An aldo-keto reductase family 1 member A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14550]
EC 1.1.1.2;
EC 1.1.1.372;
EC 1.1.1.54;
Alcohol dehydrogenase [NADP(+)];
Aldehyde reductase;
Glucuronate reductase;
1.1.1.19;
Glucuronolactone reductase;
1.1.1.20
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| zopolrestat | Homo sapiens (human) | IC50 | 19.9773 | 3 | 4 |
| valproic acid | Homo sapiens (human) | IC50 | 50.1000 | 1 | 1 |
| fr 74366 | Homo sapiens (human) | IC50 | 6.6027 | 2 | 3 |
| tolrestat | Homo sapiens (human) | IC50 | 1.1532 | 3 | 4 |
| octyl gallate | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| lidorestat | Homo sapiens (human) | IC50 | 18.0017 | 2 | 3 |
| fidarestat | Homo sapiens (human) | IC50 | 1.2000 | 2 | 2 |
| minalrestat | Homo sapiens (human) | IC50 | 0.0067 | 1 | 1 |
| sorbinil | Homo sapiens (human) | IC50 | 5.1333 | 3 | 3 |
| epalrestat | Homo sapiens (human) | IC50 | 2.6000 | 2 | 2 |
| idd 594 | Homo sapiens (human) | IC50 | 33.0000 | 1 | 1 |
| caffeic acid phenethyl ester | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| aldo-keto reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| allyl-alcohol dehydrogenase activity | molecular function | Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH. [EC:1.1.1.54, RHEA:12168] |
| L-glucuronate reductase activity | molecular function | Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH. [EC:1.1.1.19, RHEA:14909] |
| glucuronolactone reductase activity | molecular function | Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH. [EC:1.1.1.20, RHEA:18925] |
| glycerol dehydrogenase [NADP+] activity | molecular function | Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN] |
| S-nitrosoglutathione reductase (NADH) activity | molecular function | Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+. [PMID:11260719, PMID:27094420, PMID:30795534] |
| S-nitrosoglutathione reductase (NADPH) activity | molecular function | Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione. [RHEA:63500] |
| methylglyoxal reductase (NADPH) (acetol producing) activity | molecular function | Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. [PMID:16077126, RHEA:27986] |
| aldose reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| glucuronate catabolic process to xylulose 5-phosphate | biological process | The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. [GOC:go_curators] |
| L-ascorbic acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. [GOC:ma, ISBN:0198547684] |
| D-glucuronate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate. [GOC:jl, GOC:jsg, GOC:mah] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| daunorubicin metabolic process | biological process | The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989] |
| doxorubicin metabolic process | biological process | The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167] |
| aldehyde catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai] |
| cellular detoxification of aldehyde | biological process | Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw, PMID:25656103] |
| glutathione derivative biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glutathione derivative. [GOC:pr, GOC:TermGenie] |