacterium tuberculosis infected in Hartley guinea pig lung assessed as reduction in bacteria induced progression of inflammation at 100 mg/kg after 4 weeks by histological analysis relative to control | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID498582 | Antimicrobial activity against Prevotella bivia LBN 371 deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID666993 | Cytotoxicity against human HepG2 cells assessed as cell viability at 3.13 uM after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
| AID498553 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 69 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID545982 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives). |
| AID677410 | Spermicidal activity against human spermatozoa at 10 mg/ml by modified sander-cramer assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. |
| AID1683288 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites assessed as abnormal condensation of chromatin at IC50 concentration after 48 hrs by uranyl acetate staining based TEM analysis | |||
| AID1125377 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 75 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1160935 | Partition coefficient, log D of the compound at pH 7.4 | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. |
| AID375863 | Antigiardial activity against Giardia lamblia trophozoites isolates after 2 days by bactiter-glo viability assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID534468 | Antimicrobial activity against Bacteroides vulgatus GAI 0673 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID433360 | Antibacterial activity against Clostridium cadaveris isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID618301 | Cytotoxicity against rat H9c2 cells assessed as cell viability after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID498312 | Antimicrobial activity against Prevotella baroniae LBN 475 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID554620 | Prodrug activation in Helicobacter pylori CAS 015 J0 lysate assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID285559 | Bactericidal activity against 19-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 4 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID1335738 | Antiparasitic activity against metronidazole sensitive Trichomonas vaginalis ATCC 33592 after 48 hrs by trypan blue exclusion assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID1295350 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis in sc dosed mouse assessed as spleen weight at 5 ug administered daily measured after 7 days (Rvb = 0.59 g) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID534442 | Antimicrobial activity against Clostridium sordellii ATCC 9714 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID319580 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 2 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID554811 | Prodrug activation in compound-resistant Helicobacter pylori HER 126 V4 lysate assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID319581 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 4 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID1568971 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability by XTT assay | |||
| AID144209 | Antimicrobial activity was measured against Neisseria meningitidis organism. | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID520108 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at assessed as growth inhibition at 10 mg/kg following 24 days oxygen depletion by Wayne method relative to control | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. |
| AID346840 | Antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv NRP-2 stage after 3 weeks under anaerobic condition | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles. |
| AID1063476 | Antibacterial activity against Bacteroides fragilis ATCC 25285 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID522163 | Antimicrobial activity against Peptoniphilus asaccharolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1146220 | Toxicity in CF1 mouse assessed as change in sleeping time at 600 mg/kg, po administered 30 mins prior to hexobarbital sodium challenge relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID1055965 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X003899 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID1545439 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as diameter of zone inhibition at 30 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID498328 | Antimicrobial activity against Prevotella bivia LBN 374 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1456708 | In vivo antiparasitic activity against Giardia lamblia infected in human at 2000 to 2400 mg administered as single dose | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID1585769 | Antibacterial activity against Mycobacterium tuberculosis H37Rv after 5 days under normoxic condition by resazurin dye-based fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. |
| AID160386 | Minimum inhibitory concentration against Propionibacterium acnes(NCTC 7337)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID533638 | Antimicrobial activity against Propionibacterium sp. assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID557690 | Antimicrobial activity in Prevotella bergensis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID87807 | Antibacterial activity against Helicobacter pylori HP001 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1568973 | Inhibition of flavodoxin in Mnz-resistant Helicobacter pylori NCTC 11637 ATCC 43504 assessed as reduction in bacterial growth measured after 48 hrs by resazurin staining-based microdilution method | |||
| AID575003 | Antimicrobial activity against Eubacterium lentum assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID211150 | Antiprotozoal activity measured as the conc for 95-25% inhibition of Trichomonas vaginalis | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1456702 | Antiparasitic activity against Entamoeba histolytica clinical isolate after 24 hrs under anaerobic cinditions | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID1194390 | Giardicidal activity against Giardia intestinalis IMSS:0696:1 compound treated for 48 hrs followed by incubation for 48 hrs in compound-free medium by cell counting | 2015 | Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9 | Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis. |
| AID1879561 | Antibacterial activity against Gardnerella vaginalis ATCC 14018 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574732 | Antimicrobial activity against Fusobacterium varium after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1599237 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as reduction in body weight at 25 mg/kg, po administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID1136095 | Electroreduction potential of the compound assessed as alternating current reduction peak potential by polarographic technique | 1978 | Journal of medicinal chemistry, Apr, Volume: 21, Issue:4 | Activity-electroreduction relationship of antimicrobial metronidazole analogues. |
| AID498314 | Antimicrobial activity against Prevotella baroniae LBP 19 expressing nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1227231 | Antimicrobial activity against metronidazole-resistant Clostridium difficile | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12 | Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea. |
| AID750270 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID1070248 | Antiprotozoal activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis. |
| AID41276 | Minimum inhibitory concentration against Bacteroides fragilis (WSI)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID1683302 | Induction of apoptosis in Entamoeba histolytica HM1:MMS trophozoites assessed as late apoptotic cells at IC50 concentration after 48 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.7%) | |||
| AID69326 | Minimum inhibitory concentration measured against Escherichia coli AB1157 strain (Uvr+ Rec+) | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID42862 | Antimicrobial activity was measured against Clostridium difficile organism; Value ranges from 0.1-0.39 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID38347 | Antimicrobial activity was measured against B. fragilis range; Value ranges from 0.39-0.78 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID1879526 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1893 harboring rpoBL525I/D530N/rdxAR16S mutant at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574528 | Antimicrobial activity against Prevotella intermedia assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID29344 | Ionisation constant (pKa) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID1867250 | Antibiofilm activity against Helicobacter pylori G27 assessed as reduction in preformed bacterial biofilm at 4 times MIC by crystal violet staining based assay | |||
| AID522191 | Antimicrobial activity against Solobacterium moorei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574997 | Antimicrobial activity against Bifidobacterium sp. assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1295331 | Antitrichomonas activity against metronidazole-resistant trophozoite stage of Trichomonas vaginalis ATCC 50143 assessed as cell viability under anaerobic condition after 48 hrs by trypan blue exclusion assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1540928 | Effect on growth of Lactobacillus casei ATCC 334 measured after 48 hrs in anaerobic conditions by CLSI method | |||
| AID498339 | Antimicrobial activity against Prevotella bivia LBP 78 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1755802 | Antibacterial activity against Escherichia coli ATCC 8739 incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1879557 | Antibacterial activity against Clostridium sporogenes ATCC 19404 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1879535 | Antibacterial activity against fluoroquinolone-resistant Clostridioides difficile CB1939 at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID534471 | Antimicrobial activity against Bacteroides thetaiotaomicron ATCC 29741 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID29811 | Oral bioavailability in human | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID24912 | Half life for the nitro group loss in xanthine oxidase enzyme assay in 0.2%DMF at 0.1 mM | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction. |
| AID1486933 | Antiprotozoal activity against Trichomonas vaginalis GT3 trophozoites incubated for 48 hrs | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID42872 | Antimicrobial activity was measured against Campylobacter jejuni organism; Value ranges from 0.78-100 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID1294719 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 20 hrs by pour plate method (Rvb = 12.73 +/- 0.223 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID433375 | Antibacterial activity against Anaerococcus vaginalis isolated from patient with diabetic foot infection after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1063469 | Antibacterial activity against Escherichia coli ATCC 700927 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1294718 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 16 hrs by pour plate method (Rvb = 12.50 +/- 0.291 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID87928 | Antibacterial activity against Helicobacter pylori HP004 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1743043 | Antigiardial activity against Giardia duodenalis Ah2 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID296136 | Antibacterial activity against Bacteroides fragilis after 20 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. |
| AID425106 | Antimicrobial activity against Clostridium clostridioforme isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID41274 | Minimum inhibitory concentration against Bacteroides fragilis(NCTC 9343)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1879531 | Antibacterial activity against rifampicin-resistant Clostridioides difficile CB1934 harboring rpoBQ489K mutant at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498549 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 38 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID554801 | Prodrug activation in compound-resistant Helicobacter pylori 10593a/2 lysate harboring rdxA C177stop mutant gene assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1394853 | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS measured after 72 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Synthesis, antiamoebic activity and docking studies of metronidazole-triazole-styryl hybrids. |
| AID232822 | Ratio of mean intracellular to extracellular compound concentration determined under hypoxic conditions 30 mins after exposure to compound at C1.6 concentration | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID88083 | Minimum inhibitory concentration required to inhibit macroscopic colonial growth of Helicobacter pylori; ranges from(1.56-25) | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID498325 | Antimicrobial activity against Prevotella bivia LBN 361 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID637015 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives. |
| AID522139 | Antimicrobial activity against Bacteroides vulgatus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574033 | Antibacterial activity against beta-lactamase producing Micromonas micros assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1456725 | Antibacterial activity against Helicobacter pylori after 72 hrs by E-test | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID9474 | Average intracellular compound concentration where the sensitizer enhancement ratio (SER)=1.6 under hypoxia | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID1146162 | Antiprotozoal activity against Trichomonas vaginalis assessed as static effect | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID618295 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS by microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID554612 | Prodrug activation in Helicobacter pylori 10593/2 lysate assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID689773 | Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13 | Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. |
| AID698045 | Antimicrobial activity against metronidazole and clarithromycin-resistant Helicobacter pylori v1254 at pH 5 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1879534 | Antibacterial activity against fluoroquinolone-resistant Clostridioides difficile CB1939 measured after 3 days | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1879549 | Antibacterial activity against metronidazole-resistant Bacteroides thetaiotaomicron MMX 3409 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID286232 | Antiprotozoal activity against Giardia intestinalis IMSS:0696:1 trophozoites after 48 hrs | 2007 | Journal of natural products, May, Volume: 70, Issue:5 | Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa. |
| AID70072 | Antifungal activity against Epidermophyton floccosum, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID498333 | Antimicrobial activity against Prevotella bivia LBP 4 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID96068 | Antibacterial activity against Klebsiella pneumoniae was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1568974 | Inhibition of flavodoxin in Helicobacter pylori ATCC 700392 26695 assessed as reduction in bacterial growth measured after 48 hrs by resazurin staining-based microdilution method | |||
| AID1599233 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as effect on health at 12.5 to 200 mg/kg, ip administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID235834 | Safety index. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1 | Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles. |
| AID416727 | Antitrichomonas activity against Trichomonas vaginalis TVR87 after 48 hrs by trypan blue staining | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1569036 | Effect on growth of Escherichia coli DH5[alpha] after 48 hrs by resazurin-dye based microdilution assay | |||
| AID1403740 | Antibacterial activity against Salmonella typhimurium ATCC 14028 after overnight incubation by microbroth dilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID533424 | Antimicrobial activity against Anaerococcus prevotii assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID498570 | Antimicrobial activity against Prevotella bivia LBN 467 deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID554609 | Antimicrobial activity against compound-resistant Helicobacter pylori HER 126 V4 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID534467 | Antimicrobial activity against carbapenemase-producing Bacteroides fragilis GAI 30144 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID498348 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 333 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1510749 | Antibacterial activity against Clostridium difficile R20291 assessed as zone of inhibition at 2.5 ug/disc after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1743044 | Antigiardial activity against Giardia duodenalis Ac1 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID41275 | Minimum inhibitory concentration against Bacteroides fragilis(NCTC 9344)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID375865 | Therapeutic index, ratio of IC50 for human HeLa cells to EC50 for Giardia lamblia trophozoites isolates | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID554810 | Prodrug activation in compound-resistant Helicobacter pylori HER 126 V4 lysate assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1416869 | Antiparasitic activity against Trichomonas vaginalis assessed as parasite growth inhibition after 24 hrs by hemacytometer | 2017 | MedChemComm, , Volume: 8, Issue:10 | Design, Synthesis and Preliminary Antimicrobial Evaluation of |
| AID245242 | Minimal inhibitory concentration against metronidazole resistant Helicobacter pylori 19 strain | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID425110 | Antimicrobial activity against beta lactamase-positive Bacteroides fragilis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID554802 | Prodrug activation in compound-resistant Helicobacter pylori RIG 117 J56 lysate harboring rdxA R16C and frxA A40stop mutant genes assessed as compound reduction under oxygenated microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1500580 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 expressing luxABCDE operon incubated for 10 days under hypoxic conditions followed by incubation under aerobic conditions for 28 hrs by LORA method | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. |
| AID1317945 | Protein binding in human plasma at 5 uM after 30 min by ultrafiltration method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID502040 | Antimicrobial activity against Entamoeba histolytica HM-1:IMSS after 48 hrs | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas. |
| AID1055960 | Antimycobacterial activity against streptomycin-resistant Mycobacterium tuberculosis ATCC 35820 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID559493 | Antibacterial activity against Fusobacterium sp. assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID554799 | Prodrug activation in compound-resistant Helicobacter pylori 10593a/2 lysate harboring rdxA C177stop mutant gene assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID534463 | Antimicrobial activity against Bacteroides fragilis GAI 0558 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1335743 | Antiparasitic activity against Trichomonas vaginalis in po dosed mouse assessed as size of abscess at 50 mg/kg, po administered daily for 7 days measured 7 days post last dose (Rvb = 113 mm'2) | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID534677 | Antimicrobial activity against Bilophila wadsworthia WAL 7959 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID554696 | Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica NTR1 after 16 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID498321 | Antimicrobial activity against Prevotella bivia LBN 339 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID536458 | Antimicrobial activity against Candida albicans at 50 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID501583 | Antiparasitic activity against Trichomonas vaginalis T1 after 24 hrs by hemocytometric analysis | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID67522 | In vitro antiamnesic activity against HM-1:1MMS strain of Entamoeba histolytica | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Synthesis, spectral studies and screening for amoebicidal activity of new palladium(II) complexes derived from thiophene-2-carboxaldehyde thiosemicarbazones. |
| AID554703 | Ratio of EC50 for Escherichia coli JM109 transformed with empty vector PQE30 to EC50 for Escherichia coli JM109 transformed with Trichomonas vaginalis nim1 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID665066 | Antitubercular activity against Mycobacterium tuberculosis H37Rv at > 256 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID16041 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-6 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID535830 | Antibacterial activity against Mycobacterium tuberculosis infected in Hartley guinea pig lung assessed as reduction in development of new secondary lesions at 100 mg/kg after 4 weeks by histological analysis relative to control | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID416732 | Induction of mutagenicity in Salmonella Typhimurium YG1042 assessed as number of revertant per nmol after 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID1917497 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID375872 | Antigiardial activity against metronidazole-sensitive Giardia lamblia isolate 106 trophozoite after 2 days by bactiter-glo viability assay | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13 | Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. |
| AID373575 | Antimicrobial activity against Ruminococcus sp. CCRI-16110 containing vanD-like gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | vanD and vanG-like gene clusters in a Ruminococcus species isolated from human bowel flora. |
| AID498351 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 339 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID67529 | The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Synthesis and antiparasitic activity of 1H-benzimidazole derivatives. |
