Compounds > mechlorethamine
Page last updated: 2024-10-30

mechlorethamine and Necrosis

mechlorethamine has been researched along with Necrosis in 18 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" Furthermore, 5 days of allopurinol treatment (25 mg/kg iv twice daily) starting 2 days before ischemia or 3 days of oxypurinol treatment (25 mg/kg iv twice daily) starting 15 min before reperfusion did not attenuate the extent of skeletal muscle necrosis in pig LD muscles subjected to 5 h of ischemia and 48 h of reperfusion."3.68Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human. ( Boyd, B; Chiu, C; Dorion, D; Forrest, CR; Pang, CY; Zhong, A, 1993)
" Our earlier report has demonstrated the therapeutic efficacy of silibinin, a natural flavanone, in reversing monofunctional alkylating SM analog 2-chloroethyl ethyl sulfide-induced toxic effects in mouse skin."1.42Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. ( Agarwal, C; Agarwal, R; Inturi, S; Jain, AK; Kumar, D; Orlicky, DJ; Tewari-Singh, N; White, CW, 2015)
"New agents used in cancer chemotherapy are continually appearing which, in turn, leads to newer patterns of toxicity."1.27Toxic lesions of the hand associated with chemotherapy. ( Seyfer, AE; Solimando, DA, 1983)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199013 (72.22)18.7374
1990's2 (11.11)18.2507
2000's0 (0.00)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gary, C1
Gautier, V1
Lazareth, I1
Bagot, M1
Asgari, R1
Priollet, P1
Tewari-Singh, N2
Jain, AK2
Orlicky, DJ2
White, CW2
Agarwal, R2
Inturi, S1
Kumar, D1
Agarwal, C1
TYMIANSKII, RM1
HOCKMAN, RP2
MARK, JB2
CAMPBELL, WG3
BERRY, SR1
CARRINGTON, CB1
JENSCH, L1
Seyfer, AE1
Solimando, DA1
Moore, JV1
Dorion, D1
Zhong, A1
Chiu, C1
Forrest, CR1
Boyd, B1
Pang, CY1
Ben-Ishay, Z1
Farber, E1
Pérez-Tamayo, R1
Becker, I1
Montfort, I1
Pérez-Montfort, R1
Callahan, BC1
Sharer, LR1
Barondess, JA1
Silver, RT1
Gray, GF1
Mitchell, N1
Laurin, C1
Shepard, N1
Müller, M1
Skreb, N1

Other Studies

18 other studies available for mechlorethamine and Necrosis

ArticleYear
[Necrotic leg ulcers after topical application of chlormethine].
    Annales de dermatologie et de venereologie, 2019, Volume: 146, Issue:3

    Topics: Administration, Topical; Aged, 80 and over; Antineoplastic Agents, Alkylating; Female; Humans; Leg U

2019
Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Blister; Chemical Warfare Agents; Dermis; Disease Progression; Epidermis; Hyperkeratosis, E

2014
Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin.
    Toxicology and applied pharmacology, 2015, May-15, Volume: 285, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Cutaneous; Animals; Antidotes; Apoptosis; Cyclooxygenas

2015
[Bone tissue necrosis following use of Gordeev solution].
    Voprosy onkologii, 1958, Volume: 4, Issue:2

    Topics: Bone Diseases; Mechlorethamine; Necrosis; Nitrogen Mustard Compounds

1958
EFFECT OF BRONCHIAL ARTERIAL INFUSION OF MECHLORETHAMINE ON PULMONARY STRUCTURE IN THE EXPERIMENTAL ANIMAL.
    Surgical forum, 1964, Volume: 15

    Topics: Abscess; Axillary Artery; Brachial Artery; Carcinoma; Carcinoma, Bronchogenic; Dogs; Humans; Lung; L

1964
LESIONS IN SUBSYNOVIAL TISSUE. CHANGES IN RABBITS AFTER INTRA-ARTICULAR INJECTIONS OF MECHLORETHAMINE HYDROCHLORIDE ALONE AND TOGETHER WITH AN ADRENOCORTICAL STEROID.
    Archives of pathology, 1965, Volume: 79

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Animals; Arteries; Atrophy; Injections; Injections, Intra-A

1965
EXPERIMENTAL BRONCHIAL ARTERIAL INFUSION OF MECHLORETHAMINE.
    The Journal of thoracic and cardiovascular surgery, 1965, Volume: 50

    Topics: Animals; Arteries; Bronchi; Bronchial Arteries; Dogs; Infusions, Parenteral; Injections; Injections,

1965
[CYTOTOXIC DAMAGE TO THE URINARY TRACT AND KIDNEY BY NITROGEN MUSTARD DERIVATIVES].
    Zeitschrift fur Urologie, 1965, Volume: 58

    Topics: Antineoplastic Agents; Hemorrhage; Kidney; Mechlorethamine; Necrosis; Nitrogen Mustard Compounds; To

1965
Toxic lesions of the hand associated with chemotherapy.
    The Journal of hand surgery, 1983, Volume: 8, Issue:1

    Topics: Adult; Antineoplastic Agents; BCG Vaccine; Bleomycin; Bone Marrow; Burns, Chemical; Doxorubicin; Fem

1983
Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.
    British journal of cancer, 1984, Volume: 49, Issue:1

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Cyclophosphamide; Dactinomycin; Doxorubic

1984
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:1

    Topics: Adult; Allopurinol; Animals; Blood Cell Count; Chromatography, High Pressure Liquid; Female; Humans;

1993
Protective effects of an inhibitor of protein synthesis, cycloheximide, on bone marrow damage induced by cytosine arabinoside or nitrogen mustard.
    Laboratory investigation; a journal of technical methods and pathology, 1975, Volume: 33, Issue:5

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Cycloheximide; Cytarabine; Erythropoi

1975
[Role of leukocytes and amebic proteases in experimental testicular necrosis produced in the rat by Entamoeba histolytica].
    Archivos de investigacion medica, 1990, Volume: 21 Suppl 1

    Topics: alpha-Macroglobulins; Animals; Endopeptidases; Entamoeba histolytica; Entamoebiasis; Leukopenia; Mal

1990
Regeneration of synovium of rabbit knees after total chemical synovectomy by ingrowth of connective tissue-forming elements from adjacent bone. A light and electron microscopic study.
    Laboratory investigation; a journal of technical methods and pathology, 1971, Volume: 24, Issue:5

    Topics: Adenosine Triphosphate; Adipose Tissue; Animals; Cartilage, Articular; Collagen; Connective Tissue C

1971
Association of Hodgkin disease and Gaucher disease.
    Archives of pathology, 1974, Volume: 98, Issue:6

    Topics: Adult; Autopsy; Biopsy; Gaucher Disease; Hodgkin Disease; Humans; Liver; Lymph Nodes; Lymphocytes; M

1974
The effect of osmium tetroxide and nitrogen mustard on normal articular cartilage.
    The Journal of bone and joint surgery. British volume, 1973, Volume: 55, Issue:4

    Topics: Animals; Autoradiography; Cartilage, Articular; Cell Survival; Knee Joint; Mechlorethamine; Microsco

1973
Does nitrogen mustard mimic the x-ray effects in any case?
    Experientia, 1964, Feb-15, Volume: 20, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Eye; Eye Abnormalities; Female; In Vitro Techniques; Me

1964
Synovial fine structure and permeability after intra-articular nitrogen mustard.
    Archives of pathology, 1968, Volume: 85, Issue:2

    Topics: Animals; Immunochemistry; Injections, Intra-Articular; Knee Joint; Mechlorethamine; Microscopy, Elec

1968