C-C chemokine receptor type 2

A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597]

Synonyms

C-C CKR-2;
CC-CKR-2;
CCR-2;
CCR2;
Monocyte chemoattractant protein 1 receptor;
MCP-1-R

Research

Bioassay Publications (22)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (54.55)	29.6817
2010's	9 (40.91)	24.3611
2020's	1 (4.55)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amiodarone	Homo sapiens (human)	IC50	11.0860	1	0
amiodarone	Homo sapiens (human)	Ki	4.2850	1	0
disulfiram	Homo sapiens (human)	IC50	2.4680	1	0
disulfiram	Homo sapiens (human)	Ki	0.9540	1	0
fasudil	Homo sapiens (human)	IC50	35.0000	1	1
nifedipine	Homo sapiens (human)	IC50	2.1910	1	0
nifedipine	Homo sapiens (human)	Ki	0.8470	1	0
dibenzothiazyl disulfide	Homo sapiens (human)	IC50	2.4050	1	0
dibenzothiazyl disulfide	Homo sapiens (human)	Ki	0.9290	1	0
1-naphthylisothiocyanate	Homo sapiens (human)	IC50	6.6990	1	0
1-naphthylisothiocyanate	Homo sapiens (human)	Ki	2.5890	1	0
plerixafor	Homo sapiens (human)	IC50	0.0001	2	2
rosiglitazone	Homo sapiens (human)	Ki	32.6000	1	1
fasudil hydrochloride	Homo sapiens (human)	IC50	35.0000	1	1
tak 779	Homo sapiens (human)	IC50	0.0188	15	15
tak 779	Homo sapiens (human)	Ki	0.1369	14	14
bay 11-7085	Homo sapiens (human)	IC50	4.1770	1	0
bay 11-7085	Homo sapiens (human)	Ki	1.6140	1	0
ucb 35625	Homo sapiens (human)	IC50	1.0000	1	1
rs 504393	Homo sapiens (human)	IC50	0.0890	1	1
rs 504393	Homo sapiens (human)	Ki	1.2561	9	9
incb3344	Homo sapiens (human)	IC50	0.0044	2	2
amd 070	Homo sapiens (human)	IC50	10.0000	1	1
cenicriviroc	Homo sapiens (human)	IC50	0.0059	2	2
incb 3284	Homo sapiens (human)	IC50	0.0042	2	2
n-(carbamoylmethyl)-3-trifluoromethyl benzamido-4-chlorobenzyl 3-aminopyrrolidine	Homo sapiens (human)	IC50	0.8107	6	6

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-(carbamoylmethyl)-3-trifluoromethyl benzamido-4-chlorobenzyl 3-aminopyrrolidine	Homo sapiens (human)	EC50	0.0200	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
azd8309	Homo sapiens (human)	pA2	0.0060	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
chemokine receptor activity	molecular function	Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
CCR2 chemokine receptor binding	molecular function	Binding to a CCR2 chemokine receptor. [GOC:mah, GOC:nln]
chemokine (C-C motif) ligand 2 binding	molecular function	Binding to chemokine (C-C motif) ligand 2. [GOC:BHF]
chemokine (C-C motif) ligand 12 binding	molecular function	Binding to chemokine (C-C motif) ligand 12. [GOC:BHF]
chemokine (C-C motif) ligand 7 binding	molecular function	Binding to chemokine (C-C motif) ligand 7. [GOC:BHF]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
C-C chemokine binding	molecular function	Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]
C-C chemokine receptor activity	molecular function	Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]

Located In

This protein is located in 9 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
perikaryon	cellular component	The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Involved In

This protein is involved in 53 target(s):

Target	Category	Definition
blood vessel remodeling	biological process	The reorganization or renovation of existing blood vessels. [GOC:hjd]
dendritic cell chemotaxis	biological process	The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
monocyte chemotaxis	biological process	The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]
regulation of T cell cytokine production	biological process	Any process that modulates the frequency, rate, or extent of T cell cytokine production. [GOC:add]
positive regulation of T-helper 1 type immune response	biological process	Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]
negative regulation of type 2 immune response	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. [GOC:add]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
humoral immune response	biological process	An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]
cellular defense response	biological process	A defense response that is mediated by cells. [GOC:ebc]
negative regulation of adenylate cyclase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]
cell surface receptor signaling pathway via JAK-STAT	biological process	A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. [PMID:12039028]
response to wounding	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]
regulation of vascular endothelial growth factor production	biological process	Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:rl]
positive regulation of T cell chemotaxis	biological process	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of angiogenesis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators]
sensory perception of pain	biological process	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
cellular homeostasis	biological process	Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172]
hemopoiesis	biological process	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732]
positive regulation of type II interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-2 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
monocyte extravasation	biological process	The migration of a monocyte from the blood vessels into the surrounding tissue. [CL:0000576, GOC:BHF, PMID:10657654]
T-helper 17 cell chemotaxis	biological process	The directed movement of a T-helper 17 cell in response to an external stimulus. [CL:0000899, GOC:BHF]
negative regulation of eosinophil degranulation	biological process	Any process that stops, prevents, or reduces the rate of eosinophil degranulation. [ISBN:0781735149]
regulation of T cell differentiation	biological process	Any process that modulates the frequency, rate or extent of T cell differentiation. [GOC:go_curators]
positive regulation of alpha-beta T cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]
homeostasis of number of cells within a tissue	biological process	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]
positive regulation of inflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
positive regulation of T cell activation	biological process	Any process that activates or increases the frequency, rate or extent of T cell activation. [GOC:ai]
positive regulation of synaptic transmission, glutamatergic	biological process	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
leukocyte adhesion to vascular endothelial cell	biological process	The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866]
chemokine-mediated signaling pathway	biological process	The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
positive regulation of monocyte chemotaxis	biological process	Any process that increases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]
positive regulation of immune complex clearance by monocytes and macrophages	biological process	Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. [GOC:BHF]
inflammatory response to wounding	biological process	The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. [GOC:add]
neutrophil clearance	biological process	The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. [GOC:BHF, PMID:21957127]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
positive regulation of leukocyte tethering or rolling	biological process	Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
positive regulation of NMDA glutamate receptor activity	biological process	Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]
macrophage migration	biological process	The orderly movement of a macrophage from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:25749876]
regulation of macrophage migration	biological process	Any process that modulates the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
positive regulation of thymocyte migration	biological process	Any process that activates or increases the frequency, rate or extent of thymocyte migration. [GOC:mah]
positive regulation of monocyte extravasation	biological process	Any process that activates or increases the frequency, rate or extent of monocyte extravasation. [GOC:obol]
positive regulation of CD8-positive, alpha-beta T cell extravasation	biological process	Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. [GOC:obol]
positive regulation of astrocyte chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis. [GOC:obol]
positive regulation of hematopoietic stem cell migration	biological process	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. [GOC:obol]
cell chemotaxis	biological process	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]