| AID366964 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microplate method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | New Pd(II) complexes of the synthesized 1-N-substituted thiosemicarbazones of 3-indole carboxaldehyde: characterization and antiamoebic assessment against E. histolytica. |
| AID27580 | Partition coefficient (logP) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
| AID87929 | Antibacterial activity against Helicobacter pylori HP007 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1760134 | Antibacterial activity against gut Bifidobacterium longum HM-846 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID1761179 | Giardicidal activity against nitazoxanide-resistant Giardia intestinalis incubated for 48 hrs by hemocytometric counting method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. |
| AID377877 | Antifungal activity against Giardia intestinalis ATCC 30888 assessed as impairment of parasite motility after 2 hrs | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Antigiardial activity of isoflavones from Dalbergia frutescens bark. |
| AID426310 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 48 hrs by Hill culture method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles. |
| AID566971 | Cytotoxicity against Trichomonas vaginalis TV-VP60 at 50 uM after 24 hrs by trypan blue exclusion assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Candimine-induced cell death of the amitochondriate parasite Trichomonas vaginalis. |
| AID351911 | Safety index, ratio of IC50 for human kidney epithelial cells to IC50 for Entamoeba histolytica HM-1:IMSS | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity. |
| AID574728 | Antimicrobial activity against Prevotella oralis assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID598285 | Antitrypanosomal activity against Trypanosoma cruzi MHOM/MX/1994/Ninoa epimastigotes after 72 hrs by neubauer chamber | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID574502 | Antimicrobial activity against Bacteroides caccae assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1540931 | Effect on growth of Escherichia coli ATCC 25922 assessed as bacterial growth inhibition measured after 16 to 18 hrs by CLSI method | |||
| AID498550 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBP 51 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID554701 | Antimicrobial activity against Escherichia coli JM109 transformed with Trichomonas vaginalis nim1 after 16 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID424332 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1335742 | Selectivity index, ratio of IC50 for human HeLa cells to MIC for metronidazole resistant Trichomonas vaginalis ATCC 50143 | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | 2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study. |
| AID498585 | Antimicrobial activity against Prevotella nanceiensis LBN 293b deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID510493 | Antimicrobial activity against Porphyromonas gingivalis assessed as reduction in average number of microcolony area at 12.5 uM after 18 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. |
| AID1054552 | Spermicidal activity in human semen assessed as sperm immobilization at 0.1 % w/v up to 30 seconds by phase contrast microscopy | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1867111 | Antibacterial activity against Bacteroides fragilis ATCC 25285 assessed as inhibition of bacterial growth by CLSI based agar dilution susceptibility analysis | |||
| AID1676972 | Antimicrobial activity against Clostridioides difficile NR-13432 isolate 6 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID433357 | Antibacterial activity against Prevotella bivia isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID573837 | Antibacterial activity against beta-lactamase producing Clostridium tertium assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1697367 | Antimicrobial activity against Entamoeba histolytica HM1:MMS assessed as reduction in amoeba growth incubated for 72 hrs by microscopy analysis | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23 | Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents. |
| AID534674 | Antimicrobial activity against Fusobacterium nucleatum ATCC 25586 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1147717 | Antibacterial activity against Pentatrichomonas hominis ATCC 30000 after 48 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID548281 | Antimicrobial activity against Trypanosoma brucei NfxR1 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. |
| AID285160 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed as bacterial density after 7 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1731670 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Trichomonas vaginalis JH31A#4 trophozoites | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. |
| AID574004 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID379774 | Antiprotozoal activity against axenically grown trophozoites of Giardia lamblia IMSS:0989:1 after 48 hrs by MTT method | 1999 | Journal of natural products, May, Volume: 62, Issue:5 | Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum. |
| AID1403739 | Antibacterial activity against Escherichia coli ATCC 25922 after overnight incubation by microbroth dilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. |
| AID554611 | Prodrug activation in Helicobacter pylori 10593/2 lysate assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID531518 | Antibacterial activity against Bacteroides uniformis assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID574756 | Antimicrobial activity against Anaerococcus prevotii assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID498318 | Antimicrobial activity against Prevotella bivia LBN 333 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID677473 | Antimicrobial activity against Lactobacillus jensenii | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. |
| AID1486938 | Cytotoxicity against African green monkey Vero cells incubated for 24 to 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum. |
| AID1147716 | Antibacterial activity against Tritrichomonas foetus 1002-96-27 after 48 hrs by ten-fold serial dilution method | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12 | Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae. |
| AID575009 | Antimicrobial activity against Eubacterium sp. assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1327937 | Antifungal activity against Penicillium chrysogenum at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID87950 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 115 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID574778 | Antimicrobial activity against Clostridium difficile assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID533392 | Antimicrobial activity against Clostridium perfringens assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID774309 | Antiprotozoal activity against clinical isolates of Giardia lamblia IMSS:8901:1 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Hydroxyclerodanes from Salvia shannoni. |
| AID1743045 | Antigiardial activity against Giardia duodenalis Ac2 incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID1743040 | Antigiardial activity against Giardia duodenalis WB (ATCC 30957) incubated for 3 days by fluorescence method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Anti- |
| AID498563 | Antimicrobial activity against Prevotella baroniae LBN 427 expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentrations of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1879565 | Antibacterial activity against Peptococcus niger ATCC 27731 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1063470 | Antibacterial activity against Streptococcus mutans ATCC 700610 assessed as growth inhibition after 20 to 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID1755882 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for antigiardial activity against Giardia intestinalis MSS:0696:1 | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID698043 | Inhibition of Helicobacter pylori invasion to human AGS cells at 20 ug/ml after 6 hrs by gentamicin assay relative to control | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID87953 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 81 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID205565 | Antibacterial activity against Staphylococcus epidermidis was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID366938 | Antibacterial activity against metronidazole-sensitive Helicobacter pylori at 8 ug/disk after 3 to 5 days by filter paper disk diffusion method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds. |
| AID84164 | Value is expressed as the ratio of (Tritrichomonas foetus infected) animals cured / total number(15) infected at day 4 post treatment after 4 days of treatment | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Antitrichomonal activity of mesoionic thiazolo[3,2-a]pyridines. |
| AID276338 | Antimicrobial activity against Helicobacter pylori DSMZ 4867 | 2006 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21 | In vitro inhibitory activity of boropinic acid against Helicobacter pylori. |
| AID1127199 | Ratio of MIC for metronidazole-resistant Trichomonas vaginalis ATCC 50143 to metronidazole-susceptible Trichomonas vaginalis clinical isolate | 2014 | European journal of medicinal chemistry, May-22, Volume: 79 | Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis. |
| AID1755854 | Antileishmanial activity against promastigote form of Leishmania braziliensis MHOM/BR/75/M2903 measured for 7 days by cell counting method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID574724 | Antimicrobial activity against Prevotella buccae assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID66922 | Antibacterial activity against Enterococcus faecalis was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID494134 | Antibacterial activity against metronidazole-resistant Helicobacter pylori isolate 18 after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID211155 | Antimicrobial activity against Trichomonas vaginalis | 1997 | Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6 | Semisynthetic derivatives of purpuromycin as potential topical agents for vaginal infections. |
| AID574772 | Antimicrobial activity against Clostridium perfringens assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID498334 | Antimicrobial activity against Prevotella bivia LBP 38 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID454072 | Inhibition of Helicobacter pylori ATCC 43504 urease assessed as ammonia production at 1 mM after 3 hrs by indophenol method | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21 | Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors. |
| AID425098 | Antimicrobial activity against Anaerococcus prevotii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID540195 | Antibacterial activity against Helicobacter pylori SS1 assessed as inhibition of visible growth after 96 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study. |
| AID1879551 | Antibacterial activity against Bacteroides uniformis MMX 1277 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID498316 | Antimicrobial activity against Prevotella bivia LBN 331 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1294716 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 8 hrs by pour plate method (Rvb = 8.30 +/- 0.442 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1879498 | Antibacterial activity against rifampicin resistant Helicobacter pylori harboring rpoBL525I/D530N mutant | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1879569 | Antibacterial activity against metronidazole-resistant Prevotella asaccharolytica MMX 3552 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID386921 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1599225 | Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes infected in BALB/c mouse assessed as reduction in parasite load in liver at 50 mg/kg, ip administered once daily for 5 days measured 7 days post dose by giemsa staining-base | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID1204224 | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 2 hrs relative to control | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates. |
| AID416731 | Induction of mutagenicity in Salmonella Typhimurium TA100 assessed as number of revertant per ug after 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID498562 | Antimicrobial activity against Prevotella baroniae DSM 16972T expressing nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentrations of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID173917 | Lowest active dose which cured rats with Entamoeba histolytica cecal infection was measured | 1980 | Journal of medicinal chemistry, Feb, Volume: 23, Issue:2 | Antiamebic amidines and sulfonamides of 5- and 6-amino-2,3-bis(4-alkyl-1-piperazinyl)quinoxalines. |
| AID502781 | Antibacterial activity against multidrug-resistant Helicobacter pylori v1354 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID498578 | Antimicrobial activity against Prevotella baroniae LBN 432 expressing nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1529184 | Protein binding in immobilized human serum albumin by HPLC analysis | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. |
| AID1879506 | Antibacterial activity against metronidazole-resistant Helicobacter pylori CB1573 harboring rdxAR16S mutant at 1:1 compound to rifabutin molar ratio measured after 5 days in presence of rifabutin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1192646 | Inhibition of Mycobacterium smegmatis TMC 607 ATP synthase incubated for 10 mins prior to NADH addition measured after 1 hr by luminescence assay | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. |
| AID1879507 | Antibacterial activity against rifampicin-resistant Helicobacter pylori CB1903 harboring rpoBD530V mutant measured after 5 days by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID16037 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-2 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID1377042 | Antiparasitic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS after 48 hrs | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1683311 | Binding affinity to Entamoeba histolytica HM1:MMS trophozoites actin assessed as formation of pseudo-plates at IC50 concentration incubated for 1 hrs by DPAI staining based confocal microscopic analysis | |||
| AID1146212 | Toxicity in CF1 mouse assessed as reduction in body tone at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID534675 | Antimicrobial activity against Fusobacterium varium ATCC 8501 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1142218 | Antimicrobial activity against Helicobacter pylori isolated from gastrointestinal disease patient after 72 hrs by Etest method | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11 | Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori. |
| AID697912 | Antimicrobial activity against Helicobacter pylori 26695 ATCC 700392 at pH 7 by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID750267 | Cytotoxicity against human HepG2 cells assessed as cell viability at 50 to 100 uM after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID67520 | Antiprotozoal activity measured as the conc for >95% inhibition of Entamoeba histolytica | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID425088 | Antimicrobial activity against Porphyromonas asaccharolyticus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID573595 | Antibacterial activity against Fusobacterium nucleatum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID87930 | Antibacterial activity against Helicobacter pylori HP008 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID554805 | Prodrug activation in compound-resistant Helicobacter pylori RIG 117 J56 lysate harboring rdxA R16C and frxA A40stop mutant genes assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID29421 | Partition coefficient (logP) (HPLC) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
| AID433364 | Antibacterial activity against Clostridium sphenoides isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID554613 | Prodrug activation in Helicobacter pylori 10593/2 lysate assessed as compound reduction under argonized aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID533416 | Antimicrobial activity against Peptoniphilus asaccharolyticus assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1317952 | Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 24 hrs by resazurin assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID757807 | Antiprotozoal activity against trophozoite stage of Trichomonas vaginalis GT3 assessed as growth inhibition after 48 hrs by haemocytometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives. |
| AID498571 | Antimicrobial activity against Prevotella buccae LBN 465 deficient in nimI gene assessed as inhibition of growth after several passages on plates containing increasing concentration of compound by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID87947 | Inhibitory activity was determined against NCTC-11637 strain of Helicobacter pylori | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | Anti-Helicobacter pylori agents endowed with H2-antagonist properties. |
| AID1683301 | Induction of apoptosis in Entamoeba histolytica HM1:MMS trophozoites assessed as early apoptotic cells at IC50 concentration after 48 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.9%) | |||
| AID573598 | Antibacterial activity against Fusobacterium varium assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1327935 | Antifungal activity against Candida albicans IMRU 3669 at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID144206 | Antimicrobial activity was measured against Neisseria gonorrhoeae organism | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID1067245 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 0.5 ug/ml after 48 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1617939 | Antiprotozoal activity against Tritrichomonas foetus KV1 assessed as protozoal growth inhibition measured after 72 hrs under anaerobic conditions | |||
| AID498330 | Antimicrobial activity against Prevotella bivia LBN 464 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID498540 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 361 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1317950 | Antiparasitic activity against metronidazole sensitive Clostridium difficile 630 ATCC BAA-1382 after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID598284 | Antileishmanial activity against Leishmania mexicana MHOM/MX/ISETGS promastigotes after 72 hrs by neubauer chamber | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. |
| AID88248 | Minimal concentration needed to inhibit 90% of Helicobacter pylori strain | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | Anti-Helicobacter pylori agents endowed with H2-antagonist properties. |
| AID67527 | Inhibitory concentration against Entamoeba histolytica (HK-9) for antiamnesic activity | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives. |
| AID573596 | Antibacterial activity against Fusobacterium mortiferum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1146163 | Antiprotozoal activity against Trichomonas vaginalis assessed as cidal effect | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID69330 | Minimum inhibitory concentration measured against Escherichia coli SR58 strain (RecA- UvrB-) | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs. |
| AID1676974 | Antimicrobial activity against Clostridioides difficile NR-32883 P2 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID533396 | Antimicrobial activity against Clostridium innocuum assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID574760 | Antimicrobial activity against Peptoniphilus asaccharolyticus assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID574971 | Antimicrobial activity against Actinomyces israelii assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1225673 | Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 300 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method | 2015 | European journal of medicinal chemistry, Apr-13, Volume: 94 | Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. |
| AID29423 | HPLC capacity factor (k') | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID285558 | Bactericidal activity against 19-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 1 day by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID1755858 | Antiamoebic activity against Entamoeba histolytica HK9 ATCC 30015 by trypan blue staining based assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID87933 | Antibacterial activity against Helicobacter pylori HP022 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID674905 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by eosin-staining method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Metronidazole thiosalicylate conjugates: synthesis, crystal structure, docking studies and antiamoebic activity. |
| AID433367 | Antibacterial activity against Anaerococcus tetradius isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1760130 | Antibacterial activity against Clostridium difficile ATCC 43255 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID574514 | Antimicrobial activity against Bacteroides ovatus assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID664680 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis | 2012 | ACS medicinal chemistry letters, Feb-09, Volume: 3, Issue:2 | Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D-QSAR Analysis. |
| AID535824 | Antibacterial activity against Mycobacterium tuberculosis infected in Hartley guinea pig spleen assessed as reduction in bacterial load at 100 mg/kg | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. |
| AID16038 | Percent biliary excretion property by administering intravenously to rats was reported as amount of unchanged form of compound detected in bile samples collected at 0-3 hr after the treatment. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. |
| AID50983 | Compound was evaluated for antimicrobial activity against Clostridium perfringens | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID1676975 | Antimicrobial activity against Clostridioides difficile NR-32891 P13 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID554607 | Antimicrobial activity against compound-resistant Helicobacter pylori RIG 117 J56 harboring rdxA R16C and frxA A40stop mutant genes by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1348795 | Selectivity index, ratio of IC50 for human HeLa cells to MIC for metronidazole-resistant Trichomonas vaginalis CDC085 ATCC 50143 | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID554704 | Activity of Entamoeba histolytica NIM1 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID433361 | Antibacterial activity against Clostridium clostridioforme isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID1335466 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica. |
| AID377889 | Antimicrobial activity against Trichomonas | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Antigiardial activity of isoflavones from Dalbergia frutescens bark. |
| AID1676977 | Antimicrobial activity against Clostridioides difficile NR-32904 P30 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID1879558 | Antibacterial activity against rifampicin-resistant Clostridium difficile MMX 3587 | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID1192659 | Bactericidal activity against non-replicating Mycobacterium tuberculosis H37Rv Wayne model under hypoxic/oxygen depleted conditions assessed as log reduction after 4 days by serial dilution assay | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. |
| AID574746 | Antimicrobial activity against Peptostreptococcus anaerobius assessed as percent resistant isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1146216 | Toxicity in CF1 mouse assessed as flaccid paralysis at 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID554803 | Prodrug activation in compound-resistant Helicobacter pylori RIG 117 J56 lysate harboring rdxA R16C and frxA A40stop mutant genes assessed as compound reduction under argonized microaerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1879538 | Antibacterial activity against fluoroquinolone-resistant Clostridioides difficile CB1941 harboring gyrAD71Y/T82A mutant at 1:1 compound to rifampicin molar ratio measured after 3 days in presence of rifampicin | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID285572 | Bactericidal activity against 12-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 11 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID557678 | Antimicrobial activity in Prevotella baroniae by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID534441 | Antimicrobial activity against Clostridium septicum ATCC 12464 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID1367037 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1196182 | Antimicrobial activity against Helicobacter pylori by disc diffusion method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold. |
| AID172618 | The amount of unchanged compound detected in urine collected at 0-18 hr after treatment | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. |
| AID319576 | Antibacterial activity against metronidazole-resistant Helicobacter pylori assessed as inhibition zone diameter at 16 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID498317 | Antimicrobial activity against Prevotella bivia LBN 332 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID557694 | Antimicrobial activity in Prevotella salivae by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID425111 | Antimicrobial activity against beta lactamase-positive Bacteroides thetaiotaomicron isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID557698 | Antimicrobial activity in Prevotella loescheii by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1055964 | Antimycobacterial activity against Mycobacterium tuberculosis clinical isolate X004244 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID424330 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID87808 | Antibacterial activity against Helicobacter pylori HP0016 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID554695 | Antimicrobial activity against Escherichia coli JM109 transformed with empty vector PQE30 after 16 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). |
| AID250202 | Viable Mycobacterium tuberculosis in spleen of infected Mice after an 8-day drug treatment; Dose is 150 mg/kg | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21 | Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. |
| AID494130 | Antibacterial activity against metronidazole-resistant Helicobacter pylori NCTC 11637 after 72 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. |
| AID29925 | Volume of distribution in man (IV dose) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID1540930 | Effect on growth of Bifidobacterium bifidum 212A ATCC 11863 measured after 48 hrs in anerobic conditions by CLSI method | |||
| AID1676973 | Antimicrobial activity against Clostridioides difficile NR-13435 isolate 9 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID296137 | Antibacterial activity against Bacteroides thetaiotaomicron after 20 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. |
| AID1599236 | Toxicity in BALB/c mouse infected with Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as effect on health at 25 mg/kg, po administered once daily for 5 days measured up to 7 days post dose | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11 | Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis. |
| AID379776 | Cytotoxicity against human MCF7 cells after 7 days by MTT method | 1999 | Journal of natural products, May, Volume: 62, Issue:5 | Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum. |
| AID319579 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 1 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID1879520 | Antibacterial activity against metronidazole/rifampicin-resistant Helicobacter pylori CB1771 harboring rpoBL525I/D530N/rdxAE75stop mutant at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID574736 | Antimicrobial activity against Fusobacterium nucleatum after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID50732 | Compound was evaluated for antimicrobial activity against Clostridium difficile | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID1177054 | Antiprotozoan activity against Giardia lamblia G1 | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite. |
| AID1055936 | Antimycobacterial activity against Mycobacterium tuberculosis harboring luxABCDE under hypoxic condition after 10 days by MABA assay in presence of 4% bovine serum albumin | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID394719 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Bis-pyrazolines: synthesis, characterization and antiamoebic activity as inhibitors of growth of Entamoeba histolytica. |
| AID426305 | Cytotoxicity against MDCK cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles. |
| AID409951 | Inhibition of human liver MAOB | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID346841 | Antimycobacterial activity against Mycobacterium tuberculosis with cofactor F420 mutant | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles. |
| AID67528 | Tested for antiamnesic activity against HK-9 strain of Entamoeba histolytica | 2000 | Bioorganic & medicinal chemistry letters, Oct-16, Volume: 10, Issue:20 | Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives. |
| AID534466 | Antimicrobial activity against carbapenemase-producing Bacteroides fragilis GAI 30079 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID554800 | Prodrug activation in compound-resistant Helicobacter pylori 10593a/2 lysate harboring rdxA C177stop mutant gene assessed as compound reduction under oxygenated aerobic condition per mg of protein | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID689772 | Antitubercular activity against Mycobacterium tuberculosis H37Rv incubated for 10 days in anaerobic condition followed by 48 hrs incubation in aerobic condition by LORA assay | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13 | Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. |
| AID40354 | Relative stability towards beta-lactamase was determined in Bacillus fragilis FP784; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID211149 | Antiprotozoal activity measured as the conc for 100% inhibition of Trichomonas vaginalis | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1244350 | Resistance index, ratio of MIC for MTZ-resistant Trichomonas vaginalis to MIC for MTZ-susceptible Trichomonas vaginalis | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID536453 | Antimicrobial activity against Chrysosporium keratinophilum at 100 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID245243 | Minimal inhibitory concentration against metronidazole resistant Helicobacter pylori 20 strain | 2005 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3 | Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives. |
| AID1274889 | Antiparasitic activity against Giardia lamblia Portland 1 after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents. |
| AID1294232 | Trichomonacidal activity against metronidazole-sensitive Trichomonas vaginalis JH31A#4 trophozoites after 24 hrs by resazurin dye based fluorescence assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles. |
| AID425108 | Antimicrobial activity against Clostridium paraputrificum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID29363 | Dissociation constant (pKa) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID416730 | Induction of mutagenicity in Salmonella Typhimurium YG1042 assessed as number of revertant per ug after 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID1676981 | Antimicrobial activity against Escherichia coli JW55031 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID331191 | Antiprotozoal activity against Trichomonas vaginalis | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids. |
| AID574052 | Antibacterial activity against beta-lactamase producing Finegoldia magna assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID160387 | Minimum inhibitory concentration against Propionibacterium acnes(NCTC 737)(in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria. |
| AID1146219 | Toxicity in CF1 mouse assessed as change in sleeping time at 300 mg/kg, po administered 30 mins prior to hexobarbital sodium challenge relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID574744 | Antimicrobial activity against Peptostreptococcus anaerobius assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID433355 | Antibacterial activity against Porphyromonas asaccharolyticus isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID750266 | Cytotoxicity against human HepG2 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Nitroimidazolyl hydrazones are better amoebicides than their cyclized 1,3,4-oxadiazoline analogues: In vitro studies and Lipophilic efficiency analysis. |
| AID693076 | Redox potential of the compound assessed as one electron redox potential by pulse radiolysis method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. |
| AID72162 | Aerobic cytotoxicity against human melanoma FME cells in a growth inhibition microassay | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. |
| AID1317944 | Metabolic stability in human liver microsomes assessed as compound remaining at 5 uM after 2 hrs in presence of NADPH by LC/MS/MS analysis | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. |
| AID346839 | Antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 after 2 weeks | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles. |
| AID84163 | Value is expressed as the ratio of (Tritrichomonas foetus infected) animals cured / total number(15) infected at day 1 post treatment after 4 days of treatment | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Antitrichomonal activity of mesoionic thiazolo[3,2-a]pyridines. |
| AID1067246 | Trichomonacidal activity against Trichomonas vaginalis JH31A at 1 ug/ml after 48 hrs by Neubauer chamber analysis relative to control | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones. |
| AID351910 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by trypan blue exclusion method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity. |
| AID1456704 | Antiparasitic activity against Trichomonas vaginalis BRIS/92/STDL/B7268 clinical isolate after 48 hrs under anaerobic condition | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. |
| AID536459 | Antimicrobial activity against Microsporum gypseum at 100 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID1529182 | Protein binding in plasma (unknown origin) | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. |
| AID424328 | Antimicrobial activity against Dialister invisus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1055956 | Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis ATCC 35822 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID554604 | Antimicrobial activity against Helicobacter pylori CAS 015 J0 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | A redox basis for metronidazole resistance in Helicobacter pylori. |
| AID1066690 | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Structure, absolute configuration, and antidiarrheal activity of a thymol derivative from Ageratina cylindrica. |
| AID211151 | Antiprotozoal activity measured as the conc for <25% inhibition of Trichomonas vaginalis | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1617938 | Antiprotozoal activity against Giardia duodenalis 713 assessed as protozoal growth inhibition measured after 96 hrs under anaerobic conditions | |||
| AID574995 | Antimicrobial activity against Bifidobacterium sp. assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID498555 | Antimicrobial activity against slow growing colonies of Prevotella nanceiensis LBN 293b deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID7783 | Unbound fraction (plasma) | 2004 | Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5 | Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. |
| AID1295348 | Antitrichomonas activity against metronidazole-susceptible Trichomonas vaginalis in sc dosed mouse assessed as pustule formation at 5 ug administered daily measured after 5 days (Rvb = 109 mm'2) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID252981 | In vitro cytocidal activity against Trichomonas vaginalis at a dose of 2 mg/ml after 24 hours | 2005 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17 | A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: outcomes of in silico studies supported by experimental results. |
| AID1146165 | Ratio of compound ED50 to metronidazole ED50 for Trichomonas vaginalis infected in po dosed mouse | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. |
| AID498543 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 374 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1295330 | Antitrichomonas activity against trophozoite stage of Trichomonas vaginalis clinical isolate assessed as cell viability under anaerobic condition after 48 hrs by trypan blue exclusion assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID533404 | Antimicrobial activity against Clostridium subterminale assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID87810 | Antibacterial activity against Helicobacter pylori HP0018 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID211154 | Inhibitory concentration against Trichomonas vaginalis (tv-43) for anti-trichomonal activity | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives. |
| AID331195 | Antiprotozoal activity against Plasmodium berghei | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids. |
| AID285571 | Bactericidal activity against 12-day old non-replicating Mycobacterium tuberculosis H37Rv in anaerobic condition at 8 ug/ml after 4 days by Wayne dormancy culture model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. |
| AID40358 | Stability towards beta-lactamase was determined in Bacillus fragilis FP784; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1335465 | Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites incubated for 10 mins under nitrogen gassed condition measured after 72 hrs by eosin staining based micro dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica. |
| AID467622 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS trophozoites after 72 hrs by microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives. |
| AID1540927 | Effect on growth of Lactobacillus gasseri EX336960VC03 HM 400 measured after 48 hrs in anaerobic conditions by CLSI method | |||
| AID1294715 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 4 hrs by pour plate method (Rvb = 6.14 +/- 0.456 log10CFU/ml) | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. |
| AID1055959 | Antimycobacterial activity against rifampin-resistant Mycobacterium tuberculosis ATCC 35838 under normoxic condition after 7 days by MABA assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID87926 | Antibacterial activity against Helicobacter pylori HP0019 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID658931 | Antiparasitic activity against Giardia duodenalis IMSS:0989 after 48 hrs | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives. |
| AID331192 | Antiprotozoal activity against Giardia lamblia | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids. |
| AID1367032 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID1917495 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1683294 | Antimicrobial activity against Entamoeba histolytica HM1:MMS trophozoites infected in Syrian hamster assessed as ALT level at 0.1 mg/kg, ip at 4 days post infection and measured on day 8 (Rvb = 276 +/- 24 U/L) | |||
| AID1760137 | Antibacterial activity against gut Limosilactobacillus-reuteri HM-102 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID211135 | Antiprotozoal activity measured as the conc for 95-25% inhibition of Trichomonas foetus | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID574734 | Antimicrobial activity against Fusobacterium necrogenes after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1917496 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID534446 | Antimicrobial activity against Bifidobacterium bifidum JCM 1255 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID573574 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID531513 | Antibacterial activity against Bacteroides spp. assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID618302 | Selectivity index, ratio of IC50 for rat H9c2 cells to IC50 for Entamoeba histolytica HM-1:IMSS | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica. |
| AID1760133 | Antibacterial activity against gut Bacteroides fragilis HM-709 assessed as reduction in bacterial growth measured after 48 hrs by CLSI based broth microdilution method | 2021 | ACS medicinal chemistry letters, Jun-10, Volume: 12, Issue:6 | Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target |
| AID1879500 | Antibacterial activity against Helicobacter pylori ATCC 700392 at 1:1 compound to rifampicin molar ratio measured after 5 days in presence of rifampicin by agar dilution method | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. |
| AID662566 | Growth inhibition of Trichomonas vaginalis T1 after 24 hrs by hemocytometry | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine. |
| AID84679 | Lowest active dose which cured hamsters with Entamoeba histolytica hepatic infection was measured | 1980 | Journal of medicinal chemistry, Feb, Volume: 23, Issue:2 | Antiamebic amidines and sulfonamides of 5- and 6-amino-2,3-bis(4-alkyl-1-piperazinyl)quinoxalines. |
| AID1676978 | Antimicrobial activity against Clostridioides difficile ATCC 43255 assessed as reduction in microbial growth after 48 hrs by broth microdilution method | |||
| AID1264944 | Antiprotozoal activity against Giardia lamblia IMSS:1090:1 | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | ent-Kaurene Glycosides from Ageratina cylindrica. |
| AID534672 | Antimicrobial activity against Porphyromonas asaccharolyticus ATCC 25260 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1192663 | Bactericidal activity against non-replicating Mycobacterium tuberculosis H37Rv Wayne model under hypoxic/oxygen depleted conditions assessed as log reduction at 50 ug/ml after 4 days by serial dilution assay | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID573819 | Antibacterial activity against Veillonella parvula by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID631763 | Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites compound treated for 48 hrs measured after 48 hrs washout period | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Antiprotozoal activity of proton-pump inhibitors. |
| AID498340 | Antimicrobial activity against Prevotella nanceiensis LBN 293b deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1755861 | Anti-trichomonas activity against Trichomonas vaginalis JT incubated for 48 hrs by hemocytometer based eosin exclusion assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID426304 | Antiparasitic activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs by Hill culture method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles. |
| AID559492 | Antibacterial activity against Clostridium perfringens assessed as percent susceptible isolates by CLSI M11-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID637014 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives. |
| AID498343 | Antimicrobial activity against Prevotella nanceiensis LBN 410 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID600470 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Antiprotozoal activity of chloroquinoline based chalcones. |
| AID534473 | Antimicrobial activity against Bacteroides eggerthii ATCC 27754 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID88245 | Minimal concentration needed to inhibit 50% of Helicobacter pylori strain | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | Anti-Helicobacter pylori agents endowed with H2-antagonist properties. |
| AID498538 | Antimicrobial activity against slow growing colonies of Prevotella bivia LBN 346 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID531786 | Antibacterial activity against Veillonella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573798 | Antibacterial activity against Prevotella melaninogenica assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID433354 | Antibacterial activity against Parabacteroides merdae isolated from patient with diabetic foot infection assessed as percent resistant isolates after 44 to 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. |
| AID531510 | Antibacterial activity against Bacteroides stercoris assessed as percent resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID319577 | Antibacterial activity against metronidazole-resistant Helicobacter pylori assessed as inhibition zone diameter at 32 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID210260 | Antibacterial activity against Streptococcus pyogenes C, activity expressed as inhibitory zone (mm, diameter) | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Structure-activity relationships of synthetic antibiotic analogues of anisomycin. |
| AID1331803 | Cytotoxicity against CHO cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. |
| AID27575 | HPLC capacity factor (k) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID502038 | Antimicrobial activity against Giardia intestinalis IMSS:0696:1 after 48 hrs | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas. |
