Page last updated: 2024-10-19

orotic acid and Necrosis

orotic acid has been researched along with Necrosis in 18 studies

Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury."3.75Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. ( Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Veveris, M; Vilskersts, R, 2009)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199016 (88.89)18.7374
1990's1 (5.56)18.2507
2000's1 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vilskersts, R1
Liepinsh, E1
Kuka, J1
Cirule, H1
Veveris, M1
Kalvinsh, I1
Dambrova, M1
DECLOITRE, F1
LOWY, R1
Clifford, JI1
Rees, KR1
Rao, PM2
Nagamine, K1
Ho, RK1
Roomi, MW1
Laurier, C1
Rajalakshmi, S2
Sarma, DS2
Rossiello, MR1
Laconi, E1
Barbieri, L1
Gasperi-Campani, A1
Derenzini, M1
Betts, CM1
Stirpe, F1
Porta, EA2
Kopteva, LA1
Zhevaliukova, LI1
Demin, AA1
Krylov, BV1
Mitova, M1
Bednarik, B1
Klein, A1
Pappas, SC1
Gordon, P1
Wong, A1
Kellen, J1
Kolin, A1
Robinson, JB1
Malkin, A1
Raick, AN1
Burdzy, K1
Szabó, J1
Csáky, L1
Stewart, BW1
Magee, PN1
Simon, JB1
Scheig, R1
Klatskin, G1
Monserrat, AJ1
Hartroft, WS1
Badawy, AA1
White, AE1
Lathe, GH1
Zaki, GF1

Reviews

2 reviews available for orotic acid and Necrosis

ArticleYear
Nutrition and diseases of the liver and gallbladder.
    Progress in food & nutrition science, 1975, Volume: 1, Issue:5

    Topics: Alcoholism; Animals; Atrophy; Avitaminosis; Fatty Acids, Essential; Fatty Liver; Gallbladder Disease

1975
[Stimulation of the restorative processes in myocardial infarct].
    Kardiologiia, 1976, Volume: 16, Issue:10

    Topics: Amino Acids; Anabolic Agents; Animals; Cardiac Glycosides; DNA; Drug Therapy, Combination; Folic Aci

1976

Other Studies

16 other studies available for orotic acid and Necrosis

ArticleYear
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
    Cardiovascular drugs and therapy, 2009, Volume: 23, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Drug Synergism; Drug Ther

2009
[EFFECT OF OROTIC ACID ON THE PROCESSES OF NECROSIS AND TISSUE REPAIR IN THE RAT].
    Enzymologia biologica et clinica, 1964, Volume: 74

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Chemical and Drug Induced Liver Injury; Colorimetry; DN

1964
The action of aflatoxin B1 on the rat liver.
    The Biochemical journal, 1967, Volume: 102, Issue:1

    Topics: Aflatoxins; Animals; Carbon Isotopes; Chemical and Drug Induced Liver Injury; DNA; Glutamate Dehydro

1967
Dietary orotic acid enhances the incidence of gamma-glutamyltransferase positive foci in rat liver induced by chemical carcinogens.
    Carcinogenesis, 1983, Volume: 4, Issue:12

    Topics: Acyltransferases; Administration, Oral; Animals; Carcinogens; Cell Division; DNA Replication; Drug S

1983
Induction of hepatic nodules in the rat by aristolochic acid.
    Cancer letters, 1993, Jul-30, Volume: 71, Issue:1-3

    Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver

1993
Selective lesions of acinar pancreatic cells in rats poisoned with abrin. A morphological and biochemical study.
    Virchows Archiv. B, Cell pathology including molecular pathology, 1979, May-04, Volume: 30, Issue:1

    Topics: Abrin; Animals; Depression, Chemical; Male; Microscopy, Electron; Microsomes; Necrosis; Orotic Acid;

1979
[Effect of disseminated necrotic heart lesions on incorporation of radioactive precursors into the RNA of the inner membranes of rat myocardial mitochondria].
    Biulleten' eksperimental'noi biologii i meditsiny, 1977, Volume: 84, Issue:11

    Topics: Animals; Heart Diseases; Male; Membranes; Mitochondria, Heart; Necrosis; Orotic Acid; Rats; RNA

1977
Influencing heart necroses caused by application of isoproterenol, potassium orotat.
    Scripta medica, 1976, Volume: 49, Issue:6-7

    Topics: Animals; Female; Heart Diseases; Isoproterenol; Male; Necrosis; Orotic Acid; Rats

1976
The effect of nonviral liver damage on the T-lymphocyte helper/suppressor ratio.
    Clinical immunology and immunopathology, 1988, Volume: 46, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Leukocyte Count; Necrosis; Orotic Ac

1988
Ultrastructural and biochemical changes induced in mouse epidermis by a hyperplastic agent, ethylphenylpropiolate.
    Cancer research, 1973, Volume: 33, Issue:10

    Topics: Animals; Cell Differentiation; Cell Division; Cell Nucleolus; Chromatin; Cytoplasm; DNA; Endoplasmic

1973
[Myocardial necrosis induced with isoproterenol in rat heart].
    Acta pharmaceutica Hungarica, 1974, Volume: 44, Issue:1

    Topics: Animals; Carbon Radioisotopes; Heart; Hypoxia; Isoproterenol; Myocardial Infarction; Myocardium; Nec

1974
Effect of a single dose of dimethylnitrosamine on biosynthesis of nucleic acid and protein in rat liver and kidney.
    The Biochemical journal, 1971, Volume: 125, Issue:4

    Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; DNA; Female; Kidney; Kidney Neoplasms; L

1971
Protection by orotic acid against the renal necrosis and fatty liver of choline deficiency.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 129, Issue:3

    Topics: Adenine; Animals; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Male; Necrosis; Orotic

1968
Orotic acid effects on the kidney. Changes in choline-deficient weanling rats.
    Archives of pathology, 1969, Volume: 87, Issue:2

    Topics: Animals; Blood Urea Nitrogen; Cholesterol; Choline Deficiency; Diet; Kidney; Lipids; Male; Microscop

1969
The effect of tannic acid on the synthesis of protein and nucleic acid by rat liver.
    The Biochemical journal, 1969, Volume: 113, Issue:2

    Topics: Animals; Carbon Isotopes; Cell Nucleus; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Leuci

1969
Fatty cirrhosis in the rat.
    Archives of pathology, 1966, Volume: 81, Issue:6

    Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats;

1966