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Thymidylate kinase
A protein that is a translation product of the tmk gene in Mycobacterium tuberculosis H37Rv. [PRO:DNx, UniProtKB:P9WKE1]
Synonyms
EC 2.7.4.9;
Thymidine monophosphate kinase;
dTMP kinase;
TMPK
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
LEA3D: a computer-aided ligand design for structure-based drug design.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Dec-02, Volume: 47, Issue:25, 2004
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
[no title available],
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
LEA3D: a computer-aided ligand design for structure-based drug design.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Dec-02, Volume: 47, Issue:25, 2004
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Bioorganic & medicinal chemistry letters, , Oct-07, Volume: 12, Issue:19, 2002