| AID545981 | Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives). |
| AID1416871 | Antiparasitic activity against Entamoeba histolytica HM-1:IMSS trophozoites assessed as parasite growth inhibition after 48 hrs by ATP bioluminescence-based CellTiter-Glo luminescent cell viability assay | 2017 | MedChemComm, , Volume: 8, Issue:10 | Design, Synthesis and Preliminary Antimicrobial Evaluation of |
| AID1146211 | Toxicity in CF1 mouse assessed as reduction in spontaneous activity at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID574989 | Antimicrobial activity against Bifidobacterium adolescentis assessed as percent susceptible isolates after 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. |
| AID1055937 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv under normoxic condition after 7 days by MABA assay in presence of 10% fetal bovine serum | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID379777 | Cytotoxicity against human HT-29 cells after 7 days by MTT method | 1999 | Journal of natural products, May, Volume: 62, Issue:5 | Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum. |
| AID536456 | Antimicrobial activity against Chrysosporium keratinophilum at 50 ug/mL after 72 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID557682 | Antimicrobial activity in Prevotella oralis group by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID498587 | Antimicrobial activity against Bacteroides fragilis ATCC 25285T deficient in nimI gene assessed as inhibition of growth after three consecutive subcultures on compound free medium by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID416729 | Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore. |
| AID534678 | Antimicrobial activity against Desulfovibrio desulfuricans ATCC 29577 by agar dilution method in presence of 5% laked sheep blood | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. |
| AID573582 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1146226 | Toxicity in CF1 mouse assessed as ataxia at 10 to 600 mg/kg, po by Irwin test | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and biological activity of new 2-nitroimidazole derivatives. |
| AID498329 | Antimicrobial activity against Prevotella bivia LBN 445 deficient in nim gene assessed as inhibition of growth at 48 hrs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. |
| AID1135263 | Antimicrobial activity against Trichomonas vaginalis infected in sc dosed mouse | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. |
| AID87927 | Antibacterial activity against Helicobacter pylori HP003 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID557686 | Antimicrobial activity in Prevotella veroralis by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1224864 | HCS microscopy assay (F508del-CFTR) | 2016 | PloS one, , Volume: 11, Issue:10 | Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3847 (29.91) | 18.7374 |
| 1990's | 2332 (18.13) | 18.2507 |
| 2000's | 2644 (20.56) | 29.6817 |
| 2010's | 3011 (23.41) | 24.3611 |
| 2020's | 1027 (7.99) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (137.52) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,489 (17.80%) | 5.53% |
| Reviews | 1,278 (9.14%) | 6.00% |
| Case Studies | 2,226 (15.92%) | 4.05% |
| Observational | 53 (0.38%) | 0.25% |
| Other | 7,937 (56.76%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metronidazole Every 24 Hours as Part of Triple Antibiotic Therapy for Ruptured Appendicitis in Children Managed Operatively (METRO): a Noninferiority Randomized Controlled Trial [NCT02561117] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-31 | Withdrawn(stopped due to Lack of funding) | ||
| Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers [NCT00066066] | Phase 2 | 146 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| Helicobacter Pylori Eradication According to Sequencing-based 23S Ribosomal RNA Point Mutation Associated With Clarithromycin Resistance [NCT03884348] | 431 participants (Actual) | Observational | 2017-01-01 | Completed | |||
| Clinical and Microbiological Evaluation of Metronidazole as a Systemic Antimicrobial Adjunct to Periodontal Surgery in the Treatment of Patients With Periodontitis Positive to Porphyromonas Gingivalis [NCT03880448] | 17 participants (Actual) | Interventional | 2012-09-19 | Completed | |||
| Phase II Multicentered Randomized Open-label Study of Effectiveness and Safety of Lactofiltrum in Women With Bacterial Vaginosis [NCT01089348] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2010-07-31 | Recruiting | ||
| Metronidazole for the Treatment of Dientamoebiasis in Children in Denmark - A Randomized, Placebo-controlled, Double-blinded Clinical Trial [NCT01314976] | Phase 4 | 100 participants (Anticipated) | Interventional | 2011-07-31 | Completed | ||
| Helicobacter Pylori Eradication Using a Bismuth Quadruple Therapy Among Asymptomatically Infected Adults in El Paso, Texas: A Pilot Study. [NCT01335334] | Phase 4 | 50 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting | ||
| 14-day PCAB-based and Reverse Hybrid Therapy Fro Helicobacter Pylori [NCT05191888] | Phase 4 | 906 participants (Anticipated) | Interventional | 2021-08-06 | Recruiting | ||
| A Randomized Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection [NCT01219764] | Phase 4 | 200 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Twice-a-day PPI, Tetracycline, Metronidazolequadruple Therapy With Pylera® or Lactobacillus Reuteri for Treatment naïve or for Retreatment of H. Pylori: Two Randomized Pilot Studies [NCT03925818] | 99 participants (Actual) | Interventional | 2017-08-29 | Terminated(stopped due to Lactobacillus reuteri (Gastrus®) was not anymore available in the region) | |||
| Helicobacter Pylori and Gastric Cancer - the Role of Cytokine Polymorphism, Cytokine Expression and Expression of TLR on Persistence of Helicobacter Pylori Infection and Development of Gastric Cancer. [NCT01137942] | 14 participants (Anticipated) | Observational | 2008-11-30 | Recruiting | |||
| Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital [NCT04771728] | Phase 4 | 140 participants (Anticipated) | Interventional | 2020-02-01 | Recruiting | ||
| A Phase 2, Randomized, Active Comparator-Controlled, Multicenter, Double-Blind Clinical Trial to Study the Safety and Efficacy of Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem in Pediatric Subjects With Complicated Intra-Abdominal [NCT03217136] | Phase 2 | 94 participants (Actual) | Interventional | 2018-04-03 | Completed | ||
| The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial [NCT02800785] | 1,552 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| Randomized Control Trial Comparing Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer [NCT01345175] | Phase 3 | 70 participants (Actual) | Interventional | 2011-04-26 | Completed | ||
| A Comparison of Single Preoperative Dose of Co-amoxiclav Versus Postoperative Full Course of Amoxicillin/ Co-amoxiclav in Prevention of Postoperative Complications in Dentoalveolar Surgery: a Randomized Controlled Trial [NCT03844776] | 135 participants (Anticipated) | Interventional | 2019-10-02 | Recruiting | |||
| Analysis of the Impact of Helicobacter Pylori Infection and Eradication on Salivary Microbiome in Adults by 16S Pyrosequencing [NCT03730766] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study [NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| REFOCUS: Refined Fecal Microbiota Transplantation (FMT) Delivered by Oral Capsules for Induction of Remission in Mild to Moderate Ulcerative Colitis - a Phase I Study [NCT04968951] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2021-11-10 | Recruiting | ||
| Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. [NCT01211223] | Phase 4 | 42 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Randomized Placebo-controlled Study on the Effects of Antibiotic-induced Gut MicrobiomE Disruption on the Innate Immune Response Following Cardiac Surgery [NCT03939273] | 80 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | |||
| The Use of Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment [NCT03933501] | Phase 4 | 48 participants (Actual) | Interventional | 2006-01-01 | Completed | ||
| Antibiotic Susceptibility-based Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy: a Prospective Clinical Trial [NCT03708848] | Phase 4 | 112 participants (Actual) | Interventional | 2018-12-05 | Completed | ||
| Effect of Bacterial Vaginosis and Its Treatment on HIV Susceptibility and Female Genital Immunology [NCT02527941] | Phase 1 | 50 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Antimicrobial Efficacy of Synthetic Versus Herbal Intracanal Medicaments Against Enterococcus Faecalis [NCT06006663] | Phase 2/Phase 3 | 32 participants (Anticipated) | Interventional | 2023-08-26 | Not yet recruiting | ||
| Evaluation of Methods for Extrapolating or Estimating the Size of Children in Pediatric Intensive Care Compared With the Reference Method of the World Health Organization (WHO) [NCT03913247] | 477 participants (Actual) | Observational | 2019-11-29 | Completed | |||
| Comparison of the Efficacy of 14-day Sequential Therapy and 10-day Bismuth Quadruple Therapy in the Second Line Therapy for Helicobacter Pylori Infection: A Multi-center Randomized Trial [NCT03208426] | Phase 4 | 240 participants (Anticipated) | Interventional | 2017-10-01 | Recruiting | ||
| A Pilot Study for a Randomized Trial of Antibiotics Versus Surgery for Treatment of Patients With Acute Uncomplicated Appendicitis [NCT02447224] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2015-03-31 | Completed | ||
| Combination Vs Single Antibiotics for Prevention of SSI in Obese Women Undergoing CS [NCT03736187] | 280 participants (Anticipated) | Interventional | 2019-04-30 | Not yet recruiting | |||
| Clinical, Microbiological and Immunological Evaluation of the Effects of Systemic Probiotics in the Periodontal Treatment [NCT03733379] | Phase 3 | 176 participants (Anticipated) | Interventional | 2018-11-05 | Recruiting | ||
| Treatment of Giardia Lamblia Infections in Children: Randomized Open-labeled Trial Comparing Rectal Metronidazole With Oral Tinidazole [NCT02942485] | Phase 4 | 8 participants (Actual) | Interventional | 2016-12-01 | Terminated(stopped due to Extremely slow enrollment) | ||
| To Compare the Relative Bioavailability of 375 mg Metronidazole Capsules (Kali) With That of Flagyl 375 mg Capsules/( G.D. Searle, Inc) Under Fed Conditions [NCT01380522] | Phase 1 | 18 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| A Prospective, Single-center, Open-label, Clinical Trial to Compare the 10-day Sequential Therapy and 7-day Culture Based Tailored Therapy for the Eradication of Helicobacter Pylori [NCT02373280] | 600 participants (Anticipated) | Interventional | 2014-08-31 | Recruiting | |||
| Identification of Optimum Spectacle Prescriptions for Patients With Down Syndrome [NCT03367793] | 30 participants (Actual) | Interventional | 2018-01-26 | Completed | |||
| A Prospective, Randomized, Double-blinded, Multi-center Trial Assessing the Safety and Efficacy of Intravenous Administration BAY12-8039 (Moxifloxacin) 400mg Every 24 h Compared to Intravenous Ceftriaxone 2g Every 24h and Metronidazole 500mg Every 12h for [NCT00769171] | Phase 3 | 364 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection-A Randomized Clinical Trial [NCT03658746] | Phase 4 | 420 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Manipulating the Microbiome in IBD by Antibiotics and Fecal Microbiota Transplantation (FMT): a Randomized Controlled Trial [NCT02033408] | 28 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Innovative Technology for Assessing the Periodontal Disease and New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin [NCT03656484] | Phase 2 | 50 participants (Actual) | Interventional | 2019-01-15 | Completed | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT04853875] | Phase 4 | 104 participants (Actual) | Interventional | 2021-04-19 | Completed | ||
| Observational Program Neo-Penotran® Forte [NCT01335373] | 13,024 participants (Actual) | Observational | 2010-10-31 | Completed | |||
| Comparison of Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the Third-line Eradication of H. Pylori- a Multicenter Randomized Trial [NCT03555526] | Phase 4 | 320 participants (Anticipated) | Interventional | 2017-12-15 | Recruiting | ||
| Optimal Care of Complicated Appendicitis [NCT03159754] | Phase 4 | 40 participants (Actual) | Interventional | 2017-06-29 | Completed | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| A Prospective, Single-center, Randomized, Open-label, Parallel Design Clinical Trial to Compare the 14-day Bismuth Quadruple Therapy and 7-day Culture Based Tailored Therapy for the Eradication of Helicobacter as a Rescue 2nd Therapy. [NCT02359331] | 370 participants (Actual) | Interventional | 2014-08-31 | Terminated | |||
| 10-Day Antimicrobial Susceptibility Testing Guided Triple Therapy Versus 14-Day Empirical Tailored Therapy for the First-line Treatment of Helicobacter Pylori Infection-A Randomized Controlled Trail [NCT03571230] | Phase 4 | 400 participants (Anticipated) | Interventional | 2018-07-01 | Not yet recruiting | ||
| Regenerative Endodontic Therapy (RET) Using Antibiotic Pastes or Calcium Hydroxide Disinfection for the Management of Immature Non-vital Permanent Teeth in Children: A Randomized Controlled Clinical Trial [NCT03327844] | Phase 2 | 40 participants (Actual) | Interventional | 2017-03-01 | Completed | ||
| Rescue Therapy for Helicobacter Pylori Eradication: A Randomized Non-Inferiority Trial of Minocycline or Tetracycline in Bismuth Quadruple Therapy [NCT04531059] | Phase 4 | 368 participants (Actual) | Interventional | 2020-10-15 | Completed | ||
| A Multicenter, Randomized, Double-Blind, Vehicle Controlled Study Evaluating the Therapeutic Equivalence and Safety of GDC-229 (Investigational Metronidazole 0.75% Vaginal Gel) and Metronidazole 0.75% Vaginal Gel in the Treatment of Bacterial Vaginosis [NCT03091777] | Phase 3 | 871 participants (Actual) | Interventional | 2017-03-10 | Completed | ||
| To Compare the Relative Bioavailability of 375 mg Metronidazole Capsules (Kali) With That of Flagyl 375 mg Capsules( G.D. Searle, Inc) Under Fasting Conditions [NCT01380509] | Phase 1 | 28 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| Clinical and Microbiological Comparison of Two Different Systemic Antimicrobials (Azithromycin Versus Metronidazole) as Adjuncts to Periodontal Surgery in the Treatment of P.Gingivalis Periodontitis Patients [NCT03862456] | 50 participants (Actual) | Interventional | 2013-01-31 | Active, not recruiting | |||
| Anti-Helicobacter Pylori Therapy With Dexlansoprazole MR-Based Concomitant Quadruple Therapy- A Prospective Randomized Trial [NCT03829150] | 202 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| Mechanical Bowel Preparation and Oral Antibiotic Prophylaxis vs. Mechanical Bowel Preparation in Colorectal Surgery With i.v. Antibiotic Prophylaxis [NCT03759886] | 100 participants (Anticipated) | Observational [Patient Registry] | 2018-12-17 | Recruiting | |||
| Effects of Periodontal Therapy on Markers of Systemic Inflammation in Subjects at Cardiovascular Disease Risk [NCT01046435] | 186 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| A Study to Evaluate the Relative Bioavailability of Two Metronidazole Vaginal Gel Formulations [NCT01020877] | Phase 1 | 38 participants (Actual) | Interventional | 2001-11-30 | Completed | ||
| Impact of Parasitic Infections on Intestinal Epithelial Barrier and Immune Activation Among Persons Living With HIV in Lilongwe, Malawi [NCT05323396] | 100 participants (Anticipated) | Interventional | 2022-05-02 | Active, not recruiting | |||
| Effects of Metronidazole Plus Intermittent Preventive Treatment of Malaria in Pregnancy on Birth Outcomes: a Randomised Controlled Trial in Zambia [NCT04189744] | Phase 3 | 5,436 participants (Actual) | Interventional | 2019-12-15 | Completed | ||
| A Randomized Phase II Trial Combining Vaccine Therapy With PROSTVAC /TRICOM and Enzalutamide vs. Enzalutamide Alone in Men With Metastatic Castration Resistant Prostate Cancer [NCT01867333] | Phase 2 | 57 participants (Actual) | Interventional | 2013-08-12 | Completed | ||
| Tumescent Antibiotic Delivery: Pharmacokinetic Evidence for Improved Surgical Site Infection Prevention [NCT01046981] | Phase 1 | 4 participants (Anticipated) | Interventional | 2009-03-31 | Completed | ||
| Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection: A Multicenter Open Label Randomized Clinical Trial [NCT02503904] | Phase 2/Phase 3 | 400 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | ||
| Prospective, Randomized Controlled Trial Comparing High Dose Amoxicillin Versus Tetracycline Based Quadruple Therapy as Second-line Treatment for Resistant Helicobacter Pylori Infection [NCT02175927] | Phase 4 | 312 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| A Randomized Controlled Trial of Three Prophylactic Antibiotic Regimens for First Trimester Surgical Abortion [NCT02756403] | 181 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| VNRX-5133-103: A Randomized, Drug-Drug Interaction Study to Assess the Safety and Pharmacokinetics of VNRX-5133 in Healthy Adult Volunteers [NCT03332732] | Phase 1 | 42 participants (Actual) | Interventional | 2017-10-24 | Completed | ||
| Single Blind Randomized Study of Efficacy and Safety of Vaginal Cream With Association of Metronidazole, Nystatin and Dexamethasone in the Treatment of Bacterial and Fungal Vaginal Infections [NCT02186145] | Phase 3 | 160 participants (Anticipated) | Interventional | 2016-01-31 | Not yet recruiting | ||
| A Feasibility Randomized Trial of Intestinal Lavage for the Treatment of Severe C. Difficile Infections [NCT02466698] | Phase 2/Phase 3 | 20 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| A Proof of Concept (PoC) Study to Evaluate the Safety, Tolerability, and Efficacy of 12 Week Administration of BFH772 Ointment in Rosacea Patients [NCT01449591] | Phase 2 | 36 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Helicobacter Pylori Eradication Rates of Concomitant Therapy and Tailored Therapy Based on 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance: A Multicenter Prospective Randomized Study [NCT03130452] | Phase 4 | 280 participants (Anticipated) | Interventional | 2017-02-01 | Active, not recruiting | ||
| Antibiotic Therapy vs. Placebo in the Treatment of Acute Uncomplicated Appendicitis: a Randomized Double-blinded Placebo-controlled Trial - APPAC III Study [NCT03234296] | 147 participants (Anticipated) | Interventional | 2017-08-09 | Enrolling by invitation | |||
| Study of Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori [NCT02422706] | Phase 3 | 120 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition [NCT03174236] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2017-09-04 | Active, not recruiting | ||
| Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter? Randomized Control Trial [NCT02404064] | 288 participants (Anticipated) | Interventional | 2015-03-31 | Not yet recruiting | |||
| Effect of Antibiotic and Probiotic Therapies in the Adjuvant Treatment of Chronic Periodontitis: Randomized Controlled Clinical Trial. [NCT03692819] | 45 participants (Actual) | Interventional | 2018-05-02 | Completed | |||
| Randomized Controlled Trial of Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics. [NCT03436719] | 280 participants (Anticipated) | Interventional | 2017-11-06 | Recruiting | |||
| Use of a Novel Diet (UC DIET) Targeting the Microbiota for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis: An Open Label Pilot Study [NCT02345733] | Phase 4 | 20 participants (Anticipated) | Interventional | 2015-09-01 | Completed | ||
| Testing the Ability of a Microbiome - Focused Intervention to Reduce HIV Susceptibility in Ugandan Men [NCT03412071] | 125 participants (Anticipated) | Interventional | 2017-12-07 | Recruiting | |||
| The Role of the Microbiota in the Systemic Immune Response [NCT02340182] | 12 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Efficacies of Tetracycline-levofloxacin Quadruple Therapy, Standard Bismuth Quadruple Therapy and Amoxicillin-levofloxacin Quadruple Therapy in the Second-line Treatment of H Pylori Infection [NCT05850117] | 240 participants (Anticipated) | Interventional | 2020-02-10 | Recruiting | |||
| Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With [NCT02196740] | 100 participants (Anticipated) | Interventional | 2013-06-30 | Active, not recruiting | |||
| A Randomized Controlled Trial of Triple Therapy Versus Sequential Therapy Versus Concomitant Therapy as First Line Treatment for Helicobacter Pylori Infection [NCT02092506] | Phase 4 | 462 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin:a Prospective Randomized Controlled Study [NCT05129176] | Phase 4 | 106 participants (Anticipated) | Interventional | 2021-11-23 | Recruiting | ||
| Helicobacter Pylori Rescue Treatment Containing Tetracycline in Patients Allergic to Penicillin:a Prospective Randomized Controlled Study [NCT05135182] | Phase 4 | 170 participants (Anticipated) | Interventional | 2021-11-28 | Recruiting | ||
| Is the Naturally Occurring Prebiotic Lactoferrin an Acceptable Alternative to Antibiotic/Antifungal Tablets for Women With Bacterial Vaginosis or Thrush? [NCT05434104] | 114 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis Treated With Non-surgical Mechanical Therapy Associated With Systemic Antibiotic Therapy. [NCT04051255] | 30 participants (Actual) | Interventional | 2017-03-01 | Active, not recruiting | |||
| A Phase II Study of PROSTVAC-V (Vaccinia)/TRICOM and PROSTVAC-F (Fowlpox)/TRICOM With GM-CSF in Patients With PSA Progression After Local Therapy for Prostate Cancer [NCT00108732] | Phase 2 | 50 participants (Actual) | Interventional | 2006-02-28 | Completed | ||
| Effect of Probiotic Along With Scaling and Root Planing in the Treatment of Chronic Periodontitis [NCT03499184] | 60 participants (Actual) | Interventional | 2017-11-01 | Completed | |||
| The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial [NCT01318928] | Phase 4 | 184 participants (Actual) | Interventional | 2008-01-31 | Active, not recruiting | ||
| Global Impact of the COVID 19 Pandemic on Stroke Care: 1-year Follow-up Study [NCT04934020] | 345,089 participants (Actual) | Observational | 2021-04-25 | Completed | |||
| An Open-Label, Randomized Study to Determine the Safety and Efficacy of LUXSOL(TM) Cream for the Treatment of Bacterial Vaginosis: A Proof of Concept Study [NCT02197182] | Early Phase 1 | 50 participants (Actual) | Interventional | 2014-06-30 | Terminated(stopped due to Not for safety reasons) | ||
| Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response [NCT02197260] | Phase 4 | 80 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Efectividad de Saccharomyces Oulardii Para Reducir Los síntomas Gastrointestinales y Evitar el Sobrecrecimiento Bacteriano en Esclerosis sistémica [NCT03692299] | Phase 4 | 39 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Pre-Operative Mechanical Bowel Preparation And Prophylactic Oral Antibiotics For Pediatric Patients Undergoing Elective Colorectal Surgery: A Feasibility Randomized Controlled Trial [NCT03593252] | 81 participants (Anticipated) | Interventional | 2022-01-01 | Not yet recruiting | |||
| Antimicrobial Therapy for Ulcerative Colitis : Evaluation of Two Antibiotic Combinations for Refractory Ulcerative Colitis [NCT03986996] | Phase 2 | 20 participants (Actual) | Interventional | 2019-07-25 | Terminated(stopped due to There is no feasibility to conduct the study) | ||
| Study the Efficacy of Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy in Egyptian Patients [NCT04445948] | Phase 4 | 400 participants (Actual) | Interventional | 2019-11-30 | Completed | ||
| Local Effect of Periodontal Debridement Associated With Different Systemic Antibiotic Protocols and Single or Repeated Application of Photodynamic Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial [NCT03132714] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Comparative Randomized, Single Dose, Three-Period Crossover Open-Label Study to Determine the Bioequivalence Of Terix Labs Ltd Metronidazole Benzoate (400 mg Metronidazole Per Sachet Oral Granules (Formula A)) Relative to 500 mg From Sanofi-aventis Flagyl [NCT02146209] | Phase 1 | 6 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Intestinal Microbiota Therapy Versus Metronidazole for Primary Clostridium Difficile Infection: a Randomized Controlled Trial [NCT02301000] | Phase 2/Phase 3 | 21 participants (Actual) | Interventional | 2015-02-22 | Terminated(stopped due to Slow recruitment in pilot phase. A follow-up trial is launched (NCT03796650).) | ||
| Efficacy of the Use of Metronidazole After Laparoscopic Hysterectomy for the Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess. Multicentric Triple-blind Randomized Controlled Trial [NCT03917134] | 600 participants (Anticipated) | Interventional | 2019-05-01 | Not yet recruiting | |||
| Validation of a Novel Diagnostic, Prognostic Assay for Bacterial Vaginosis [NCT02185456] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | ||
| Rifabutin-containing Triple Therapy for Helicobacter Pylori Rescue Treatment: a Randomized Controlled Trial [NCT05874544] | Phase 4 | 357 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | ||
| Preoperative Treatment With Metronidazole to Evaluate the Efficacy in Reducing Fusobacterium Nucleatum Tumor Colonization in Patients With Colorectal Cancer (CRC): a Proof-of-concept Trial [NCT05748145] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-09-11 | Recruiting | ||
| Does the Microbiome Change With Flagyl Treatment After Ileocolic Resection for Crohn's Disease [NCT04682522] | Phase 4 | 4 participants (Actual) | Interventional | 2021-03-21 | Completed | ||
| Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial, a Double-blind, Placebo-controlled, Randomized Trial [NCT05385887] | 298 participants (Anticipated) | Interventional | 2021-12-23 | Recruiting | |||
| Comparative Study of the Efficacy and Safety of Vaginally Applied Dequalinium Chloride (10 mg) and Orally Applied Metronidazole (2 x 500 mg) in the Treatment of Bacterial Vaginosis [NCT05788991] | Phase 4 | 151 participants (Actual) | Interventional | 2021-07-26 | Terminated(stopped due to Slow recruitment) | ||
| The Regenerative Potential of Immature Necrotic Teeth With Apical Periodontitis Based on Clinical and Radiographic Assessments [NCT03507556] | 40 participants (Anticipated) | Interventional | 2010-06-28 | Active, not recruiting | |||
| A Pilot Study of Gut Microbiome Modulation to Enable Efficacy of Checkpoint-based Immunotherapy in Pancreatic Adenocarcinoma [NCT03891979] | Phase 4 | 0 participants (Actual) | Interventional | 2019-06-25 | Withdrawn(stopped due to Suspended due to Primary Investigator's decision) | ||
| Medico-economic Evaluation of a Therapeutic Strategy Based on Molecular Detection of Antibiotic Resistance in the Management of H Pylori Infection [NCT01168063] | 1,386 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery [NCT01194115] | 475 participants (Anticipated) | Interventional | 2010-09-30 | Enrolling by invitation | |||
| Rabeprazole Based Sequential-Concommitant Hybrid Therapies for H. Pylori Infections [NCT01566643] | Phase 4 | 231 participants (Anticipated) | Interventional | 2011-01-31 | Recruiting | ||
| Efficacy of Tailored for Helicobacter Pylori Rescue Treatment Based on Antimicrobial-susceptibility Testing [NCT03413020] | Phase 4 | 200 participants (Actual) | Interventional | 2018-01-03 | Completed | ||
| "Drug Use Surveillance of Takecab Tablets Supplement to Helicobacter Pylori Eradication" [NCT03219723] | 560 participants (Actual) | Observational | 2015-09-01 | Completed | |||
| Glycemic Control in Type-2 Diabetes Mellitus Patients Through Non-Surgical Periodontal Therapy: A Randomized Controlled Trial [NCT03343366] | Phase 2/Phase 3 | 150 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| Single Center, Open Label, Controlled Study to Assess the Safety & Efficacy of Oral Ciprodiazole Versus Currently Used Ciprofloxacin & Metronidazole Tablets in Pelvi-abdominal Infections and Following IV Antibiotics in Post-operative Period [NCT05863832] | Phase 4 | 312 participants (Anticipated) | Interventional | 2021-08-17 | Recruiting | ||
| A Phase 1, Randomized, Open-Label, Single Dose, Two Sequence, Crossover, Relative Bioavailability and Taste Test Study of ATI-1501 in Healthy Adult Volunteers [NCT03337126] | Phase 1 | 48 participants (Actual) | Interventional | 2017-11-06 | Completed | ||
| Use of Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis: A Randomised Trial [NCT03794765] | Phase 2 | 50 participants (Actual) | Interventional | 2019-04-01 | Completed | ||
| Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment [NCT03791099] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-04-23 | Active, not recruiting | ||
| The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) [NCT03783845] | Phase 4 | 44 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| Efficacy of Two-week Therapy With Levofloxacin-based Concomitant Regimen Versus Levofloxacin-based Sequential Regimen for Helicobacter Pylori Infection in Syrian Population: a Prospective Single-center Randomized Controlled Trial [NCT06065267] | Phase 4 | 150 participants (Anticipated) | Interventional | 2024-01-02 | Not yet recruiting | ||
| Efficacy of Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical Trial [NCT05726734] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-02-06 | Not yet recruiting | ||
| A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection [NCT06050824] | Phase 4 | 200 participants (Actual) | Interventional | 2022-07-21 | Completed | ||
| Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice [NCT01273441] | Phase 4 | 338 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Comparative Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control on the Gastric Lesions Induced by the Aspirin With the Low Dose Among Patients Treated With the Long Course [NCT00713947] | Phase 4 | 0 participants (Actual) | Interventional | 2008-04-30 | Withdrawn(stopped due to no inclusion) | ||
| Multi-Centre, Prospective, Open Label, Randomized Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Levofloxacin Plus Metronidazole in the Treatment of Community-Acquired Pneumonia With Aspiration Factors [NCT00752947] | Phase 4 | 186 participants (Anticipated) | Interventional | 2008-09-30 | Recruiting | ||
| Efficacy and Safety of Quadruple Therapy by Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Given X 10 Days With Omeprazole in Eradication of Helicobacter Pylori: A Comparison to Omeprazole, Amoxicillin and Clarithromycin Given X 7 Days [NCT00669955] | Phase 3 | 440 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Tailored Therapy Versus Standard Triple Therapy for Helicobacter Pylori Eradication in Children: A Randomized Trial [NCT02635191] | Phase 4 | 200 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | ||
| Fusobacterium Nucleatum Eradication in Postoperative Stage II/III Colorectal Cancer(FINER-PACE)by Oral Metronidazole: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. [NCT04264676] | Phase 2 | 294 participants (Anticipated) | Interventional | 2020-03-31 | Recruiting | ||
| Single Centre, Prospective, Comparative, Open-label, Randomised Study to Evaluate the Efficacy and Tolerability of the Combination of Moxifloxacin Plus Metronidazole Versus Piperacillin/Tazobactam for the Treatment of Patients With Intra-abdominal Abscess [NCT00629135] | Phase 3 | 180 participants (Actual) | Interventional | 2005-11-15 | Completed | ||
| A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Metronidazole, Diltiazem and Lidocaine on Post-Operative Pain Following Excisional Haemorrhoidectomy [NCT04276298] | Phase 2/Phase 3 | 192 participants (Actual) | Interventional | 2020-09-01 | Completed | ||
| Randomized Clinical Trial: the Comparison of 15-day Sequential and 10-day Sequential Therapy to PPI-based Triple Therapy for Helicobacter Pylori Infection in Korea [NCT01887249] | Phase 4 | 287 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT) Trial [NCT05977868] | Phase 4 | 135 participants (Anticipated) | Interventional | 2023-08-04 | Enrolling by invitation | ||
| Randomized-controlled Trial to Assess Whether Feedback on a New Stewardship Metric Can Improve Antibiotic-prescribing for Acute Respiratory Tract Infections in Urgent Care Clinics [NCT06144242] | 90 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| Evaluation of Effects of Subgingival Administration of Metronidazole Hydrogel 25% in Stage II and III Periodontitis: Randomized, Split Mouth, Single-blind Trial. [NCT04983849] | Phase 4 | 40 participants (Actual) | Interventional | 2021-07-07 | Completed | ||
| Treatment of Bacterial Vaginosis Prior to Active Labor and Infectious Morbidity: A Randomized Controlled Trial [NCT03954990] | Phase 1 | 75 participants (Actual) | Interventional | 2019-10-11 | Terminated(stopped due to Lack of significance/futile study) | ||
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds. [NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Comparing the Efficacy and Impact on Gastrointestinal Microbiome of Reverse Hybrid Therapy and Bismuth Quadruple Therapy in Helicobacter Pylori Eradication [NCT02547038] | 352 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Phase II-b Randomized Double-Blind Placebo-Controlled Trial of Lactobacillus Crispatus CTV-05 (LACTIN-V) to Prevent the Recurrence of Bacterial Vaginosis [NCT02766023] | Phase 2 | 228 participants (Actual) | Interventional | 2016-06-03 | Completed | ||
| Comparative Randomized, Single Dose, Two-Way Crossover Open Label Bioequivalence Study of Terix Labs Ltd Metronidazole Benzoate (400 mg Metronidazole Per Sachet Oral Granules) Versus Zentiva Flagyl™ 400 mg Tablets (400 mg Metronidazole Per Film Coated Tab [NCT02402283] | Phase 1 | 20 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| VMT-01: Safety and Efficacy of Vaginal Microbiota Transplant (VMT) in Women With Bacterial Vaginosis (BV) [NCT03769688] | Phase 1 | 0 participants (Actual) | Interventional | 2022-03-31 | Withdrawn(stopped due to Replaced with different study at another site.) | ||
| A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Versus Oral Metronidazole in Reducing Post-Operative Pain Following Excisional Haemorrhoidectomy [NCT03343509] | Phase 4 | 120 participants (Actual) | Interventional | 2019-03-11 | Completed | ||
| Metronidazole as an Adjunct of Non- Surgical Treatment of Peri-implantitis : a 6-months Placebo- Controlled Clinical Trial in Humans [NCT03564301] | Phase 4 | 20 participants (Actual) | Interventional | 2018-03-03 | Completed | ||
| Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud [NCT03326661] | 128 participants (Anticipated) | Interventional | 2017-11-10 | Not yet recruiting | |||
| Efficacy of High-dose Dual Therapy Versus Bismuth-containing Quadruple Therapy for First-line Treatment of Helicobacter Pylori Infection - A Prospective, Randomized, Comparative Study [NCT02483715] | Phase 4 | 589 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Helicobacter Eradication to Prevent Ulcer Bleeding in Aspirin Users: a Large Simple Randomised Controlled Trial [NCT01506986] | Phase 4 | 30,024 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Comparing the Efficacy and Impact on Gastrointestinal Microbiota of Reverse Hybrid Therapy and Concomitant Therapy in Helicobacter Pylori Eradication [NCT02646332] | 248 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice: A PBRN Clinical Trial [NCT06131021] | Phase 3 | 544 participants (Anticipated) | Interventional | 2024-04-30 | Not yet recruiting | ||
| PROMIZE: A Phase I/II Trial to Assess the Safety, Tolerability and Preliminary Anti-tumour Activity of Oral Combination Antibiotic Therapy to Modulate the Microbiome in Combination With Enzalutamide With Metastatic Castration Resistant Prostate Cancer (mC [NCT06126731] | Phase 1/Phase 2 | 39 participants (Anticipated) | Interventional | 2023-11-02 | Recruiting | ||
| Efficacy of High Dose of Amoxicillin And Metronidazole Plus Bismuth For Helicobacter Pylori Treatment In Naive Patients : A Randomized Clinical Trial [NCT03557437] | Phase 4 | 216 participants (Actual) | Interventional | 2018-05-25 | Completed | ||
| Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis: a Prospective Randomised Multicenter Study (The APPAC II Study) [NCT03236961] | 552 participants (Anticipated) | Interventional | 2017-04-03 | Active, not recruiting | |||
| Effect of Intravenous Administration of C1-inhibitor on Inflammation and Coagulation After Bronchial Instillation of House Dust Mite Allergen and Lipopolysaccharide in Allergic Asthma Patients [NCT03051698] | Phase 4 | 37 participants (Actual) | Interventional | 2016-11-16 | Terminated(stopped due to Interim analysis showed no differences between groups) | ||
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia [NCT02127749] | 16 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Prospective, Randomized Controlled Trial Comparing Amoxicillin and Metronidazole Based Bismuth-containing Quadruple Therapy With Amoxicillin and Clarithromycin Based Quadruple Therapy for First-line Helicobacter Pylori Eradication [NCT02175901] | Phase 4 | 215 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Exploration of the Role of Vision on Spatial Cognition [NCT06088797] | 100 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients [NCT06027151] | 380 participants (Actual) | Interventional | 2022-10-06 | Completed | |||
| Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma: a Clinical Proof-of-concept Intervention Study MEFO Trial [NCT04312360] | Phase 2 | 28 participants (Actual) | Interventional | 2020-01-16 | Completed | ||
| Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots [NCT01976065] | Phase 1 | 125 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 Shedding [NCT00464542] | Phase 4 | 12 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| Phase 1 Trial of Multi-strain Lactobacillus Crispatus Vaginal Live Biotherapeutic Product [NCT06135974] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2023-10-19 | Recruiting | ||
| Evaluation of the Congruity of Methods Used in the Diagnostics of Chronic Endometritis in the Course of Infertility and the Effectiveness of Antibiotic Therapy in the Context of Remission of Symptoms and Obstetric Results [NCT05946655] | 100 participants (Actual) | Interventional | 2021-04-01 | Completed | |||
| Pilot Study of Gut Microbiome Modulation to Enable Efficacy of Neoadjuvant Checkpoint-based Immunotherapy Following Chemotherapy in Pancreatic Adenocarcinoma [NCT05462496] | Phase 2 | 3 participants (Anticipated) | Interventional | 2023-03-13 | Recruiting | ||
| Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone [NCT04827537] | Phase 2/Phase 3 | 200 participants (Anticipated) | Interventional | 2021-01-01 | Active, not recruiting | ||
| Prevention of Persistence of Bacterial Vaginosis: The Effects of High Dose Intravaginal Metronidazole [NCT00741845] | Phase 3 | 117 participants (Actual) | Interventional | 2008-06-30 | Terminated(stopped due to Terminated for site documentation and monitoring issues - not safety, study drug, or adverse event issues.) | ||
| Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic: A Randomized Controlled Study [NCT04009772] | Phase 2/Phase 3 | 500 participants (Anticipated) | Interventional | 2019-07-01 | Recruiting | ||
| Vaginal Microbiota Transplant to Promote Lactobacillus-dominant Cervicovaginal Communities [NCT04046900] | Phase 1/Phase 2 | 134 participants (Anticipated) | Interventional | 2021-04-22 | Recruiting | ||
| A Phase II Trial Assessing Metronidazol Actavis 1% Topical Cream in the Prevention and Treatment of Erlotinib Associated Rash [NCT00642473] | Phase 2 | 34 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Efficacy of Empirical Ciprofloxacin Plus Metronidazole and Cefixime Plus Metronidazole Therapy for the Treatment of Liver Abscess: A Randomised Controlled Clinical Trial [NCT03969758] | Phase 3 | 140 participants (Anticipated) | Interventional | 2019-07-31 | Not yet recruiting | ||
| Control of Periodontal Infections [NCT01098448] | Phase 3 | 187 participants (Actual) | Interventional | 1999-09-30 | Completed | ||
| Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid [NCT04632238] | 7,950 participants (Anticipated) | Interventional | 2020-07-01 | Recruiting | |||
| Efficiency of Triple Antibiotic Mixture and Propolis as Intracanal Medication in Revascularization Process in Immature Apex: A Clinical Study [NCT03533231] | Phase 4 | 40 participants (Actual) | Interventional | 2015-01-16 | Completed | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT03524833] | Phase 4 | 20 participants (Actual) | Interventional | 2018-05-07 | Completed | ||
| A Multicenter, Open-label, Noncomparative, Japanese Phase III Study to Assess the Efficacy and Safety of Ceftolozane/Tazobactam (MK-7625A) Used in Combination With Metronidazole in Japanese Patients With Complicated Intra-abdominal Infection. [NCT02739997] | Phase 3 | 100 participants (Actual) | Interventional | 2016-04-08 | Completed | ||
| The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori [NCT06004401] | 400 participants (Anticipated) | Interventional | 2023-08-20 | Not yet recruiting | |||
| Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and Quality of Life After Surgical Extraction of Impacted Mandibular Third Molars [NCT05681312] | Phase 3 | 55 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | ||
| Construction and Application of the Treatment of Refractory Helicobacter Pylori Infection Based on the High-throughput Sequencing Technologies [NCT02741414] | 4,428 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | |||
| Chemical, Biological and Comparative Clinical Evaluation of Entoban to Determine Safety and Efficacy for the Treatment of Chronic Diarrhea [NCT02642250] | Phase 2/Phase 3 | 70 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| A Randomized Clinical Trial of Clarithromycin/Bismuth Containing Quadruple Therapy for Helicobacter Pylori First-line Treatment [NCT02732249] | Phase 4 | 66 participants (Actual) | Interventional | 2016-04-01 | Completed | ||
| A Multi-Center, Double-Blind, Parallel Group Study Comparing the Bioequivalence of Teva Pharmaceuticals, USA's Generic Formulation of Metronidazole Vaginal Gel, 0.75% and MetroGel-Vaginal® Metronidazole Vaginal Gel, 0.75% in the Treatment of Bacterial Vag [NCT01020396] | Phase 1/Phase 2 | 579 participants (Actual) | Interventional | 2002-01-31 | Completed | ||
| A Study of Patient Preferences and Drivers of Treatment Satisfaction in Patients With Rosacea [NCT02602470] | 206 participants (Actual) | Observational | 2015-01-08 | Completed | |||
| A Prospective, Randomized, Double Dummy, Double Blind, Multi-center Multinational Trial Comparing the Efficacy and Safety of Moxifloxacin 400 mg PO QD 24 Hours for 14 Days to That of Levofloxacin 500 mg PO QD 24 Hours Plus Metronidazole 500 mg BID for 14 [NCT00453349] | Phase 3 | 460 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization [NCT00707369] | Phase 4 | 540 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| PROJECT PREVENT: Metronidazole Antibiotic Per Vagina Before Hysterectomy: Is Additional Antibiotic Prophylaxis Beneficial? [NCT04478617] | Phase 4 | 136 participants (Anticipated) | Interventional | 2020-07-15 | Active, not recruiting | ||
| Multicenter, Randomized, And Double-Blind Study To Evaluate The Safety Of Tigecycline Versus A Ceftriaxone Regimen In The Treatment Of Complicated Intra-Abdominal Infections And Community-Acquired Pneumonia In Subjects Of 8-17 Years [NCT00914888] | Phase 3 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn | ||
| Comparison Between Tailored Therapy Guided by a Non-invasive Antibiotic Susceptibility Test and Empiric Treatment for First-line Helicobacter Pylori Eradication in Patients With Dyspepsia: a Randomized Controlled Trial. [NCT04107194] | Phase 3 | 362 participants (Anticipated) | Interventional | 2020-01-14 | Recruiting | ||
| Biomarker-based Multidisciplinary Team Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease [NCT04082559] | 170 participants (Anticipated) | Interventional | 2019-06-11 | Recruiting | |||
| Inflammation and Treatment of Bacterial Vaginosis Near Term [NCT00720291] | 59 participants (Actual) | Interventional | 2006-02-28 | Completed | |||
| A Randomized Phase 2.5 Study of (153)Sm-EDTMP (Quadramet) With or Without a PSA/TRICOM Vaccine in Men With Androgen-Insensitive Metastatic Prostate Cancer [NCT00450619] | Phase 2 | 44 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| An Open-Label, Randomized, Crossover Study to Evaluate the Pharmacokinetic Interaction After Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers [NCT04066257] | Phase 1 | 32 participants (Actual) | Interventional | 2019-01-17 | Completed | ||
| Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis [NCT00805558] | Phase 4 | 76 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial [NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection [NCT02686645] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2016-12-31 | Not yet recruiting | ||
| Randomized Phase II Trial of Docetaxel With or Without PSA-TRICOM Vaccine in Patients With Castrate-Resistant Metastatic Prostate Cancer [NCT01145508] | Phase 2 | 10 participants (Actual) | Interventional | 2010-08-31 | Terminated(stopped due to Poor accrual) | ||
| Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection - A Prospective Randomized, Comparative Study [NCT05332444] | Phase 4 | 450 participants (Anticipated) | Interventional | 2022-04-11 | Recruiting | ||
