Page last updated: 2024-08-07 20:43:43
Reverse transcriptase
[no definition available]
Synonyms
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nevirapine | Human immunodeficiency virus 1 | IC50 | 198.6700 | 7 | 7 |
| efavirenz | Human immunodeficiency virus 1 | IC50 | 0.0643 | 7 | 7 |
| etravirine | Human immunodeficiency virus 1 | IC50 | 0.0186 | 7 | 7 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nevirapine | Human immunodeficiency virus 1 | EC50 | 247.8373 | 10 | 10 |
| efavirenz | Human immunodeficiency virus 1 | EC50 | 0.1053 | 10 | 10 |
| etravirine | Human immunodeficiency virus 1 | EC50 | 0.0121 | 10 | 10 |
| rilpivirine | Human immunodeficiency virus 1 | EC50 | 0.0010 | 4 | 4 |
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020