Peptidyl-prolyl cis-trans isomerase FKBP4

A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02790]

Synonyms

PPIase FKBP4;
EC 5.2.1.8;
51 kDa FK506-binding protein;
FKBP51;
52 kDa FK506-binding protein;
52 kDa FKBP;
FKBP-52;
59 kDa immunophilin;
p59;
FK506-binding protein 4;
FKBP-4;
FKBP59;
HSP-binding immunophili

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	2 (50.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cycloheximide	Homo sapiens (human)	Ki	24.2000	1	1
3-(3-pyridyl)-1-propyl-(2s)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate	Homo sapiens (human)	IC50	100.0000	1	1
biricodar	Homo sapiens (human)	IC50	7.3700	1	1
pd 407824	Homo sapiens (human)	IC50	50.0000	2	2
l 683590	Homo sapiens (human)	IC50	8.0000	1	1
cyclosporine	Homo sapiens (human)	IC50	0.0160	1	1
timcodar	Homo sapiens (human)	IC50	100.0000	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
peptidyl-prolyl cis-trans isomerase activity	molecular function	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]
FK506 binding	molecular function	Binding to a 23-membered macrolide lactone FK506. [GOC:jl]
protein-macromolecule adaptor activity	molecular function	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
heat shock protein binding	molecular function	Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]
copper-dependent protein binding	molecular function	Binding to a protein or protein complex, in the presence of copper. [GOC:ecd, PMID:16884690]
nuclear glucocorticoid receptor binding	molecular function	Binding to a nuclear glucocorticoid receptor. [GOC:bf]
tau protein binding	molecular function	Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]
phosphoprotein binding	molecular function	Binding to a phosphorylated protein. [GOC:ai]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
microtubule	cellular component	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
axonal growth cone	cellular component	The migrating motile tip of a growing nerve cell axon. [GOC:jl, NIF_Subcellular:sao203987954]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
steroid hormone receptor complex assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. [GOC:jl, Wikipedia:Steroid_hormone_receptor]
copper ion transport	biological process	The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
embryo implantation	biological process	Attachment of the blastocyst to the uterine lining. [GOC:isa_complete, http://www.medterms.com]
negative regulation of neuron projection development	biological process	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
androgen receptor signaling pathway	biological process	The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]
prostate gland development	biological process	The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. [PMID:11839751]
negative regulation of microtubule polymerization or depolymerization	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. [GOC:mah]
negative regulation of microtubule polymerization	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. [GOC:mah]
protein-containing complex localization	biological process	A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. [GOC:mah]
male sex differentiation	biological process	The establishment of the sex of a male organism by physical differentiation. [GOC:bf]
chaperone-mediated protein folding	biological process	The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. [GOC:dph, GOC:vw]
protein peptidyl-prolyl isomerization	biological process	The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570]