| A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Metronidazole Combined With Antituberculous Chemotherapy vs. Antituberculous Chemotherapy With Placebo in Subjects With Multi-Drug Resistant Pulmonary Tuberculosis [NCT00425113] | Phase 2 | 35 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| MOBILE Trial. Mechanical and Oral Antibiotic Bowel Preparation Versus no Bowel preparatIon for eLEctive Colectomy - a Multicenter, Prospective, Randomized, Controlled Trial. [NCT02652637] | Phase 4 | 417 participants (Actual) | Interventional | 2016-03-31 | Active, not recruiting | ||
| Evaluation of Uncemented Echo Bi-Metric Full Proximal Profile THA Stem Versus Uncemented Bi-Metric Porous Primary THA Stem in a Randomized Controlled Trial Using RSA and DXA [NCT02656771] | 62 participants (Actual) | Interventional | 2016-01-31 | Active, not recruiting | |||
| The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in Helicobacter Pylori Patients [NCT02648659] | Phase 4 | 50 participants (Actual) | Interventional | 2016-03-02 | Completed | ||
| A Randomized Clinical Trial to Examine the Efficacy of a Clarithromycin-, Amoxicillin-, and Metronidazole-Based Regimen to Eradicate Helicobacter Pylori Infections in Pasto, Colombia [NCT00719420] | Phase 3 | 151 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Efficacy Evaluation of Enterogermina, 2 Billion Bacillus Clausii Spores, on Eradication of Small Intestinal Bacterial Overgrowth: a Randomised, Parallel-group, Open Study. [NCT00331994] | Phase 4 | 250 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Comparison of Dual Amoxicillin/Vonoprazan Therapy and Triple Vonoprazan/Amoxicillin/Clarithromycin or Metronidazole Therapy for H. Pylori Eradication [NCT02827942] | Phase 3 | 112 participants (Actual) | Interventional | 2016-07-01 | Completed | ||
| Effect of Helicobacter Pylori Treatment on Remission of Idiopathic Central Serous Chorioretinopathy (ICSCR) [NCT00817245] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Double-blind, Randomized, Controlled Trial to Evaluate the Effect of a Yoghurt Containing Four Probiotic Lactobacillus Strains (L. Crispatus, L. Gasseri, L. Rhamnosus, L. Jensenii) on Bacterial Vaginosis (BV) in Adult Women [NCT02744638] | 36 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Non Operative Treatment With Antibiotics Vs Surgery for Acute Non Perforated Appendicitis in Children: A Randomized Controlled Trial. [NCT04030741] | Phase 2/Phase 3 | 180 participants (Actual) | Interventional | 2018-09-01 | Completed | ||
| Single Dose Ceftriaxone and Metronidazole Versus Multiple Doses for Antibiotic Prophylaxis at Elective Cesarean Section in Mulago Hospital. A Randomized Clinical Trial. [NCT02736682] | Phase 4 | 174 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Pharmacokinetic Considerations and Dosing Strategies of Amoxicillin and Metronidazole or Azithromycin as Adjunct to Non-surgical Periodontal Therapy. A Randomized,6-month, Parallel-group, Clinical Trial. [NCT04669717] | Phase 4 | 45 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| The Impact of Obesity on Nonsurgical Periodontal Treatment of Destructive Periodontal Diseases [NCT01405365] | 96 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | |||
| Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital [NCT03894813] | Phase 4 | 126 participants (Actual) | Interventional | 2019-03-26 | Completed | ||
| The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery: A Prospective, Randomized, Placebo-Controlled Trial [NCT04554693] | Phase 4 | 90 participants (Anticipated) | Interventional | 2020-10-19 | Recruiting | ||
| Preoperative Mechanical Bowel Preparation With Oral Antibiotics Reduces Surgical Site Infection After Elective Colorectal Surgery for Malignancies: a Propensity Matching Analysis [NCT04258098] | 806 participants (Actual) | Observational | 2011-01-01 | Completed | |||
| A Double-Blind, Randomized Trial of Monthly Treatment With Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories Versus Placebo for Preventing Vaginal Infections in HIV-seronegative Women [NCT01230814] | Phase 2 | 234 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Home Screening for Bacterial Vaginosis to Prevent STDs [NCT00667368] | Phase 3 | 1,370 participants (Actual) | Interventional | 2008-07-28 | Completed | ||
| Increased Second-line Eradication Rate of Helicobacter Pylori by Adding N-acetylcystein or Metronidazole to the Conventional Triple Therapy. [NCT01572597] | Phase 4 | 120 participants (Anticipated) | Interventional | 2011-06-30 | Recruiting | ||
| Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis [NCT02789865] | Phase 2 | 240 participants (Anticipated) | Interventional | 2016-05-31 | Not yet recruiting | ||
| Phase 2 Study Evaluation of Topical 10% Metronidazole Ointment for the Reduction of Pain After Haemorrhoidectomy [NCT00774722] | Phase 2/Phase 3 | 59 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Randomized Trial of Antimicrobials Versus Placebo in Addition to Fecal Microbiota Therapy in for the Induction of Remission in Active Ulcerative Colitis [NCT02606032] | Phase 2 | 75 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Prospective, Multicenter, Double-blind, Randomized, Comparative Study to Estimate the Safety, Tolerability and Efficacy of NXL104/Ceftazidime Plus Metronidazole vs. Meropenem in the Treatment of Complicated Intra-abdominal Infections in Hospitalized Adu [NCT00752219] | Phase 2 | 204 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| A Randomized Clinical Trial of Radiotherapy and Metronidazole Versus Radiotherapy Alone in Anaemic Patients With Advanced Cervical Cancer In Mulago [NCT01937650] | Phase 2/Phase 3 | 38 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication. [NCT00841854] | Phase 4 | 199 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Efficacies of High-dose Dual Therapy With or Without Bismuth Versus Amoxicillin-metronidazole Bismuth Quadruple Therapy for First-line Helicobacter Pylori Eradication - A Prospective, Randomized, Comparative Study [NCT03897244] | Phase 4 | 702 participants (Anticipated) | Interventional | 2019-05-30 | Recruiting | ||
| Back to BASICS: Boric Acid, Alternate Solution for Intravaginal Colonization, Comparing Intravaginal Metronidazole to Boric Acid in Women Symptomatic for Bacterial Vaginosis [NCT00799214] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection [NCT00230971] | Phase 4 | 473 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| The Effect of Probiotic Supplementation With Lactobacillus GR-1 and RC-14,on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients; a Randomised, Placebo Controlled Trial [NCT00536848] | Phase 2/Phase 3 | 65 participants (Actual) | Interventional | 2007-10-31 | Active, not recruiting | ||
| A Prospective, Multicenter, Open, Randomized, Comparative Study to Evaluate the Safety and Efficacy of Ertapenem Versus it's Comparator in the Treatment of Complicated Intra-abdominal Infections in Adults [NCT00157898] | Phase 4 | 134 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| "Prevention of Dry Socket by Means of Single Preoperative Oral Dose of Metronidazole and Amoxicillin Compared to Conventional Therapy" [NCT03992144] | Phase 2 | 225 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| [NCT01059890] | Phase 1 | 18 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage Trial - (PARFAIT) A Vanguard Randomized Controlled Trial [NCT04549311] | Phase 3 | 15 participants (Actual) | Interventional | 2021-11-18 | Active, not recruiting | ||
| A Pilot Trial of a CEA-TRICOM Based Vaccine and Radiation to Liver Metastasis in Adults With CEA Positive Solid Tumors [NCT00081848] | Phase 1 | 12 participants (Actual) | Interventional | 2004-04-20 | Completed | ||
| Full-mouth Periodontal Debridement With or Without Adjunctive Metronidazole Gel in Smoking Patients With Chronic Periodontitis [NCT01938183] | Phase 2 | 30 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Bismuth-Metronidazole Triple Versus Quadruple Therapy for Helicobacter Pylori First-line Treatment: A Randomized Controlled Trial [NCT04667299] | Phase 4 | 270 participants (Anticipated) | Interventional | 2020-12-20 | Recruiting | ||
| A Phase I Study of Sequential Vaccinations With Fowlpox-CEA(6D)-Tricom (B7.1/ICAM/LFA3) and Vaccinia-CEA (6D)-Tricom, in Combination With GM-CSF and Interferon-Alfa-2B in Patients With CEA-Expressing Carcinomas [NCT00217373] | Phase 1 | 33 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait [NCT04617613] | Phase 4 | 603 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation [NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| In Vivo Drug Interaction Pharmacokinetic Study of Tenofovir 1% Gel and Three Commonly Used Vaginal Products [NCT01813162] | Phase 1 | 101 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Evidence Based Management of Acute Biliary Pancreatitis [NCT04615702] | 30 participants (Actual) | Observational [Patient Registry] | 2017-05-15 | Completed | |||
| Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis [NCT01992198] | Phase 4 | 60 participants (Anticipated) | Interventional | 2012-07-31 | Recruiting | ||
| "A Screen and Treat Helicobacter Pylori Eradication Trial in 14-18 Years Old Adolescents Residing in Three Regions of Chile: Effectiveness and Microbiological-host Implications" [NCT05926804] | 500 participants (Anticipated) | Interventional | 2022-08-02 | Recruiting | |||
| Macroscopic Evaluation of Colon Cancer Resection Specimens to Predict Metastatic Lymph Node Yield [NCT04260139] | 50 participants (Actual) | Observational | 2019-09-01 | Completed | |||
| A Randomised Control Trial to Determine Whether a 5 Day Course of Antibiotics is More Clinically and Cost Effective Than a 24 Hour Prophylactic Course for the Prevention of Surgical Site Infection Following Lower Limb Amputation [NCT02018094] | Phase 4 | 160 participants (Actual) | Interventional | 2013-10-08 | Completed | ||
| The Use of Erythritol Powder and Locally Derived Metronidazole for the Non-surgical Treatment of Periodontitis: a Split-mouth Randomized Controlled Clinical Trial [NCT02023840] | Phase 4 | 20 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| The Use of Erythritol Powder and Locally Derived Metronidazole for the Non-surgical Treatment of Peri-implant Mucositis and Peri-implantitis. [NCT02023853] | Phase 4 | 20 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Genotypic Resistance-guided Triple Therapy Versus Empirical Concomitant Therapy for First-line H. Pylori Eradication. [NCT04090021] | Phase 4 | 304 participants (Anticipated) | Interventional | 2019-09-01 | Recruiting | ||
| A Randomized Controlled Trial: Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori Infection [NCT04621487] | 80 participants (Actual) | Interventional | 2019-01-15 | Completed | |||
| Impact of Non-surgical Periodontal Therapy With or Without Antibiotics on Oral and Gut Microbiome in Patients With Stage III/IV and Grade C Periodontitis [NCT04580355] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-07-31 | Recruiting | ||
| Effects of Elliptical Training Versus Ergo-meter on Cardiopulmonary Parameters in Post CABG Patients [NCT04615481] | 92 participants (Actual) | Interventional | 2020-09-08 | Completed | |||
| Split-Face Tolerability Comparison Between MetroGel® (Metronidazole Gel) 1% vs Finacea® (Azelaic Acid) 15% in Subjects With Healthy Skin [NCT01139047] | Phase 4 | 77 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Split-Face Tolerability Comparison Between MetroGel® (Metronidazole Gel) 1% Versus Finacea® (Azelaic Acid) Gel 15% in Subjects With Healthy Skin [NCT01139008] | Phase 4 | 80 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection [NCT00195351] | Phase 4 | 467 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| An Open Label Non Randomized Pilot Study: Use of the Ulcerative Colitis Diet for Induction of Remission. [NCT02217722] | 9 participants (Actual) | Interventional | 2014-10-31 | Terminated(stopped due to We have submitted a multi center study, with the same nutritional therapy) | |||
| Comparison of the Efficacy of Clarithromycin-based Triple Therapy for 14 Days Versus Sequential Therapy for 10 Days in the First Line Therapy for Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial [NCT01607918] | Phase 4 | 1,300 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | ||
| Phase 1 Study to Evaluate the Pharmacokinetics of Metronidazole 10% Ointment Applied Peri-Anally in Healthy Volunteers and Patients With Perianal Crohn's Disease [NCT00774969] | Phase 1 | 19 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| A Multicentric Randomized Double-Blind Phase 3 Trial Evaluating the Efficacy of an Adapted Antibiotherapy in Hurley Stage 2 Active Hidradenitis Suppurativa Patients Versus Tetracycline Derivative [NCT05821478] | Phase 3 | 92 participants (Anticipated) | Interventional | 2023-11-15 | Not yet recruiting | ||
| Non-surgical Treatment of Peri-implantitis With Electrolytic Cleaning: a Pilot Study [NCT05275894] | 25 participants (Anticipated) | Interventional | 2022-10-12 | Active, not recruiting | |||
| Phase III, Multicenter, Randomized, Parallel, Open Label, Controlled and Comparative Study to Evaluate the Efficacy and Safety of the Association of Clotrimazole 200mg and Metronidazole 0,75% (Colpistatin 5DT®) Compared to Gynecological Flagyl®(Metronidaz [NCT02713139] | Phase 3 | 0 participants (Actual) | Interventional | 2013-09-30 | Withdrawn(stopped due to Due to budget limitations, the company decided to withdraw this study.) | ||
| A Prospective, Randomized, Blind, Multicenter Trial Comparing Orally Administered Trimethoprim-sulfamethoxazole With Intravenously Administered Cefuroxime and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery [NCT00613769] | Phase 4 | 1,073 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Double-blind, Placebo-controlled, Randomized Study for Assesment of the Efficiency and Safety Quadruple Therapy for Helicobacter Pylori Infection With or Without the Addition of Saccharomyces Boulardi Probiotic [NCT03997279] | Phase 4 | 200 participants (Anticipated) | Interventional | 2019-06-30 | Not yet recruiting | ||
| Fourteen-Day Vonoprazan-Based Dual Therapy With Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy: A Randomized Controlled Trial in Taiwan [NCT06156085] | Phase 4 | 318 participants (Anticipated) | Interventional | 2023-11-14 | Recruiting | ||
| The Importance of Anti-anaerobic Therapy for Acute PID [NCT01160640] | Phase 2 | 233 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis): A Comparison Between Photodynamic Therapy and Antibiotic Therapy as an Adjunct to Non-Surgical Periodontal Treatment [NCT05655338] | 20 participants (Actual) | Interventional | 2015-01-10 | Completed | |||
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition [NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| An Exploratory, Multicenter, Investigator-blinded, Active-controlled Study to Investigate the Efficacy of Topical Azelaic Acid (AzA)15% Gel Twice Daily or Metronidazole Topical Gel 1% Once Daily, Plus Anti-inflammatory Dose Doxycycline (40mg) Once Daily i [NCT00855595] | Phase 4 | 207 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Penicillin and Metronidazole in Treatment of Peritonsillar Abscess - Prospective, Double-blind, Randomized, Placebo-controlled Study [NCT01255670] | 200 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| Doxycycline-containing Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment: a Randomized Controlled Trial [NCT05874570] | Phase 4 | 368 participants (Anticipated) | Interventional | 2023-06-20 | Recruiting | ||
| A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Efficacy and Safety of Ertapenem Sodium (MK-0826) Versus Ceftriaxone Sodium/Metronidazole for the Prophylaxis of Surgical Site Infection Following Elective Col [NCT01254344] | Phase 3 | 599 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| The Use of Colposeptine in Bacterial Vaginosis. A Randomized, Controlled Study [NCT01153958] | Phase 4 | 133 participants (Actual) | Interventional | 2010-07-31 | Terminated | ||
| A Multicenter, Double-Blind, Randomized, Phase 2 Study to Compare the Safety and Efficacy of Intravenous CXA 101/ Tazobactam and Metronidazole With That of Meropenem in Complicated Intraabdominal Infections [NCT01147640] | Phase 2 | 122 participants (Actual) | Interventional | 2010-06-25 | Completed | ||
| Analysis of Mechanism on the Efficacy of Oral Antibiotic Prophylaxis in Elective Colon and Rectal Surgery With Primary Anastomosis [NCT05779254] | 100 participants (Anticipated) | Observational | 2023-02-01 | Recruiting | |||
| Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile [NCT02857582] | Phase 2 | 60 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| A Phase 1, Open Study To Assess The Safety, Tolerability And Pharmacokinetics Of Metronidazole Following Single And Multiple Intravenous Infusion In Healthy Japanese Adult Subjects [NCT01407016] | Phase 1 | 6 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| A Multicenter, Randomized, Investigator-Blinded, Phase 2, Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis [NCT01055106] | Phase 2 | 255 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Are Post-operative Antibiotics Indicated in Simple Appendicitis? A Prospective Randomized Trial [NCT01420367] | 300 participants (Anticipated) | Interventional | 2011-11-30 | Not yet recruiting | |||
| Controlled, Multicenter, Randomized Parallel Group Pilot Study With 2 Treatment Arms in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis (BV) [NCT02042287] | Phase 4 | 32 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Phase II Study of Intratumoral Injection of rF-TRICOMTM in Patients With Metastatic Melanoma Who Have Detectable Tumor Associated T Cells [NCT00087373] | Phase 2 | 28 participants (Actual) | Interventional | 2004-06-30 | Terminated | ||
| Randomized Single Institution Pilot Study of Vaccinia-CEA(6D)-TRICOM and Fowlpox-CEA(6D)-TRICOM With GM-CSF in Combination With Docetaxel in Patients With CEA-Bearing Cancers [NCT00088933] | Phase 1 | 60 participants (Actual) | Interventional | 2004-06-30 | Terminated | ||
| A Pilot Trial of a CEA/TRICOM-Based Vaccine in Combination With Combined Chemotherapy/Radiotherapy in Patients With Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC) [NCT00091039] | 0 participants | Interventional | 2004-08-31 | Completed | |||
| Prophylactic Antibiotics After Cesarean [NCT03187106] | Phase 1 | 321 participants (Actual) | Interventional | 2017-08-01 | Completed | ||
| Effects of Anti-Giardia and Antihelmintic Treatment on Infant Nutritional and Biochemical Status and Intestinal Permeability in Rural Bangladesh [NCT00607074] | 410 participants (Actual) | Interventional | 2003-06-30 | Completed | |||
| A Phase 3, Double-blind, Multicentre, Randomised, Placebo-controlled Study to Determine the Efficacy and Safety of SPL7013 Gel to Prevent the Recurrence of Bacterial Vaginosis. [NCT02236156] | Phase 3 | 637 participants (Actual) | Interventional | 2014-10-03 | Completed | ||
| Prospective, Randomized Study of Oral Metronidazole vs. Oral Metronidazole and Rifampin for Treatment of Clostridium Difficile-associated Diarrhea (CDAD) [NCT00182429] | Phase 3 | 100 participants | Interventional | 2004-02-29 | Completed | ||
| Effectivity and Safety of Metronidazole 1% Cream in Rosacea Therapy [NCT05861310] | Phase 1 | 48 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | ||
| Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders [NCT03739645] | 150 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | |||
| A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI) in Subjects Undergoing Abdominal Operation [NCT01863407] | Phase 3 | 480 participants (Anticipated) | Interventional | 2013-04-30 | Recruiting | ||
| A Randomised Study Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (REaCT-NSQIP) [NCT03663504] | Phase 4 | 432 participants (Anticipated) | Interventional | 2018-10-23 | Recruiting | ||
| An Open Label, Single-site Pharmaco-Scintigraphic Phase I - Study in Healthy Subjects to Evaluate the Gastrointestinal Transit and Release Profile of Radio-labelled Metronidazole Benzoate Capsules [NCT02911298] | Phase 1 | 18 participants (Actual) | Interventional | 2016-11-25 | Completed | ||
| [NCT01481844] | Phase 3 | 101 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Appropriate Antimicrobial Therapy in Critical Care: A Pilot Randomized Controlled Trial [NCT00438269] | Phase 2 | 80 participants | Interventional | 2003-02-28 | Completed | ||
| [NCT00475527] | Phase 4 | 0 participants (Actual) | Interventional | Withdrawn(stopped due to problem of accrual) | |||
| Evaluation of the Bioavailability of Metronidazole Dermal Products [NCT03271983] | Early Phase 1 | 7 participants (Actual) | Interventional | 2019-04-09 | Completed | ||
| Randomized Study of Conservative Versus Surgical Treatment of Appendicitis; Analyses of Result and Economics [NCT00469430] | Phase 2 | 360 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| [NCT00484250] | Phase 2 | 20 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Antimicrobial Pharmacokinetics in High Risk Infants (Urinary Proteomics in Antimicrobial/Antifungal-Treated Newborns - add-on Study) [NCT00491426] | 450 participants (Actual) | Observational | 2006-01-31 | Completed | |||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial. [NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Phase III Study to Evaluate the Effect of 10% Metronidazole Ointment, Applied Topically Three Times a Day in and Around the Anus and the Change in Perianal Crohn's Disease Activity [NCT00509639] | Phase 3 | 74 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial [NCT02947763] | Phase 1 | 44 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| Efficacy of Antibiotic Susceptibility-based Tailored Versus Empiric Therapy for Helicobacter Pylori First-line Treatment：a Randomized Clinical Trial [NCT02935010] | Phase 4 | 382 participants (Actual) | Interventional | 2017-02-05 | Completed | ||
| Efficacies of Hybrid and High-dose Dual Therapies for the First-line Anti-H Pylori Treatment - a Randomized Trial [NCT05152004] | 240 participants (Actual) | Interventional | 2018-09-01 | Completed | |||
| Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases [NCT04462588] | 64 participants (Actual) | Observational [Patient Registry] | 2019-06-01 | Completed | |||
| A Phase 3, Multicenter, Unblind, Non-Comparative Study To Confirm Efficacy And Safety Of Intravenous Metronidazole In Patients With Intrabdominal Infection In Combination With Intravenous Ceftriaxone [NCT01473836] | Phase 3 | 38 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| A Pilot Study of Efficacy and Safety of Oral Metronidazole Versus Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent the Recurrence of Bacterial Vaginosis [NCT03099408] | Phase 4 | 66 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Conventional Therapy vs Sequential Therapy for the Treatment of Helicobacter Pylori Infection [NCT01723059] | 184 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | |||
