| Excerpt | Reference | Relevance |
|---|
| " The lesions of urinary bladder were judged as S-1090-induced toxic changes and the NOAEL of S-1090 in this study was assessed to be 100 mg potency/kg/day." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (7)--Three-month repeated oral dose toxicity study in juvenile dogs].
Hayashi, T; Karaki, K; Kato, I; Kimura, Y; Mizushima, Y; Moriyama, T; Nakano, M; Nishimura, K; Sawada, T; Yoneyama, S, 2001) | 0.64 |
| "Cefmatilen hydrochloride hydrate (S-1090) was administered daily by gavage to rats at doses of 100, 300 or 1000 mg potency/kg/day prior to and in the early stage of pregnancy to assess its adverse effects on parental reproductive ability and embryo-fetal development." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (1)--A study on oral administration prior to and in the early stages of pregnancy in rats].
Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Muraoka, Y; Uchida, H; Yoshida, T, 2001) | 2 |
| " No adverse effects were observed in F2 offspring." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (2)--A study on oral administration during the period of organogenesis in rats].
Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Uchida, H; Yoshida, T, 2001) | 0.55 |
| " No adverse effects were observed in F2 fetuses and offspring." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (4)--A study on oral administration during the perinatal and lactation periods in rats].
Andou, M; Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Ito, M; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Muraoka, Y; Uchida, H; Yoshida, T, 2001) | 0.55 |
| Excerpt | Relevance | Reference |
|---|
| " Diarrhea occurred on the dosing day and slightly soft feces lasted until 6 days after administration." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (1)--Single oral and intravenous dose toxicity studies in rats].
Furukawa, H; Harihara, A; Kato, I; Kii, Y; Kitamura, T; Miyauchi, H; Muraoka, Y; Nishimura, K; Sato, K; Yabuuchi, K; Yahara, I, 2001) | 0.64 |
| " The changes observed in both studies were soft feces, abdominal distention, increased food and water consumption, decreases of urine volume and pH, and a decrease of blood neutrophils in almost all treated groups, reddish-brown feces (due to chelated products of S-1090 and its decomposition products with Fe3+ in the diet) in groups dosed at 300 mg potency/kg or more, and a lower mature granulocyte ratio in the bone marrow in groups dosed at 1000 mg potency/kg or more." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (3)--One- and three-month repeated oral dose toxicity studies in rats].
Furukawa, H; Harihara, A; Hirata, M; Inoue, S; Kato, I; Kitamura, T; Moriyama, T; Muraoka, Y; Nishimura, K; Sato, K; Ueno, M; Yabuuchi, K, 2001) | 0.64 |
| " In the thyroids, an increased weight in some animals in the groups dosed at 100 mg potency/kg or more and an increased follicular colloid in the 400 mg potency/kg group were observed." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (7)--Three-month repeated oral dose toxicity study in juvenile dogs].
Hayashi, T; Karaki, K; Kato, I; Kimura, Y; Mizushima, Y; Moriyama, T; Nakano, M; Nishimura, K; Sawada, T; Yoneyama, S, 2001) | 0.64 |
| " Loose and/or reddish brown feces were observed in both males and females of all the S-1090 dosing groups, and abdominal distention was also observed in males throughout the dosing period." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (1)--A study on oral administration prior to and in the early stages of pregnancy in rats].
Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Muraoka, Y; Uchida, H; Yoshida, T, 2001) | 0.55 |
| " Loose or reddish-brown feces were observed in dams of all the S-1090 dosing groups." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (2)--A study on oral administration during the period of organogenesis in rats].
Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Uchida, H; Yoshida, T, 2001) | 0.55 |
| " In dams, loose feces/reddish brown feces, increased cecum weight, decreased weights of the heart, spleen and submaxillary gland in all the S-1090 dosing groups and a decreased weight of the thymus in the 1000 mg potency/kg dosing group were observed." | ( [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (4)--A study on oral administration during the perinatal and lactation periods in rats].
Andou, M; Hara, K; Hirashiba, M; Hishikawa, A; Ikeuchi, K; Ito, M; Kanamori, S; Kaneto, M; Kawai, M; Kishi, K; Muranaka, R; Muraoka, Y; Uchida, H; Yoshida, T, 2001) | 0.55 |
| "5% aqueous methylcellulose was administered by oral gavage up to 2000 mg/kg/day in single and double dosing groups." | ( [Genotoxicity studies of cefmatilen hydrochloride hydrate (S-1090)].
Kondo, K; Miyajima, H; Miyake, Y; Nishimoto, Y; Shiratori, O; Takase, S, 2001) | 0.61 |
| " Vomiting, diarrhea or mucous feces occurred on the dosing day, and reddish-brown feces (due to chelated products of S-1090 and its decomposition products with Fe3+ in the diet) were also observed on the dosing and next day." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (2)--Single oral dose toxicity study in dogs].
Furukawa, H; Harihara, A; Hirata, M; Inoue, S; Kato, I; Kimura, Y; Miyauchi, H; Nishimura, K; Sato, K; Ueno, M; Yabuuchi, K, 2001) | 0.64 |
| " Decreased intestinal flora were noted in all the groups treated with S-1090 or CFDN at the end of the dosing period." | ( [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (5)--Six-month repeated oral dose toxicity study and supplement study in rats].
Chihaya, Y; Furukawa, H; Itoh, F; Kato, I; Mizushima, Y; Nishimura, Y; Ohno, K; Omori, M; Sameshima, H; Ueno, M; Yabuuchi, K; Yahara, I; Yoshida, I, 2001) | 0.64 |