Proteins > Gag-Pol polyprotein
Page last updated: 2024-08-07 20:37:08
Gag-Pol polyprotein
A lentivirus-type gag-pol polyprotein that is encoded in the genome of human immunodeficiency virus type 1 group M subtype B (isolate HXB2). [PRO:DAN]
Synonyms
Pr160Gag-Pol
Research
Bioassay Publications (59)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (38.98) | 18.2507 |
| 2000's | 26 (44.07) | 29.6817 |
| 2010's | 10 (16.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (50)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ag-1549 | HIV-1 M:B_HXB2R | IC50 | 0.0587 | 1 | 3 |
| nevirapine | HIV-1 M:B_HXB2R | IC50 | 19.1534 | 21 | 39 |
| nevirapine | HIV-1 M:B_HXB2R | Ki | 11.7714 | 1 | 7 |
| delavirdine | HIV-1 M:B_HXB2R | IC50 | 3.3269 | 5 | 9 |
| alizarin | HIV-1 M:B_HXB2R | IC50 | 79.0000 | 1 | 1 |
| methylamine | HIV-1 M:B_HXB2R | IC50 | 2.7000 | 1 | 1 |
| l 697639 | HIV-1 M:B_HXB2R | IC50 | 0.0200 | 2 | 2 |
| atevirdine | HIV-1 M:B_HXB2R | IC50 | 23.1943 | 4 | 7 |
| efavirenz | HIV-1 M:B_HXB2R | IC50 | 2.1778 | 15 | 25 |
| efavirenz | HIV-1 M:B_HXB2R | Ki | 0.1400 | 1 | 7 |
| nelfinavir | HIV-1 M:B_HXB2R | Ki | 0.2687 | 2 | 12 |
| nsc 624231 | HIV-1 M:B_HXB2R | IC50 | 33.2500 | 2 | 2 |
| 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine | HIV-1 M:B_HXB2R | IC50 | 17.0000 | 1 | 1 |
| l 693593 | HIV-1 M:B_HXB2R | IC50 | 3.7000 | 2 | 2 |
| l-697661 | HIV-1 M:B_HXB2R | IC50 | 6.9986 | 8 | 14 |
| emivirine | HIV-1 M:B_HXB2R | IC50 | 0.0400 | 3 | 4 |
| amprenavir | HIV-1 M:B_HXB2R | Ki | 0.0163 | 1 | 4 |
| 4-fluorobenzylamine | HIV-1 M:B_HXB2R | IC50 | 4.0500 | 1 | 1 |
| u 88204 | HIV-1 M:B_HXB2R | IC50 | 1.2000 | 1 | 1 |
| beta-thujaplicinol | HIV-1 M:B_HXB2R | IC50 | 3.8000 | 1 | 1 |
| 4-methoxybenzylamine | HIV-1 M:B_HXB2R | IC50 | 3.9200 | 1 | 1 |
| 1-(2',6'-difluorophenyl)-1h,3h-thiazolo(3,4-a)benzimidazole | HIV-1 M:B_HXB2R | IC50 | 24.5700 | 1 | 1 |
| l 696040 | HIV-1 M:B_HXB2R | IC50 | 0.2100 | 2 | 2 |
| dmp 450 | HIV-1 M:B_HXB2R | Ki | 0.0003 | 1 | 1 |
| gw420867x | HIV-1 M:B_HXB2R | IC50 | 0.1790 | 1 | 1 |
| l 734005 | HIV-1 M:B_HXB2R | IC50 | 0.8380 | 1 | 3 |
| 2-benzyloxybenzaldehyde | HIV-1 M:B_HXB2R | IC50 | 1.7500 | 1 | 1 |
| ritonavir | HIV-1 M:B_HXB2R | Ki | 0.3932 | 2 | 12 |
| adam ii | HIV-1 M:B_HXB2R | IC50 | 0.6200 | 4 | 5 |
| saquinavir | HIV-1 M:B_HXB2R | Ki | 0.6764 | 1 | 4 |
| a 76928 | HIV-1 M:B_HXB2R | Ki | 0.0052 | 1 | 2 |
| je 2147 | HIV-1 M:B_HXB2R | Ki | 0.0023 | 1 | 8 |
| l 737126 | HIV-1 M:B_HXB2R | IC50 | 0.8958 | 2 | 6 |
| bevirimat | HIV-1 M:B_HXB2R | IC50 | 0.5520 | 1 | 1 |
| 5-(1,1-dioxido-1,2-thiazinan-2-yl)-n-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide | HIV-1 M:B_HXB2R | IC50 | 0.0285 | 2 | 2 |
| dpc 961 | HIV-1 M:B_HXB2R | IC50 | 0.0320 | 1 | 1 |
| l 731988 | HIV-1 M:B_HXB2R | IC50 | 0.0370 | 1 | 1 |
| l 708906 | HIV-1 M:B_HXB2R | IC50 | 0.0590 | 1 | 1 |
| 3-dimethylamino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1h)-one | HIV-1 M:B_HXB2R | IC50 | 0.0200 | 1 | 1 |
| r-82913 | HIV-1 M:B_HXB2R | IC50 | 13.2473 | 3 | 7 |
