A kynurenine 3-monooxygenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15229]
[no title available]Bioorganic & medicinal chemistry letters, , 04-15, Volume: 27, Issue:8, 2017
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:12, 2012
| Target | Category | Definition |
|---|
| kynurenine 3-monooxygenase activity | molecular function | Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+. [EC:1.14.13.9, RHEA:20545] |
| NAD(P)H oxidase H2O2-forming activity | molecular function | Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874, RHEA:11260] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
| FAD binding | molecular function | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah] |
| Target | Category | Definition |
|---|
| tryptophan catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684] |
| response to salt stress | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl] |
| NAD metabolic process | biological process | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153] |
| quinolinate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. [GOC:ai] |
| kynurenic acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. [GOC:mah] |
| 'de novo' NAD biosynthetic process from tryptophan | biological process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [PMID:17161604] |
| anthranilate metabolic process | biological process | The chemical reactions and pathways involving anthranilate (2-aminobenzoate). [GOC:jl] |
| kynurenine metabolic process | biological process | The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. [CHEBI:28683, GOC:mah, GOC:rph] |
| cellular response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah] |
| cellular response to interleukin-1 | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah] |
| L-kynurenine metabolic process | biological process | The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf] |
| positive regulation of glutamate secretion, neurotransmission | biological process | Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter. [GO_REF:0000058, GOC:TermGenie, PMID:16782817] |