Replicase polyprotein 1ab

[no definition available]

Synonyms

pp1ab;
ORF1ab polyprotein

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	3 (75.00)	2.80

Compounds (82)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
carmofur	Human coronavirus 229E	IC50	1.8200	1	1
chloroquine	Human coronavirus 229E	IC50	5.4700	1	1
chlorpromazine	Human coronavirus 229E	IC50	11.2400	1	2
disulfiram	Human coronavirus 229E	IC50	9.3500	1	1
ebselen	Human coronavirus 229E	IC50	0.6700	1	1
emodin	Human coronavirus 229E	IC50	10.0000	1	1
ethacrynic acid	Human coronavirus 229E	Ki	375.0000	1	1
fluphenazine	Human coronavirus 229E	IC50	11.8000	1	2
niclosamide	Human coronavirus 229E	IC50	50.0000	2	2
promethazine	Human coronavirus 229E	IC50	13.6450	1	2
pyrithione zinc	Human coronavirus 229E	Ki	0.1700	1	1
zinc ethylphenyldithiocarbamate	Human coronavirus 229E	Ki	1.0000	1	1
tanshinone ii a	Human coronavirus 229E	IC50	0.8000	1	1
1-methylpropyl-2-imidazolyl disulfide	Human coronavirus 229E	IC50	21.0000	1	2
1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide	Human coronavirus 229E	IC50	0.3700	1	1
hirsutanone	Human coronavirus 229E	IC50	4.1000	1	1
CID 2131972	Human coronavirus 229E	Ki	9.1100	1	1
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate	Human coronavirus 229E	IC50	3.0000	2	2
N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide	Human coronavirus 229E	IC50	18.1000	2	4
8-(Trifluoromethyl)-9H-purin-6-amine	Human coronavirus 229E	IC50	13.9000	1	1
ginkgetin	Human coronavirus 229E	IC50	32.7000	1	1
apigenin	Human coronavirus 229E	IC50	280.0000	1	1
amentoflavone	Human coronavirus 229E	IC50	8.3000	1	1
hyperoside	Human coronavirus 229E	IC50	42.7000	1	1
sciadopitysin	Human coronavirus 229E	IC50	38.4000	1	1
savinin	Human coronavirus 229E	IC50	25.0000	1	1
broussochalcone a	Human coronavirus 229E	IC50	25.6500	1	2
rupintrivir	Human coronavirus 229E	IC50	410.0000	1	2
rupintrivir	Human coronavirus 229E	Ki	10.0000	1	2
5-Chloro-3-pyridinyl 2-furoate	Human coronavirus 229E	IC50	0.0600	2	2
np 031112	Human coronavirus 229E	IC50	1.5500	1	1
PF-00835231	Human coronavirus 229E	Ki	0.0009	1	12
Benzotriazol-1-yl 1H-indole-5-carboxylate	Human coronavirus 229E	Ki	0.0075	1	1
5-Bromopyridin-3-yl furan-2-carboxylate	Human coronavirus 229E	IC50	0.0500	1	1
5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate	Human coronavirus 229E	IC50	0.0630	2	2
(5-Chloropyridin-3-yl) 1H-indole-5-carboxylate	Human coronavirus 229E	IC50	0.3100	2	2
5-Chloropyridin-3-yl 1H-indole-2-carboxylate	Human coronavirus 229E	IC50	0.0650	2	2
phenylmercuric acetate	Human coronavirus 229E	Ki	0.7000	1	1
GRL-0617	Human coronavirus 229E	IC50	0.6000	1	1
(5-Chloropyridin-3-yl) 1H-indole-4-carboxylate	Human coronavirus 229E	IC50	0.0300	2	2
KOM70144	Human coronavirus 229E	IC50	0.5600	1	1
Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate	Human coronavirus 229E	Ki	2.2000	1	1
N-[(1R)-2-(tert-butylamino)-2-oxo-1-(3-pyridinyl)ethyl]-N-(4-tert-butylphenyl)-2-furancarboxamide	Human coronavirus 229E	IC50	1.5000	2	2