| hby 097 | HIV-1 M:B_HXB2R | IC50 | 0.0243 | 1 | 3 |
| trovirdine | HIV-1 M:B_HXB2R | IC50 | 0.7400 | 2 | 4 |
| ly 73497 | HIV-1 M:B_HXB2R | IC50 | 0.9000 | 1 | 1 |
| dpc 083 | HIV-1 M:B_HXB2R | IC50 | 0.0230 | 1 | 1 |
| indinavir sulfate | HIV-1 M:B_HXB2R | Ki | 0.5246 | 3 | 22 |
| l 682679 | HIV-1 M:B_HXB2R | IC50 | 0.0006 | 1 | 1 |
| brecanavir | HIV-1 M:B_HXB2R | Ki | 0.0000 | 1 | 4 |
| rilpivirine | HIV-1 M:B_HXB2R | IC50 | 0.0680 | 1 | 1 |
| n-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide | HIV-1 M:B_HXB2R | IC50 | 0.0120 | 1 | 1 |
| raltegravir | HIV-1 M:B_HXB2R | IC50 | 0.0150 | 1 | 1 |
| tipranavir | HIV-1 M:B_HXB2R | Ki | 0.0000 | 1 | 1 |
| 2-(methylthio)-6-(phenylmethyl)-1H-pyrimidin-4-one | HIV-1 M:B_HXB2R | IC50 | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bevirimat | HIV-1 M:B_HXB2R | EC50 | 0.4369 | 5 | 5 |
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
[no title available]
Biochemistry, , Jan-10, Volume: 56, Issue:1, 2017
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic chemistry, , Volume: 70, 2017
Synthesis and HIV-1 RT inhibitory action of novel (4/6-substituted benzo[d]thiazol -2-yl)thiazolidin-4-ones. Divergence from the non-competitive inhibition mechanism.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:1, 2013
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 12, Issue:23, 2004
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Aug-02, Volume: 44, Issue:16, 2001
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.
Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.
Journal of medicinal chemistry, , May-09, Volume: 40, Issue:10, 1997
5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry, , Volume: 4, Issue:6, 1996
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.
Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Biochemistry, , Jan-10, Volume: 56, Issue:1, 2017
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic chemistry, , Volume: 70, 2017
Synthesis and HIV-1 RT inhibitory action of novel (4/6-substituted benzo[d]thiazol -2-yl)thiazolidin-4-ones. Divergence from the non-competitive inhibition mechanism.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:1, 2013
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 12, Issue:23, 2004
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Aug-02, Volume: 44, Issue:16, 2001
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.
Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.
Journal of medicinal chemistry, , May-09, Volume: 40, Issue:10, 1997
5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry, , Volume: 4, Issue:6, 1996
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.
Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: a potent lead for the design of novel NNRTIs.
Bioorganic & medicinal chemistry letters, , Feb-07, Volume: 10, Issue:3, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Bioorganic & medicinal chemistry letters, , Feb-07, Volume: 10, Issue:3, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives.
