2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Necrosis
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Necrosis in 15 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis." | 7.71 | Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. ( Bhagat, L; Cantley, LC; Saluja, AK; Singh, VP; Soltoff, SP; Song, AM; Steer, ML; van Acker, GJ, 2001) |
"The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor) and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells." | 4.02 | Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment. ( Bądziul, D; Hułas-Stasiak, M; Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Pawelec, J; Pawlikowska-Pawlęga, B; Reichert, M; Rzeski, W; Sumorek-Wiadro, J; Wasiak, M; Wertel, I; Zając, A, 2021) |
"Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis." | 3.71 | Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. ( Bhagat, L; Cantley, LC; Saluja, AK; Singh, VP; Soltoff, SP; Song, AM; Steer, ML; van Acker, GJ, 2001) |
"Necrosis was significantly reduced (P < 0." | 1.33 | MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro. ( Cunningham, C; Frankenberry, K; Jackson, BJ; McFadden, DW; Riggs, DR; Szwerc, MF; Vona-Davis, L, 2005) |
Research
Studies (15)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (20.00) | 18.2507 |
2000's | 7 (46.67) | 29.6817 |
2010's | 4 (26.67) | 24.3611 |
2020's | 1 (6.67) | 2.80 |
Authors
Authors | Studies |
---|---|
Zając, A | 1 |
Sumorek-Wiadro, J | 1 |
Langner, E | 1 |
Wertel, I | 1 |
Maciejczyk, A | 1 |
Pawlikowska-Pawlęga, B | 1 |
Pawelec, J | 1 |
Wasiak, M | 1 |
Hułas-Stasiak, M | 1 |
Bądziul, D | 1 |
Rzeski, W | 1 |
Reichert, M | 1 |
Jakubowicz-Gil, J | 1 |
Zheng, K | 1 |
Sheng, Z | 1 |
Li, Y | 1 |
Lu, H | 1 |
Huang, J | 1 |
Yue, S | 1 |
Ke, B | 1 |
Zhu, J | 1 |
Shen, XD | 1 |
Zhai, Y | 1 |
Yamamoto, M | 1 |
Busuttil, RW | 1 |
Kupiec-Weglinski, JW | 1 |
Zhu, Y | 1 |
Zhao, KK | 1 |
Tong, Y | 1 |
Zhou, YL | 1 |
Wang, YX | 1 |
Zhao, PQ | 1 |
Wang, ZY | 1 |
Song, JQ | 1 |
Teng, X | 1 |
Cai, Y | 1 |
Tang, CS | 1 |
Qi, YF | 1 |
Ho, WH | 1 |
Lee, YY | 1 |
Chang, LY | 1 |
Chen, YT | 1 |
Liu, TY | 1 |
Hung, SL | 1 |
Regan, SE | 1 |
Broad, M | 1 |
Byford, AM | 1 |
Lankford, AR | 1 |
Cerniway, RJ | 1 |
Mayo, MW | 1 |
Matherne, GP | 1 |
Spagnuolo, G | 1 |
Galler, K | 1 |
Schmalz, G | 1 |
Cosentino, C | 1 |
Rengo, S | 1 |
Schweikl, H | 1 |
Penna, C | 1 |
Alloatti, G | 1 |
Cappello, S | 1 |
Gattullo, D | 1 |
Berta, G | 1 |
Mognetti, B | 1 |
Losano, G | 1 |
Pagliaro, P | 1 |
Vona-Davis, L | 1 |
Frankenberry, K | 1 |
Cunningham, C | 1 |
Riggs, DR | 1 |
Jackson, BJ | 1 |
Szwerc, MF | 1 |
McFadden, DW | 1 |
Caravatta, L | 1 |
Sancilio, S | 1 |
di Giacomo, V | 1 |
Rana, R | 1 |
Cataldi, A | 1 |
Di Pietro, R | 1 |
Villalba, M | 1 |
Bockaert, J | 1 |
Journot, L | 1 |
Klinz, F | 1 |
Bloch, W | 1 |
Addicks, K | 1 |
Hescheler, J | 1 |
Ryu, BR | 1 |
Ko, HW | 1 |
Jou, I | 1 |
Noh, JS | 1 |
Gwag, BJ | 1 |
Singh, VP | 1 |
Saluja, AK | 1 |
Bhagat, L | 1 |
van Acker, GJ | 1 |
Song, AM | 1 |
Soltoff, SP | 1 |
Cantley, LC | 1 |
Steer, ML | 1 |
Other Studies
15 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Necrosis
Article | Year |
---|---|
Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Chromones; Drug | 2021 |
Salidroside inhibits oxygen glucose deprivation (OGD)/re-oxygenation-induced H9c2 cell necrosis through activating of Akt-Nrf2 signaling.
Topics: Animals; Chromones; Cyclophilins; Gene Expression Regulation; Glucose; Glucosides; Membrane Potentia | 2014 |
Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.
Topics: Animals; Apoptosis; Chromones; Forkhead Box Protein O1; Forkhead Transcription Factors; Homeostasis; | 2014 |
Exogenous NAD(+) decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy.
Topics: Autophagy; Cell Survival; Cells, Cultured; Chromones; Humans; Hydrogen Peroxide; Macular Degeneratio | 2016 |
Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion.
Topics: Adrenomedullin; Animals; Apoptosis; Cardiotonic Agents; Chromones; Glycogen Synthase Kinase 3; Glyco | 2009 |
Effects of areca nut extract on the apoptosis pathways in human neutrophils.
Topics: Adult; Apoptosis; Areca; Caspase 8; Caspase Inhibitors; Cell Degranulation; Cell Size; Cell Survival | 2010 |
A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chromones; Enzyme Inhibitors; Female; Heart; In Vitro Techn | 2003 |
Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Chromones; Composite Resins; Dental Pulp; Enzyme Inhibito | 2004 |
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulat | 2005 |
MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro.
Topics: Adenocarcinoma; Apoptosis; Barrett Esophagus; Butadienes; Cell Division; Cell Line, Tumor; Cell Surv | 2005 |
PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL.
Topics: Apoptosis; Caspase 3; Cell Culture Techniques; Chromones; Clone Cells; Cyclic AMP Response Element-B | 2008 |
Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal.
Topics: Androstadienes; Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chromone | 1997 |
Inhibition of phosphatidylinositol-3-kinase blocks development of functional embryonic cardiomyocytes.
Topics: Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Chromones; Embryo, Mammalian; Mice; Morph | 1999 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodul | 1999 |
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.
Topics: Acute Disease; Androstadienes; Animals; Cells, Cultured; Ceruletide; Chromones; Cytoskeleton; Dose-R | 2001 |