A 14 kDa phosphohistidine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRX4]
EC 3.9.1.3;
Phosphohistidine phosphatase 1;
PHPT1;
Protein histidine phosphatase;
PHP;
Protein janus-A homolog
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| acetarsol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ethacrynic acid | Homo sapiens (human) | IC50 | 18.3000 | 1 | 1 |
| ethacrynic acid | Homo sapiens (human) | Ki | 183.0000 | 1 | 1 |
| ethylmaleimide | Homo sapiens (human) | Ki | 209.0000 | 1 | 1 |
| roxarsone | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| stictic acid | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| norstictic acid | Homo sapiens (human) | IC50 | 7.9000 | 1 | 1 |
| norstictic acid | Homo sapiens (human) | Ki | 90.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| calcium channel inhibitor activity | molecular function | Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah] |
| transmembrane transporter binding | molecular function | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372] |
| actin filament binding | molecular function | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732] |
| protein histidine phosphatase activity | molecular function | Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. [GOC:mec, RHEA:47964] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
| leading edge of lamellipodium | cellular component | That part of the lamellipodium which represents the distal part of the structure. [PMID:22339865] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |
| actin cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah] |
| peptidyl-histidine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. [GOC:BHF, GOC:vk, PMID:12383260] |
| negative regulation of T cell receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai] |
| negative regulation of lyase activity | biological process | Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:ai] |
| lamellipodium organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. [GOC:als, PMID:16054028] |
| positive regulation of cell motility | biological process | Any process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah] |
| negative regulation of ATP citrate synthase activity | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity. [GOC:BHF] |