1,1,1,2-tetrafluoro-2-chloroethane profile

1,1,1,2-Tetrafluoro-2-chloroethane (also known as **HCFC-133a**) is a **halogenated hydrocarbon** that is **no longer commercially produced** due to its environmental impact.

Here's why it was used in research and why it's no longer important:

**Past Research Importance:**

* **Refrigerant:** HCFC-133a was used as a refrigerant due to its good thermodynamic properties, including a high heat capacity and low boiling point.
* **Propellant:** It found applications as a propellant in aerosols and other products.
* **Solvent:** Its low polarity and good solvent properties made it suitable for some chemical processes.
* **Model Compound:** In chemical research, it served as a model compound for studying the effects of halogenation on molecular properties.

**Why it's No Longer Important:**

* **Ozone Depletion:** HCFC-133a, like many other halogenated hydrocarbons, contributes to the depletion of the ozone layer. It contains chlorine, which can catalytically destroy ozone molecules in the stratosphere.
* **Global Warming:** HCFC-133a is also a potent greenhouse gas, contributing to climate change.
* **International Regulations:** Due to its environmental impact, HCFC-133a was phased out under the Montreal Protocol, an international agreement aimed at protecting the ozone layer.

**Alternatives:**

* **Hydrofluorocarbons (HFCs):** HFCs are often used as replacements for HCFCs, as they do not contain chlorine and have a lower ozone depletion potential. However, HFCs are still potent greenhouse gases.
* **Natural Refrigerants:** Ammonia, carbon dioxide, and hydrocarbons are emerging as environmentally friendly alternatives to synthetic refrigerants.

**In summary,** while 1,1,1,2-tetrafluoro-2-chloroethane (HCFC-133a) was important in research and applications, it is no longer commercially produced due to its negative impact on the environment. The phasing out of HCFCs and the development of more sustainable alternatives are crucial steps towards protecting the ozone layer and mitigating climate change.

1,1,1,2-tetrafluoro-2-chloroethane: refrigerant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	17822
SCHEMBL ID	254501
MeSH ID	M0197406

Synonym
ethane, 2-chloro-1,1,1,2-tetrafluoro-
cf3chfcl
2837-89-0
chlorotetrafluoroethane
2-chloro-1,1,1,2-tetrafluoroethane
freon 124
einecs 220-629-6
1,1,1,2-tetrafluoro-2-chloroethane
r 124
hfa-124
1,1,1,2-tetrafluorochloroethane
hcfc 124
1-chloro-1,2,2,2-tetrafluoroethane
hsdb 6754
hcfc-124
un1021
r-124
2-chloro-1,1,1,2-tetrafuoroethane
n00845eg42 ,
ccris 8516
1-chloro-1,2,2,2-tetrafluoroethane or refrigerant gas r 124 [un1021] [nonflammable gas]
1-chloro-1,2,2,2-tetrafluoroethane or refrigerant gas r 124
unii-n00845eg42
AKOS006228032
FT-0611669
1,1,1,2-tetrafluoro-2-chloroethane [hsdb]
cfc-124
khladon 124
freon-124
SCHEMBL254501
2-chloro-1,1,1,2-tetrafluoroethane #
cfc 124
DTXSID7029245
Q752098

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" There were no compound-related, adverse effects on body weight, food consumption, survival, clinical signs of toxicity, ophthalmoscopically observable ocular lesions, serum hormone concentrations, or clinical pathology parameters at any exposure concentration in either male or female rats."	( Chronic toxicity, oncogenicity, and mutagenicity studies with chlorotetrafluoroethane (HCFC-124). Bentley, KS; Brock, WJ; Elliott, GS; Frame, SR; Malley, LA; Rusch, GM; Trochimowicz, HJ, 1998)	0.3

Pharmacokinetics

Excerpt	Reference	Relevance
" The production and excretion of trifluoroacetic acid, the major urinary metabolite of HCFC-124, were also simulated in rats and mice, but not in hamsters, by the physiologically based pharmacokinetic model when the in vivo metabolic rate constants obtained in the gas-uptake simulation studies were used."	( Gas-uptake pharmacokinetics and metabolism of 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124) in the rat, mouse, and hamster. Anders, MW; Loizou, GD, 1995)	0.29

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (63.64)	18.2507
2000's	1 (9.09)	29.6817
2010's	1 (9.09)	24.3611
2020's	2 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.14%)	6.00%
Case Studies	1 (7.14%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
trichlorofluoromethane trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.	3.27	1	chlorofluorocarbon; halomethane	environmental contaminant; NMR chemical shift reference compound; NMR solvent; refrigerant
dichlorodifluoromethane dichlorodifluoromethane: refrigerant,aerosol propellant	3.27	1
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2.39	2	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
1,1,2-trichloro-1,2,2-trifluoroethane [no description available]	3.27	1	chlorofluorocarbon; haloalkane	NMR solvent; refrigerant
freon 114 Freon 114: InChIKey: DDMOUSALMHHKOS-UHFFFAOYSA-N	3.27	1
2,2-dichloro-1,1,1-trifluoroethane 2,2-dichloro-1,1,1-trifluoroethane: structure given in first source. hydrochlorofluorocarbon : An organochlorine compound derived from methane, ethane or propane that contains atoms of hydrogen, chlorine, fluorine, and carbon only.	4.35	6
bromochlorodifluoromethane bromochlorodifluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by two fluorines, a bromine, and a chlorine. Widely used in 'vapourising liquid'-type fire extinguishers, its use is now generally banned under the Montreal Protocol (ozone-depleting substances), although it is still used in certain applications (e.g. aviation).	1.98	1	one-carbon compound; organobromine compound; organochlorine compound; organofluorine compound
pentafluoroethane [no description available]	3.27	1
1,1,1-trichloro-2,2,2-trifluoroethane [no description available]	3.27	1
perflexane perfluorohexane : A fluoroalkane that is hexane in which all of the hydrogens have been replaced by fluorines.	1.98	1	fluoroalkane; fluorocarbon; volatile organic compound	non-polar solvent; radioopaque medium
1,1,1-trifluoroethane [no description available]	3.27	1
norflurane norflurane: may replace R 12 as air-conditioning refrigerant; structure given in first source	3.27	1
1,1-dichloro-1-fluoroethane [no description available]	3.27	1
fluorides [no description available]	1.99	1	halide anion; monoatomic fluorine
1,1,1,3,3-pentafluoropropane [no description available]	3.27	1
2,3,3,3-tetrafluoropropene 2,3,3,3-tetrafluoropropene: structure in first source	3.27	1

Condition	Relationship Strength	Studies
Chronic Primary Open Angle Glaucoma [description not available]	2.6	1
Glaucoma, Open-Angle Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.	2.6	1
Intraocular Pressure The pressure of the fluids in the eye.	2.6	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.39	2
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.99	1
Acute Liver Injury, Drug-Induced [description not available]	2.68	3
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.68	3
Fibroadenoma An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)	1.99	1
Abnormalities, Autosome [description not available]	1.99	1
Liver Steatosis [description not available]	2	1
Fatty Liver Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.	2	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2	1

1,1,1,2-tetrafluoro-2-chloroethane

Description

Cross-References

Synonyms (34)

Research Excerpts

Toxicity

Pharmacokinetics

Research

Studies (11)

Market Indicators

Research Demand Index: 12.23

Study Types

1,1,1,2-tetrafluoro-2-chloroethane

Description

Cross-References

Synonyms (34)

Research Excerpts

Toxicity

Pharmacokinetics

Research

Studies (11)

Market Indicators

Research Demand Index: 12.23

Study Types

Related Drugs (17)

Related Conditions (12)