Ubiquitin-like domain-containing CTD phosphatase 1

A ubiquitin-like domain-containing CTD phosphatase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WVY7]

EC 3.1.3.16;
Nuclear proteasome inhibitor UBLCP1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
salicylic acid	Homo sapiens (human)	IC50	66,000.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
protein serine/threonine phosphatase activity	molecular function	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
proteasome regulatory particle binding	molecular function	Binding to a proteasome regulatory particle. [GOC:TermGenie, PMID:16096059]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 3 target(s):

Target	Category	Definition
negative regulation of ATP-dependent activity	biological process	Any process that stops or reduces the rate of an ATP-dependent activity. [GOC:mah]
regulation of proteasome assembly	biological process	Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex. [GOC:dph, GOC:elh, GOC:tb]
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]