Bioorganic chemistry, , Volume: 72, 2017
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.
Chembiochem : a European journal of chemical biology, , 02-16, Volume: 18, Issue:4, 2017
Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives.
Bioorganic chemistry, , Volume: 67, 2016
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives.
Bioorganic & medicinal chemistry, , Feb-15, Volume: 13, Issue:4, 2005
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 12, Issue:23, 2004
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jul-23, Volume: 11, Issue:14, 2001
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).
Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 9, Issue:22, 1999
Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 9, Issue:19, 1999
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Bioorganic chemistry, , Volume: 72, 2017
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.
Chembiochem : a European journal of chemical biology, , 02-16, Volume: 18, Issue:4, 2017
Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives.
Bioorganic chemistry, , Volume: 67, 2016
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
Journal of medicinal chemistry, , Feb-26, Volume: 52, Issue:4, 2009
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives.
Bioorganic & medicinal chemistry, , Feb-15, Volume: 13, Issue:4, 2005
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 12, Issue:23, 2004
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jul-23, Volume: 11, Issue:14, 2001
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).
Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 9, Issue:22, 1999
Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 9, Issue:19, 1999
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Journal of medicinal chemistry, , Jun-07, Volume: 44, Issue:12, 2001
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Journal of medicinal chemistry, , Jun-07, Volume: 44, Issue:12, 2001
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C varia
Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C varia
Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Aug-02, Volume: 44, Issue:16, 2001
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Aug-02, Volume: 44, Issue:16, 2001
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Inhibition of wild-type and mutant human immunodeficiency virus type 1 proteases by GW0385 and other arylsulfonamides.
Biochemistry, , Nov-16, Volume: 43, Issue:45, 2004
Biochemistry, , Nov-16, Volume: 43, Issue:45, 2004
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.
The Journal of biological chemistry, , Jun-06, Volume: 289, Issue:23, 2014
The Journal of biological chemistry, , Jun-06, Volume: 289, Issue:23, 2014
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors.
Journal of medicinal chemistry, , Jan-14, Volume: 42, Issue:1, 1999
Journal of medicinal chemistry, , Jan-14, Volume: 42, Issue:1, 1999
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Journal of combinatorial chemistry, , Volume: 12, Issue:1
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings.
Bioorganic & medicinal chemistry, , Volume: 10, Issue:2, 2002
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Nov-18, Volume: 42, Issue:23, 1999
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Bioorganic & medicinal chemistry, , Volume: 10, Issue:2, 2002
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Nov-18, Volume: 42, Issue:23, 1999
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorganic & medicinal chemistry letters, , 05-15, Volume: 28, Issue:9, 2018
Bioorganic & medicinal chemistry letters, , 05-15, Volume: 28, Issue:9, 2018
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
Discovery of HIV-1 integrase inhibitors: pharmacophore mapping, virtual screening, molecular docking, synthesis, and biological evaluation.
Chemical biology & drug design, , Volume: 83, Issue:2, 2014
Chemical biology & drug design, , Volume: 83, Issue:2, 2014
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.
Proceedings of the National Academy of Sciences of the United States of America, , Apr-26, Volume: 91, Issue:9, 1994
Biochemistry, , Sep-28, Volume: 43, Issue:38, 2004
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.
Proceedings of the National Academy of Sciences of the United States of America, , Apr-26, Volume: 91, Issue:9, 1994
Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Inhibition of wild-type and mutant human immunodeficiency virus type 1 proteases by GW0385 and other arylsulfonamides.
Biochemistry, , Nov-16, Volume: 43, Issue:45, 2004
Biochemistry, , Nov-16, Volume: 43, Issue:45, 2004
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic chemistry, , Volume: 70, 2017
Bioorganic chemistry, , Volume: 70, 2017
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines.
Journal of medicinal chemistry, , Aug-18, Volume: 38, Issue:17, 1995
Journal of medicinal chemistry, , Aug-18, Volume: 38, Issue:17, 1995