| Helicobacter Pylori Eradication and Follow-up in Zhongshan Hospital [NCT05061732] | Phase 4 | 4,447 participants (Anticipated) | Interventional | 2021-09-30 | Recruiting | ||
| Rifabutin-containing Triple Therapy for Rescue Treatment of Helicobacter Pylori: A Randomized Clinical Trial [NCT04879992] | 413 participants (Actual) | Interventional | 2021-05-07 | Completed | |||
| Randomized Phase IV Trial of Metronidazole Single Dose Versus 7 Day Dose for Treatment of Trichomonas Vaginalis Among HIV-infected Women [NCT01018095] | Phase 4 | 270 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| CURRENT PRACTICE STUDY OF ANTIBIOTIC TREATMENT OF GASTRIC MALT LYMPHOMA [NCT00002682] | Phase 2 | 5 participants (Actual) | Interventional | 1995-08-10 | Completed | ||
| Use of Antibiotics to Eradicate Bacterial Pathogens Colonising the Colonic Mucosa in Ulcerative Colitis Patients [NCT00355602] | 40 participants (Anticipated) | Interventional | 2006-07-31 | Completed | |||
| The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet for the Treatment of Bacterial Vaginosis [NCT03080740] | Phase 4 | 300 participants (Anticipated) | Interventional | 2016-07-31 | Recruiting | ||
| Prospective Study of Clostridium Difficile in Children Undergoing Colonoscopy [NCT01472978] | 0 participants (Actual) | Interventional | 2011-12-31 | Withdrawn(stopped due to Too difficult to enroll patients.) | |||
| Comparison of Efficacy and Safety of Triple Regimen Based on Clarithromycin VS Metronidazole in Pediatric Population in Pakistan [NCT04721704] | 36 participants (Anticipated) | Interventional | 2020-09-14 | Recruiting | |||
| A Phase I Trial of An Admixture of Recombinant Vaccinia Virus That Express DF3/MUC1 and rV-TRICOM (B7.ICAM-1, and LFA-3) in Patients With Metastatic Adenocarcinoma of The Breast [NCT00071942] | Phase 1 | 22 participants (Anticipated) | Interventional | 2003-10-31 | Terminated | ||
| Phase I Study of Intravesical Recombinant Fowlpox - GM-CSF (rF-GM-CSF) and/or Recombinant Fowlpox-TRICOM (rF-TRICOM) in Patients With Bladder Carcinoma Scheduled for Cystectomy [NCT00072137] | Phase 1 | 21 participants (Actual) | Interventional | 2003-10-31 | Terminated | ||
| A Multicenter, Double-Blind, Randomized, Phase 3 Study to Compare the Efficacy and Safety of Intravenous CXA-201 With That of Meropenem in Complicated Intraabdominal Infections [NCT01445678] | Phase 3 | 494 participants (Actual) | Interventional | 2011-12-23 | Completed | ||
| The Response of Clostridium Difficile Infection to Metronidazole Therapy [NCT00304369] | 290 participants (Anticipated) | Observational | 2005-06-30 | Completed | |||
| A Multicenter, Phase II, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial of Serial Endoscopic Surveillance (SES) and Direct Topical Antibiotics (DTA) to Define the Role of Microbes in Anastomotic Healing [NCT02682485] | Phase 2 | 0 participants (Actual) | Interventional | 2017-03-03 | Withdrawn(stopped due to Lack of funding) | ||
| Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Multicenter Randomized Clinical Trial of 10 and 14 Days [NCT05049902] | Phase 4 | 1,300 participants (Actual) | Interventional | 2021-09-21 | Completed | ||
| Phase II Randomized, Placebo-Controlled Trial of PROSTVAC (PSA-TRICOM) in Patients With Clinically Localized Prostate Cancer Undergoing Active Surveillance [NCT02326805] | Phase 2 | 154 participants (Actual) | Interventional | 2015-06-03 | Completed | ||
| A Phase I Feasibility Study of an Intraprostatic PSA-Based Vaccine in Men With Prostate Cancer and Local Failure Following Radiotherapy or Cryotherapy or Clinical Progression on Androgen Deprivation Therapy in the Absence of Local Definitive Therapy [NCT00096551] | Phase 1 | 21 participants (Actual) | Interventional | 2004-11-01 | Completed | ||
| A Randomized Clinical Trial on the Use or Not of Antibiotics After Hospital Discharge in Septic Abortion. [NCT00353743] | 56 participants (Actual) | Interventional | 2006-05-31 | Terminated(stopped due to Rate of cure was higher than expected, IRB suspended for no additional benefit) | |||
| Phase I Trial of a PSA Based Vaccine and an Anti-CTLA-4 Antibody in Adults With Metastatic Androgen Independent Prostrate Cancer [NCT00113984] | Phase 1 | 30 participants (Actual) | Interventional | 2005-06-08 | Completed | ||
| A Prospective, Multicenter, Open-Label, Randomized, Comparative Study to Evaluate the Efficacy, Safety, and Tolerability of Ertapenem Versus Ceftriaxone/Metronidazole in the Treatment of Intra-Abdominal Infections in Adults [NCT00481702] | Phase 3 | 300 participants | Interventional | 2001-12-31 | Completed | ||
| Determine the Effects of COL-101 Administered Once Daily With Metronidazole Topical Gel, 1% Versus Doxycycline Hyclate 100 mg Administered Once Daily With Metronidazole Topical Gel, 1% in Patients With Moderate to Severe Rosacea [NCT00495313] | Phase 4 | 91 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network [NCT00503542] | Early Phase 1 | 46 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Treatment of Low-Grade Gastric Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type Stages IE & II1E (HELYX-Study) [NCT00154440] | Phase 3 | 200 participants | Interventional | 2001-11-30 | Recruiting | ||
| Randomized Controlled Trial of Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery: Oral and Systemic Versus Systemic Antibiotics [NCT00508690] | Phase 3 | 584 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Prospective Randomised Trial of First and Second Line Treatments of Helicobacter Pylori Infection in Slovenia [NCT04359966] | 560 participants (Anticipated) | Interventional | 2020-05-10 | Not yet recruiting | |||
| A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis [NCT01085760] | Phase 1 | 35 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| A Phase I Study of Sequential Vaccinations With Fowlpox-CEA(6D)-TRICOM (B7.1/ICAM/LFA-3) Alone, and in Combination With Vaccinia-CEA(6D)-TRICOM, and the Role of GM-CSF, in Patients With CEA Expressing Carcinomas [NCT00009958] | Phase 1 | 42 participants (Actual) | Interventional | 2000-11-30 | Terminated | ||
| Dual Therapy With High-Dose of Rabeprazole and Amoxicilline Versus Triple Therapy With Rabeprazole, Amoxicilline and Metronidazole as the Second Line Therapy for the Cure of H. Pylori Infection [NCT00197418] | Phase 2/Phase 3 | 0 participants | Interventional | 2003-08-31 | Recruiting | ||
| Role of Delay and Antibiotics on PERForation Rate While Waiting appendECTomy - Randomized Non-inferiority Trial [NCT04378868] | Phase 4 | 1,800 participants (Actual) | Interventional | 2020-05-18 | Completed | ||
| Malabsorption as a Cause of Iron Treatment Failure in Infants - A Clinical Observational Study [NCT00456729] | 100 participants | Interventional | 2006-05-31 | Completed | |||
| Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease [NCT01519310] | Early Phase 1 | 4 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Phase 3 Study of Antibiotic Prophylaxis Use Prior Emergent Surgery, Because of Acute Appendicitis [NCT01524081] | Phase 3 | 187 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| A Phase I, Open-Label, 3-way Crossover, Pharmacokinetic and Drug-Drug Interaction Study of Ceftazidime Avibactam (CAZ-AVI) and Metronidazole When Administered Alone and in Combination in Healthy Subjects [NCT01534247] | Phase 1 | 28 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| A Randomized, Double-Blind, Placebo Controlled, Parallel Design, Multi-Site Clinical Study to Compare the Bioequivalence of Two Metronidazole 1% Topical Gel Formulations in Patients With Moderate to Severe Rosacea [NCT01513863] | Phase 1 | 602 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| A Pilot Study Of Sequential Vaccinations With Recombinant Vaccinia-CEA(6D)-TRICOM, And Recombinant Fowlpox-CEA(6D)-TRICOM (B7.1/ICIAM-1/LFA-3) With Sargramostim (GM-CSF), In Conjunction With Standard Adjuvant Chemotherapy In High Risk Breast Cancer Patien [NCT00052351] | Phase 2 | 0 participants | Interventional | 2002-09-30 | Completed | ||
| The Effect of Systemically Administered Metronidazole Alone and in Combination With Professional Supragingival Plaque Removal on Plaque Composition [NCT00066001] | Phase 2 | 154 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| [NCT00140764] | Phase 3 | 0 participants | Interventional | 2003-01-31 | Completed | ||
| Treating Periodontal Infection: Effects on Glycemic Control in People With Type 2 Diabetes [NCT00016835] | Phase 2 | 46 participants (Actual) | Interventional | 2001-10-17 | Completed | ||
| A Phase I Study Of Active Immunotherapy With Autologous Dendritic Cells Infected With CEA-6D Expressing Fowlpox -Tricom In Patients With Advanced Or Metastatic Malignancies Expressing CEA [NCT00027534] | Phase 1 | 14 participants (Actual) | Interventional | 2002-01-31 | Completed | ||
| Intra-Lesional rF-B7.1 Versus rF-Tricom Vaccine In The Treatment Of Metastatic Cancer [NCT00030693] | Phase 1 | 42 participants (Actual) | Interventional | 2001-12-31 | Terminated(stopped due to Administratively complete.) | ||
| Randomized Controlled Trial to Evaluate the Optimal Timing of Surgical Antimicrobial Prophylaxis [NCT01790529] | Phase 4 | 5,000 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission [NCT00021671] | Phase 3 | 3,720 participants | Interventional | Completed | |||
| Phase I Study of a Recombinant Fowl Pox Vaccine rF-CEA (6D)/TRICOM Alone or With GM-CSF in Patients With Advanced CEA Expressing Adenocarinomas [NCT00028496] | Phase 1 | 48 participants (Actual) | Interventional | 2001-11-30 | Completed | ||
| Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy (Randomized Trial of BV Treatment in Pregnancy) [NCT00153517] | Phase 2 | 126 participants | Interventional | 1999-10-31 | Completed | ||
| Tinidazole for the Treatment of Bacterial Vaginosis [NCT00334633] | Phase 4 | 593 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| A Randomized Phase II Trial Combining Vaccine Therapy With PROSTVAC/TRICOM and Flutamide vs. Flutamide Alone in Men With Androgen Insensitive, Non-Metastatic (D0.5) Prostate Cancer [NCT00450463] | Phase 2 | 64 participants (Actual) | Interventional | 2007-02-23 | Completed | ||
| Optimized Treatment for Uncomplicated Acute Appendicitis; Active Observation With or Without Antibiotic Treatment [NCT03985514] | Phase 4 | 126 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial [NCT03508999] | Phase 4 | 63 participants (Actual) | Interventional | 2018-05-23 | Completed | ||
| Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam [NCT00589329] | 20 participants (Actual) | Interventional | 2007-12-31 | Terminated(stopped due to published data suggest potential harm in other investigations.) | |||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial [NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| [NCT01792700] | Phase 4 | 648 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Combined Treatment With GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative Ileal Pouch Anal Anastomosis Surgery [NCT04979832] | Phase 1/Phase 2 | 18 participants (Anticipated) | Interventional | 2021-09-06 | Recruiting | ||
| Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection [NCT05720559] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-03-01 | Not yet recruiting | ||
| Long-term Effects of Sub Gingival Debridement Associated With Antibiotics in Individual Undergoing Maintenance Periodontal Therapy [NCT05934227] | 50 participants (Anticipated) | Interventional | 2023-07-01 | Enrolling by invitation | |||
| Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture [NCT05206500] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-05-17 | Recruiting | ||
| A Prospective, Multi-center, Randomized, Open-label, Parallel Design Clinical Trial to Compare 10-day Sequential Therapy and 14-day Modified Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea [NCT02159976] | 390 participants (Actual) | Interventional | 2014-07-31 | Completed | |||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial [NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Safety and Pharmacokinetics of Multiple Dose Metronidazole in Premature Infants [NCT01222585] | Phase 1 | 24 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Comparison of Hybrid and Bismuth Containing Quadruple Therapies for Helicobacter Pylori Eradication: a Randomized Controlled Trial [NCT02541864] | 330 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans [NCT05024188] | 50 participants (Anticipated) | Interventional | 2022-01-20 | Not yet recruiting | |||
| Comparing 10-day Reverse Hybrid Therapy and 10-day Triple Therapy Plus Bismuth Therapy on Helicobacter Pylori Eradication [NCT04566211] | 440 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | |||
| A Multi-center, Open-label, Randomized Study to Compare the Safety and Efficacy of Once Daily Levofloxacin Along With Once Daily Metronidazole Versus Piperacillin/Tazobactam in the Treatment of Complicated Appendicitis [NCT00236912] | Phase 4 | 139 participants (Actual) | Interventional | 2003-07-31 | Terminated(stopped due to This study was terminated due to low enrollment.) | ||
| A Phase II, Randomized, Partial-Blind, Parallel-Group, Active- and Vehicle-Controlled, Multicenter Study of the Safety and Efficacy of ACZONE™ (Dapsone) Gel, 5% in Subjects With Papulopustular Rosacea [NCT00249782] | Phase 2 | 400 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| Study of Novel Triple Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori in Children [NCT04415983] | Phase 3 | 100 participants (Anticipated) | Interventional | 2020-06-01 | Recruiting | ||
| Metronidazole and Ciprofloxacin in the Treatment of Colonic Crohn's Disease: The MACINTOCC Trial. [NCT00257699] | Phase 2 | 12 participants (Actual) | Interventional | 2006-05-31 | Terminated(stopped due to Inadequate recruitment to meet completion date) | ||
| A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge [NCT00313131] | Phase 3 | 1,524 participants | Interventional | 2004-01-31 | Completed | ||
| A Multi-center, Double-blind, Randomized, Vehicle-controlled, Parallel-group Study Comparing Metronidazole Gel 1%, to Metrogel® (Metronidazole Gel) 1% in the Treatment of Rosacea [NCT02393937] | Phase 3 | 963 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Multicenter, Double Blind, Metronidazole Controlled, Dose Range Finding Study of Nitazoxanide in the Treatment of Clostridium Difficile Colitis [NCT00417872] | Phase 2 | 114 participants | Interventional | 2004-01-31 | Completed | ||
| Pharmacokinetic Interaction Study Between Budesonide and Metronidazole in Healthy Volunteers [NCT00338910] | Phase 4 | 12 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Conventional Antibiotics for Perforated Appendicitis - a Pivotal Quasi-randomized Controlled Trial [NCT03435900] | Phase 2 | 13 participants (Actual) | Interventional | 2018-02-14 | Completed | ||
| Efficacies of Hybrid, High-dose Dual and Bismuth Quadruple Therapies for the First-line Anti-H Pylori Treatment and Tetracycline-levofloxacin Quadruple Therapy for the Second-line Anti-H Pylori Treatment - a Multicentre Randomized Trial [NCT03779074] | Phase 3 | 918 participants (Actual) | Interventional | 2018-09-03 | Completed | ||
| [NCT01658852] | Phase 3 | 0 participants (Actual) | Interventional | 2011-05-31 | Withdrawn(stopped due to Because of difficulties on recruiting participants) | ||
| Clinical Efficacy and Health Economic Evaluation of Susceptibility-Guided Therapy for Helicobacter Pylori Infection Treatment：Multicenter Randomized Controlled Study [NCT05250050] | Phase 4 | 388 participants (Anticipated) | Interventional | 2022-03-25 | Recruiting | ||
| Helicobacter Pylori Treatment [NCT01668927] | Phase 4 | 424 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| Efficacy and Safety of CD5024 1% Cream Versus Metronidazole 0.75% Cream in Subjects With Papulopustular Rosacea Over 16 Weeks Treatment, Followed by a 36-week Extension Period. [NCT01493947] | Phase 3 | 962 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| [NCT01275560] | Phase 3 | 16 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| The Effect of an Antibiotic-antifungal Rinse on Periodontal Disease [NCT01718912] | 11 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| [NCT01742429] | Phase 4 | 200 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Acute Appendicitis and Microbiota - Ethology of Appendicitis and Effects of the Antimicrobial Treatment - The MAPPAC (Microbiology Appendicitis Acuta) Trial [NCT03257423] | 200 participants (Anticipated) | Interventional | 2017-04-04 | Enrolling by invitation | |||
| Ten Days Quadruple Versus Sequential Therapy as Empirical First and Second Line Treatment for Helicobacter Pylori Eradication: a Randomized Crossover Trial [NCT01760824] | 391 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| An Open-Label, Randomized Study to Determine the Safety and Efficacy of GoldenCareTM for the Treatment of Bacterial Vaginosis [NCT01762670] | Phase 1/Phase 2 | 8 participants (Actual) | Interventional | 2013-02-28 | Terminated(stopped due to Company decided to stop study for reasons other than safety) | ||
| Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial [NCT05943223] | Phase 2 | 16 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Studying the Role of N-Acetyl Cysteine Either Alone or in Combination With Metronidazole in Treatment of Bacterial Vaginosis [NCT01841411] | Phase 4 | 90 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | ||
| Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis: A Cluster Randomized Cluster Crossover Non-Inferiority Study. [NCT04803422] | 2,631 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Neo-Penotran Forte Vaginal Suppository for Vaginal Trichomoniasis [NCT01361048] | Phase 2 | 40 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Efficacy of Two Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment [NCT02988089] | Phase 4 | 480 participants (Anticipated) | Interventional | 2017-04-20 | Recruiting | ||
| Antibiotic Safety in Infants With Complicated Intra-Abdominal Infections (SCAMP Trial) [NCT01994993] | Phase 2/Phase 3 | 260 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Exploratory Study of Impact of Oral Metronidazole, Vancomycin and Fidaxomicin on the Extent and Quantity of Host Carriage and Environmental Contamination With C. Difficile [NCT02057198] | Phase 4 | 33 participants (Actual) | Interventional | 2014-06-10 | Completed | ||
| Effects of Metric-based Feedback Training on Acquisition of Sonographic Skills Relevant to Performance of Ultrasound Guided Axillary Brachial Plexus Block [NCT02976623] | 13 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| "Phase 4, Prospective, Randomized Study Comparing 14-day Non-bismuth Quadruple Hybrid and Concomitant Therapies for Helicobacter Pylori Eradication in Settings With High Clarithromycin Resistance" [NCT01464060] | Phase 4 | 400 participants (Anticipated) | Interventional | 2011-09-30 | Recruiting | ||
| Standard Versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes After Whipple's Procedure (SPARROW): a Multicenter, Randomized Controlled Trial [NCT05784311] | Phase 4 | 322 participants (Anticipated) | Interventional | 2023-03-06 | Recruiting | ||
| Prospective, Phase 3, Randomized, Multi-center, Double-blind Study of Efiicacy, Tolerability & Safety of Sulopenem & Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro-metronidazole for Treatment of cIAI in Adults [NCT03358576] | Phase 3 | 674 participants (Actual) | Interventional | 2018-09-18 | Completed | ||
| Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in the Treatment of Periodontitis in Patients With Diabetes [NCT03374176] | Phase 3 | 42 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| A Post-Market, Multi-Center, Randomized Controlled Trial on Robotic Instrumentation in Patients Undergoing Total Hip Arthroplasty [NCT05497206] | 176 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
| A Prospective, Single-arm, Single-center, Phase II Clinical Trial to Evaluate the Efficacy of Quintuple Method for the Treatment of Multiple Refractory Colorectal Liver Metastases [NCT05774964] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-03-15 | Not yet recruiting | ||
| A Phase 3, Multicenter, Double-blind, Randomized, Active-controlled Clinical Study to Evaluate the Efficacy and Safety of Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem in Chinese Participants With Complicated Intra-abdominal Infect [NCT03830333] | Phase 3 | 268 participants (Actual) | Interventional | 2019-03-20 | Completed | ||
| A Double Blind Randomized Study for Treatment of Helicobacter Pylori Infection: 14-day Non-bismuth Quadruple Therapy Versus Triple Therapy. [NCT04769583] | Phase 4 | 121 participants (Actual) | Interventional | 2019-02-10 | Completed | ||
| Oral Antibiotics for Anal Abscess to Diminish the Developement of Perianal Fistula [NCT03643198] | 210 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | |||
| Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori [NCT01922765] | Phase 4 | 540 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | ||
| Oral + Parenteral Antibiotic Prophylaxis Before Colonic Surgery With vs Without Mechanical Bowel Preparation: a Prospective, Multicentric, Randomised, Controlled Trial. [NCT04161599] | Phase 4 | 968 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| A Randomized Controlled Trial of Treatment of Bacterial Vaginosis in Late Third Trimester to Prevent Maternal Peripartum Infection [NCT04578015] | Phase 4 | 16 participants (Actual) | Interventional | 2021-04-26 | Terminated(stopped due to After screening many patients for BV, it was determined that the rate of BV is less in our population that the 30% rate mentioned in the literature. It was determined that completing the study will not be feasible due to cost and time constraints.) | ||
| Is it Effective to Treat Patients With Blastocystis Hominis Infection? A Double-blind Placebo Controlled Randomized Trial [NCT01521403] | Phase 4 | 200 participants (Anticipated) | Interventional | 2012-11-30 | Active, not recruiting | ||
| Prospective Randomized Clinical Trial for the Management of Uncomplicated Diverticulitis in Right Colon; Non-antibiotics Versus Antibiotics [NCT02314013] | 132 participants (Anticipated) | Interventional | 2014-04-30 | Active, not recruiting | |||
| The Safety and Pharmacokinetics of Intraperitoneal Administration of Granulocyte-macrophage Colony-stimulating Factor, Fosfomycin, and Metronidazole in Patients Undergoing Appendectomy for Uncomplicated Appendicitis [NCT03046758] | Phase 2 | 14 participants (Actual) | Interventional | 2017-02-24 | Completed | ||
| The Efficacy of 10-day Metronidazole and Levofloxacin Containing Sequential Therapy and 10-day Levofloxacin-containing Triple Therapy In Second Line Helicobacter Pylori Eradication Therapies [NCT02596620] | 164 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Randomised Trial Comparing Pre-operative Administration of Single Dose Kefazolin to Kefazolin Plus Metronidazole to Reduce Postpartum Infection [NCT04792710] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2021-03-08 | Not yet recruiting | ||
