Proteins > Sodium/glucose cotransporter 1

Page last updated: 2024-08-07 15:58:00

Sodium/glucose cotransporter 1

A sodium/glucose cotransporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13866]

Synonyms

Na(+)/glucose cotransporter 1;
High affinity sodium-glucose cotransporter;
Solute carrier family 5 member 1

Research

Bioassay Publications (33)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (18.18)	29.6817
2010's	23 (69.70)	24.3611
2020's	4 (12.12)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phloretin	Homo sapiens (human)	IC50	12.4000	1	1
phloretin	Homo sapiens (human)	Ki	86.0000	1	1
phlorhizin	Homo sapiens (human)	IC50	15.6205	13	13
phlorhizin	Homo sapiens (human)	Ki	0.1800	1	1
vexibinol	Homo sapiens (human)	IC50	18.7000	1	1
2',4',6'-Trihydroxydihydrochalcone	Homo sapiens (human)	IC50	7.9000	1	1
2',4',6'-trihydroxychalcone	Homo sapiens (human)	IC50	25.4000	1	1
sergliflozin etabonate	Homo sapiens (human)	IC50	22.0000	2	2
sergliflozin etabonate	Homo sapiens (human)	Ki	7.5400	1	1
remogliflozin etabonate	Homo sapiens (human)	IC50	100.0000	2	2
dapagliflozin	Homo sapiens (human)	IC50	1.9084	15	15
ipragliflozin	Homo sapiens (human)	IC50	1.8760	1	1
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	Homo sapiens (human)	IC50	3.9900	2	2
nothofagin	Homo sapiens (human)	IC50	19.0000	1	1
canagliflozin	Homo sapiens (human)	IC50	0.9497	3	3
pf 04971729	Homo sapiens (human)	IC50	1.4373	3	3
deberza	Homo sapiens (human)	IC50	8.4440	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phlorhizin	Homo sapiens (human)	EC50	0.2009	6	7
dapagliflozin	Homo sapiens (human)	EC50	0.8661	6	7
ipragliflozin	Homo sapiens (human)	EC50	1.9000	1	1
empagliflozin	Homo sapiens (human)	EC50	8.3000	1	1
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	Homo sapiens (human)	EC50	4.0000	1	1
canagliflozin	Homo sapiens (human)	EC50	0.9100	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
galactose transmembrane transporter activity	molecular function	Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729, RHEA:34915]
glucose transmembrane transporter activity	molecular function	Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
myo-inositol:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). [TC:2.A.21.4.-]
water transmembrane transporter activity	molecular function	Enables the transfer of water (H2O) from one side of a membrane to the other. [GOC:ai]
glucose:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
pentose transmembrane transporter activity	molecular function	Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
fucose transmembrane transporter activity	molecular function	Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
alpha-glucoside transmembrane transporter activity	molecular function	Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]
galactose:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]
D-glucose transmembrane transporter activity	molecular function	Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:jid, GOC:jsg, GOC:mah]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
brush border membrane	cellular component	The portion of the plasma membrane surrounding the brush border. [GOC:mah]
intracellular organelle	cellular component	Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
intracellular vesicle	cellular component	Any vesicle that is part of the intracellular region. [GOC:vesicles]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
alpha-glucoside transport	biological process	The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, ISBN:0198506732, PMID:9919658]
intestinal D-glucose absorption	biological process	Uptake of D-glucose into the blood by absorption from the small intestine. [GOC:mgi_curators, PMID:5601832]
response to inorganic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
pentose transmembrane transport	biological process	The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule. [GOC:ai]
fucose transmembrane transport	biological process	The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. [GOC:ai]
galactose transmembrane transport	biological process	The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [GOC:ai]
myo-inositol transport	biological process	The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:ai]
transepithelial water transport	biological process	The directed movement of water (H2O) from one side of an epithelium to the other. [GOC:yaf]
renal glucose absorption	biological process	A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:yaf, PMID:11269503]
glucose import across plasma membrane	biological process	The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
sodium ion import across plasma membrane	biological process	The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
intestinal hexose absorption	biological process	Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine. [GOC:hjd]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
glucose transmembrane transport	biological process	The process in which glucose is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:9090050]
sodium ion transport	biological process	The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]