Proteins > Receptor-type tyrosine-protein phosphatase beta
Page last updated: 2024-08-07 16:14:20
Receptor-type tyrosine-protein phosphatase beta
A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23467]
Synonyms
Protein-tyrosine phosphatase beta;
R-PTP-beta;
EC 3.1.3.48;
Vascular endothelial protein tyrosine phosphatase;
VE-PTP
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (18)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-nitrophenylphosphate | Homo sapiens (human) | Km | 1,336.0000 | 1 | 1 |
| pyridoxal phosphate | Homo sapiens (human) | Kis | 5.6650 | 2 | 2 |
| (4-tert-Butyl-phenoxy)-acetic acid | Homo sapiens (human) | Kis | 450.0000 | 1 | 1 |
| methyl fluorone black | Homo sapiens (human) | Kii | 31.7000 | 1 | 1 |
| methyl fluorone black | Homo sapiens (human) | Kis | 13.5000 | 1 | 1 |
| 2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one | Homo sapiens (human) | Kis | 18.8000 | 1 | 1 |
| biotin | Homo sapiens (human) | Kis | 2,330.0000 | 1 | 1 |
| 1-Anilino-9,10-dioxo-2-anthroic acid | Homo sapiens (human) | Kis | 161.0000 | 1 | 1 |
| 4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acid | Homo sapiens (human) | Kis | 1,563.0000 | 1 | 1 |
| 3-(3-pyridinyl)propanoic acid | Homo sapiens (human) | Kis | 66,500.0000 | 1 | 1 |
| myricitrin | Homo sapiens (human) | Kis | 125.7000 | 1 | 1 |
| streptovaricin c | Homo sapiens (human) | Kis | 93.8700 | 1 | 1 |
| galloflavin | Homo sapiens (human) | Kis | 10.8000 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| transmembrane receptor protein tyrosine phosphatase activity | molecular function | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| specific granule membrane | cellular component | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| tertiary granule membrane | cellular component | The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| receptor complex | cellular component | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |
| phosphate-containing compound metabolic process | biological process | The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai] |
| glial cell migration | biological process | The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. [GOC:jl, GOC:mtg_sensu] |
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |
| angiogenesis | biological process | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] |
| peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity | biological process | Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. [PMID:7501024] |