orotic acid has been researched along with Necrosis in 18 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury." | 3.75 | Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. ( Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Veveris, M; Vilskersts, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vilskersts, R | 1 |
| Liepinsh, E | 1 |
| Kuka, J | 1 |
| Cirule, H | 1 |
| Veveris, M | 1 |
| Kalvinsh, I | 1 |
| Dambrova, M | 1 |
| DECLOITRE, F | 1 |
| LOWY, R | 1 |
| Clifford, JI | 1 |
| Rees, KR | 1 |
| Rao, PM | 2 |
| Nagamine, K | 1 |
| Ho, RK | 1 |
| Roomi, MW | 1 |
| Laurier, C | 1 |
| Rajalakshmi, S | 2 |
| Sarma, DS | 2 |
| Rossiello, MR | 1 |
| Laconi, E | 1 |
| Barbieri, L | 1 |
| Gasperi-Campani, A | 1 |
| Derenzini, M | 1 |
| Betts, CM | 1 |
| Stirpe, F | 1 |
| Porta, EA | 2 |
| Kopteva, LA | 1 |
| Zhevaliukova, LI | 1 |
| Demin, AA | 1 |
| Krylov, BV | 1 |
| Mitova, M | 1 |
| Bednarik, B | 1 |
| Klein, A | 1 |
| Pappas, SC | 1 |
| Gordon, P | 1 |
| Wong, A | 1 |
| Kellen, J | 1 |
| Kolin, A | 1 |
| Robinson, JB | 1 |
| Malkin, A | 1 |
| Raick, AN | 1 |
| Burdzy, K | 1 |
| Szabó, J | 1 |
| Csáky, L | 1 |
| Stewart, BW | 1 |
| Magee, PN | 1 |
| Simon, JB | 1 |
| Scheig, R | 1 |
| Klatskin, G | 1 |
| Monserrat, AJ | 1 |
| Hartroft, WS | 1 |
| Badawy, AA | 1 |
| White, AE | 1 |
| Lathe, GH | 1 |
| Zaki, GF | 1 |
2 reviews available for orotic acid and Necrosis
| Article | Year |
|---|---|
Nutrition and diseases of the liver and gallbladder.
Topics: Alcoholism; Animals; Atrophy; Avitaminosis; Fatty Acids, Essential; Fatty Liver; Gallbladder Disease | 1975 |
[Stimulation of the restorative processes in myocardial infarct].
Topics: Amino Acids; Anabolic Agents; Animals; Cardiac Glycosides; DNA; Drug Therapy, Combination; Folic Aci | 1976 |
16 other studies available for orotic acid and Necrosis
| Article | Year |
|---|---|
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Drug Synergism; Drug Ther | 2009 |
[EFFECT OF OROTIC ACID ON THE PROCESSES OF NECROSIS AND TISSUE REPAIR IN THE RAT].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Chemical and Drug Induced Liver Injury; Colorimetry; DN | 1964 |
The action of aflatoxin B1 on the rat liver.
Topics: Aflatoxins; Animals; Carbon Isotopes; Chemical and Drug Induced Liver Injury; DNA; Glutamate Dehydro | 1967 |
Dietary orotic acid enhances the incidence of gamma-glutamyltransferase positive foci in rat liver induced by chemical carcinogens.
Topics: Acyltransferases; Administration, Oral; Animals; Carcinogens; Cell Division; DNA Replication; Drug S | 1983 |
Induction of hepatic nodules in the rat by aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver | 1993 |
Selective lesions of acinar pancreatic cells in rats poisoned with abrin. A morphological and biochemical study.
Topics: Abrin; Animals; Depression, Chemical; Male; Microscopy, Electron; Microsomes; Necrosis; Orotic Acid; | 1979 |
[Effect of disseminated necrotic heart lesions on incorporation of radioactive precursors into the RNA of the inner membranes of rat myocardial mitochondria].
Topics: Animals; Heart Diseases; Male; Membranes; Mitochondria, Heart; Necrosis; Orotic Acid; Rats; RNA | 1977 |
Influencing heart necroses caused by application of isoproterenol, potassium orotat.
Topics: Animals; Female; Heart Diseases; Isoproterenol; Male; Necrosis; Orotic Acid; Rats | 1976 |
The effect of nonviral liver damage on the T-lymphocyte helper/suppressor ratio.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Leukocyte Count; Necrosis; Orotic Ac | 1988 |
Ultrastructural and biochemical changes induced in mouse epidermis by a hyperplastic agent, ethylphenylpropiolate.
Topics: Animals; Cell Differentiation; Cell Division; Cell Nucleolus; Chromatin; Cytoplasm; DNA; Endoplasmic | 1973 |
[Myocardial necrosis induced with isoproterenol in rat heart].
Topics: Animals; Carbon Radioisotopes; Heart; Hypoxia; Isoproterenol; Myocardial Infarction; Myocardium; Nec | 1974 |
Effect of a single dose of dimethylnitrosamine on biosynthesis of nucleic acid and protein in rat liver and kidney.
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; DNA; Female; Kidney; Kidney Neoplasms; L | 1971 |
Protection by orotic acid against the renal necrosis and fatty liver of choline deficiency.
Topics: Adenine; Animals; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Male; Necrosis; Orotic | 1968 |
Orotic acid effects on the kidney. Changes in choline-deficient weanling rats.
Topics: Animals; Blood Urea Nitrogen; Cholesterol; Choline Deficiency; Diet; Kidney; Lipids; Male; Microscop | 1969 |
The effect of tannic acid on the synthesis of protein and nucleic acid by rat liver.
Topics: Animals; Carbon Isotopes; Cell Nucleus; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Leuci | 1969 |
Fatty cirrhosis in the rat.
Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats; | 1966 |