Page last updated: 2024-08-07 18:39:50
Pantothenate synthetase
[no definition available]
Synonyms
PS;
EC 6.3.2.1;
Pantoate--beta-alanine ligase;
Pantoate-activating enzyme
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| isoniazid | Mycobacterium tuberculosis H37Rv | IC50 | 25.0000 | 3 | 3 |
| ethambutol | Mycobacterium tuberculosis H37Rv | IC50 | 25.0000 | 3 | 3 |
| nafronyloxalate | Mycobacterium tuberculosis H37Rv | IC50 | 398.3900 | 1 | 1 |
| dactinomycin | Mycobacterium tuberculosis H37Rv | IC50 | 250.7200 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 5-methoxyindole | Mycobacterium tuberculosis H37Rv | Kd | 1,100.0000 | 1 | 1 |
| 5'-thioadenosine | Mycobacterium tuberculosis H37Rv | Kd | 380.0000 | 2 | 2 |
Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 24, Issue:6, 2016
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 24, Issue:6, 2016
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
ATP-binding site of bacterial enzymes as a target for antibacterial drug design.Journal of medicinal chemistry, , Feb-24, Volume: 54, Issue:4, 2011
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.Chembiochem : a European journal of chemical biology, , Nov-23, Volume: 10, Issue:17, 2009
Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors.European journal of medicinal chemistry, , Volume: 69, 2013
A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011