Page last updated: 2024-12-06

dioxidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dioxidine is a synthetic antibacterial agent with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. Its chemical name is 5-amino-1,3-bis(2-hydroxyethyl)-1,3-dihydro-2H-imidazol-2-thione. It is synthesized through a series of reactions involving the condensation of ethylenediamine with carbon disulfide and formaldehyde. Dioxidine exerts its antibacterial effects by inhibiting bacterial DNA synthesis and protein synthesis. It is used topically for the treatment of skin and soft tissue infections, as well as for the prevention of postoperative infections. Dioxidine is also used in veterinary medicine for the treatment of various infections in animals. It is studied for its potential to treat infections that are resistant to other antibiotics, as well as for its possible role in the development of new anti-cancer agents.'

dioxidine: Russian drug; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID28467
SCHEMBL ID11144192
MeSH IDM0041165

Synonyms (46)

Synonym
HMS1473C16
dioxydine
2,3-quinoxalinedimethanol 1,4-dioxide
dioxidine
2,3-quinoxalinedimethanol, 1,4-dioxide
dioxidin
SDCCGMLS-0064536.P001
[3-(hydroxymethyl)-1,4-dioxido-quinoxaline-1,4-diium-2-yl]methanol
(3-hydroxymethyl-1,4-dioxy-quinoxalin-2-yl)-methanol
[3-(hydroxymethyl)-1,4-dioxido-2-quinoxalinyl]methanol
AG-690/11354175
CBDIVE_002950
IDI1_019378
OPREA1_028820
CHEMDIV3_000060
STK366604
(1,4-dioxidoquinoxaline-2,3-diyl)dimethanol
STL069540
2,3-bis(hydroxymethyl)-1-oxoquinoxalin-1-ium-4(1h)-olate
BRD-K62858371-001-01-0
AKOS005111023
AKOS000541267
[3-(hydroxymethyl)-1-oxido-4-oxoquinoxalin-4-ium-2-yl]methanol
A811489
17311-31-8
16bop9xe0f ,
FT-0682662
BBL027205
SCHEMBL11144192
2,3-bis(hydroxymethyl)quinoxaline-1,4-diium-1,4-bis(olate)
2,3-di(hydroxymethyl)quinoxaline 1,4-di-n-oxide
208583-13-5
metrosept
chinoxalindimethanol dioxide
chinoxalindimethanol dioxide [who-dd]
2,3-di(hydroxymethyl)quinoxaline di-n-oxide
hydroxymethylquinoxalindioxyde
sulfonium, trimethyl-, 2,3-bis(hydroxymethyl)quinoxaline-1,4-di-n-oxide
DTXSID00169525
SR-01000390051-1
sr-01000390051
2,3-bis-hydroxymethyl-2,3-dihydro-quinoxaline-1,4-dioxide
Q4138123
2,3-bis(hydroxymethyl)-1-oxo-1,4-dihydro-1??-quinoxalin-1-ylium-4-olate
VS-08499
dioxydinum

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (107)

TimeframeStudies, This Drug (%)All Drugs %
pre-199038 (35.51)18.7374
1990's40 (37.38)18.2507
2000's14 (13.08)29.6817
2010's11 (10.28)24.3611
2020's4 (3.74)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.90 (24.57)
Research Supply Index5.07 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index62.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (41.90)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.64%)5.53%
Reviews1 (0.64%)6.00%
Case Studies8 (5.10%)4.05%
Observational0 (0.00%)0.25%
Other147 (93.63%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]