GTP-binding protein Rheb

A GTP-binding protein Rheb that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15382]

Synonyms

Ras homolog enriched in brain

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bisphenol a	Homo sapiens (human)	Kd	1,800.0000	1	1
4,4'-dihydroxybiphenyl	Homo sapiens (human)	Kd	1,500.0000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
GTPase activity	molecular function	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]
GDP binding	molecular function	Binding to GDP, guanosine 5'-diphosphate. [GOC:ai]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein kinase activator activity	molecular function	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]
protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 4 target(s):

Target	Category	Definition
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endomembrane system	cellular component	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. [GOC:lh]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
spliceosomal complex	cellular component	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
regulation of macroautophagy	biological process	Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]
cellular response to nutrient levels	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]
positive regulation of TOR signaling	biological process	Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]
oligodendrocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015]
positive regulation of oligodendrocyte differentiation	biological process	Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]
regulation of cell cycle	biological process	Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]
negative regulation of cold-induced thermogenesis	biological process	Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]
positive regulation of TORC1 signaling	biological process	Any process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
regulation of type B pancreatic cell development	biological process	Any process that modulates the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]
small GTPase-mediated signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah]