14 kDa phosphohistidine phosphatase

A 14 kDa phosphohistidine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRX4]

Synonyms

EC 3.9.1.3;
Phosphohistidine phosphatase 1;
PHPT1;
Protein histidine phosphatase;
PHP;
Protein janus-A homolog

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (100.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acetarsol	Homo sapiens (human)	IC50	100.0000	1	1
ethacrynic acid	Homo sapiens (human)	IC50	18.3000	1	1
ethacrynic acid	Homo sapiens (human)	Ki	183.0000	1	1
ethylmaleimide	Homo sapiens (human)	Ki	209.0000	1	1
roxarsone	Homo sapiens (human)	IC50	80.0000	1	1
stictic acid	Homo sapiens (human)	IC50	22.0000	1	1
norstictic acid	Homo sapiens (human)	IC50	7.9000	1	1
norstictic acid	Homo sapiens (human)	Ki	90.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calcium channel inhibitor activity	molecular function	Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
actin filament binding	molecular function	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]
protein histidine phosphatase activity	molecular function	Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. [GOC:mec, RHEA:47964]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
nuclear body	cellular component	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
leading edge of lamellipodium	cellular component	That part of the lamellipodium which represents the distal part of the structure. [PMID:22339865]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
actin cytoskeleton organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
peptidyl-histidine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. [GOC:BHF, GOC:vk, PMID:12383260]
negative regulation of T cell receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]
negative regulation of lyase activity	biological process	Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:ai]
lamellipodium organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. [GOC:als, PMID:16054028]
positive regulation of cell motility	biological process	Any process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah]
negative regulation of ATP citrate synthase activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity. [GOC:BHF]

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