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2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Necrosis

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Necrosis in 15 studies

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis."7.71Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. ( Bhagat, L; Cantley, LC; Saluja, AK; Singh, VP; Soltoff, SP; Song, AM; Steer, ML; van Acker, GJ, 2001)
"The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor) and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells."4.02Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment. ( Bądziul, D; Hułas-Stasiak, M; Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Pawelec, J; Pawlikowska-Pawlęga, B; Reichert, M; Rzeski, W; Sumorek-Wiadro, J; Wasiak, M; Wertel, I; Zając, A, 2021)
"Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis."3.71Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. ( Bhagat, L; Cantley, LC; Saluja, AK; Singh, VP; Soltoff, SP; Song, AM; Steer, ML; van Acker, GJ, 2001)
"Necrosis was significantly reduced (P < 0."1.33MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro. ( Cunningham, C; Frankenberry, K; Jackson, BJ; McFadden, DW; Riggs, DR; Szwerc, MF; Vona-Davis, L, 2005)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (20.00)18.2507
2000's7 (46.67)29.6817
2010's4 (26.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Zając, A1
Sumorek-Wiadro, J1
Langner, E1
Wertel, I1
Maciejczyk, A1
Pawlikowska-Pawlęga, B1
Pawelec, J1
Wasiak, M1
Hułas-Stasiak, M1
Bądziul, D1
Rzeski, W1
Reichert, M1
Jakubowicz-Gil, J1
Zheng, K1
Sheng, Z1
Li, Y1
Lu, H1
Huang, J1
Yue, S1
Ke, B1
Zhu, J1
Shen, XD1
Zhai, Y1
Yamamoto, M1
Busuttil, RW1
Kupiec-Weglinski, JW1
Zhu, Y1
Zhao, KK1
Tong, Y1
Zhou, YL1
Wang, YX1
Zhao, PQ1
Wang, ZY1
Song, JQ1
Teng, X1
Cai, Y1
Tang, CS1
Qi, YF1
Ho, WH1
Lee, YY1
Chang, LY1
Chen, YT1
Liu, TY1
Hung, SL1
Regan, SE1
Broad, M1
Byford, AM1
Lankford, AR1
Cerniway, RJ1
Mayo, MW1
Matherne, GP1
Spagnuolo, G1
Galler, K1
Schmalz, G1
Cosentino, C1
Rengo, S1
Schweikl, H1
Penna, C1
Alloatti, G1
Cappello, S1
Gattullo, D1
Berta, G1
Mognetti, B1
Losano, G1
Pagliaro, P1
Vona-Davis, L1
Frankenberry, K1
Cunningham, C1
Riggs, DR1
Jackson, BJ1
Szwerc, MF1
McFadden, DW1
Caravatta, L1
Sancilio, S1
di Giacomo, V1
Rana, R1
Cataldi, A1
Di Pietro, R1
Villalba, M1
Bockaert, J1
Journot, L1
Klinz, F1
Bloch, W1
Addicks, K1
Hescheler, J1
Ryu, BR1
Ko, HW1
Jou, I1
Noh, JS1
Gwag, BJ1
Singh, VP1
Saluja, AK1
Bhagat, L1
van Acker, GJ1
Song, AM1
Soltoff, SP1
Cantley, LC1
Steer, ML1

Other Studies

15 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Necrosis

ArticleYear
Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment.
    International journal of molecular sciences, 2021, May-13, Volume: 22, Issue:10

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Chromones; Drug

2021
Salidroside inhibits oxygen glucose deprivation (OGD)/re-oxygenation-induced H9c2 cell necrosis through activating of Akt-Nrf2 signaling.
    Biochemical and biophysical research communications, 2014, Aug-15, Volume: 451, Issue:1

    Topics: Animals; Chromones; Cyclophilins; Gene Expression Regulation; Glucose; Glucosides; Membrane Potentia

2014
Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.
    Transplantation, 2014, Oct-15, Volume: 98, Issue:7

    Topics: Animals; Apoptosis; Chromones; Forkhead Box Protein O1; Forkhead Transcription Factors; Homeostasis;

2014
Exogenous NAD(+) decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy.
    Scientific reports, 2016, 05-31, Volume: 6

    Topics: Autophagy; Cell Survival; Cells, Cultured; Chromones; Humans; Hydrogen Peroxide; Macular Degeneratio

2016
Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion.
    Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:9

    Topics: Adrenomedullin; Animals; Apoptosis; Cardiotonic Agents; Chromones; Glycogen Synthase Kinase 3; Glyco

2009
Effects of areca nut extract on the apoptosis pathways in human neutrophils.
    Journal of periodontal research, 2010, Volume: 45, Issue:3

    Topics: Adult; Apoptosis; Areca; Caspase 8; Caspase Inhibitors; Cell Degranulation; Cell Size; Cell Survival

2010
A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:3

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Chromones; Enzyme Inhibitors; Female; Heart; In Vitro Techn

2003
Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells.
    Journal of dental research, 2004, Volume: 83, Issue:9

    Topics: Apoptosis; Cell Survival; Cells, Cultured; Chromones; Composite Resins; Dental Pulp; Enzyme Inhibito

2004
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5

    Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulat

2005
MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro.
    The Journal of surgical research, 2005, Jul-01, Volume: 127, Issue:1

    Topics: Adenocarcinoma; Apoptosis; Barrett Esophagus; Butadienes; Cell Division; Cell Line, Tumor; Cell Surv

2005
PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL.
    Journal of cellular physiology, 2008, Volume: 214, Issue:1

    Topics: Apoptosis; Caspase 3; Cell Culture Techniques; Chromones; Clone Cells; Cyclic AMP Response Element-B

2008
Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal.
    Neuroreport, 1997, Mar-03, Volume: 8, Issue:4

    Topics: Androstadienes; Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chromone

1997
Inhibition of phosphatidylinositol-3-kinase blocks development of functional embryonic cardiomyocytes.
    Experimental cell research, 1999, Feb-25, Volume: 247, Issue:1

    Topics: Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Chromones; Embryo, Mammalian; Mice; Morph

1999
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
    Journal of neurobiology, 1999, Jun-15, Volume: 39, Issue:4

    Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodul

1999
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:9

    Topics: Acute Disease; Androstadienes; Animals; Cells, Cultured; Ceruletide; Chromones; Cytoskeleton; Dose-R

2001
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