A sorbitol dehydrogenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00796]
SDH;
EC 1.1.1.-;
(R,R)-butanediol dehydrogenase;
1.1.1.4;
L-iditol 2-dehydrogenase;
1.1.1.14;
Polyol dehydrogenase;
Ribitol dehydrogenase;
RDH;
1.1.1.56;
Xylitol dehydrogenase;
XDH;
1.1.1.9
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| coumarin | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| herniarin | Homo sapiens (human) | IC50 | 124.0000 | 1 | 1 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | IC50 | 106.0000 | 1 | 1 |
| isoscopoletin | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| cp-166,572 | Homo sapiens (human) | IC50 | 0.4953 | 3 | 3 |
| epalrestat | Homo sapiens (human) | IC50 | 67.7000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 106.3000 | 2 | 2 |
| scopoletin | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| hymecromone | Homo sapiens (human) | IC50 | 153.0000 | 1 | 1 |
| esculetin | Homo sapiens (human) | IC50 | 82.9000 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| 4-methylesculetin | Homo sapiens (human) | IC50 | 212.0000 | 1 | 1 |
| 7-hydroxycoumarin-4-acetic acid | Homo sapiens (human) | IC50 | 163.0000 | 1 | 1 |
| 4-hydroxycoumarin | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| (R,R)-butanediol dehydrogenase activity | molecular function | Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+. [EC:1.1.1.4] |
| L-iditol 2-dehydrogenase activity | molecular function | Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. [EC:1.1.1.14] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| D-xylulose reductase activity | molecular function | Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH. [EC:1.1.1.9, RHEA:20433] |
| D-sorbitol dehydrogenase (acceptor) activity | molecular function | Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] |
| ribitol 2-dehydrogenase activity | molecular function | Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH. [EC:1.1.1.56, RHEA:20053] |
| NAD binding | molecular function | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| motile cilium | cellular component | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] |
| mitochondrial membrane | cellular component | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| glucose metabolic process | biological process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732] |
| sorbitol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. [ISBN:0198506732] |
| glucuronate catabolic process to xylulose 5-phosphate | biological process | The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. [GOC:go_curators] |
| flagellated sperm motility | biological process | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] |
| fructose biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose. [GOC:ai] |
| L-xylitol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. [GOC:ai] |
| L-xylitol metabolic process | biological process | The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. [GOC:ai] |