| A Multicenter Phase I-II Study of Tumor Vaccine Following Chemotherapy in Patients With Metastatic Breast Cancer Untreated With Chemo/Radiation in the Previous 18 Months: Vaccine-Induced Bias of T-Cell Repertoire Reconstitution After T-Cell Re-Infusion [NCT00048893] | Phase 1/Phase 2 | 37 participants (Actual) | Interventional | 2002-11-30 | Terminated(stopped due to The study was closed to accrual due to very poor enrollment.) | ||
| Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. [NCT01837199] | Phase 4 | 64 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| A Randomized, Open Label, Active Control, Safety, Tolerability and Pharmacokinetics Study of Two Dr. Reddy's Formulations of Metronidazole Versus Immediate Release Metronidazole (Flagyl) in Patients With Mild to Moderate C. Difficile Associated Diarrhea ( [NCT01559545] | Phase 2 | 60 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Adalimumab on Preventing Postoperative Recurrence of Crohn's Disease [NCT01564823] | Phase 3 | 86 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Randomized, Single Blinded, Controlled, Multi Center Phase 4 Study for Induction of Remission in Active Pediatric Crohn's Disease, Using 2 Months Antibiotic Course of Azithromycin Combined With Metronidazole vs. Metronidazole Alone. [NCT01596894] | Phase 4 | 73 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Multicenter, Randomized, And Double-Blind Study To Evaluate The Safety Of Tigecycline Versus A Ceftriaxone Regimen In The Treatment Of Complicated Intra-Abdominal Infections And Community-Acquired Pneumonia In Subjects Of 8-17 Years [NCT01602874] | Phase 3 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn | ||
| Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies [NCT01722708] | 169 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| A Phase I/II Pilot Study of Sequential Vaccinations With rFowlpox-PSA (L155)-TRICOM (PROSTVAC-F/TRICOM) Alone, or in Combination With rVaccinia-PSA (L155)-TRICOM (PROSTVAC-V/TRICOM), and the Role of GM-CSF, in Men With Prostate Cancer [NCT00060528] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2003-05-22 | Completed | ||
| Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients: A Randomized Clinical Trial [NCT02200328] | Phase 4 | 76 participants (Actual) | Interventional | 2014-08-31 | Terminated(stopped due to Patients noncompliant with instructions and follow ups could not be completed.) | ||
| Therapy and Prevention for Sexually Associated Bacterial Vaginosis [NCT00324818] | Phase 4 | 600 participants | Interventional | 2002-07-31 | Completed | ||
| A Single Blind, Randomised, Multi-centre, Active Controlled, Trial To Evaluate Safety, Tolerability, Pharmacokinetics And Efficacy Of Ceftazidime And Avibactam When Given In Combination With Metronidazole, Compared With Meropenem, In Children From 3 Month [NCT02475733] | Phase 2 | 83 participants (Actual) | Interventional | 2015-08-01 | Completed | ||
| A Phase II Clinical Trial of Anti-Helicobacter Pylori Treatment in Endoscopically Diagnosed Low-Grade Localized Gastric Lymphoma [NCT00003151] | Phase 2 | 96 participants (Anticipated) | Interventional | 1997-09-30 | Completed | ||
| A Phase II Trial of Enzalutamide in Combination With PSA-TRICOM in Patients With Non-Metastatic Castration Sensitive Prostate Cancer [NCT01875250] | Phase 2 | 38 participants (Actual) | Interventional | 2013-07-22 | Completed | ||
| Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis (A Randomized Controlled Clinical Trial) [NCT06153706] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2022-06-01 | Completed | ||
| Comparison of 7-day Triple, 10-day Sequential, and 7-day Concomitant Therapies for Helicobacter Pylori Infection in Taiwan [NCT01769365] | Phase 4 | 307 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| A Phase 3, Double-blind, Multicentre, Randomised, Placebo-controlled Study to Determine the Efficacy and Safety of SPL7013 Gel to Prevent the Recurrence of Bacterial Vaginosis [NCT02237950] | Phase 3 | 586 participants (Actual) | Interventional | 2014-10-13 | Completed | ||
| The HYsteroscopic Miscarriage MaNagement (HYMMN) Trial [NCT04751500] | 149 participants (Actual) | Interventional | 2021-01-31 | Completed | |||
| A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Metronidazole Vaginal Gel 1.3% in Adolescent Female Subjects With Bacterial Vaginosis [NCT02392026] | Phase 4 | 60 participants (Actual) | Interventional | 2015-08-12 | Completed | ||
| Prolonged Treatment for Infected Abortion After Hospital Discharge. [NCT00376493] | Phase 4 | 56 participants (Actual) | Interventional | 2006-05-31 | Terminated(stopped due to The rate of cure in both arms was higher than expected) | ||
| A Randomized, Open Label, Multicentre Phase Iv Study To Evaluate The Efficacy And Safety Of Magnex (Cefoperazone-Sulbactam) In Comparison With Ceftazidime Plus Amikacin And Metronidazole In The Treatment Of Intra-Abdominal Infections [NCT00360607] | Phase 4 | 307 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
| Prospective Evaluation of the Impact of Bacterial Vaginosis and Its Treatment on Mucosal Susceptibility to HIV-1 Infection and Endpoints of Cervico-Vaginal Safety [NCT01347632] | 35 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of Rifaximin Vaginal Tablets in the Treatment of Bacterial Vaginosis [NCT02376972] | Phase 2 | 392 participants (Actual) | Interventional | 2015-04-30 | Terminated(stopped due to According to the Recommendation of the Indipendent Data Monitoring Committee) | ||
| Prophylatic Effect of Preoperative Antibiotics With Mechanical Bowel Preparation Compare With Simple Mechanical Bowel Preparation Before Laparoscopic Colorectal Surgery: a Randomized Controlled Trial [NCT03856671] | 309 participants (Actual) | Interventional | 2019-01-17 | Completed | |||
| Effectiveness of Metronidazole Versus Homologated Placebo in Pain Control Posthemorrhoidectomy [NCT02328144] | Phase 3 | 44 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Immunotherapy for Unresectable Pancreas Cancer: A Phase 1 Study of Intratumoral Recombinant Fowlpox PANVAC (PANVAC-F) Plus Subcutaneous Recombinant Vaccinia PANVAC (PANVAC-V), PANVAC-F and Recombinant Granulocyte-Macrophage Colony Stimulating Factor (rH-G [NCT00669734] | Phase 1 | 18 participants (Actual) | Interventional | 2010-02-01 | Active, not recruiting | ||
| Recurrent Bacterial Vaginosis (RBV): Efficiency of Metronidazole in Comparison to Metronidazole and Intravaginal Acidifying Gel: A Randomized Investigator-blinded Controlled Trial [NCT00545181] | 55 participants (Actual) | Interventional | 2007-09-30 | Completed | |||
| Topical Versus Oral Metronidazole for Pain Relief After Surgery for Benign Anorectal Conditions; a Prospective Randomized Study [NCT05038605] | 108 participants (Actual) | Interventional | 2020-01-24 | Completed | |||
| Compare 14-day Reverse Hybrid Therapy and 14-day Triple Therapy Plus Bismuth on Helicobacter Pylori Eradication [NCT03321773] | 440 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | |||
| Efficacy of High-dose Dual Therapy Versus Bismuth-containing Quadruple Therapy for Rescue Treatment of Helicobacter Pylori Infection - A Prospective, Randomized, Comparative Study [NCT02490839] | Phase 4 | 450 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Intravenous Administration of Metronidazole, Levofloxacin and Esomeprazole Triple Therapy in the Treatment of Helicobacter Pylori Infection and Related Complications Caused by Active Peptic Ulcer Disease [NCT04432233] | Phase 4 | 60 participants (Anticipated) | Interventional | 2020-06-15 | Recruiting | ||
| Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth: A Randomized, Double-Blind, Placebo-Controlled Trial Comparing Ciprofloxacin and Metronidazole [NCT02458781] | Phase 4 | 180 participants (Anticipated) | Interventional | 2015-01-31 | Enrolling by invitation | ||
| Preoperative Oral Antibiotics and Surgical Site Infections in Colon Surgery Without Mechanical Bowel Preparation. A Prospective, Multicentre, Single Blinded, Randomized Trial (ORALEV Study) [NCT02505581] | Phase 4 | 536 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Don't Throw Your Heart Away: Patient Study 4 [NCT04809051] | 400 participants (Anticipated) | Interventional | 2021-04-01 | Recruiting | |||
| "PreFem: What Happens to the Vaginal Microbiota When a BV Infection is Treated With Metronidazole?" [NCT03187457] | 60 participants (Actual) | Interventional | 2017-09-04 | Completed | |||
| Perioperative Tissue Penetration of Antimicrobials in Infants [NCT04299867] | 23 participants (Actual) | Observational | 2020-07-15 | Completed | |||
| Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide: Randomized Clinical Trial [NCT02394821] | Phase 3 | 24 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Multicentre, Prospective Study of First-line Antibiotic Therapy for Early-stage H. Pylori-Positive Gastric Pure (de Novo) Diffuse Large B-cell Lymphoma and Potential Predicting Factor for Treatment Outcome [NCT02388581] | Phase 2 | 30 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis: A Randomized Clinical Trial [NCT03142607] | Phase 3 | 90 participants (Anticipated) | Interventional | 2017-02-03 | Recruiting | ||
| A PHASE IIA PROSPECTIVE, OPEN-LABEL, MULTICENTER STUDY TO DETERMINE THE PHARMACOKINETICS (PK) AND SAFETY AND TOLERABILITY OF AZTREONAM-AVIBACTAM (ATM-AVI) FOR THE TREATMENT OF COMPLICATED INTRA-ABDOMINAL INFECTIONS (CIAIS) IN HOSPITALIZED ADULTS [NCT02655419] | Phase 2 | 40 participants (Actual) | Interventional | 2016-05-19 | Completed | ||
| An Open, Uncontrolled Study Investigating the Safety and Efficacy of GK567 in the Deodorization of Malodorous Infected Cutaneous Fungating Neoplastic Tumours, Over 14 Days of Treatment [NCT01541930] | Phase 3 | 21 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Clarithromycin-, Metronidazole-, or Levofloxacin-containing Therapy for Helicobacter Pylori-infected Penicillin-allergic Patients: A Randomized Controlled Trial [NCT05023577] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-08-26 | Recruiting | ||
| Proton Pump Inhibitor and Amoxicillin Combined Bismuth or Metronidazole for Helicobacter Pylori First-line Treatment: A Randomized Controlled Trial [NCT05014685] | Phase 4 | 732 participants (Anticipated) | Interventional | 2021-08-20 | Recruiting | ||
| The Clinical Effects of Nitazoxanide in Hepatic Encephalopathy Patients: A Pilot Study [NCT02334163] | Phase 2 | 36 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Metronidazole Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects [NCT01418365] | Phase 1 | 30 participants (Actual) | Interventional | 2011-08-22 | Completed | ||
| Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis [NCT03006809] | Phase 1 | 30 participants (Actual) | Interventional | 2017-03-02 | Completed | ||
| Probiotic and Antibiotic Therapies in Women With Unexplained Infertility [NCT04955574] | Phase 2 | 0 participants (Actual) | Interventional | 2023-01-31 | Withdrawn(stopped due to Change in departmental research focus.) | ||
| Combined Mechanical and Oral Antibiotic Bowel Preparation Versus Oral Antibiotics Alone for the Reduction of Surgical Site Infection Following Elective Colorectal Resection [NCT03042091] | Early Phase 1 | 224 participants (Anticipated) | Interventional | 2016-09-30 | Recruiting | ||
| Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis. [NCT04353362] | Phase 4 | 74 participants (Actual) | Interventional | 2017-04-01 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled Study to Determine the Efficacy of a Multi-strain Synbiotic (SH-DS01) to Restore Gut Barrier Integrity and Gut Microbiota Composition After Antibiotic Administration. [NCT04171466] | 46 participants (Actual) | Interventional | 2020-08-12 | Completed | |||
| Comparison of 14-day Sequential and Hybrid Therapies for H Pylori Infection [NCT01085786] | Phase 4 | 240 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| The Effect of Autogenous Demineralized Dentin Graft Combined With Injectable PRF Loaded With Metronidazole Versus Autogenous Demineralized Dentin Graft Alone on Alveolar Ridge Preservation of Infected Sockets: A Randomized Controlled Clinical Trial [NCT05470673] | 20 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | |||
| A Phase III, Randomized, Multicenter, Double Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-Abdo [NCT01726023] | Phase 3 | 486 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Deliberate Practice With Validated Metrics Improves Skill Acquisition in Performance of Ultrasound Guided Peripheral Nerve Block in a Simulated Setting [NCT03154372] | 18 participants (Actual) | Interventional | 2016-09-20 | Completed | |||
| Impact of Formulation on the Pharmacokinetics of Micropatch-assisted Delivery of Metronidazole [NCT05929794] | Phase 4 | 24 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| " Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Modification With Antibiotics in Children" [NCT03069976] | 15 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| Clinical and Microbiological Effects of Local and Systemic Antimicrobials as an Adjunctive Therapy in Periodontitis Stages 2 and 3 [NCT05608564] | 40 participants (Actual) | Interventional | 2022-01-17 | Active, not recruiting | |||
| Locally Delivered Antibiotics for the Treatment of Periodontitis Topical Doxycycline Versus Minocycline Gels as an Adjunct to Mechanical Treatment [NCT04125706] | 44 participants (Anticipated) | Interventional | 2019-11-01 | Not yet recruiting | |||
| Parasitic Infection in Anemic Pregnant Women. Prevalence and Effects in Rural Area in Egypt. [NCT04391998] | Phase 4 | 200 participants (Anticipated) | Interventional | 2020-05-13 | Recruiting | ||
| Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection - a Randomized Controlled Trial (REHYTRI Study) [NCT02359435] | 440 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® Capsules Compared to Placebo After an Initial 12 Week Treatment Regimen With Oracea® and MetroGel® 1% in Adults With Rosacea [NCT01426269] | Phase 4 | 235 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Efficacy of High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori Rescue Treatment: A Randomized Clinical Trial [NCT04024527] | Phase 4 | 306 participants (Actual) | Interventional | 2019-07-25 | Completed | ||
| [NCT01799356] | Phase 4 | 1,303 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Systemic Antibiotic Therapy (Amoxicillin Plus Metronidazole) as an Adjunct to Initial Non-surgical Treatment of Peri-implantitis; a Single Blind Randomized Controlled Study [NCT04149327] | Phase 4 | 62 participants (Actual) | Interventional | 2012-08-01 | Completed | ||
| A Phase II Trial of Broad Spectrum Antibiotic Therapy for Early Stage, Non-progressive Chronic Lymphocytic Leukaemia Without Adverse Prognostic Factors [NCT01279252] | Phase 2 | 71 participants (Anticipated) | Interventional | 2011-07-31 | Completed | ||
| Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children [NCT01678365] | Phase 4 | 43 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Multicenter Randomized Clinical Trial of 10 and 14 Days [NCT04901117] | Phase 4 | 1,300 participants (Anticipated) | Interventional | 2021-06-30 | Not yet recruiting | ||
| A Prospective Clinical Study of Regenerative Endodontic Treatment of Traumatised Non-vital Immature Teeth Using Bi-antibiotic Paste [NCT03045185] | 15 participants (Actual) | Interventional | 2013-01-01 | Completed | |||
| Bismuth Quadruple Therapy With Tetracycline Versus Doxycycline as Rescue Therapy for Helicobacter Pylori Infection: a Randomized Controlled Trial [NCT05018923] | Phase 4 | 242 participants (Anticipated) | Interventional | 2021-08-24 | Recruiting | ||
| Systems Biology of Inactivated Rabies Vaccine in Healthy Adults With or Without Use of Broad Spectrum Antibiotics [NCT03557008] | Phase 4 | 37 participants (Actual) | Interventional | 2018-07-05 | Completed | ||
| Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis [NCT00462020] | 102 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| Randomized Controlled Trial of Treatment of Male Partners of Women With BV [NCT02209519] | Phase 3 | 214 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial [NCT02969928] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Tuberculosis- Learning the Impact of Nutrition [NCT03598842] | 123 participants (Actual) | Interventional | 2019-07-12 | Active, not recruiting | |||
| Local Installation of Acetylcysteine, Doxycycline and Fibrin Glue and Surgical Closure of Fistula Openings for Treatment of Perianal Fistulae. An Open Label, Prospective, Multicentric Pilot Study [NCT03322488] | 40 participants (Anticipated) | Interventional | 2017-06-20 | Recruiting | |||
| A PHASE 3, MULTICENTER, OPEN-LABEL, SINGLE-ARM STUDY TO ASSESS THE EFFICACY AND SAFETY OF CEFTAZIDIME-AVIBACTAM (PF-06947386) PLUS METRONIDAZOLE IN JAPANESE ADULT PATIENTS WITH COMPLICATED INTRA-ABDOMINAL INFECTION REQUIRING HOSPITALIZATION [NCT04927312] | Phase 3 | 60 participants (Actual) | Interventional | 2021-10-01 | Completed | ||
| Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics A Prospective, Double Blind, Randomized, Three Armed, Parallel, Placebo Controlled Clinical Trial [NCT02185209] | Phase 4 | 77 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| MetroGel 1% Hydration Study: A Kinetic Regression Study [NCT00436527] | Phase 4 | 26 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection. [NCT03583476] | 1,821 participants (Anticipated) | Observational | 2018-04-01 | Recruiting | |||
| Helicobacter Pylori and Body Iron in Adults [NCT03146325] | Phase 4 | 0 participants (Actual) | Interventional | 2012-11-30 | Withdrawn(stopped due to Study was not funded and PI has left the institution) | ||
| Diagnosis of Demodex Blapharitis and Treatment With Ivermectin Gel 0.1%/ Metronidazole 1% [NCT02236403] | Phase 3 | 60 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Phase 3 Study of IV to Oral 6-Day Tedizolid Phosphate Compared With 10-day Comparator in Subjects 12 to < 18 Years With cSSTI. [NCT02276482] | Phase 3 | 120 participants (Actual) | Interventional | 2015-03-25 | Completed | ||
| Kinematic Analysis in Stroke Patients Using Microsoft Kinect and Akira Software: Kinect-Akira Movement Study [NCT04464863] | 140 participants (Anticipated) | Observational | 2020-01-29 | Recruiting | |||
| Pregnancy Outcomes Following Preconception Treatment of Asymptomatic Bacterial Vaginosis in an Infertility Population: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. [NCT01322971] | 2 participants (Actual) | Interventional | 2011-02-28 | Terminated(stopped due to Disease prevalence lower than expected in population.) | |||
| The Efficacy and Safety Study of Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis [NCT03446443] | Phase 4 | 240 participants (Anticipated) | Interventional | 2018-07-26 | Recruiting | ||
| Comparison of Two Novel First-line Anti-Helicobacter Pylori Therapy: A Prospective Randomized Trial [NCT03383003] | 240 participants (Actual) | Interventional | 2016-03-01 | Completed | |||
| 10 Day Concomitant Versus 14 Day Hybrid Regimen as First Line H. Pylori Eradication Treatment in a High Clarithromycin Resistance Area. A Multicenter Randomized Equivalence Trial [NCT03592069] | Phase 4 | 345 participants (Actual) | Interventional | 2018-02-21 | Completed | ||
| A Phase III, Randomized, Multicenter, Double Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-Abdo [NCT01499290] | Phase 3 | 493 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Efficacy on Helicobacter Pylori Eradication With Sequential Antibiotic Compared to Triple Therapy for 14 Days [NCT02395458] | Phase 4 | 142 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Pilot Trial of Fecal Microbiota Transplantation and Re-Introduction of Anti-PD-1 Therapy in dMMR Colorectal Adenocarcinoma Anti-PD-1 Non-Responders [NCT04729322] | Phase 2 | 15 participants (Anticipated) | Interventional | 2021-02-22 | Recruiting | ||
| Solubilized Metronidazole And/oR Terconazole Gels Intra-Vaginal Efficacy and Safety [NCT02308033] | Phase 3 | 204 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Strategy on the Increment of H. Pylori Eradication Rate and Investigating the Gastric Pathology and Antimicrobial Resistance in Diabetic Patients [NCT02466919] | Phase 4 | 114 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| The Studies of Integrating Gastric and Gut Microbiota, F. Prausnitzii Metabolites, Microenvironment, and Epigenetics to Identify the Cancer Risk of H. Pylori-related Precancerous Conditions Through an AI System and Control the Risky by Probiotic Supplemen [NCT04527055] | Phase 4 | 312 participants (Anticipated) | Interventional | 2020-05-06 | Enrolling by invitation | ||
| Personalized AZithromycin/metronidAZole, in Combination With Standard Induction Therapy, to Achieve a Fecal Microbiome Community Structure and Metagenome Changes Associated With Sustained Remission in Pediatric Crohn's Disease (CD): a Pilot Study [NCT04186247] | Phase 2 | 20 participants (Anticipated) | Interventional | 2021-08-13 | Recruiting | ||
| An Evaluation of the Cosmetic Appearance of Metronidazole Gel (MetroGel®) 1% [NCT00668655] | 30 participants (Actual) | Observational | 2008-02-29 | Completed | |||
| Investigating Trends in Compliance With Quality Assurance Metrics [NCT03119532] | 672 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Preparing for a Clinical Trial of Interventions to Maintain Normal Vaginal Microbiota for Preventing Adverse Reproductive Health Outcomes in Africa [NCT02459665] | 68 participants (Actual) | Interventional | 2015-06-05 | Completed | |||
| An Open-Label, Randomized, Multicenter, Phase III Study of Ceftazidime Avibactam (CAZ-AVI, Formerly CAZ104) and Best Available Therapy for the Treatment of Infections Due to Ceftazidime Resistant Gram Negative Pathogens [NCT01644643] | Phase 3 | 345 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Solubilized Metronidazole And/oR Terconazole Gels Intra-Vaginal Efficacy and Safety [NCT02308007] | Phase 3 | 475 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Systems Biology of Inactivated Influenza Vaccine (IIV) in Healthy Adults With or Without Use of Broad Spectrum Antibiotics [NCT02154061] | 33 participants (Actual) | Interventional | 2015-04-30 | Completed | |||
| Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) [NCT02168816] | Phase 2 | 30 participants (Actual) | Interventional | 2014-03-19 | Terminated(stopped due to The study was stopped for feasibility (i.e., low recruitment)) | ||
| A Phase II Study of Neoadjuvant rFowlpox-PSA (L155)-TRICOM (Prostvac-F/TRICOM) in Combination With rVaccinia-PSA (L155)-TRICOM (Prostvac-V/TRICOM) in Men With Prostate Cancer Undergoing Treatment With Radical Prostatectomy [NCT02153918] | Phase 2 | 27 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||