Page last updated: 2024-08-07 23:14:30
Galectin-1
A galectin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09382]
Synonyms
Gal-1;
14 kDa laminin-binding protein;
HLBP14;
14 kDa lectin;
Beta-galactoside-binding lectin L-14-I;
Galaptin;
HBL;
HPL;
Lactose-binding lectin 1;
Lectin galactoside-binding soluble 1;
Putative MAPK-activating pro
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 5 (45.45) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lactose | Homo sapiens (human) | IC50 | 800.0000 | 1 | 1 |
| galactose | Homo sapiens (human) | IC50 | 50,000.0000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lactose | Homo sapiens (human) | Activity | 800.0000 | 1 | 1 |
| galactose | Homo sapiens (human) | Activity | 50,000.0000 | 1 | 1 |
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Synthesis of stable and selective inhibitors of human galectins-1 and -3.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: role of electrostatic potential at O-3.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 16, Issue:6, 2006
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.ACS medicinal chemistry letters, , Nov-11, Volume: 12, Issue:11, 2021
[no title available]ACS medicinal chemistry letters, , Jan-09, Volume: 11, Issue:1, 2020
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors.MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia.Journal of medicinal chemistry, , 04-28, Volume: 65, Issue:8, 2022
Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Synthesis of stable and selective inhibitors of human galectins-1 and -3.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: role of electrostatic potential at O-3.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 16, Issue:6, 2006
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| laminin binding | molecular function | Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. [GOC:ecd] |
| lactose binding | molecular function | Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. [GOC:jl, ISBN:0192800981] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| galectin complex | cellular component | A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes. [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940] |
Involved In
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|
| plasma cell differentiation | biological process | The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. [GOC:jal] |
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| T cell costimulation | biological process | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149] |
| regulation of apoptotic process | biological process | Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation of canonical NF-kappaB signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl] |
| myoblast differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle] |
| positive regulation of viral entry into host cell | biological process | Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. [GOC:jl] |
| positive regulation of inflammatory response | biological process | Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| cell-cell adhesion | biological process | The attachment of one cell to another cell via adhesion molecules. [GOC:dos] |