N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide	Human coronavirus 229E	IC50	0.0500	1	1
3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide	Human coronavirus 229E	IC50	0.0400	1	1
nirmatrelvir	Human coronavirus 229E	IC50	0.1450	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amodiaquine	Human coronavirus 229E	EC50	3.1933	1	3
astemizole	Human coronavirus 229E	EC50	5.2350	1	2
camostat	Human coronavirus 229E	EC50	10.0000	1	2
chloroquine	Human coronavirus 229E	EC50	5.3333	1	6
chlorpromazine	Human coronavirus 229E	EC50	7.7360	1	5
clomipramine	Human coronavirus 229E	EC50	11.2800	1	2
ebselen	Human coronavirus 229E	EC50	4.6700	1	1
emodin	Human coronavirus 229E	EC50	200.0000	1	2
fluphenazine	Human coronavirus 229E	EC50	16.2400	1	3
fluspirilene	Human coronavirus 229E	EC50	6.7150	1	2
hydroxychloroquine	Human coronavirus 229E	EC50	5.6567	1	3
hydroxyzine	Human coronavirus 229E	EC50	14.4000	1	1
loperamide	Human coronavirus 229E	EC50	5.0800	1	5
mefloquine hydrochloride	Human coronavirus 229E	EC50	11.4800	1	2
promethazine	Human coronavirus 229E	EC50	9.6700	1	2
imatinib	Human coronavirus 229E	EC50	12.5000	1	3
thiethylperazine	Human coronavirus 229E	EC50	7.8600	1	1
triflupromazine	Human coronavirus 229E	EC50	6.0700	1	2
cycloheximide	Human coronavirus 229E	EC50	0.1145	1	2
chlorphenoxamine	Human coronavirus 229E	EC50	16.3350	1	2
triparanol	Human coronavirus 229E	EC50	5.2800	1	1
emetine	Human coronavirus 229E	EC50	0.0325	1	2
acetophenazine	Human coronavirus 229E	EC50	23.6000	1	1
ribavirin	Human coronavirus 229E	EC50	109.5000	1	1
gemcitabine	Human coronavirus 229E	EC50	3.0800	1	2
methotrimeprazine	Human coronavirus 229E	EC50	2.5000	1	1
lopinavir	Human coronavirus 229E	EC50	12.8200	1	5
nutlin 3	Human coronavirus 229E	EC50	36.9000	1	1
anisomycin	Human coronavirus 229E	EC50	0.0965	1	2
homoharringtonine	Human coronavirus 229E	EC50	0.0710	1	1
terconazole	Human coronavirus 229E	EC50	13.7600	1	2
thiothixene	Human coronavirus 229E	EC50	7.3000	1	2
benztropine	Human coronavirus 229E	EC50	19.1150	1	2
tamoxifen	Human coronavirus 229E	EC50	51.4950	1	2
toremifene	Human coronavirus 229E	EC50	12.4350	1	2
dasatinib	Human coronavirus 229E	EC50	0.0325	1	2
quercetin	Human coronavirus 229E	EC50	83.4000	2	2
luteolin	Human coronavirus 229E	EC50	10.6000	2	2
dothiepin hydrochloride	Human coronavirus 229E	EC50	3.4000	1	1
sotrastaurin	Human coronavirus 229E	EC50	9.7000	1	1
saracatinib	Human coronavirus 229E	EC50	2.9000	1	1
(5-Chloropyridin-3-yl) 1H-indole-5-carboxylate	Human coronavirus 229E	EC50	24.0000	2	2
(5-Chloropyridin-3-yl) 1H-indole-4-carboxylate	Human coronavirus 229E	EC50	6.9000	2	2
s 8932	Human coronavirus 229E	EC50	0.7700	1	1
N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide	Human coronavirus 229E	EC50	0.4200	1	1
molnupiravir	Human coronavirus 229E	EC50	0.1540	1	1
3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide	Human coronavirus 229E	EC50	0.3300	1	1